Immunity and Genetics 1. List at least 5 ways that immunity and genetics are related. a. 1st line of defense related to genetics i. skin ii. mucous membranes iii. chemicals in tears, saliva and other bodily fluids b. 2nd line of defense i. phagocytes ii. cytokines iii. Inflammation 1. Phagocytes (engulf invaders) c. Self vs. nonself i. Blood type ii. Rh factor iii. HLA (Human Leukocyte antigens)- used to identify cell surfaces d. Humoral response- lymphocytes (white blood cells) i. Macrophages (degrade bacteria) ii. B cells iii. antibodies iv. memory cells e. Cellular immune response i. T cells ii. cytokines iii. memory cells 2. Define the following terms a. Lymphocyte- white blood cell b. T Cell- type of lymphocyte that produces cytokines and coordinates the immune response c. Helper T Cells- Lymphocytes that recognize foreign antigens on macrophages, activate B cells and Cytotoxic T cells, and secrete cytokines d. Cytotoxic T Cells- lymphocytes that attack nonself cells by binding them and releasing chemicals that attack the cell e. B Cell- lymphocyte that secretes antibody proteins in response to nonself antigens displayed on other immune system cells. f. Phagocyte- Cells that surround a smaller cell or particle and destroy it g. Primary Immune Response- response to a first encounter with a foreign antigen. h. Secondary Immune Response- response to a second or subsequent encounter with a foreign antigen 3. What physically causes allergies? the body’s overreaction to a normally harmless antigen 4. Can allergies be genetic? Why? Yes, immune response is controlled by over 20,000 genes 5. How do transplants relate to genetics and immunity? Immune system recognizes donor tissue as self or nonself. Nonself tissues can be attacked 6. Define the following terms. a. Autograft-tissue from one part of the body to another b. Isograft-tissue from an identical twin c. Allograft- from an individual who is not genetically identical, but same species d. Xenograft-transplant from one species to another 7. Give 3 real life examples of a xenograft. VARY