Department of Physics and Physical Oceanography Colloquium “Magnetic resonance imaging: making the invisible visible” Dr. Tamara Branca Department of Physics and Astronomy, UNC School of Medicine Magnetic Resonance Imaging (MRI) is a mature non-invasive diagnostic technique that has the potential to image some events at the cellular level. With the aim to develop this capability we are investigating non-linear MR effects that come from previously ignored “multiple quantum transitions”. I will discuss the physical origin of this signal as well as some of the unique features that enable us to use it to enhance tissue contrast, to acquire high resolution spectra in vivo, to measure tissue structure on a distance scale that is "invisible" to conventional MR methods, and finally to accurately measure tissue temperature. I will also present our most recent work in which we use hyperpolarized xenon gas as an MR contrast agent. We have used this technique to detect fatty tissue metabolism and to measure tissue temperature with a sensitivity much higher than what is currently possible with conventional 1H MRI techniques. Friday, February 21, 2014 2:00 PM DeLoach Hall, Room 212