EIIBARGO BY SCIENCE II,AGAZINES
(PDf) Thursday,
Broadcast Media -- 3 p.[.
Print
l,tedia -- Friday,
oct.
L6, L992
Oct.
15,
L992
For Information:
Sue Pondrom
News Bureau Manager
(6L9) 554-8290office
#LOL592-O4
SCRIPPS RESEARCHERSDETERT{INE STRUCTUREOF DNA REPAIR ENZY}IE
Inplications
for
LA JOLLA, CALIFORNIA Oct.
Scripps
Research
role
in
the
Since
structure
recognition
the
understand
cancer
results
in
this
better
understand
Tainer
says.
week's
cancer
and aging,
for
the
The
have determined
plays
the
an important
damaged DNA.
in
many degenerative
researchers
how it
since
cancer
issue
the
Ph.D.,
of
better
at TSRI has published
Science,
Advancement of
structure
of
recognizes
ttultimately,
for
rnay help
at
and aging.
Association
responsible
La Jolla
of
by John A. Tainer,
frUnderstanding
Researchers
an enzyme that
and repair
new findings
A team led
American
of
in
DNA damage has been implicated
processes,
its
L992 --
L6,
(TSRI)
Institute
three-dimensional
Caneer and Aging
this
this
unrepaired
the
help
us
damaged DNA, rl
help
DNA qenerates
and degenerative
I,TORE
enzyme will
also
of
Science.
and repairs
should
journal
the
diseases.rl
us deal
mutations
with
PAGE 2 --
In
of
THE SCRIPPS RESEARCE INSTITUTE
addition,
DNA-repair
enzymes to
For example,
decrease
tumors
inhibitors
repair
in
to
utilizes
help
the
in
repair
endonuclease
III,
damaged DNA of
of
E. coli
Iess
which
the
They said
glycosylase,
lyase,
rebuilding
its
drugs.
be used to
in
IIf
of
by the
nicks
the
of
enzymes
several
DNA
altered
enzymes
was
and repairs
that
since
enzymes are
the
bacterial,
sirnilar,
the
to more complex
study
and
and has rbroad
DNA repair.rl
III
rracts both
pyrinidines
as a DNA N-
from DNA, and an Ap
damaged DNA segrment in
by DNA polymerase
are
a
coli.
human ceIIs,
endonuclease
oxidized
DNA repair
researchers
cleaves
applicable
including
within
and DNA ligase.
Science
is
of
Additional
Escherichia
understanding
that
information
a sJ-ngle type
removal.
recognizes,
noted
removing
rr which
structures
destruction
Among these
recognize
and human DNA-repair
in
the
types
record.
bacteria
systems,
inplications
genetic
of
enzlrme studied
endonuclease
defined
anti-cancer
and improve
DNA polymerase
are
The researchers
bovine
of
enzymes could
50 different
each of which
The DNA-repair
yeast,
cells
genetic
the
DNA and cataLyze
involved
use the
new types
DNA-repair
source
more than
glycosylases,
base in
of
to
and chemotherapies.
is
maintain
design
cancer
by radiation
DNA, which
cell,
at TSRI plan
scientists
preparation
for
PAGE 3 --
In
determining
surprised
well
TEE SCRIPPS RESEARCH IN8TITUTE
to
the
find
to
phosphate
DNA repair
be in
binding
backbone
of
pure
to
in
protein
measure
to
the
Additional
researchers
L.
Fisher,
which
determine
x-rays
are
position
Biochemistry
any of
primary
Its
the
hrere
the
other
function
enzyme and the
of
the
enzyme structure
bounced
of
Che-Fu Kuo, Ph.D.,
Ph.D.;
researchers
rrunlike
between
the
off
pattern
a distinctive
authors
Cunningharn, Ph.D.
for
enzymes.rr
the
DNA.
create
exact
cluster
interactions
The method used to
diffraction
structure,
an iron-sulfur
characterized
appears
enzlrme's
a tiny
that
was x-ray
crystal
of
can be analyzed
each atorn.
Science
article
were TSRI
Duncan E. McRee, Ph.D.,
and Cindy
and Suzanne O'Hand1ey, Ph.D. and Richard
p.
of
Center
the
Department
and Biophysics,
of
State
Albany.
###
Biological-
Science,
University
of
New york
at