A CASE OF INFECTIOUS AND AUTOIMMUNE DISEASE COEXISTENCE Elisabetta Miserocchi MD Department of Ophthalmology and Visual Sciences University Hospital San Raffaele, Milan, Italy CLINICAL CASE • 36 year old woman, Caucasian • Occupation: nurse in a nursing home • Chief Complain 12/2005: - Loss of vision OD>OS lasting 5 months PAST OCULAR HISTORY • 7/05: loss of vision OD>OS • Previous hospitalization in another center: - Diagnosis of bilateral optic disc edema - Neurologic consult: negative (CT, MRI, LP) - Treatment with oral steroids (prn 75 mg) for 5 months : no visual improvement EXAMINATION • • • • VA: OD: CF OS: 4/10 Anterior Segment OU: Normal IOP: 13 mmHg Fundus: RETINAL VASCULITIS VISUAL FIELD PAST MEDICAL HISTORY • 3/05: Pneumonia with blood coughing treated with systemic antibiotic • 6/05: Headache, constant and frontal REVIEW OF SYSTEM • Obesity • Hypercholesterolemia ASSESSMENT • Bilateral optic neuropathy OD>OS • Bilateral retinal vasculitis ? NEW WORK-UP IN OUR OPHTHALMOLOGY DEPT • • • • • Chest CT scan: pleural thickening Brain and orbit MRI: normal Laboratory tests: HLA-A29 positive PPD + 50 mm induration Neurophthalmology consult: presumed tubercular optic neuropathy • Infectious disease consult: anti-tubercular treatment was began Follow up • 3/06 visual acuity improvement OD: 4/10 OS:9/10 • 6/06 Vitriitis OU • Corticosteroids + CSA added 4/07 Visual acuity restoration OD: 9/10 OS:10/10 Normal visual field Late occurrence of typical chorio-retinal lesions FINAL DIAGNOSIS • Presumed tubercular optic neuropathy - response to anti-TB treatment alone - Restoration of visual acuity and visual field • Birdshot retinochoroidopathy - Bilateral vitritis, retinal vasculitis, late occurrence of typical chorioretinal lesions - Response to corticosteroids treatment - HLA-A29 + Our take home message • Diagnosis of ocular tuberculosis is often presumptive. • The absence of clinically evident systemic TB does not rule out the possibility of ocular TB. • TB is increasing in Italy in the last 10 years: PPD test should be tested in all uveitis pts. • Different pathogenetic mechanisms (infectious and autoimmune) may coexist and complicate the clinical spectrum of ocular inflammation.