Professor Abigail Doyle
Princeton University
New Electrophiles and
Ligands for Ni-Catalyzed
Cross Coupling
Tuesday
February 17, 2015
3:30 pm
Room 1315
Chemistry
Transition metal-catalyzed cross coupling has
revolutionized the way that chemists assemble
carbon–carbon (C–C) bonds. These reactions
typically involve aryl or alkyl (pseudo)halide
reaction partners, which represent a small subset
of the electrophiles used in organic synthesis. Our
laboratory is interested in developing new
strategies for alkyl cross-coupling such that classic
electrophiles in organic synthesis (epoxides,
aziridines, iminium and oxocarbenium ions and
their stable precursors) can participate in bond
formation. This lecture will describe some of our
recent progress in this area involving methodology
development, ligand design, mechanistic investigations, and applications that permit modular and
efficient access to enantioenriched amines and
ethers.