Stephen M. Hall, PE January 21, 2016

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Stephen   M.

  Hall,   PE

January   21,   2016

Plan

• Operations

• Flows/Conditions

• Systems

Requirements

• Soils

• Acceptance  

Criteria

• Costs

Inventory

• Tanks

• Equipment

• Piping

Level   branch   connections   in   horizontal   pipeline

Flow   direction   into   a   TEE

Reynolds   number   –

It’s

 

not

 

that

 

easy!

Type   of   Solid Flow   Velocity,   ft/s

Fine 3 to   5

Sand 5   to   7

Pipe   Size Flow for   5   ft/s Re  

(water @25   C)

1   inch

1   ½   inch

9.3

23.0

  gpm 38,200

60,200

2   inch

3   inch

42.8

100.8

82,200

126,100

P1

NPSHa   =

H

VP

Δ P

P1   =   Tank   Pressure,   psia

H   =   Liquid   Height,   ft

Δ P   =   Pressure   Loss   to   Friction,   psi

VP   =   Vapor   Pressure,   psia

         P1   x   2.31

      +   H

     ‐ Δ P   x   2.31

     ‐  VP   x   2.31

PSI   x   2.31

  =   feet   H

2

O

Pity

 

the

 

poor

 

operator

Equipment   setup

Manual   cleaning   steps

Monitoring

Documentation

Plan

Regulatory

Flow  

Rates/Paths

Hydraulics

Utilities/  

Infrastructure

Operations

Validation

Take   inventory   – know   what   needs   to   be   cleaned

Establish   acceptance   criteria   – write   a   URS

Clean in   a   Reproducible   and   Effective manner

Find   a   path   to   every   pipe,   component   and   equipment

Calculate   pressure   drops

Remember   NPSH   requirements   for   pumps

Purified   water   and   WFI   consumption   rates establish   size(s)   for   CIP   tank(s)

Valves   vs.

  flow   panels   /   swing   elbows

Equipment   setup   /   COP

Acceptance   criteria   from   URS

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