Stephen   M.
Hall,   PE
January   21,   2016

Plan
• Operations
• Flows/Conditions
• Systems
Requirements
• Soils
• Acceptance
Criteria
• Costs
Inventory
• Tanks
• Equipment
• Piping

Level   branch   connections   in   horizontal   pipeline
Flow   direction   into   a   TEE

Type   of   Solid Flow   Velocity,   ft/s
Fine 3 to   5
Sand 5   to   7
Pipe   Size Flow for   5   ft/s Re
(water @25   C)
1   inch
1   ½   inch
9.3
23.0
gpm 38,200
60,200
2   inch
3   inch
42.8
100.8
82,200
126,100

P1
NPSHa   =
H
VP
Δ P
P1   =   Tank   Pressure,   psia
H   =   Liquid   Height,   ft
Δ P   =   Pressure   Loss   to   Friction,   psi
VP   =   Vapor   Pressure,   psia
P1   x   2.31
+   H
‐ Δ P   x   2.31
‐  VP   x   2.31
PSI   x   2.31
=   feet   H
2
O

Equipment   setup
Manual   cleaning   steps
Monitoring
Documentation

Plan
Regulatory
Flow
Rates/Paths
Hydraulics
Utilities/
Infrastructure
Operations
Validation
Take   inventory   – know   what   needs   to   be   cleaned
Establish   acceptance   criteria   – write   a   URS
Clean in   a   Reproducible   and   Effective manner
Find   a   path   to   every   pipe,   component   and   equipment
Calculate   pressure   drops
Remember   NPSH   requirements   for   pumps
Purified   water   and   WFI   consumption   rates establish   size(s)   for   CIP   tank(s)
Valves   vs.
flow   panels   /   swing   elbows
Equipment   setup   /   COP
Acceptance   criteria   from   URS