Leasure Hall, Room 13
Thursday, February 11, 2016
4:00 P.M.
Coffee and Cookies
Leasure Hall, Room 13 Alcove
3:45 P.M.
iochemistry
olecular
iophysics
How to choose the perfect strand:
what influences microRNA strand selection?
Anna Zinovyeva
Division of Biology
Kansas State University
MicroRNAs are small non-coding RNAs that, together with Argonaute proteins, posttranscriptionally regulate expression of many genes. A key step during microRNA biogenesis is
the selection of one dominant microRNA strand from a double-stranded RNA precursor. I
will describe identification and characterization of a new set of mutations in C. elegans
Argonaute ALG-1 that reveal a novel role for Argonaute in microRNA strand selection. In
addition, I will describe an approach to identify and characterize factors that may function in
microRNA strand selection.