Specialization: 010900 Applied Mathematics and Physics
Course: Nanobiophysics
Department of Molecular Biophysics
Scientific advisor: Assoc. Prof. S.V. Paston
Reviewer: Prof. N.A. Kasyanenko
Study of DNA interaction with phenathroline metallocomplex
Platonov D.A.
Work is devoted to determining character the interaction of compounds
[Zn2(phen)6](CH3COO)4 with DNA.
The paper discusses the methods interaction of DNA with low molecular weight
ligands and metallocomplexes phenathroline. Also by UV-spectrophotometry and
viscosity studies was investigated between complex [Zn2(phen)6](CH3COO)4 and
DNA. Based on these experiments, data was obtained:
1. In absorption spectra, the absorption intensity of the complex increased
(hyperchromism) with increasing concentration of [Zn2(phen)6](CH3COO)4, it
means than the interaction between DNA and [Zn2(phen)6](CH3COO)4.
2. Increase of the relative viscosity of DNA in the presence of the
[Zn2(phen)6](CH3COO)4 and spectral data showed that the intercalative
binding between DNA and [Zn2(phen)6](CH3COO)4 must be predominant.