Mechanisms of Recombination 2016
Alicante, Spain
Conference Program
Monday, May 16
Arrival
17:00 – 18:30
Registration
18:30 – 19:30
Welcome reception
19:30 – 20:05
Keynote: Rodney Rothstein (Columbia University, US)
Beginning of the ends…and beyond
20:05 – 20:40
Keynote: Neil Hunter (University of California, Davis, US)
Regulating destruction to recombine the genome
Dinner
Tuesday, May 17
Breakfast
Session 1
09:00 – 09:25
Chair: Alain Nicolas
Scott Keeney (Memorial Sloan-Kettering Cancer Center, US)
Formation and processing of meiotic DNA double-strand breaks
09:25 – 09:50
Bernard de Massy (Institute of Human Genetics, CNRS, France)
A TopoVI-like complex is required for meiotic DNA double strand break formation
09:50 – 10:15
Michael Lichten (National Cancer Institute, US)
Local and global influences on meiotic recombination biochemistry
10:15 – 10:30
Matthew Whitby (University of Oxford, UK)
Recombination at the termination of DNA replication
Break
11:00 – 11:25
Akira Shinohara (Osaka University, Japan)
Control of meiotic recombination by Rad51/Dmc1 mediators and DNA helicases
11:25 – 11:50
Hiroshi Iwasaki (Tokyo Institute of Technology, Japan)
Real-time analysis of Rad51-mediated DNA strand exchange activation by Swi5-Sfr1 complex
11:50 – 12:15
Maria Jasin (Memorial Sloan-Kettering Cancer Center, US)
Protecting the genome by homologous recombination: Role of the BRCA2 tumor suppressor
12:15 – 12:30
Douglas Bishop (University of Chicago, US)
Biochemical reconstitution of meiotic recombination
12:30 – 12:40
Abcam
Lunch
Free time
16:00 – 18:00
Poster Session 1 (odd numbered posters present)
Session 2
Chair: Jim Haber
18.00 – 18:25
Steve West (Francis Crick Institute, UK)
Activation of MUS81 by formation of the SMX trinuclease complex
18:25 – 18:50
Stephen Kowalczykowski (University of California, Davis, US)
Molecular Functions of BRCA1, BRCA2, and RAD51 paralogs in homologous recombination
18:50 – 19:15
John Rouse (University of Dundee, UK)
Twists and turns in repairing inter-strand DNA crosslinks
19:15 – 19:40
Pierre-Henri Gaillard (INSERM, France)
SLX4 and EME1 struggle with SUMO to maintain genome stability
19:40 – 20:05
Dana Branzei (IFOM Foundation, Italy)
SUMO-mediated global and local control of recombination
20:05 – 20:20
Francesca Storici (Georgia Institute of Technology, US)
DNA double-strand break repair by transcript RNA
Dinner
Wednesday, May 18
Breakfast
Session 3
09:00 – 09:25
Chair: Dale Wigley
David Sherratt (University of Oxford, UK)
In vivo single-molecule biochemistry of bacterial DNA repair and chromosome processing
09:25 – 09:50
Massimo Lopes (University of Zurich, Switzerland)
Replication fork remodeling upon DNA replication stress
09:50 – 10:15
Ian Hickson (University of Copenhagen, Denmark)
Recombination-associated mutagenesis at a single stalled replication fork
10:15 – 10:30
Jeff Sekelsky (University of North Carolina at Chapel Hill, US)
Functions of the Ankle1 GIY-YIG nuclease in Drosophila
Break
11:00 – 11:25
Ralph Scully (Beth Israel Deaconess Medical Center, US)
BRCA1 suppresses tandem duplications at Tus/Ter-stalled replication forks
11:25 – 11:50
Jo Murray (University of Sussex, UK)
Visualisation of HR-dependent chromosome rearrangements in real time
11:50 – 12:15
Petr Cejka (University of Zurich, Switzerland)
Phosphorylation regulates DNA end resection by Sae2 and MRX
12:15 – 12:30
Kara Bernstein (University of Pittsburgh School of Medicine, US)
The concerted function of the Shu complex and the Rad51 paralogs in Rad51 presynaptic assembly
Lunch
Free time
Session 4
18.00 – 18:25
Chair: David Leach
Jim Haber (Brandeis University, US)
Rules for efficient homologous recombination to repair a broken chromosome
18:25 – 18:50
Andres Aguilera (University of Seville, Spain)
New factor involved in recombination-mediated restart of broken forks
18:50 – 19:15
Lorraine Symington (Columbia University, US)
Xrs2 is dispensable for DNA end resection but is required for Tel1 signaling and end joining functions of
the Mre11-Rad50 complex
19:15 – 19:35
Matthew Neale (Genome Damage and Stability Centre, UK)
Spatial patterning of meiotic recombination by DNA damage checkpoint kinases
19:35 – 19:55
Gaelle Legube (University of Toulouse, France)
Chromatin and chromosome dynamics during DNA double strand break repair
19:55 – 20:10
Joao Matos (ETH Zurich, Switzerland)
A mechanism for controlled breakage of under-replicated chromosomes during mitosis
20:10 – 20:25
Boris Pfander (Max-Planck Institute of Biochemistry, Germany)
Novel regulators in the cell cycle control of JM resolution by Mus81-Mms4
Dinner
Thursday, May 19
Breakfast
Session 5
09:00 – 09:25
Chair: Titia de Lange
John Petrini (Sloan Kettering Institute, US, US)
The Mre11 interaction domain of Nbs1 is necessary and sufficient for Mre11 complex functions
09:25 – 09:50
David Leach (University of Edinburgh, UK)
Recombination and replication associated with DNA double-strand break repair in E. coli
09:50 – 10:15
Evi Soutoglou (IGBMC, France)
Temporal and spatial uncoupling of DNA double strand break repair pathways within mammalian
heterochromatin
10:15 – 10:30
Valerie Borde (Institut Curie, France)
The MutLß complex limits the extent of meiotic recombination by interacting with the Mer3/HFM1
helicase
Break
11:00 – 11:25
Simon Boulton (Francis Crick Institute, UK)
tbc
11:25 – 11:50
Niels Mailand (NNF Center for Protein Research, Denmark)
Signaling mechanisms in DNA double-strand break repair
11:50 – 12:05
Vincenzo Costanzo (IFOM, Firc Insitute of Molecular Oncology, Italy)
Dissecting BRCA2 and Rad51 paralogs function in vertebrate DNA replication
12:05 – 12:20
Remi Buisson (Harvard Medical School, US)
ATR-dependent regulation of PALB2 at DNA double-strand breaks
Lunch
Free time
16:00 – 18:00
Poster Session 2 (even numbered posters present)
Session 6
Chair: David Sherratt
18.00 – 18:25
David Lilley (University of Dundee, UK)
The structure of GEN1 bound to a DNA junction
18:25 – 18:50
Michael Cox (University of Wisconsin-Madison, US)
Facilitating replication restart with the MgsA/RarA protein of Escherichia coli
18:50 – 19:15
Wolf-Dietrich Heyer (University of California, Davis, US)
Multiple invasions-induced chromosomal rearrangements
19:15 – 19:40
Roland Kanaar (Erasmus Medical Center, The Netherlands)
The DNA damage response as a selection tool for precision cancer treatment
19:40 – 19:55
Maria Spies (University of Iowa, US)
Assembly, dynamics and regulation of the RAD51 nucleoprotein filament
19:55 – 20:30
Keynote: Titia de Lange (The Rockefeller University, US)
Chromothripsis and kateagis induced by telomere crisis
Gala dinner
Friday, May 20
Breakfast
Depart