UNIT -1 IMPORTANCE OF FOOD AND NUTRITION INRELATION TO HUMAN BEINGS & NUTRITIONAL ELEMENTS General objective ►After completion of the Unit-1, the students should be able to recognize the importance of food and nutrition and the functions which food contributes to the body. Specific Objectives: ►After completion of the class students should be able to: ►Define food. ►Define Nutrition. ►Define Nutrient. ►Define Calorie. ►Recognize the functions of food and nutrition in relation to human being. Definitions ►Nutrition: It is defined as the science of food and its relationship to health. ►Nutrients: Defined as the food or other substance that provides energy or building material for the survival and growth of a living organism. ►Food: Anything which taken in to the body, serves to nourish or build up tissues or to supply body heat. ►Calories: The power of the animal body of developing and maintaining heat. ►Balanced Diet: This is the diet which provides adequate amount of all nutrients, not too much or not too little. Functions of food and Nutrition in relation to the human being ► Provide body fluid and to help regulate body temperature. ► As fuel for energy for body heat and work. ► For growth and repair. ► For developing body tissues. ► For metabolic processes and protection. ► To form a vehicle for other nutrients, add bulk to the diet. ► Provide a habitat for bacterial flora and assist proper elimination of refuse. Factors contributing to increased food intake Advertising of high – calorie foods targeted at children and adults Vending machine selling high-sugar drinks and highfat snacks Greater number of meals eaten in restaurants Continuous snacking Indications of Food and Nutrition Signals The nutritional health of an individual is referred to as his or her nutritional status and describes how well nutrient needs are being met. Measurements used to evaluate Nutritional status ►It is related to ►Dietary intake Where and when food is eaten Use of dietary supplement Food sources Special diet if any Cooking facilities ► Biochemical measurements Blood vitamin levels Blood Protein levels Blood Lipid Levels ► Anthropometric Measurements Body weight or height (Body Mass index) Skin fold Thickness Waist circumference ► Clinical Measures Skin Hair Eyes Importance of culture and religion in food Judaism: Meat:- Pork is forbidden, but other forms of poultry are allowed. Meat must be rigidly cleansed of all blood. Meat and milk may not be combined. Orthodox homes maintain two sets of dishes and cooking utensils – one for serving meat and the other for meals containing dairy products. Fish with fins and scales are allowed in the diet, but no shell fish is allowed. Islamic food culture Muslim dietary laws are derived from Islamic teachings I the Koran. Alchohol is strictly forbidden Pork is strictly forbidden. Chinese: Chinese cooks believe that refrigeration diminishes natural flavors, so they select the freshest foods available NUTRITIONAL ELEMENTS CARBOHYDRATE ►General objective ►After completion of the Unit-2, the students should be able to understand about the nutritional element – carbohydrate. ►Specific Objectives: ►After completion of the class students should be able to: ►Recognize the functions of carbohydrate. ►Identify the food sources of carbohydrate. ►Recognize the recommended amount of dietary carbohydrates. ►Discuss the classification of carbohydrate. CARBOHYDRATES ►Carbohydrates are the body's most preferred source of energy. They make up, by far, the largest volume (60%) of our daily food. They are taken in the form of all foods made up of grain flour, cereals, pasta, potatoes and other vegetables, and also in the form of sugars contained in fruits, syrups, honey and candy, as well as in the pure crystalline form of our familiar table "sugar". Functions of Carbohydrate: ►Keeping and regulating body temperature. ►Supply energy for all cells in the body. ►As a part in mothers milk content. ►As a part in glycoprotein. ►To complete oxidation of fats. ►Protect protein from breakdown in the body. ►Very essential for nervous system. Classification of carbohydrate ► The carbohydrate is a class of chemical compound composed of carbon, hydrogen and oxygen. ►MONOSACCHARIDE ►DISACCHARIDES ►POLYSACCHARIDES 1 Monosaccharide The simplest carbohydrates are the monosaccharide, or simple sugars. These sugars can pass through the wall of the alimentary tract without being changed by the digestive enzymes. The three most common are glucose, fructose and galactose. a) Glucose, sometimes also called dextrose, is present in fruit, sweet potatoes, onions and other plant substances. Glucose is oxidized to produce energy, heat and carbon dioxide, which is exhaled in breathing. b) Fructose is present in honey and some fruit juices. c) Galactose is a monosaccharide that is formed, along with glucose, when the milk sugar lactose is broken down by the digestive enzymes. 2 Disaccharides The disaccharides, composed of simple sugars, need to be converted by the body into monosaccharide before they can be absorbed from the alimentary tract. Examples of disaccharides are sucrose, lactose and maltose. a) Sucrose is the scientific name for table sugar (the kind that is used, for example, to sweeten tea). It is most commonly produced from sugar cane but is also produced from beets. Sucrose is also present in carrots and pineapple. b) Lactose is the disaccharide present in human and animal milk. It is much less sweet than sucrose. c) Maltose is found in germinating seeds. 3 Polysaccharides The polysaccharides are chemically the most complicated carbohydrates. They tend to be insoluble in water, and only some can be used by human beings to produce energy. Examples of polysaccharides are starch, glycogen and cellulose. a) Starch is an important source of energy for humans. It occurs in cereal grains as well as in root foods such as potatoes . Starch is liberated during cooking when the starch granules rupture because of heating. b) Glycogen is made in the human body and is sometimes known as animal starch. It is formed from monosaccharide produced by the digestion of dietary starch. c) Cellulose is sometimes called unavailable carbohydrates because humans cannot digest them. IMPORTANT SOURCES OF CARBOHYDRATES Most carbohydrates - Foods of plant origin. Lactose - in milk. Sugar - Fruit, fruit juice, table sugar, honey, soft drinks, and other sweets Starch - Bread, cereal, potatoes, pasta, rice, and legumes (dried peas and beans) Fiber - Whole-grain foods, raw vegetables and fruit (especially the seeds and skins), legumes, nuts, seeds and popcorn Utilization: (the supply of energy to the tissue) ►The routes along which dietary carbohydrates may pass before utilization in the tissues as a source of energy shows in the figure. ►Intake -------------Alimentary canal ►Transport--------Blood & lymph ►Storage ---------Liver, muscles ► adipose tissue ►Transport ------Blood ►Utilization------Tissue Recommended amount of dietary Carbohydrates The recommended dietary allowance (RDA) for carbohydrate is same for all persons above one year of age. Children, adolescents and adults should take in a minimum of 130 g/day. NUTRITIONAL ELEMENTS PROTEINS & FATS ►General objective After completion of the Unit-3, the students should be able to understand about the nutritional elements – Proteins and Fats. ►Specific Objectives: After completion of the class students should be able to: Recognize the functions of Protein. Recognize essential and non essential amino acids. Discuss the food sources of Protein. Identify the dietary requirement of protein. Understand functions of fats. Recognize the types of fat. Identify the food sources of fats. Understand the daily requirement of fat. Discuss about cholesterol. Protein Protein is one of the most important nutrients in our food because it is the chief constituent of the body cells, of body tissues and of body fluids. Functions of Protein: ►Growth factor. ► Body tissue repair. ►Formation of globins. ►Formation of enzymes and hormones. ►Equilibrium of the osmotic pressure. ►Formation of immune system. Essential and Nonessential Amino acids Amino acids are the chemical building blocks from which new proteins are made. The value of proteins is dependent upon combinations of amino acids that build the protein. Essential Amino acids: There are nine amino acids that are essential to human health and nutrition. A food that has all the essential amino acids an individual needs is called a complete protein. Complete proteins support growth and normal maintenance of body tissues. . Milk, eggs, cheese, fish and meat have all the amino acids. Nonessential Aminoacids: Some plant foods contain protein, but do not have all the essential amino acids the human body needs. They are called incomplete proteins or non essential amino acids. Incomplete proteins lack one or more essential amino acids but will neither support growth nor provide normal maintenance of body tissues. Rice, wheat and corn, for example, are missing some of the nine essential amino acids. Recommended amount of Proteins The daily requirements of the body for proteins are approximately 1 gram/kilograms of normal bodyweight. During pregnancy the requirement increases to 1.3 – 1.5 gm/ kg and 2 gm / kg during lactation. Important Sources of Protein Plant Sources : Bread, cereal, rice and pasta group, dry beans & nuts, fruits (small amount of protein in fruits). Animal Sources: Milk, yogurt and cheese group, meat, poultry and fish. Protein Deficiency 1 Growth slows down or stops for young child. 2 Failure to digest and absorb the food leading to diarrhea and loss of water and electrolytes. 3 Failure of the liver to maintain normal structure and function leading to edema. 4 Failure to maintain the structure of skeletal muscles and the production of red blood cells leading to muscle wasting and anemia. Secondary or conditioned protein deficiency may arise as a result of pathological processes. The following are examples: 1 Loss of protein in the urine as a result of disease of the kidneys. 2 Loss of protein from the body by other source, such as hemorrhage and serous exudates from wounds. 3 Failure to absorb protein in various disorders of the intestine. 4 Failure by a damaged liver to synthesize protein. 5 Damage to tissues (trauma), injuries such as burns, fractured bones or surgical operations. NUTRITIONAL ELEMENT FAT FAT Fat (Lipids) provide a concentrated source of energy. Lipid which covers all the chemical substances included in the housewife's fat. Triglycerides, phospholipids, steroids….etc. Lipids have been defined as substance which are insoluble in water but soluble in organic solvents such as ether, chloroform and benzene. FUNCTION OF FAT: 1 The main source of energy in the body. 2 Transfer of vitamins. 3 Protective layer under the skin. 4 Keeping body temperature. 5 Protective layer around all organs in the body. 6 Formation of cholesterol (essential substance in brain structure). Lipid Classification: ►1 Triglycerides (Neutral fats) ►2 Phospholipids: Contain phosphate ►3 Sphingolipids: Contain sphingosine. ►4 Glycolipids: Contain carbohydrate ►5 Steroids: Are high molecular weight compounds include cholesterol. ►6 Waxes: Are esters of fatty acids with alcohol. Problems Associated with excess Fat ►1 Fat is often associated with cholesterol and health problems. ►2 Excessive amounts of fat taken with meals interfere with digestion and, of course, if persisted in, will result in obesity. Being overweight is the cause of many troubles in the body, besides much inconvenience. Types of Fat ►FATTY ACIDS are the basic chemical units or organic acids which make up fat. All fat is one of three types of fatty acid: ►SATURATED - found in animal sources such as milk, cream, cheese, butter, meat, and poultry. Also in coconut and palm oil. Because it can be made from saturated fatty acids, cholesterol levels in the blood are related to the amount of saturated fat eaten. Appear to raise LDL or bad cholesterol. ►POLYUNSATURATED - are better than saturated fats. They are found in vegetable oils and fish. Seem to help lower cholesterol levels. ►MONOUNSATURATED - the best type of fat. It is found in olives, avocados, nuts, and olive, canola and peanut oils. Most margarines and hydrogenated vegetable oils are highly monounsaturated. These seem to lower LDL and raise HDL levels. All three types of fats have the same number of calories. Recommended amount of Fat ►For 2,000 calorie recommends 6 teaspoons of oil per day. 10% of your total calories should come from fat, or about 22 grams of fat/day. Important Sources of Fat 1) Animal fats They are obtained from: Animal foods: Full cream milk, cheese, egg yolk and fatty meats of animals, poultry and fish Prepared Fat : Cream, butter, and cooking fat ghee 2) Vegetable oils a) Plant foods: Sesame, olives, peanuts and nuts b) b) Prepared Oils: Prepared from variety of plant seeds as olives and corn. Fat Absorption: • In the process of digestion and absorption, the fatty acids are mixed, so that the triglycerides of the food, loss their identity and new triglycerides partly characteristic of the animal species are formed. • After re synthesis, the triglycerides enter the lacteals of the small intestine as small particles form 0.1-0.6um in diameter known as chylomicrons. • These pass into the lacteals and the mesenteric lymph vessels, enter the thoracic duct and then the systemic circulation via the right sub clavian vein. • The major part of the fat absorbed enters the circulation via the thoracic duct except for most short and medium chain fatty acids which pass to the liver via the portal CHOLESTEROL CHOLESTEROL is a fat-like substance made by the body which is manufactured by the liver from the fatty foods we eat and plays a vital part in allowing the body to function normally. It has some useful functions: ►Found in every body cell. ►Part of skin tissue. ►Transports essential fatty acids. ►Needed to produce hormones. A diet of foods high in cholesterol and saturated fat will increase the "blood cholesterol level" of many people. As a result plaque can build up in the arteries (atherosclerosis) which increases the risk of heart attack and stroke. Your body makes the cholesterol it needs, eliminating the need to include it in your diet. It is present in all animal tissues, milk products and egg yolks, chicken legs, fins or wings anything that can walk, swim or fly. Cholesterol is not found in foods of plant origin such as fruits, vegetables, grains, dry beans and peas. Cholesterol is found in the membrane between the cells not in the cells or fleshy part of the meat. Types of Cholesterol: Sometimes you hear about “good” and “bad” cholesterol. 1. LDL or low-density lipoprotein takes cholesterol from the liver to wherever it is needed. Excess amounts of LDL can build up on artery walls and increase risk for heart disease. LDL is the “bad” cholesterol. 2. HDL or high-density lipoprotein, the “good” cholesterol, picks up excess cholesterol and takes it back to the liver for excretion. (Food for Life) Amount of Cholesterol: Amount of cholesterol can be ranged from 3.6 – 7.8 mmol / liter. A level above 6mmol/liter is considered as high and a risk factor for arterial disease. Recommended target of cholesterol level is less than 5 mmol/ liter. VITAMINS, MINERALS & WATER BALANCE General objective After completion of this Unit, the students should be able to recognize the importance of vitamins in the body. Specific Objectives: After completion of the class students should be able to: Understand the importance of vitamins. Know the causes of vitamins deficiency in the body. Identify the fat-soluble vitamins from the water- soluble vitamins. Recognize the general functions of minerals. Identify major minerals from trace minerals. Discuss the functions of water in the body and its requirements. Recognize the acid base balance. VITAMINS Vitamins are chemicals of an organic nature that occur in minute quantities in foods and are necessary for life and growth and found in nearly all the foods. They do not supply energy as carbohydrates, fats and proteins do, but they are essential because they regulate the body chemistry and body functions. Vitamins cannot be produced by our bodies. They must be ingested (eaten in our food). Vitamins assist the body in using food by bringing about biochemical reactions so life can be maintained. Avitaminosis- Means without vitamins, it denotes a deficiency or lack of sufficient vitamins to carry out normal body function. Hypervitaminosis- Is an excessive accumulation of a vitamin in the body leading to toxic symptoms. Importance of Vitamins Metabolic control agent – “Co enzyme partner”: In many cell reactions a particular vitamin is necessary as a coenzyme partner with the regular cell enzyme to allow the reaction to proceed. Tissue Structure: Some vitamins act as tissue or bone building component. For example vitamin C. Antioxidants: Vitamins act as antioxidant to protect cell structure and to prevent free radial damage. Prevention of deficiency diseases: If the vitamin is not taken adequately deficiency diseases occur according to the functions of that vitamin. Causes of Vitamin Deficiency in the Body a) Life cycle needs: Vitamins needs change with age and situation through out the life cycle. 1. Pregnancy and Lactation: Women may find it difficult to meet the increase need of pregnancy by diet alone because of nutrient tolerance, food preferences or other factors that can lead to a marginal diet. 2. Infancy: Rapid growth in infant demand more vitamins. 3. Children and adolescent: This age utilizes more total nutrient including all vitamins than during adulthood. During adulthood growth has slowed or stopped. 4. Aging: The aging process may increase the need for some nutrients because of decreased food intake and impaired nutrient absorption, storage and usage. b) Life Style : Personal life style choices or habits may influence the individual needs for nutrient supplementation. Oral Contraceptive Use: Woman using oral contraceptive agents find that this practice lowers serum levels of several B vitamins including pyridoxine and niacin as well as vitamin C. Restricted Diet: Person who is always dieting may find it difficult to meet many of the nutrient standards, particularly if their meals provide less than 1200 kcal/ day. Exercise programs: Woman on extended exercise program may increase their requirement of riboflavin. Smoking: This unhealthy habit, especially among women during their childbearing years, affects health and can reduce vitamin c levels. Alcohol: Chronic or abusive use of alcohol can interfere with absorption of B complex vitamins, especially thiamin. Caffeine: In large quantities caffeine flushes water soluble vitamins out of the body faster than usual. Classification of Vitamins Fat Soluble vitamins: Fat-soluble vitamins are absorbed from the intestine and transported in to the circulation. Once absorbed in to the circulation these vitamins are carried to the liver where they are stored. 2 Water Soluble Vitamins: Water-soluble vitamins are dissolved in water and transported through the body. They are stored in the body for only a period of time and are then excreted by the kidneys. FAT-SOLUBLE VITAMINS Vitamin A Vitamin D Vitamin E Vitamin K WATER-SOLUBLE VITAMINS Vitamin C (ascorbic acid) Vitamin B Complex B1 (thiamin) B2 (riboflavin) Niacin B6 (pyridoxine) B12 (cobalamin) Folacin (Folate or Folic Acid) Fat Soluble Vitamins Vitamins 1 Vitamin A (BetaCarotene or Retinol Functions It combines with a protein to form "the protein pigment" retinal or visual purple which is responsible for light adaptation. 2 It maintains the integrity of the epithelial structure. 3 It participate in the formation of mucopolysacchri des in the matrix of bone and teeth. Sources Signs Of Deficiency Beef, liver, carrots, spinach and tomatoes. 1 Night blindness, Xerophthalmia (dryness of conjuctiva), and Keratomalacia (softening of the cornea) 2 The columnar epithelial cells change into stratified form which invites infection, so we get recurrent attacks of bronchitis, gastroenteritis..et c. 3 Faulty epiphyseal bone formation. Dietary Treatment 4000-5000 Units/Day Vitamins 2 Vitamin D Functions 1. Mobilize the calcium from fully calcified bone making it available for the formation of new bone. 2. Maintain calcium level. 3.Prevents rickets Sources Signs Of Deficiency Fish , Milk, liver oils, exposure to ultraviolet rays. 1 1 Rickets in children 2.Osteo malacia 3 Infantile tetany 4 Dental decay Dietary Treatment 400 I.U./day Vitamins 3 Vitamin E Functions Helps breakdown polyunsaturated fats Antioxidant, protecting blood cell membranes from over exposure to oxygen (no proof of a role in aging, sexual performance, or prevention of cancer and/or heart disease) Sources Pure vegetable oils, wheat, whole meal bread and cereals, egg yolk, nuts , sunflower seeds, whole grain vegetables and seed oils Signs Of Deficiency Dietary Treatment Muscle wasting, red For Men – 10 mg Women – 8 mg blood cell damage, hemolytic anemia, hemorrhaging, reproductive failure, neurological abnormalities Vitamins 4 Vitamin K Functions Essential for clotting of blood Found in foods and manufactur ed by Vitamin K producing bacteria in the small intestines Blood calcium regulation Protein synthesis Sources Signs Of Deficiency Dietary Treatment Dark green vegetables, cabbage type vegetables Bleeding due For Men –8 mg Women – 6 mg to delay clotting times caused by lack of clotting factors. Patients may show signs of bruising easily and have nose bleeds. Vitamins 1 Vitamin C (ascorbic acid) Functions Water Soluble Sources Vitamins 1 Helps form collagen or body cement 2 Helps in growth and repair of body tissue and blood vessels 3. Prevents scurvy 4. Essential for maintenanc e of bones, teeth and gums 5. Necessary for ensuring normal immune response to infection, wound healing and iron absorption Citrus fruits, berries, mangos, papayas, melons, tomatoes , green leafy vegetables Signs Of Deficiency Dietary Treatment Anemia, scurvy, depression, infections, bleeding gums, muscle degeneration, poor wound healing, capillary hemorrhaging For Men & Women – 40 mg Water Soluble Vitamins Vitamins 1 Vitamin C (ascorbic acid) Functions 1 Helps form collagen or body cement 2 Helps in growth and repair of body tissue and blood vessels Prevents scurvy Essential for maintenanc e of bones, teeth and gums Necessary for ensuring normal immune response to infection, wound healing and iron absorption Sources Signs Of Deficiency Dietary Treatment Citrus fruits, berries, mangos, papayas, melons, tomatoes , green leafy vegetables Anemia, scurvy, depression, infections, bleeding gums, muscle degeneration, poor wound healing, capillary hemorrhaging For Men & Women – 40 mg Vitamin B Complex Vitamins Functions Sources Signs Of Deficiency Dietary Treatment 1 B1 - Thiamine Energy metabolism , nerve function, & muscle control Yeast, egg, yolk, liver, wheat germ, nuts, red meat, fish, whole grain breads and cereals Fatigue, irritability, loss of appetite, severe deficiency can lead to Beriberi 2 B2 - Riboflavin Involved in use of fat, protein and carbohydra tes Liver red meat, dairy product, eggs ,dark green vegetable, , yogurt, bread Pernicious anemia, paralysis, Men-1.3 mg Women – 1.1 mg 3 Niacin Energy metabolism , maintain healthy nervous system and skin Yeast, meat, eggs, liver, cereal, seeds, milk, green leafy vegetables, fish, nuts Pellagra, dermatitis on body parts exposed to sun, diarrhea, loss of appetite, weakness, fatigue Men-19 mg Women – 15 mg Men - 1mg For Women – .8mg Vitamin B Complex Vitamins Functions Sources Signs Of Deficiency Dietary Treatment 1 B6 (Pyridoxine) Normal immune and nervous system Meat, fish green leafy vegetable, bananas Central nerve system disorder, seizure, anemia, muscle weakness Men-1.4 mg Women – 1.2 mg 2 B12 Producing antibodies, helps folacin function, maintenance of nerve tissue Meat, fish, milk eggs, yeast, cheese Paralysis, smooth tongue, fatigue, dementia, depression Men & Women -.002 mg Synthesize DNA Cell division Liver, meat, eggs, milk, fruits, cereals Glossitis, cheilosis, gastrointestinal disturbances like diarrhea, abdominal distention Men & Women – .2 mg (Cobalamin) 3 Folacin ( folic acid) MINERALS Minerals are found in nearly all the foods but they do not supply energy as carbohydrates, fats and proteins do, but they are essential because they regulate the body chemistry and body functions. Minerals cannot be produced by our bodies. They must be ingested (eaten in our food). Minerals are sometimes chemical constituents of vitamins. Minerals are also found in enzymes, hormones, bones and muscles. Minerals can become part of the body’s structure. There are about sixty different minerals that make up about four percent of the body. Science is still learning about many of the functions of minerals. Minerals are also divided into two groups: 1. Macro minerals (Major Minerals) are found in relatively large amounts. Required Intake is ≥ 100 mg/day. 2. Trace minerals are found in very small amounts in the body. Required Intake is ≤ 100 mg/day. Macronutrients Calcium The body of an adult normally contains about 1200g of calcium. Atleast 90% of this amount is present in skeleton and teeth. Sources: Milk, dairy products Excretion: - In the feces where most of the calcium found in the stool. -In the urine -In the sweat. Recommended Intake: Age Allowance (mg daily) 0-12 month 1-9 month 10-15 month 16-19 month 500-600 mg/day 400-500 mg/day 600-700 mg/day 500-600 mg/day I. Hypocalcaemia (Calcium deficiency): In infants: Rickets, soft bone, enlarged joints, deformed skull, spinal curvature, bowed legs. In adults: Osteomalacia, weak bone. II. Hypercalcaemia: A) In infants: Loss of appetite, vomiting, wasting, constipation, flabby muscles, and a characteristic facial appearance. B)In Adults: There is no danger of excessive calcium intake, since the homeostatic mechanism of the body ensure that the amount of calcium retained from the food does not exceed the amount needed to replace the wear and tear of bones and soft tissues. (2) Phosphorus: Phosphorus is present in all natural foods; Most of the phosphate in the body is present in bone and teeth. (3) Magnesium: All human contains small amount of magnesium. The whole adult body contains about 25 gm, the greater part of this amount is present in the bone, and about one-fifth of the total magnesium in the body is present in the soft tissues, where it is apparently mainly bound to protein. Magnesium Deficiency: Occurs when excessive losses of magnesium in the faeces or urine occur in many diseases and the resulting magnesium deficiency leads to apathy and muscle weakness and sometimes to tetany and convulsions. (4) Sulphur: All living matter contain proteins and all proteins contain sulphur, which is essential for life. The greater part of the Sulphur in the human body is present in the two Sulphur containing amino acids; methionine and cystine. Two known vitamins, thiamine and biotine contain sulphur. Most of the sulphur in the diet is provided by the sulphur containing amino acids. (5) Iron: The amount of iron in the body is about 4 grams, distributed in the body as follows: 2.5 g in haemoglobin, 0.3 g in tissue iron, and 1.0 g in iron stores. Tissue iron is present in myoglobin and the cytochrome. Iron is thus an essential component of three different processes involved in the transfer of oxygen, and hence is of great importance in human nutrition deficient supply of iron is a very common cause of anemia. (6) Zinc: The total body content of zinc in an adult is over 2.0 g. It is necessary part of more than 20 enzymes. The tissues that contain the highest concentration of zinc are the choroids of the eye and the prostate. Deficiency state: A clinical syndrome characterized by small stature, hypogonadism and mild anemia. II.TRACE ELEMENTS (1) Iodine: The adult body 20-50 mg of iodine, about 8 mg in the thyroid gland. Source: Sea foods. Deficiency: Goiter (enlarged thyroid gland). (2) Fluorine: Present in human tissue, notably the bones, teeth, thyroid gland and skin. Sources: Drinking water, the fluoride in food stuff is of little importance, sea fish may contain relatively large amounts, another significant source is tea. Deficiency: leads to dental caries, osteoporosis. Excessive intake: leads to fluorosis, which is mottling of the teeth by brown pigmentation. The Fluoride deposits in dental enamel. (3) Copper: Normal adult diet provides 1-3 mg/day. Green vegetables and liver are good sources whereas milk, meat, bread is a poor sources. Function: is a component of many enzyme systems. Deficiency: may lead to anemia or chronic diarrhea. (4) Cobalt: Is a constituent of vitamin B12. (5) Chromium. (6) Manganese. (7) Molybdenum. (8) Nickel. (9) Silicon. (10) Aluminum. Mineral Elements Gm I- Macronutrients: Calcium Phosphorus Sulphur Iron Zinc II- Micronutrients: Iodine Fluorine Manganese Copper Selenium Cobalt Principal location in the body 1050-1540 560-840 175 2.8 99% in bone and teeth 80-90% in bone and teeth. Associated with proteins Hemoglobin, liver 0.02 0.21 0.11 Thyroid gland Bone and teeth Vitamin B12 molecule Summary of Mineral Elements (A) Macronutrients Element Function Utilization Daily Allowance Calcium 99% in bones, teeth, nervous stimulation, muscle contraction, blood clotting, activates enzymes. 10-40% absorbed aided by vitamin D and lactose, parathyroid hormone, regulates blood level. Phosphorus 80-90% in bone, teeth, acid – balance, transport of fats, enzymes for energy metabolism. Vitamin D favors absorption and use. RDA: 800mg Milk, cheese, meat, fish, cereal, nuts Magnesium 60% in bone, teeth, transmit nerve impulse, muscle contraction, enzyme for energy metabolism. Salts relatively insoluble acid favors. RDA: 300-350 RDA: 800mg Milk, cheese, ice cream, mustard. Element Function Utilization Daily Allowance RDA: Men: 10 mg Female: 18 mg Iron Mostly in hemoglobin, muscle myoglobin, oxidizing enzymes. 5-20% absorption, acid and vitamin C aid absorption, daily losses in urine, feces, menstrual losses, anemia is common. Zinc Enzymes for transfer or carbon dioxide taste. Little like hood of deficiency or excess Iodine Form thyroxin for energy metabolism. Chiefly in thyroid gland, deficiency leads to endemic goiter. Prevent tooth decay Dental enamel Fluorine RDA; 15mg, plant and animal protein. RDA: 100-140mg, iodize salt, shellfish, salt water fish. Fluoridated water. FLUID AND ELECTROLYTE BALANCE FLUID AND ELECTROLYTE BALANCE About 50-60% of the total body weight is made up of water; the proportion varies somewhat, with fat persons having less body water than lean persons; infants and young children have more body water than older persons, about 3/4 of the water in the body is within the cells, this is referred to as intracellular fluid. The remaining water is in the blood and lymph circular and in the fluids around the cells and tissues this is called extra cellular fluid. The body of a 65 kg man contains approximately 40 litres of water, of the about 25 litres are within the cells and about 15 litres in the extra-cellular fluids. Functions: 1. Water is the solvent for materials within the body, the food we eat are digested by enzymes in an abundance of digestive juices: 2. The nutrients are carried in solution across the intestinal wall, the blood transports nutrients to all body tissues: 3. Materials dissolved in water are transported across the cell membrane, chemical reactions take place in the presence of water and body waste are carried by the blood for elimination by the kidneys, lungs, skin and bowel. 4. Water is also a lubricant, it avoid friction between moving body parts and regulates the body temperature, thus giving a cooling effect. Water balance The water intakes comprise the fluid drunk and the water in the food eaten. The water formed by the oxidation of carbohydrate, protein, and fat is also available. The output consists of the urine, the water in the faeces and the water evaporated from the skin and lungs. Water retention and depletion: Edema: This is the condition when excess fluid in the body causes the subcutaneous tissues to swell and pit when pressure is applied with the finger. It is important to remember, however ,that this simple clinical test is not very sensitive: edema is not usually apparent until the limb volume is increased by 10% or more. Over hydration sometimes results in edema of the lungs which causes difficulty in breathing. Dehydration: This can be suspected from the sunken features, particularly the eyes which recede into the orbits. The skin and tongue are dry, the skin becomes loose and lacks elasticity. On pinching it stands up, away from the subcutaneous tissue. The patient is usually, but not always, thirsty. Sodium and potassium in the body The body of a 65 kg man contains about 4000 mmol of Na, equivalent to 256 g NaCl, of this the major part, just over half, is in the extra-cellular fluid, about 1500 mmol is in bone and less than 500 mmol in the cells. By contrast, the potassium content of the extracellular fluids is only about 80 mmol, whereas the tissues contain about 3500mmol. Four fifths of this amount is in the skeletal muscles. Intake of sodium: Most normal people ingest 5-18 g NaCl/day, corresponding to 70-300 mmol Na. The food as served seldom contains more than 200 mmol NaCl/day: the remainder is taken as table salt. In general, natural foods contain relatively little sodium, but large amounts may be added in cooking, either as NaCl or as sodium bicarbonate in baking powder also in most forms of processing and preserving, salt is added. Intake of potassium: The potassium contains of food stuff is very variable: natural diets provide from 50-150 mmol k/day. The usual figure is about 65 mmol/day, equivalent to 5 g of potassium chloride. Potassium deficiency or excess rarely arise primarily as a result of dietary deficiency or excess common foods contain moderate amounts. Cereals(including rice and wheat),cheese, eggs, fats and almost all fresh fruits contain less than 8 mmol/100g have been used in constructing low potassium diets. Sodium depletion: Is characteristically associated with dehydration, as for instance in heat exhaustion. The essential chemical pathology is a reduction in the extra-cellular fluid as a result of the low blood volume, the veins are collapsed, blood pressure is low. Sodium excess: An excess of sodium in the body accumulates in the extracellular fluid. The increased concentration of sodium is partially by increase in these fluids. Sodium excess result in edema, with high blood pressure. Potassium deficiency: Features of potassium deficiency are muscular weakness and mental confusion. They are probably caused by a periodic over secretion of aldosterone by the adrenal cortex. The smooth muscle of the small intestine may become paralized(paralytic ileus). Potassium excess: The toxic effects of K fall on skeletal and cardiac muscle. Muscular weakness and mental apathy are generally marked. Causes of potassium excess include rental failure, adrenal insufficiency or shock after injury.