Product datasheet
Anti-Angiotensin III antibody ab47689
Overview
Product name
Anti-Angiotensin III antibody
Description
Rabbit polyclonal to Angiotensin III
Tested applications
RIA, ELISA
Species reactivity
Reacts with: Human
Immunogen
Synthetic peptide:
RVYIHPF
conjugated to KLH, corresponding to amino acids 35-41 of Human Angiotensin III
Run BLAST with
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Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol, PBS, pH 7.5
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab47689 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
Notes
RIA
Use at an assay dependent dilution.
ELISA
Use at an assay dependent dilution.
Target
Relevance
Angiotensin III is an eptapeptide drived from cleavage of full length angiotensin (AGT). AGT is a
polypeptide vasopressor hormone formed by the catalytic action of renin, which is released
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mainly by the kidneys in response to low blood volume or low sodium content in the body. The
juxtaglomerular cells release renin when juxtaglomerular apparatus decreases in the kidneys.
Renin (called angiotensinogenase) is an enzyme of the hydrolase class that catalyzes cleavage
of the leucine leucine bond in angiotensinogen (a serum globulin) to generate angiotensin I in the
liver. Angiotensin I acts mainly as a precursor to angiotensin II, which is a vasopressor and
stimulator of aldosterone secretion by the adrenal cortex, and also functions as a
neurotransmitter. Angiotensin III (heptapeptide) is a degradation product of angiotensin II, and
has less vasopressor activity than the parent compound. However, Angiotensin III does stimulate
aldosterone release. The renin-angiotensin system plays an important role in the regulation of
blood volume and blood pressure, stimulates antidiuretic hormone and aldosterone production,
and the hypothalamus to activate the thirst reflex, but is crucial in the pathogenesis of
hypertension patients due to blood vessels constrict, retention of fluid and raising blood
pressure.
Cellular localization
Secreted
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Terms and conditions
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