MBV4120
spring2016
Eukaryotic Genes and Genomes
Paul Grini & Pål Falnes
Introduction to MBV4120
MBV4120 is given in English
MBV4120 is based on the use of
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http://fronter.uio.no
What will you learn?
Course content
The course
gives a
comparative
introduction
on the
size, structure
and
organisation
of eukaryotic
genes and
genomes, and
put an emphasis
on the
functional
significance
of the
organisation
and chromatinstructure of
genomes
What will you learn?
?
Genome Size?
Protein coding genes?
?
What will you learn?
What is the content of eukaryote genomes?
What will you learn?
After completing this course your competence is expected to:
ü  To be able to give an account for the complexity, size and composition of
eukaryotic genomes.
ü  Knowledge of the content of eukaryotic genomes, such as unique and repeated
sequences, mobile elements and coding- and non-coding DNA.
ü  To know the principles of different levels and types of gene-regulation, and to
understand the importance of chromatin modification and small non-coding RNA
for epigenetic regulation.
ü  To be able to give an account for different types of rearrangement and modification
of DNA and RNA.
ü  To know the main principles and mechanisms for genetic manipulation of
eukaryotic genomes and to be able to make an account for how genetic methodology
in model organisms is used in molecular biology research.
Lectures and Topics
Lecture I & II
Lecture III
Lecture IV
Lecture V
Lecture VI
Nuclear Genomes
Organelle Genomes
Non-coding RNA
Transposons and Retrotransposons
Reading and Repairing Genomes
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Lecture VII
Lecture VIII
Chromosomes and Nucleosomes
Epigenetics
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Lecture IX
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Lecture X
Rearrangement and modification of DNA
(General methodology)
Rearrangement and modification of DNA
(General methodology in model organisms)
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Lectures and Topics
Lecture I & II
Lecture III
Lecture IV
Lecture V
Lecture VI
Nuclear Genomes
Organelle Genomes
Non-coding RNA
Transposons and Retrotransposons
Reading and Repairing Genomes
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Lecture VII
Lecture VIII
Chromosomes and Nucleosomes
Epigenetics
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Lecture IX
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Lecture X
Rearrangement and modification of DNA
(General methodology)
Rearrangement and modification of DNA
(General methodology in model organisms)
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Group-work and oral presentations
Text Book and Course Material
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Selected chapters from
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Lewins “Genes XI”
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Selected original articles and reviews
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Online databases and tools
Colloquia
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10 colloquia with group exercises on each topic
Group exercises found on fronter
Compulsory and additional articles
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One or two compulsory articles
Supplementary articles: Ideally, the group covers all articles
Oral presentations of group-work
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Topic: Model organisms in genome research, methodology for
genetic manipulation of their genomes - possibilities and
restrictions.
Teaching plan
The first lecture starts 09:15 and end at latest 12:00.
All other lectures start at 09:15 and end 11:00
All colloquia start at 09:15 and end at 12:00
Teaching plan
Teaching plan
Teaching plan
Teaching plan
Teaching plan
Where you get information
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http://fronter.uio.no
Where you get information
}
http://fronter.uio.no
Contact information
Room 3223
Contact information
Room 3223
Suggestion
Colloquia Groups
Group1
Group2
Group3
Group4
If you for whatever reason wants to
change within the groups:
1.  Find an exchange partner
2. Notify the course responsible.
Group5
Group6
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
Anker,
Agos.ni,
Bakh.,
Bissenova,
Couso,
Dejolli,
Dybdal,
Engh,
Eriksen,
Ghimire,
Gjølberg,
Grønsberg,
Haaland,
Hauge,
Haukanes,
Heiberg,
HuSer,
Høyland,
Mari
Kris.ne
Antonio
Daniel
Samal
Rocio
Roca
Tosca
Jan-Morgan
Tora
Daniela
Mina
Baarnes
Nabin
Torleif
Tollefsrud
Ida
AndrieSa
Astrid
Sissel
Benedikte
Hallvard
Katharina Maren
19
20
21
22
23
24
25
26
27
28
29
30
Ingebrigtsen,
Iversen,
Kropf
Ladegård,
Løvestad,
Nyhus,
Qadri,
Reinseth,
Stonyte,
Vevik,
Zuhairi,
Öndes,
S.an
Vegard
Correia,
Marie
Alexander
Erik
Rojin
Ingvild
Vilte
Eskil
Fawzi
Nuray
Eide
Fernanda
Kris.ne
Yanez
Sanderud
Sveum
Rahmadiyan
Break
Lecture I starts at 10.30