Toxicology Graduate Student Handbook TOXICOLOGY CENTRE WWW.USASK.CA/TOXICOLOGY TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY TABLE OF CONTENTS FIELDOFTOXICOLOGY................................................................................................................................................3 ABOUTTHEPROGRAM.................................................................................................................................................3 ABOUTTHEUNIVERSITYOFSASKATCHEWAN...........................................................................................................4 ABOUTTHECITYOFSASKATOONANDPROVINCEOFSASKATCHEWAN....................................................................5 ADMISSIONREQUIREMENTS.......................................................................................................................................6 SELECTIONOFASUPERVISOR.....................................................................................................................................6 APPLICATIONPROCEDURES........................................................................................................................................7 THEACADEMICYEAR...................................................................................................................................................8 PROGRAMDESCRIPTION.............................................................................................................................................8 COURSES......................................................................................................................................................................9 STRUCTUREANDOPERATIONOFADVISORYCOMMITTEES....................................................................................17 MONITORINGSTUDENTPROGRESS..........................................................................................................................17 ACADEMICSTANDARDS............................................................................................................................................17 SEMINARS..................................................................................................................................................................17 QUALIFYINGANDCOMPREHENSIVEEXAMINATIONS..............................................................................................18 TRANSFERFROMANMSCTOAPHD.........................................................................................................................19 THESISREQUIREMENTS............................................................................................................................................19 SCHOLARSHIPSANDAWARDSPROGRAM................................................................................................................20 TOXICOLOGYGROUPFACULTYANDRESEARCHINTERESTS...................................................................................23 RESEARCHFACILITIES..............................................................................................................................................26 JOBOPPORTUNITIESFORGRADUATESOFTHEPROGRAM.....................................................................................27 COSTOFSTUDY.........................................................................................................................................................28 LIVINGANDHOUSINGCOSTS...................................................................................................................................28 INFORMATIONFORINTERNATIONALSTUDENTS....................................................................................................29 TOXICOLOGYGRADUATESTUDENTASSOCIATION.................................................................................................30 RECREATIONALANDARTSOPPORTUNITIES...........................................................................................................30 CONTACTINFORMATION.........................................................................................................................................31 SUMMARYOFAPPLICATIONSUBMISSIONDOCUMENTS.........................................................................................31 Interdisciplinary Graduate Program in Toxicology – May 2016 2 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY Interdisciplinary Graduate Program in Toxicology FIELD OF TOXICOLOGY Toxicology is the scientific discipline that deals with the harmful effects of chemical and physical agents on living organisms. It is essentially the study of poisons and pollutants. At the University of Saskatchewan (U of S), research and postgraduate teaching in toxicology is coordi‐
nated and led by the Toxicology Centre, with significant participation from members of the University's Toxicology Group. The Toxicology Group is an interdisciplinary body under the umbrella of the College of Graduate Studies and Research (CGSR) that consists of faculty members from many University depart‐
ments, as well as scientists and adjunct faculty from various government research institutions located on or near campus. Most Toxicology Group faculty are available to serve as supervisors for prospective graduate students. Members of the Toxicology Group are actively engaged in research across a broad spectrum of toxicolo‐
gy sub‐disciplines, thus providing prospective graduate students with varied research opportunities. ABOUT THE PROGRAM The Graduate Program in Toxicology was established in 1981, the first of its kind in Canada. The Program offers both conventional PhD and MSc programs (with research and thesis). In the future, the Program hopes to offer a Non‐Thesis Masters Program. The primary objective of this proposed program is to provide advanced training in toxicology with an applied rather than a research intensive focus. The Non‐Thesis Masters Program is currently under development. In addition to general toxicology, activities and specializations within the Program include analytical toxicology, aquatic toxicology, ecotoxicology, forensic toxicology, immunotoxicology, molecular and biochemical toxicology, nutritional toxicology, radiation and radionuclide toxicology, veterinary toxicology, and wildlife toxicology. The Masters and Doctoral programs allow candidates to develop Interdisciplinary Graduate Program in Toxicology – May 2016 3 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY toxicology as their major area of research expertise. The durations of most MSc and PhD programs are 2‐3 and 3‐5 years, respectively. The interdisciplinary nature of the U of S Toxicology Program provides students with a diverse array of potential research opportunities in toxicology. Prospective students can apply to the program from such varied undergraduate backgrounds as agriculture, biology, chemistry, ecology, environmental sciences, medicine, physiology, pharmacology, toxicology, and veterinary medicine, to name but a few. ABOUT THE UNIVERSITY OF SASKATCHEWAN The University of Saskatchewan is widely renowned for its striking collegiate gothic architecture. With its traditional stone buildings, the University of Saskatchewan campus was chosen as one of the twenty most beautiful places in Canada by Canadian Living magazine. Overlooking the South Saskatchewan River on a 981 hectare site, the U of S campus has 14 colleges offering a wide range of undergraduate and graduate programs, is home to federal and provincial research institutes, and has an annual enrolment of around 20,000 students, including ~2,800 graduate students. It is the only university in Canada with six health science colleges (medicine, veterinary medicine, dentistry, nursing, pharmacy and nutrition, kinesiology) and a major teaching hospital on the same campus. Innovation Place, Western Canada’s first operating research park and one of the largest in Canada, is home to over 115 high‐technology companies engaged in everything from the development of nutraceuticals to satellite communications. Canada’s largest science project in a generation, the $224 million Canadian Light Source synchrotron, officially opened in October 2004. Owned by the U of S, the facility will be a national resource for researchers in academia, government and industry. Designed to probe the molecular structure of matter, it will provide unprecedented opportunities for scientific discovery and innovation in fields such as pharmaceuticals, agriculture, health, advanced materials, earth sciences, micro‐electronics, and toxicology. Interdisciplinary Graduate Program in Toxicology – May 2016 4 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY ABOUT THE CITY OF SASKATOON AND PROVINCE OF SASKATCHEWAN Saskatoon is the main educational and cultural centre for the province of Saskatchewan. It has a population of approximately 250,000 people and a trading area of half a million. The city straddles the banks of the South Saskatchewan River, which flows through the heart of the downtown core, with kilometres of paved trails for walking and cycling. One of the most picturesque cities in Canada, Saskatoon is friendly and both culturally alive and diverse. There are five permanent theatre groups, several art galleries, and a symphony orchestra in the city. The internationally renowned Jazz Festival takes place each summer, as does The Fringe Festival, The International Folkfest, the Children’s Festival, and an annual Exhibition. Opportunities for recreation abound in the city’s abundant leisure facilities, parks, golf courses, and nearby lakes. A two hour drive north takes you to the breathtaking wilderness and lakes of Canada’s boreal forest. According to the Canada Mortgage and Housing Corporation’s Affordability Index, Saskatoon remains one of the most affordable places to live in Canada. Apartment rentals range from approximately $800 to $1,200 CDN per month and single rooms are considerably less. The price of an average three‐
bedroom detached home is around $320,000. Saskatoon has a number of modern shopping malls, along with many boutiques and specialty shops, a good public transportation system, and a large variety of both traditional and ethnic restaurants. The Saskatoon International Airport, served by both Canadian and US major airlines, has direct connections to Vancouver, Calgary, Edmonton, Regina, Winnipeg, Minneapolis/St. Paul, Denver, Toronto, Ottawa, and other centres. Saskatoon is located on the scenic Yellowhead Highway between Winnipeg and Edmonton. Saskatchewan is located in the heart of North America, neighbouring the provinces of Manitoba and Alberta. To the south, it borders the American states of Montana and North Dakota, and to the north, the Northwest Territories. Saskatchewan covers 651,900 square kilometres‐more than a quarter million square miles. Contrary to popular belief, fully one half of the province is covered by forest, one‐third is Interdisciplinary Graduate Program in Toxicology – May 2016 5 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY farmland, and one‐eighth is fresh water with nearly 100,000 lakes. Less than two hours drive north of Saskatoon is Prince Albert National Park, one of Saskatchewan’s most popular four‐season destinations. Here you can mix northern wilderness encounters with the comforts of a lakeside resort. The park covers some 388,000 hectares, or nearly one million acres of parkland, boreal forest, patches of fescue grassland and some 1,500 lakes and streams. Saskatchewan produces more than half of the wheat grown in Canada and while agriculture is still very important to the economy, generating almost $2 billion annually, mining, manufacturing, tourism, and service‐based sectors also make a significant impact. ADMISSION REQUIREMENTS The basic requirements for admission to the College of Graduate Studies and Research (CGSR) at the University of Saskatchewan should be consulted. Applicants to the Toxicology Graduate Program must possess a recognized undergraduate degree in the life sciences, such as a BSc, BSA, BSP, or a clinical doctoral degree such as an MD or DVM. Undergraduate training should, at a minimum, include basic courses in biology, chemistry, biochemistry, and mammalian physiology, and a working knowledge of statistical methods. Courses in toxicology, environmental chemistry, ecology, and pharmacology are desirable. Students will not be officially accepted into the research‐based MSc or PhD programs until a suitable supervisor with adequate research funding has been identified. A supervisor will not be required for admission into the proposed Non‐Thesis Masters Program. SELECTION OF A SUPERVISOR It is suggested that applicants (1) identify toxicology group member(s) that are doing research that interests them, and then (2) contact the faculty directly to see if there is mutual interest and funding in place for a position. If a potential supervisor is secured, then applicants should proceed with a formal application to the program. Interdisciplinary Graduate Program in Toxicology – May 2016 6 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY It is preferable to identify a supervisor first, then apply, but it is not a requirement. Applicants can also apply formally, pay the application fee, and then their application will be posted online to faculty following successful review by the Graduate Chair. Successful applications will be advertised to all toxicology group members in the chance that a position becomes available and faculty need to find a student. When contacting a potential supervisor it is useful to include a statement of research interests and a CV. A list of potential supervisors and their research interests is provided further on the Toxicology Centre website (http://www.usask.ca/toxicology). APPLICATION PROCEDURES Application procedures for admission to the College of Graduate Studies & Research (CGSR) are outlined in the calendar. Application for admission is done through the online application (see CGSR website http://www.usask.ca/cgsr). All applicants must arrange for official transcripts of their academic records from each institution attended to be included with their application. Official transcripts are to be directly submitted to the Toxicology Graduate Program by each institution. At least three confidential letters of recommendation must also be submitted through an online form by referees. Graduate Record Examination (GRE) scores may be submitted, but are not required for admission. Some faculty may request GRE scores. Inclusion of a résumé or curriculum vitae is highly desirable, although not strictly required. As stated in the CGSR calendar, payment of an application fee of $90 is required. It is encouraged that prospective students contact a potential supervisor before providing the application fee. Again, this entire package should be submitted to the Graduate Chair for the Toxicology Graduate Program, not to the College of Graduate Studies and Research. Applications are accepted year round, but most decisions regarding scholarships and admission are made in April of each year. Preferred starting dates for the Program are May and September, although students can technically start any time pending approval from their chosen supervisor. Interdisciplinary Graduate Program in Toxicology – May 2016 7 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY THE ACADEMIC YEAR The Regular Session consists of two 13‐week terms; the first, or Fall term, runs from September through December and the second, or Winter term, from January through April. In general, a one‐term course is worth three credit units and a two‐term course six credit units. Currently, all Toxicology Graduate Program courses are offered during the Regular Session. (Some of the CREATE courses are offered in the summer term.) Research components of our graduate programs continue during the spring and summer sessions (May to August). Other departments may offer courses at these times (spring and summer). PROGRAM DESCRIPTION Master's and Doctoral programs require anywhere from 6 to 15 credit units from the core toxicology courses (depending on the student’s academic background) and research work resulting in an acceptable thesis. Additional courses may be requested by the student’s Advisory Committee if there is a perceived need for the student to learn more in a specific area. A working knowledge of statistical methods is required of all candidates. Minimum requirements for the proposed non‐thesis MSc program consist of 24 credit units (program still under development), including 18 credit units from core toxicology courses (see courses below). A 6 credit research project will also be included in the proposed non‐thesis MSc program. General guide for course requirements MSc program:  No background in toxicology ‐ 15 credit units will likely be required including undergraduate and core graduate level courses.  Previous BSc in toxicology (or similar) ‐ 9 credit units of core graduate courses will be required. PhD program:  No formal training in toxicology ‐ 15 credit units of core graduate courses  Previous MSc in toxicology ‐ 6 credit units of core graduate courses will be required Interdisciplinary Graduate Program in Toxicology – May 2016 8 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY COURSES Plans are currently underway to expand the existing academic program. The revision will result in the creation of several new graduate core courses. Core Courses Key to Course Descriptions: Subject Area Identifier
Course Number
Credit Units
PHYS 111.6 – 1&2 (3L-2P-1T)
General Physics
Course Title
Term in Which Class is Held
Number of Scheduled
Meeting Hours Each
Week (L-Lecture
L-LecT-Tutorial
S-SemiS-Seminar
P-Practicum/Lab)
ACB 821.3 Advanced Topics in Developmental Biology ‐ 1/2 (4S) A review of recent advances in the study of developmental biology. Special emphasis is placed on the contributions of different experimental animal systems to research in a variety of areas in the field. Prerequisite(s): ACB 330; or equivalent and permission of the instructor. BIOL 898.3 Physiology and Toxicology of Aquatic Animals ‐ 2 (1L) Designed to explore the fundamental aspects of how aquatic animals function and respond when exposed to natural and/or anthropogenic stresses. The primary emphasis is placed on understanding the physiological mechanisms by which aquatic animals acclimate or adapt to a challenging environment as well as the physiological perturbations induced by stressors that lead to the onset of toxicity. Prerequisite(s): Animal Physiology and Environmental Toxicology at Undergraduate level and permission of the Instructor. Interdisciplinary Graduate Program in Toxicology – May 2016 9 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY ENVS 832.3 Risk Assessment & Negotiation of Environmental Issues ‐ 2 (1L) The course aims to expose students to the different viewpoints and approaches used by various stakeholders typically involved with the negotiation and assessment of environmental issues. Experts from local, provincial or federal agencies, as well as experts in the areas of environmental journalism, law, and industry will give presentations on specific topics. An overview of the concept of risk assessment will be given, and similarities and differences between human and ecological risk assessments will be explored. Prerequisite(s): None MCIM 820.3 DNA Repair & Mutagenesis ‐ 1 (3L) Explores the process of DNA damage, repair, mutagenesis and impacts on cell survival, molecular evolution and human diseases. Emphasis is given to molecular, cellular, genetic and biochemical analysis of each repair pathway in various organisms. Students are expected to be familiar with the technologies and strategies in the investigations. Prerequisite(s): None PHAR 848.3 Advanced Pharmacokinetics and Pharmacodynamics ‐ 2 (3L‐2P) Qualitative and quantitative aspects of drug absorption, disposition, metabolism and excretion, and drug pharmacodynamics. The course emphasizes the use of pharmacokinetic/pharmacodynamic equations and the analysis of the data. Prerequisite(s): Basic course in pharmacokinetics or permission of the instructor. PHAR 854.3 Metabolic Transformation of Xenobiotics ‐ 1/2 (3L) An advanced study of the basic principles of the metabolism of foreign compounds in mammals. The xenobiotics covered will include drugs, food additives, agricultural chemicals, and industrial chemicals. The detoxification and toxicological implications of metabolism are emphasized. Prerequisite(s): None Interdisciplinary Graduate Program in Toxicology – May 2016 10 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY PHAR 898.3 Analytical Mass Spectrometry ‐ 2 (2L) This course will cover modern state‐of‐the‐art mass spectrometry techniques and their usefulness in research and discovery. The course will examine instrumentation‐related topics, such as ionization sources, mass analyzers and hybrid tandem mass spectrometers. The advantages of each technique will be highlighted and discussed. A second portion of the course will focus on mass spectra interpretation and the various applications of applied mass spectrometry, namely structural elucidation, quantification, proteomics, and related biomedical and environmental applications. The course will also include practical demonstration of the use of tandem mass spectrometry. Prerequisite(s): None TOX 810.3 Radiation and Radionuclide Toxicology ‐ 1/2 (3L) Describes the basic properties of ionizing radiation, the interaction of radiation with matter, radiation detection, units and dosimetry. Discusses the natural radiation environment, radioactivity and its distribution and accumulation by chemical and biological processes. Presents the biological effects of radiation, particularly carcinogenesis, both at the epidemiological and molecular level. Prerequisite(s): Minimum of one university‐level course in any four of physics, chemistry, microbiology, statistics, cell biology, or ecology. TOX 820.3 Advanced Multimedia Environmental Fate Models ‐ 1/2 (3L) Students will gain a detailed understanding of multi‐media (water, soil, atmosphere) environmental fate models and hands‐on use of current fugacity models. Topics covered include the incorporation of snow, environmental feedback, and bioaccumulation assessments into environmental fugacity fate models. Students will develop a detailed environmental fate model of an inorganic and organic compound of interest to them. Prerequisite(s): None TOX 821.3 Human Health Chemical Risk Assessment ‐ 2 (3L) Human health risk assessment is now playing a major role in the environmental management of chemicals, from both operational and regulatory perspectives. The overall objective of this course is to Interdisciplinary Graduate Program in Toxicology – May 2016 11 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY provide the basic knowledge to conduct, evaluate and interpret human health risk assessments of chemicals present in the natural and built environments. Prerequisite(s): None. TOX 840.3 Wildlife and Eco Risk Toxicology ‐ Spring (1 week short course) Provides a broad exposure to the principles and practices of ecological risk assessment in Canada, with an emphasis on terrestrial habitats and wildlife receptors. In vitro and in vivo laboratory methods and field studies to assess toxicity and sub‐lethal exposure in fish and wildlife will also be discussed. Prerequisite(s): TOX 300 and TOX 301, or permission of instructor. TOX 842.3 Biochemical Toxicology ‐ 2(2L) Students will gain a comprehensive understanding of various biochemical mechanisms of toxicity, from both biomedical (human) and ecotoxicological perspectives. The focus will be on applying basic knowledge of biochemisty and physiology to the science of toxicology. Classes will involve discussions on topics related to the current scientific literature. Prerequisite(s): Background knowledge in toxicology. TOX 843.3 Environmental Chemodynamics ‐ 2 (3L) Provides students with an understanding of the processes that control the movement of organic and inorganic contaminants in the atmosphere, hydrosphere and lithosphere, and will also provide an understanding of the methods used to monitor environmental behaviour of potentially toxic contaminants in biotic and abiotic matrices. Prerequisite(s): One course in ecology or environmental biology and one course in general or environmental chemistry, or permission of the instructor and student's advisor/advisory committee. TOX 844.3 Toxicology Techniques ‐ 1 (1L‐3P) Provides theoretical background and hands‐on experience in methods and techniques typically applied by toxicology professionals in academia, industry, and government. It is a modular course that covers a broad spectrum of procedures, ranging from proper handling of field equipment to biological test methods and analytical processing of samples. Permission of course coordinator required. Interdisciplinary Graduate Program in Toxicology – May 2016 12 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY Prerequisite(s): Successful completion of Laboratory Safety course and GSR 962. TOX 850.3 Aquatic Toxicology ‐ 1 (3L‐2P) A comprehensive overview of the technical aspects of predicting, monitoring, and evaluating the effects of toxic substances in aquatic systems. The class will cover levels of biological organization from sub‐
cellular to ecosystem. It is designed as an in‐depth coverage of aquatic toxicology for students pursuing graduate degrees in the aquatic sciences. Students will be exposed to materials that will be useful in setting exposure standards and assessing hazards to aquatic ecosystems due to point or non‐point releases of toxic substances. Prerequisite(s): Permission of the instructor. TOX 860.3 Applied Toxicology ‐ 1&2 (1L‐S/T) Provides students an opportunity to evaluate practical problems associated with various aspects of biomedical and veterinary toxicology. Students will be presented with specific toxicological questions or concerns which will be examined outside the classroom using research data and scientific literature. Prerequisite(s): Registration in the Toxicology Graduate Program or permission of the instructor. Note: Recommended additional credit units in TOX. TOX 898.3 Environmental Effects Assessment & Monitoring ‐ Spring (2 week short course) This course will introduce students to key principles for designing robust environmental effects studies from industrial activities on the landscape. It will cover selection of appropriate ecological effects and measurable parameters (endpoints) that can be used for both pre‐construction environmental assessments in regulatory approval applications and post‐construction environmental effects monitoring programs, with an emphasis on mechanisms of physical and chemical effects on invertebrates, fish and wildlife. Prerequisite(s): Interdisciplinary Graduate Program in Toxicology – May 2016 13 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY VBMS 833.3 Subclinical Toxicology ‐ 1/2 (3L‐1S) Discusses subclinical manifestations to toxic agents. The emphasis will be on immunological and behavioral alterations produced by a variety of chemical agents. Animal models and testing methods used to evaluate the effects will be discussed, along with various public health considerations and significance. Prerequisite(s): Permission of the instructor or registration in the Toxicology Graduate Program. VBMS 840.3 Vascular Biology and Toxicology ‐ 2 (3L) This course examines the physiology of blood vessels at the tissue, cellular and molecular level. The interaction of blood vessels with blood, the pathophysiology of common vascular diseases and the effect of toxicants on the circulation are discussed. Prerequisite(s): None, Permission of the Instructor. VBMS 855.3 Integrative Cardiovascular Physiology & Toxicology ‐ 2 (1L) The course will build on the content of VBMS 840 (Vascular Physiology & Toxicology) which is focused strictly on vascular tissue, examine ventricular/arterial coupling as well as how cardiac, pulmonary, renal, endocrine and/or neural systems integrate with cardiovascular responses for homeostatic control of blood pressure, examine how these homeostatic mechanisms are altered in pathological processes associated with major human diseases and toxic agents encountered by humans. Relative emphasis on disease versus toxicants will be adjusted according to students’ backgrounds each year. Prerequisite(s): VBMS 840, Permission of the Instructor. In addition to the core courses, the following special topics courses are currently being offered: ANSC 825.3 Nutritional Toxicology – 1 (3L) Naturally occurring toxicants. Bacterial toxins and mycotoxins. Additives and residues. Contaminants. Drug‐nutrient interrelationships. Nutrient toxicity. Safety and regulatory aspects. Prerequisite(s): Undergraduate biochemistry and nutrition courses and permission of the instructor. Interdisciplinary Graduate Program in Toxicology – May 2016 14 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY APMC 825.3 Carcinogens and Mutagens – 2 (2L‐1S) Provides some understanding of carcinogens and mutagens, their mechanism of action at organismic, cellular, and molecular levels, and of their testing and assessment. Short seminar discussions of current developments will be included. Prerequisite(s): One course in each of biochemistry, cell biology (e.g., ANAT 201), and general microbiology, and permission of the instructor. BIOE 850.3 Synchrotron X‐Ray Imaging ‐ 1/2 (3L) Will introduce some synchrotron specific imaging modalities such as K‐edge subtraction, diffraction enhanced imaging, and phase contrast imaging with connections made to conventional imaging. The first part of the course will cover x‐ray interactions, detection, dose estimation and source properties (conventional and synchrotron). Prerequisite(s): Permission of the instructor. GEOL 898.3 Advanced X‐Ray Absorption Spectroscopy ‐ 2 (3L) The course will describe the physical principles, experimental technique and data analysis of X‐ray absorption spectroscopy. Frequent reference to practical applications will be included, and relevant synchrotron technology will also be reviewed. This course will equip the student with a practical working knowledge of the technique and its capabilities. Prerequisite(s): Permission of the instructor. PHAR 856.3 Forensic Toxicology – 1 (3L‐4P) Deals with the analytical procedures involved in the detection of chemicals and drugs in the body tissues and fluids, and the identification of drugs of abuse. Appropriate analytical chemical techniques are discussed and used during the practical component of the course. Prerequisite(s): None VTPA 841.3 Toxicologic Pathology – 2 (1L‐1S‐2P) Covers mechanisms of toxicology as well as basic pathology, focusing on several major organ systems. The students' understanding of how clinical, environmental or pharmacological toxicants damage Interdisciplinary Graduate Program in Toxicology – May 2016 15 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY specific organs will be supported through didactic instruction, case studies, web‐based cases, directed readings and structured group discussion. Prerequisite(s): VTPA 342 & 343, or equivalent; or, TOX 402 & PATH 205, or permission of the instructor. TOX/ENVB 6530.3 Toxicological Risk Characterization ‐ 3 (3L) A biologically based, advanced course that will give students working knowledge of current processes and techniques for toxicological risk characterization. The course material will cover the topics: Problem definition; effect characterization; exposure characterization; risk assessment; and risk management decision making. Prerequisite(s): None. TOX 898.6 Special Topics in Toxicology Offered occasionally by existing and visiting faculty, and in other special situations to cover, in depth, topics that are not thoroughly covered in regularly offered courses. Required courses which students must maintain continuous registration for the duration of their program: TOX 990 Toxicology Seminar Weekly seminars presented by graduate students and invited speakers. Graduate students are required to attend and to present seminars. TOX 994 Research Students writing a Master's thesis must register for this course. TOX 996 Research Students writing a PhD thesis must register for this course. Interdisciplinary Graduate Program in Toxicology – May 2016 16 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY STRUCTURE AND OPERATION OF ADVISORY COMMITTEES All students registered in MSc and PhD thesis programs will require an advisory committee. After a student has met the admission requirements, he or she will be matched with a supervisor appropriate to the student's area of proposed study. After that, an advisory committee will be established. For MSc candidates, the advisory committee will consist of the Graduate Chair (or designate), who is chair of the committee, the student's supervisor, and at least one additional member. For PhD candidates, the advisory committee will consist of the Graduate Chair (or designate), who is chair of the committee, the student's supervisor, one cognate member, and at least two additional members. The advisory committee will establish a program of study (POS), supervise the student's progress, participate in qualifying and comprehensive examinations, provide guidance and advice to the student, and approve the student's research proposal and final thesis. MONITORING STUDENT PROGRESS Monitoring a student's progress is the responsibility of the advisory committee. Progress is reported by the Graduate Chair (or designate) to the Toxicology Group Executive and to the College of Graduate Studies and Research. ACADEMIC STANDARDS All MSc students must maintain a 70% grade point average (GPA), with a minimum of 65% in each course. Undergraduate courses, if part of the student’s POS, must be passed with a minimum of 70%. PhD students must maintain a 70% GPA, with a minimum of 70% in each course. PhD and MSc students must also maintain satisfactory progress in their research project. SEMINARS All graduate students will be required to participate in the TOX 990 seminar series, as part of the degree requirements. All MSc students must present one seminar before defending or graduating (usually in their second year), while PhD students must present two seminars during their program. Interdisciplinary Graduate Program in Toxicology – May 2016 17 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY Graduate students are required to regularly attend TOX 990 seminars throughout their graduate pro‐
gram (when based in Saskatoon) as partial fulfillment of their degree requirements, as prescribed by the College of Graduate Studies and Research (CGSR) and as mentioned in the Toxicology Graduate Student Handbook. Attendance will be recorded at each TOX 990 seminar, and if a student is absent an email will be sent by the toxicology graduate secretary to the student, the supervisor(s), and the graduate chair noting the absence. In addition, a summary of the missed recorded TOX 990 seminar or subse‐
quent TOX 990 seminar will be required to be handed into the course coordinator for each unexcused absence by a student. The summary will be due within 5 days of the identified seminar. The TOX 990 attendance policy requires that graduate students attend a minimum of 75% of seminars in each term (fall and winter semesters). In instances where a student attends less than 75% of seminars for a given term, their case will be reviewed by the Graduate Studies Committee, which determines if absences were justified. Students who did not meet the attendance requirement, and who did not have acceptable reasons for their absences, will be required to perform a Toxicology Program service function identified by the Graduate Chair, and/or write a review paper on a topic selected by the Graduate Stud‐
ies Committee. In addition, students in violation of the policy will not be eligible for future Toxicology scholarships, teaching fellowships, and other awards administered through the Toxicology Centre. It is realized that certain justifiable commitments may prevent attendance at all seminars, such as at‐
tending scientific conferences, conducting field research, spending time working in laboratories at other institutions, illness, and approved leaves. Such absences, if documented, will not be included in the at‐
tendance calculation. It is therefore important that students maintain a document recording the rea‐
sons for absences during each academic year, should such occur. It is, however, expected that both stu‐
dents and supervisors schedule research and other activities around TOX 990 seminars, as far as that is feasible. QUALIFYING AND COMPREHENSIVE EXAMINATIONS Qualifying and comprehensive examinations are not required of MSc candidates (PhD program only). Qualifying examinations for PhD students will take the form of an oral examination, usually within 12 months of entry into the program. This exam is primarily used to evaluate a student’s background Interdisciplinary Graduate Program in Toxicology – May 2016 18 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY knowledge of toxicology when they do not possess a prior degree in toxicology. Comprehensive examinations for PhD candidates will include oral and written examination components and is usually taken during the third year in the program. The Examination Committee will consist of five members of the Advisory Committee (chair, supervisor, cognate, and two regular members). TRANSFER FROM AN MSc TO A PhD Students registered in the MSc program who already hold an MSc degree in another discipline may transfer to a PhD program if they have: successfully completed a qualifying examination; attained a minimum 85% GPA in courses taken as part of their MSc program; shown satisfactory progress and evidence of originality in their research; and demonstrated adequate written and verbal communication skills (as evidenced by a submitted peer‐reviewed manuscript with the student being the first author). Transfer (i.e. the Qualifying Exam) from a MSc to a PhD program needs to occur during the first two years of study. Students registered in the MSc program who do not hold an MSc degree in another discipline may transfer into a PhD program if exceptional progress is evident, including: outstanding performance during a qualifying examination; a minimum 85% GPA; a high level of productivity and originality in their research as indicated by peer‐review research publications/submitted manuscripts (with the student being the first author) or exceptional progress; and demonstrated excellent written and verbal communications skills. This option is available to only a limited number of outstanding students. Students are considered outstanding if, in addition to the criteria listed above (85% GPA, submitted peer‐review research manuscript), they are eligible or holding an NSERC award, Dean’s scholarship, or have received other national scholarships. Transfer from MSc to PhD programs needs to occur during the second year of study in most instances. THESIS REQUIREMENTS For MSc and PhD degrees, a thesis must be prepared by the student on their research. The thesis must be defended by the student subsequent to approval by the advisory committee. For each MSc and PhD defense, an external examiner is added to the examination committee. An electronic copy of the thesis Interdisciplinary Graduate Program in Toxicology – May 2016 19 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY must be submitted to CGSR. A bound copy of the thesis is required by the program at the Toxicology Centre. SCHOLARSHIPS AND AWARDS PROGRAM Available Scholarships The Toxicology Graduate Program offers full and partial scholarships to outstanding students each year. Full scholarships are currently valued at $18,000 and $21,000 for MSc and PhD students, respectively. Although full scholarships are occasionally awarded, it is more common that students receive half scholarships. The remaining stipend is usually paid from the faculty supervisor’s research funds or other sources. MSc and PhD scholarships may be held for a maximum of 24 and 36 months, respectively. Partial or Full Tuition Supplements for national scholarship holders (e.g. NSERC) will also be considered. These range in value from $1,000 to $3,000 per year. MSc candidates who transfer to a PhD program may hold the combined scholarships for only 48 months. The award of scholarships will be decided by the Toxicology Awards Committee consisting of the Chair of the Toxicology Group, the Graduate Chair, and at least one additional representative from the Toxicology Group Executive. Under normal circumstances, applications for scholarships are reviewed in March‐April for the following fiscal year (starting in May). A limited number of scholarships or partial scholarships may be awarded throughout the year. Minimum Criteria for Scholarships 1) An academic standing of 80% or equivalent in the final two years of full‐time undergraduate study or previous or current graduate study. 2) Acceptance as a fully‐qualified student in the Toxicology Graduate Program. 3) Identification of a supervisor who is a member of the Toxicology Group. 4) A commitment by the supervisor to provide ongoing financial support for the student's research project, including salary if only a partial scholarship is awarded. A student must remain in the Toxicology Graduate Program with acceptable academic standing and satisfactory research progress to maintain award eligibility. Interdisciplinary Graduate Program in Toxicology – May 2016 20 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY Allocation of Scholarship Funds The value of full MSc and PhD stipends will generally be consistent with national or CGSR awards guidelines. At the present time, the minimum stipend values are: MSc ‐ $18,600 per year; PhD ‐ $21,600 per year. In some cases, the Toxicology Graduate Program may exceed these funding guidelines to attract exceptional students who possess unusually high academic standards or demonstrate other unique attributes related to past research credentials or equity issues. These awards are known as Tuition Supplements. They are awarded at three levels: $1,000 per year; $2,000 per year; or $3,000 per year. The level of the award will be influenced by available funding and the tuition assessment for the current academic year. Tuition supplements will be used, in many instances, as an incentive to attract students who have been awarded national scholarships from outside agencies or organizations (e.g., NSERC, CIHR). All NSERC and CIHR award holders are guaranteed a supplement. Graduate Teaching Fellowship One or more graduate teaching fellowships (GTF) are also available to students in the Toxicology Graduate Program. The recipients of these fellowships are required to provide teaching assistance with undergraduate courses of up to 12 hours per week, although less time is generally required. The value of each full fellowship is approximately $5,000 for each term. Selection of candidates is made by the Toxicology Awards Committee. Preference is generally given to PhD or MSc students with leadership qualities and strong academic standing. Internal Awards In addition to standard graduate scholarships and fellowships, the Toxicology Graduate Program provides the following special awards to full‐time graduate students: C.S. Sisodia Award The C.S. Sisodia Award is presented annually to a full‐time graduate student registered in the Toxicology Graduate Program who has completed a minimum of two years of formal course work. The $1,000 award recognizes academic excellence in the field of toxicology. Interdisciplinary Graduate Program in Toxicology – May 2016 21 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY Toxicology Centre Graduate Student Poster Competition Awards At the Toxicology Group Annual General Meeting students have an opportunity to present their research findings in poster format and offer a five minute oral presentation on the material provided in their poster. Awards of $300 (first place), $200 (second place), and $100 (third place) are provided annually to students working towards a MSc or PhD in toxicology. Judging is focussed primarily on the quality of research material provided, the physical nature and overall appearance of the poster, and the clarity and conciseness of the oral presentation. H.B. (Bruno) Schiefer Graduate Student Travel Award This award is intended to provide two travel grants of $500 (one award of $500 will be awarded in the Fall Term and one award of $500 will be award in the Winter Term of each year) to a graduate student(s) in the Toxicology Graduate Program. Students must be presenting research findings from their University of Saskatchewan toxicology graduate work (in either platform or poster format) at a national or international scientific meeting in order to be eligible for the award. Selection will be based on a combination of research progress and quality, academic standing, and financial need. Toxicology Graduate Student’s Association Travel Award The purpose of this award is to give monetary assistance to students who have not had an opportunity to attend a conference. To be eligible, the student must be in the Toxicology Graduate Program, have never attended a conference out of the province during their current degree, show financial need, and have actively participated in activities associated with the TGSA or another organization related to their field of study. To apply, the following need to be submitted: (1) a personal letter outlining financial need (including a detailed budget of conference expenses), status of project and research, conference importance, and length of time the student has been in program, (2) student’s C.V., (3) proof of commitment from the student’s primary supervisor to cover costs of attending the conference not covered by the award, through a brief letter of support, and (4) abstract being submitted by the student to present at the conference. The award is $500 and will be awarded annually or biannually depending on the availability of funds from the TGSA. The award will be posted mid‐August and the applications will be accepted until the end of September. Notification of the award winner will be sent out in October. Interdisciplinary Graduate Program in Toxicology – May 2016 22 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY AREVA Travel Award The AREVA Travel Award of $1,000 will be presented annually to a full‐time student enrolled in the Toxicology Graduate Program. The travel grant can be awarded to either a single student, or can be split into two partial grants totaling $1,000 per year. The purpose of this travel award is to financially support graduate students planning short‐term visits to and special training opportunities at research laboratories at other universities, or provincial and federal research institutions. During their visit, award recipients have to give an oral presentation/guest lecture about their research at the Toxicology Centre.. Alternatively, the award can be used for expenses related to international conference travel outside North America. A letter of thanks must be sent by the award recipients to AREVA Resources Canada Inc. upon return. TOXICOLOGY GROUP FACULTY AND RESEARCH INTERESTS Members of the Toxicology Group who may be in a position to supervise students within the Toxicology Graduate Program are listed below. Names have been grouped within sub‐disciplines of toxicology and a brief description of each member's research interests provided. Please contact the Graduate Chair (see Contact Information) for further information on faculty who might be actively seeking graduate students in conjunction with specific research projects. (Affiliations of members who are not University of Saskatchewan faculty but Adjunct Faculty are given in parentheses.) Analytical and Forensic Toxicology George, G. Sulfur K‐edge X‐ray absorption spectroscopy as a probe of sulfur biochemistry in intact tissues. Headley, J. Environmental mass spectrometry. (Environment Canada) Nazarali, A. Teratogenicity; DNA‐protein interactions; transcriptional factors; expression of developmental genes in mice embryos. Pickering, I. Synchrotron studies of metals and other elements of concern to determine chemical speciation and microscopic distribution; including both environmental studies and vertebrate and human toxicology. Wang, D. Analytical, environmental, and drinking water quality. Interdisciplinary Graduate Program in Toxicology – May 2016 23 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY Biomedical and Human Toxicology Alcorn, J. Infant exposure to xenobiotics; maturation of clearance mechanisms; toxicokinetics. Berry, M. Endogenous regulators of CNS neuronal activity; cell death mechanisms in neurons; regulation of cell death in normal and cancer cells. Bharadwaj, L. Cardiovascular toxicology. Baerwald, A. Effects of endocrine disrupting chemicals on human reproduction and development. Blakley, P. Clinical teratology; Fetal Alcohol Syndrome; genetic predisposition to teratogenesis. Hiebert, L. Vascular biology/toxicology; injury by free radicals. Krol, E. Xenobiotic metabolism of naturally occurring phenols; reactive intermediates. Krone, P. Endocrine modulation/developmental toxicology; use of stress proteins as biomonitors of toxicity in fish embryos. Paterson, P. Biochemical and physiological functions of trace elements; nutrition and eye function; effects of nutrients on antioxidant pathways in stroke. Pierson, R. Reproductive toxicology; ovarian biology; reproductive ultrasonography; image analysis; embryology. Qureshi, A. Clinical toxicology and therapeutic drug monitoring; drugs of abuse; homocystine; immunosuppressive drugs. Rosenberg, A. Environmental toxin exposure and induction of autoimmunity. Semchuk, K. Human epidemiology ‐ general, occupational, environmental; environmental and occupational risk assessment; herbicide exposures Singh, B. Nanotoxicology and nanomedicine; molecular mechanisms of lung inflammation. Weber, L. Tobacco smoke and air pollution effects on cardiovascular disease; pathophysiological mechanisms, animal models, role of polycyclic aromatic hydrocarbons. Whiting, S. Nutritional toxicology; diet and osteoporosis, with emphasis on nutrition‐bone relationship; safety of foods produced through biotechnology; dietary fibre. Xiao, W. Mechanisms of action of genotoxic chemicals and cellular responses to DNA damage. Zello, G. Protein and amino acid metabolism in humans and animals investigated using stable isotope methodology; effects of drugs on protein metabolism, drug‐nutrient interactions. Interdisciplinary Graduate Program in Toxicology – May 2016 24 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY Veterinary and Wildlife Toxicology Blakley, B. Immunotoxicology ‐ environmental aspects, nutritional states; applied veterinary toxicology; heavy metal toxicity (Pb, Cd). Leighton, F. Wild animal disease surveillance, including poisonings; diagnosis of anti‐cholinesterase pesticide poisoning; petroleum oil toxicity to birds. Morrissey, C. Avian ecology and ecotoxicology. Testing biomarkers of exposure (ecophysiological, stable isotope methods) and effects of pollutants in wild birds. Wickstrom, M. Effects of pesticides and metals in wildlife; cyanobacterial toxins; clinical veterinary toxicology; environmental risk assessment. Ecological and Aquatic Toxicology Armstrong, S. Fate and effects of petrochemicals and petroleum products in the environment and environmental risk assessment of industrial processes. (Shell Oil) Cessna, A. Atmospheric transport and fate of pesticides; transport of pesticides in runoff waters and subsurface waters. (Environment Canada) Davies, J‐M. Nutrient impacts on algal ecology; drinking water quality. (Saskatchewan Watershed Authority) Evans, M. Biomagnification of persistent organochlorines and mercury. (Environment Canada) Farrell, R. Metal speciation/bioavailability in soils and sediments; phytoremediation systems for TPH and metal contaminated sites. Giesy, J. Discovery and assessment of emerging contaminants of concern, including perfluorinated and endocrine modulating compounds; development of novel bioanalytical tools; biochemical indicators of stress in aquatic organisms. Hecker, M. Development, validation and application of novel bioanalytical techniques; endocrine disruption and reproductive toxicology in oviparous vertebrates; ecotoxicological risk assessment of persistent organic compounds, pesticides and metals in vertebrates. Hogan, N. Developmental, reproductive and immune toxicology in aquatic species. Janz, D. Reproductive physiology and endocrinology of oviparous vertebrates; endocrine toxicity; biochemical toxicology; mechanisms of toxicity; cytochrome P450. Interdisciplinary Graduate Program in Toxicology – May 2016 25 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY Jardine, T. Use of stable isotopes to investigate linkages between hydrology, ecology and food web trophodynamics in contaminated aquatic ecosystems. Jones, P. Fate and effects of organic pollutants in the environment and wildlife. Use of biochemical and molecular biology techniques in environmental toxicology. Liber, K. Metal bioavailability and toxicity in aquatic ecosystems, especially in sediments; mining impacts on aquatic ecosystems. Niyogi, S. Assessment of waterborne metal bioavailability and toxicity using the Biotic Ligand Model (BLM) approach; uptake, regulation, and toxicity of dietary metals in freshwater fish. Raine, J. Developmental physiology and endocrinology; endocrine disruption; mechanisms of toxicity; thyroid hormone regulation and signaling Siciliano, S. Soil ecotoxicology, investigation of trace contaminant effects in northern terrestrial ecosystems using molecular tools. Somers, C. Environmental exposures and DNA damage in wildlife and indicator species. Processes in the germline that contribute to trans‐generational effects due to contaminant exposure. Thomas, P. Environmental transport and food chain transfer of radionuclides; radiation dosimetry and risk assessment; radiation biology of animal and human cell types. RESEARCH FACILITIES In 2006/2007, the Toxicology Centre underwent significant expansion and renovation resulting into state‐of‐the art research facilities for analytical, aquatic, biochemical, environmental, mechanistic, radiation, and wildlife toxicology research from the molecular to ecosystem levels. The flagship of the expansion is the Aquatic Toxicology Research Facility, a 7,100 sq‐ft laboratory, which is the first of its kind in Canada and one of only a few similar research resources worldwide. It was specifically designed with areas provided with different water qualities and temperatures ranging from 6‐45 oC to perform both static and dynamic toxicological experiments with algae, crustaceans, insects, clams, amphibians or fish as large as 10 kg. New in‐house research facilities also include five walk‐in controlled‐environment chambers, four with purified water supplies for conducting both acute and chronic aquatic toxicity tests with several species of freshwater invertebrates, small fish, and algae, and an analytical laboratory for water quality analysis. Interdisciplinary Graduate Program in Toxicology – May 2016 26 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY To directly investigate toxic effects of polluted waters on fish and other aquatic organisms in the field, a mobile trailer artificial stream system is available now at the Toxicology Centre. Our brand new laboratories are equipped with prime instrumentation to detect organic and inorganic chemicals and metabolites toxic to wildlife and humans. Analytical procedures involve gas chromatography (GC) with FID, ECD, and NP detection capabilities, high performance liquid chromatography (HPLC), UV/visible spectrophotometry, atomic absorption spectrophotometry (AAS), and inductively coupled plasma‐mass spectrometry (ICP‐MS), to name but a few. The biochemistry and molecular facilities are capable of doing just about any type of biochemistry and molecular work used on the toxicology field. They have the equipment (centrifuges, water baths, incubators, etc.) and capacity to run anything from gel electrophoresis and western blotting to ELISA’s and enzyme activity (EROD, MROD and Aromatase). Finally, based on the interdisciplinary nature of our program there is easy access to a variety of techniques and instrumentation in other labs on and off campus. The various Toxicology Group members have a broad array of sophisticated analytical and laboratory equipment available for toxicology research, including automated atmospheric sampling equipment using mini‐tube technology, an artificial stream system, computerized pulmonary function testing, scanning tunnelling microscopy, specialized shape‐analysis and macromolecular electron density software, radioisotope counters, microcosm test systems, separate specialized facilities to undertake avian and mammalian studies, and much more. JOB OPPORTUNITIES FOR GRADUATES OF THE PROGRAM There is a great demand for toxicology graduates both in Canada and internationally. Graduates find jobs in the chemical, drug, food and resource industries; environmental consulting firms; federal and provincial government research laboratories and regulatory departments; or university‐based research centres. Most students completing MSc or PhD degrees have been actively recruited by prospective employers in both the public and private sectors. Interdisciplinary Graduate Program in Toxicology – May 2016 27 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY The Toxicology Program offers research training and formal course requirements that are unique in Canada. These features enable our graduates to pursue a diversity of careers in toxicology. Consult our website for the current status of our alumni. COST OF STUDY Tuition fees for Canadian MSc and PhD students are $1,300 per term ($3,900 per academic year) for the duration of the program. Tuition fees for International MSc and PhD students are $1,950 per term ($5,850 per academic year) for the duration of the program. Please refer to the Tuition Information website of the CGSR for details. All graduate students registered full‐time in Term 1 and who are members (including international students) of the Graduate Students’ Association (GSA) are automatically covered by a health and dental plan, providing a comprehensive package of health, dental, vision, and travel insurance benefits. For details contact the Health & Dental Plan Office at the U of S, or visit their website: www.ihaveaplan.ca. LIVING AND HOUSING COSTS Housing costs in Saskatoon are reasonable. Rental costs for apartments and suites range from $500‐
$800 for a bachelor apartment, $800‐$1,000 for a 1‐bedroom apartment, and $1,000+ for a 2‐bedroom apartment. Rental costs for houses average $900‐$1,500, depending on condition and the number of bedrooms. The average house in Saskatoon sells for approximately $320,000. An estimate of minimum expenses, including tuition, books and supplies, living accommodation and food, local transportation, clothing, personal needs and entertainment, etc. is roughly $16,200 per year (Please see “International Student Cost‐Estimate Sheet” http://explore.usask.ca/international/tuition for detailed information). You can also search the University of Saskatchewan Students' Union Housing Registry Database: http://www.ussu.ca/housing/index.shtml. The University of Saskatchewan Graduate House is a newly built residence for graduate students. For more information visit www.livewithus.usask.ca, or contact the Residence Office at residence@usask.ca or 1‐306‐966‐6775. Interdisciplinary Graduate Program in Toxicology – May 2016 28 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY INFORMATION FOR INTERNATIONAL STUDENTS The language of instruction at the University of Saskatchewan is English. Applicants for admission whose first language is not English must present evidence of proficiency in English. The following will be accepted as satisfactory evidence: (1) Three years of full‐time attendance in a Saskatchewan high school (or from an institution where English is the language of instruction and examination) including complete secondary level standing and successful completion of English Literature and Composition in each of Grades 10, 11 and 12. Or (2) A score of at least: 580 (paper based) or 237 (computer based) on the Test of English as a Foreign Language (TOEFL), Band 6.5 on the Academic Reading and Writing Modules of the International English Language Testing System (IELTS), Band 4.5 of the Canadian Test of English for Scholars and Trainees (CanTEST), 63 on the Canadian Academic English Language (CAEL) test, 60% on Advanced Level (ESL 050) of the University of Regina's Intensive English as a Second Language program plus completion of Academic Writing Elective A, C or higher on the University of Cambridge Certificate of Proficiency in English (CPE) test, or 85 on the Michigan English Language Assessment Battery (MELAB). (For more details check the Language Requirements website of the CGSR.) All test scores must be forwarded directly to the Toxicology Centre by the testing centre. Or (3) Successful completion of at least 18 credit units of transferable university‐level courses at an institution where English is the official language of instruction and examination. Or (4) Successful completion of the ESL (English as a Second Language) program (Level 50: Advanced) offered by the Centre for Second Language Instruction. These courses are considered the equivalent of full‐time studies for immigration purposes. For more information about the ESL Interdisciplinary Graduate Program in Toxicology – May 2016 29 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY program contact: The Language Centre, Telephone: (306) 966‐4351, E‐mail: international.esl@usask.ca, Website: www.extension.usask.ca For further information, please see the brochures directed towards international students. Additional information can also be found on the CGSR website: http://www.usask.ca/cgsr/english.php. TOXICOLOGY GRADUATE STUDENT ASSOCIATION The Toxicology Graduate Student Association (TGSA) is a student council group that represents toxicology graduate students and provides a link to the University of Saskatchewan Graduate Students Association (GSA). The TGSA holds various student social, fundraising, outreach, and sports activities during the academic year. In the past, the TGSA holds welcome potlucks and barbeques in the fall and winter sessions, clothing sales, winter retreats, various tours on and off campus, fund‐raising events, and presentations to school groups. The TGSA participates regularly in campus recreational sports. It represents toxicology graduate students and provides information and support for students regarding campus activities and policies. RECREATIONAL AND ARTS OPPORTUNITIES A variety of campus recreational activities are available at the U of S, with campus rec leagues devoted to men’s, women’s, co‐rec sports, and a spectacular new Physical Activity Complex. Sports such as basketball, curling, football, floor hockey, ice hockey, badminton, soccer, and volleyball attract students from across campus. The Arts are well represented with student participation in such organizations as the Greystone theatre, the Greystone singers, and various bands and ensembles. Interdisciplinary Graduate Program in Toxicology – May 2016 30 | P a g e
TOXICOLOGY CENTRE | WWW.USASK.CA/TOXICOLOGY CONTACT INFORMATION For further information on the Interdisciplinary Graduate Program in Toxicology, please contact: Graduate Chair Toxicology Graduate Program Toxicology Centre 44 Campus Drive University of Saskatchewan Saskatoon, Saskatchewan S7N 5B3 CANADA Telephone: (306) 966‐7441 Facsimile: (306) 931‐1664 E‐mail: tox.centre@usask.ca For additional information visit: Toxicology Centre website ‐ http://www.usask.ca/toxicology University of Saskatchewan website ‐ http://www.usask.ca College of Graduate Studies and Research website ‐ http://www.usask.ca/cgsr Numerous links to more information about the University, the City of Saskatoon, and the Province of Saskatchewan are available through the U of S website. SUMMARY OF APPLICATION SUBMISSION DOCUMENTS 
Online application 
Three Confidential Letter of Recommendation (included in the online application) 
Official transcripts 
TOEFL / English proficiency test 
Letter outlining experience and interests in Toxicology 
Application fee of $90 Interdisciplinary Graduate Program in Toxicology – May 2016 31 | P a g e