Chem 3550
Chapter 16:
Production of NADH and NADPH: The
Citric Acid Cycle, the Glyoxylate Cycle
(Skip), and the Pentose Phosphate
Pathway
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Effective 10/30/06
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These are all very important! Know names and cofactors, as well
as reactants and products.
6 Carbons
4 Carbons
Oxidation of alcohol to
ketone (note use of
NAD+)
Rearrange to facilitate
later oxidation (cannot
oxidize 3° carbon)
Hydration Reaction
is stereospecific
Loss of CO2
Oxidation of
alkane to alkene
(note use of
FAD); Succ.
Deh. Is a
membranebound enzyme
Oxidation of alcohol to
ketone (note use of
NAD+)
5 Carbons
4 Carbons
GTP (or ATP) production
High Energy Compound
Similar to PDC
reactions for AcetylCoA formation
This is something you should be very comfortable with
Know this!
Regulation is very important!
Summary
Second level of control of PDC in eukaryotes
Also known
as E1
Kinase: enzyme to puts on a phosphate
Phosphatase: enzyme that takes of a phosphate
Amphibolic nature
of CAC
X
Pentose Phosphate Pathway
NADPH produced!
Used for lipid
biosynthesis