EIIBARGO BY SCIENCE II,AGAZINES (PDf) Thursday, Broadcast Media -- 3 p.[. Print l,tedia -- Friday, oct. L6, L992 Oct. 15, L992 For Information: Sue Pondrom News Bureau Manager (6L9) 554-8290office #LOL592-O4 SCRIPPS RESEARCHERSDETERT{INE STRUCTUREOF DNA REPAIR ENZY}IE Inplications for LA JOLLA, CALIFORNIA Oct. Scripps Research role in the Since structure recognition the understand cancer results in this better understand Tainer says. week's cancer and aging, for the The have determined plays the an important damaged DNA. in many degenerative researchers how it since cancer issue the Ph.D., of better at TSRI has published Science, Advancement of structure of recognizes ttultimately, for rnay help at and aging. Association responsible La Jolla of by John A. Tainer, frUnderstanding Researchers an enzyme that and repair new findings A team led American of in DNA damage has been implicated processes, its L992 -- L6, (TSRI) Institute three-dimensional Caneer and Aging this this unrepaired the help us damaged DNA, rl help DNA qenerates and degenerative I,TORE enzyme will also of Science. and repairs should journal the diseases.rl us deal mutations with PAGE 2 -- In of THE SCRIPPS RESEARCE INSTITUTE addition, DNA-repair enzymes to For example, decrease tumors inhibitors repair in to utilizes help the in repair endonuclease III, damaged DNA of of E. coli Iess which the They said glycosylase, lyase, rebuilding its drugs. be used to in IIf of by the nicks the of enzymes several DNA altered enzymes was and repairs that since enzymes are the bacterial, sirnilar, the to more complex study and and has rbroad DNA repair.rl III rracts both pyrinidines as a DNA N- from DNA, and an Ap damaged DNA segrment in by DNA polymerase are a coli. human ceIIs, endonuclease oxidized DNA repair researchers cleaves applicable including within and DNA ligase. Science is of Additional Escherichia understanding that information a sJ-ngle type removal. recognizes, noted removing rr which structures destruction Among these recognize and human DNA-repair in the types record. bacteria systems, inplications genetic of enzlrme studied endonuclease defined anti-cancer and improve DNA polymerase are The researchers bovine of enzymes could 50 different each of which The DNA-repair yeast, cells genetic the DNA and cataLyze involved use the new types DNA-repair source more than glycosylases, base in of to and chemotherapies. is maintain design cancer by radiation DNA, which cell, at TSRI plan scientists preparation for PAGE 3 -- In determining surprised well TEE SCRIPPS RESEARCH IN8TITUTE to the find to phosphate DNA repair be in binding backbone of pure to in protein measure to the Additional researchers L. Fisher, which determine x-rays are position Biochemistry any of primary Its the hrere the other function enzyme and the of the enzyme structure bounced of Che-Fu Kuo, Ph.D., Ph.D.; researchers rrunlike between the off pattern a distinctive authors Cunningharn, Ph.D. for enzymes.rr the DNA. create exact cluster interactions The method used to diffraction structure, an iron-sulfur characterized appears enzlrme's a tiny that was x-ray crystal of can be analyzed each atorn. Science article were TSRI Duncan E. McRee, Ph.D., and Cindy and Suzanne O'Hand1ey, Ph.D. and Richard p. of Center the Department and Biophysics, of State Albany. ### Biological- Science, University of New york at