CDC’s Health Protection
Research Initiative
Tanja Popovic, MD, PhD, FAAM
Acting Associate Director for Science
Centers for Disease Control and prevention
CDC’s Futures Initiative
Health Protection in the 21st Century
Achieving maximum health impact is the driving force
Two overarching health protection goals
– Health protection of people in all communities through
preparedness
• Infectious disease threats
• Environmental threats
• Terrorism threats
– Health protection through health promotion and
prevention of disease, disability and injury
• People in all communities will achieve their expected life
span with the best possible quality of life in every stag
Death ….
Illness…
Health ….
Life ….
Public Health Research Workgroup – Phase I
Requests for Applications FY2004
Office of Public Health Research
Public Health Research Workgroup – Phase II
CDC’s Futures Initiative
Areas of Emphasis
Public Health Research
Workgroup
Charge
Develop a set of strategic directions for CDC-wide research agendasetting process addressing the following:
• Research issues and needs that are priorities for CDC’s customers and consistent with
departmental policies for an intra-agency stewardship of the health research enterprise
• Ways in which CDC needs to adapt its current practices in conducting and supporting
public health research
• Assurance that CDC-sponsored research is being effectively applied by practitioners and
policymakers
Guiding Principles
• Public health research agenda needs to be developed in
concert with the agency’s overall health protection goals.
• Gaps in knowledge needed to achieve those goals will be
primary driver of research agenda.
• Research agenda will be set with external participation.
Input
Public Health Research
Workgroup deliberations
Outside-in approach:
meetings
conferences
consultations
Fast Track Process
&
Fast track Meeting
Other FI Workgroups
Excellence in Science Committee
Consultancies with Dr. Gerberding
& CDC senior staff
Public Health Research Workgroup
Options and Recommendations
Key Strategic Issues
Strategic Direction for
Agenda-setting Process
Step 1
Public Participation
Level of Specificity
Criteria
Option 1
Option 2
Step 2
Step 3
Step 4
Step 5
Step 6
Option 3
Agenda-setting Process
Step 1. Develop a broad public health research framework
Step 2. Generate a list of possible research priorities
Step 3. Obtain input from broad range of outside groups and CDC
staff
Step 4. Synthesize input and generate a draft agenda
Step 5. Obtain broad public review of draft agenda
Step 6. Revise and finalize document
Step 1.
Research-to-practice Cycle
• Attempts to consider research needs which might
arise in each of several phases of the PH approach
to population health problems
• Early phase – problem identification and search for
causes
• Mid-phase – design and implementation of
interventions
• Late phase – evaluation
Level of Specificity
Levels
Disease, Injury or
Disability-related
Cross-cutting topics
1. Broadest
Chronic diseases
Genomics
2. Very broad
Cancer
Public health genomics
3. Broad
Breast cancer
Genetic screening
4. Specific
Effectiveness of
interventions to prevent
breast cancer
Effectiveness of family
screening programs
5. Very
specific
Effectiveness of
mammography
Effectiveness of computerbased family screening
programs
6. Most
specific
Effectiveness of
mammography in women
40-49 yrs of age
Effectiveness of computerbased family screening
programs among Medicaid
populations
Public Participation
•
Breadth of participation: How broad? Who plays?
-- health organizations considered as
traditional partners
-- new health and non-health related
organizations
-- lay representatives from community-based
individual public
•
Depth of engagement: How intense? At what level?
-- inform
-- consult
-- involve
-- collaborate
-- empower
Criteria
Option 1.
Core set of criteria linked to CDC’s mission
-- public health need
-- potential impact
-- relevance
Option 2.
Option 1
and widely accepted national goal
-- reduction of health disparities
and widely accepted unmet need
-- cross-cutting across the CIOs
CDC Public Health Research Agenda
for FY 2004
Expert Panel
“Fast Track” Meeting
November 2003
Requests for Application
(RFAs) for FY 2004
Overall goal for all RFAs is to influence priority health
protection research addressing the following:
Health protection of all people in all communities through
preparedness for
• Infectious disease threats
• Environmental threats
• Terrorism threats
Health protection through health promotion and prevention of
disease, disability and injury assuring that:
• People in all communities will achieve their expected life span with
the best possible quality of life in every stage
Investigator-initiated (RO1)
$ 14M for 20-40 grants
Purpose
To support investigator-initiated public health research projects that have
a high probability of influencing priority public health research.
Research objectives
•This year priority is given to research that identifies innovative cost-effective health
promotion policies, programs and activities in the workplace or that affect the
workplace.
•Future funding cycles will expand this initiative to address health protection research
relevant to other populations and sectors.
Strategy
Design and evaluation of interventions and identification of determinants affecting the
successful implementation of evidence-based cost-effective interventions in the
workplace or that have impact on the workplace.
Career Development (KO1)
$ 10M for 20-30 grants
Purpose
To support intensive supervised career development experience for researchers
in a variety of disciplines engaged in all types of public health research that have
a high probability of influencing priority public health issues.
Research objectives
To develop qualified, experienced, and sustainable cadre of independent public
health researchers to support nation’s and CDC’s public health priorities.
Institutional Training
$ 4M for 2-4 grants
Purpose
To develop or enhance training opportunities for individuals, selected by the
institution, who are training for careers in specified areas of public health
research that that have a high probability of influencing priority public health
issues.
Research objectives
To ensure a continuing supply of well-trained scientists prepared to lead efforts
in conducting cutting-edge public health research.
Career Development (KO1) and
Institutional Training
Strategies
Etiology and needs
Social, ecologic and developmental determinants of health
Determinants of individual behaviors that impact health
Assessing impact of social trends on population health needs
Prevention
Determinants of successful implementation of evidence-based interventions
Reduction of health disparities
Effectiveness of community-based interventions
Application of genetic information to population health
Methods and Infrastructure
Impact of infrastructure and policy alternatives on health outcomes
Economic factors and health
Improved surveillance methods
Early detection of public health risks
Communication strategies
Workforce needs and training issues
Centers of Excellence in
Health Promotion
Economics
$ 1M for 1 grant
Purpose
To develop institutional capacity in Heath Promotion Economics.
Research objectives
To explore economic barriers, priorities, solutions and impact (including costeffectiveness) of developing, evaluating and implementing health promotion
guidelines, recommendations, policies and programs to prevent disease, injury
and disability so that all people can achieve their expected life span with the best
possible quality of health at every life stage.
Strategies
Linking key academic, public and private entities across disciplines
Conducting and facilitating Health Promotion Economics research
Providing Health Promotion Economics training.
Office of Public Health Research
A. Research Oversight, Strategy, and
Evaluation
1. Establish Public Health Research Priorities
• Establish and maintain CDC research
agenda
• Facilitate research agenda processes
• Translate agenda into strategic plan for
research
A. Research Oversight, Strategy, and
Evaluation
2. Develop a Balanced Research Portfolio
• Translate strategic CDC-wide goals into
scientific goals
• Ensure balance of research between
intramural and extramural
• Build focus on outcomes into research
planning process
A. Research Oversight, Strategy, and
Evaluation
3. Evaluate Research Progress and Outcomes
•
•
•
•
Work on developing evaluations
Quality – Use of peer review
Relevance – Conduct relevance review
Performance – Track research
outcomes. Develop research metrics
B. Extramural Research and Peer
Review
• Develop scientific policy for CDC extramural
research and peer review
• Provide guidance on extramural issues
• Develop centralized peer review capabilities
• House CDC-wide cross-cutting grants program
Futures Initiative Stage II:
Implementation Teams
• The Organizations Design
How we can work faster; be more connected across our agency and
with our partners; how we can better respond to our customers
needs
• The Health Protection Goals
• The Strategic Imperatives
Implementation of recommendations form
the initial 4 Workgroups
• The Business Services Improvement
Improve our business practices and help create performance-based
culture at CDC
Public
Health
Research
Implementation
Team
Two Component Team Structure
Core •
Team •
•
Leadership for overall effort
Specific charge to Action Teams
Responsible for action implementation
Action
Team
Action
Team
•
•
Action
Team
Core
Action
Team
Propose innovative programs
Team
and initiatives that support
workgroup recommendations
Present best ideas and
Action
Action
collaborate with other Action Teams
Team
Team
and the Core Team to arrive
at “best in class” programs and initiatives
Major Charge
• Defining public health research agenda and
coordination with the agency’s overall health
protection goals
• Implementation of agenda-setting process
CDC ‘treasures”
Social determinants of health
Workforce
Scientific creativity
and synergy
Information technology and
systems to support science
Measuring the impact of
research
http://www.cdc.gov/futures