Science SCI.III.3.1 Grade: 8th Strand III: Using Scientific Knowledge in Life Science Standard 3: Heredity - All students will investigate and explain how characteristics of living things are passed on through generations. Explain why organisms within a species are different from one another; and explain how new traits can be established by changing or manipulating genes. Benchmark 1: Explain how characteristics of living things are passed on from generation to generation. Constructing and Reflecting: SCI.I.1.1 – Ask questions that can be investigated empirically. SCI.I.1.2 – Design and conduct scientific investigations. SCI.II.1.1 – Justify plans or explanations on a theoretical or empirical basis. SCI.II.1.3 – Show how common themes of science, mathematics and technology apply in real world contexts. Vocabulary Context • • • • • • • • • • • • • Common contexts: • Inheritance of a human genetic disease/disorder: sickle cell anemia • A family tree focused on certain traits • Examining animal or plant pedigrees • Human Genome Project • • • • • • • • • • • • • Dominant Recessive Gene pair Gene combination Gene sorting Homozygous Heterozygous Genotype Phenotype Allele Genetic engineering Selective breeding Sex linked genes, traits, diseases, disorders Autosomes Sex chromosomes Diploid Haploid Mitosis Meiosis Crossing over Punnett Square Pedigree Gregor Mendel Monohybrid Cross Dihybrid Cross Human Genome Project Knowledge and Skills Students will: • Diagram how the gene pair in one parent will separate, making sex cells that will combine with sex cells from the other parent to form offspring. • • • Predict the characteristics of possible offspring, given the gene combinations of the parents. Trace a trait from generation to generation (e.g. sickle cell anemia). Students will use Punnett squares to predict possible outcomes of different genetic combinations Resources Coloma Resources: Holt Science & Technology Book C Chapter 3 pg 54-83 Other Resources: • Scope – Fundamentals of Genetics • National Human Genome Research Institute • PBS Series Online – The DNA Files • Web Genetics Resource Page • • Isolate your own DNA – and other labs from the Museum of Science and Industry www.msichicago.org Brain Pop – online movies • www.biologycorner.com • Michigan Teacher Network – 18 resources for genetics education • Punnett Practice Page • Fruit fly and Rapid radish kits • DNA model • Science sleuths video disc- Twins or not program • Mitosis and Meiosis slides • Howard Hughes Medical Institute – incredible free resources Resources Videoconferences Available For more information, see www.remc11.k12.mi.us/dl or call Janine Lim 471-7725x101 or email jlim@remc11.k12.mi.us III.3.HS.1 • Genetics: Mendel’s Peas from the Camden Children's Garden • Agricultural Biotechnology from the Center for Agricultural Science and Heritage, Inc. • Genetically Profiling Cancer from COSI Columbus • Genetic Counseling: What You Should Know About Your Family History from COSI Columbus • The Gene Scene from Discovery Center of Springfield • Genetic Revolution from HealthSpace Cleveland • Behind the Story: The Genetics of Fairytales from Hook's Discovery & Learning Center • In The News - Genetically Modified Organisms from Hook's Discovery & Learning Center • 2025: A Genetic Odyssey from Indiana State Museum Instruction Assessment • Create a pedigree chart based on a given • characteristic (attached and free ear lobes, sickle cell anemia, tongue rolling, etc.) Identify dominant and recessive gene • combinations (e.g. aa, Aa, AA, A?-can’t be determined) for individuals on the chart. • - Extension: Predict the possible gene combinations for a cross with one of your offspring and a recessive individual. Teachers should be aware that this only works for single allele traits (not hair color, eye color, etc.). • Blood typing kits • Genotype comparison lab • Probability labs • Punnett squares • Given a pedigree chart with phenotypes listed for all individuals, provide the gene combinations for all individuals (e.g. aa, AA, Aa, A?). Each student will pick a genetic trait and build a pedigree for their family. The must also do the possible Punnett squares for the parent’s offspring. Students will write a report on a genetic disorder using the Internet to research symptoms and which chromosome the disorder is located on. Corresponds to Standard I.1.5 & I.1.4 Criteria Apprent. • Meets Exceeds Completeness of list Identifies condition and zero to one healthy behaviors with appropriate technology. Identifies condition and two healthy behaviors with appropriate technology. Identifies condition and three healthy behaviors with appropriate technology. Identifies condition and four or more healthy behaviors with appropriate technology. Completeness of dialogue Conversation is incomplete and/or not believable. Conversation has main ideas but no details. It is not quite believable. Conversation has main ideas and some details. It is believable. Conversation has main ideas, many details, and is very believable. • Genetic corn • Basic Analyzing karotypes Science Olympiad-Process Skills for Life Science (Bio Lab) See Appendix Teacher Notes: Focus Question: How can a trait be traced from generation to generation? Investigate and explain how characteristics of living things are passed on through generations. Like produces like. To enable a child to understand why grandparents claim that they look just like their parents at their age requires many learning experiences. Elementary students should be able to provide evidence that visible traits are passed on from parents to children by comparisons of color, structure, and direct measurements. They should be able to match offspring to corresponding parents. By middle school, students should know how characteristics of living things are passed from generation to generation. Common traits controlled by a single gene pair should be taught in the middle school years as well as the reproductive cells which facilitate this happening. They should be aware that when the sperm fertilizes the egg, the sperm passes the genetic material (genes) of the father to the egg. The genes of the father's sperm and mother's egg then contribute to the formation of an entirely new individual having characteristics from both parents. Students at the high school level should understand that genes occur and act in pairs. If a dominant gene is present, it is fully expressed. A recessive gene will not be expressed in the presence of a dominant gene. A cross or combination of other gene pairs can show what future generations may inherit, or predict those chances of traits being exhibited such as sickle cell anemia and other genetic disorders. Explain why organisms within a species are different from one another. The characteristics of offspring are not only determined by the heredity from the parents. There are acquired traits like spoken language, size of a superfertilized plant vs. a tundra plant, or length of hair, which contributes to the individuality of the offspring. High school students should also be aware of how genetic material is passed from parent to offspring during sexual and asexual reproduction. Cell division of non-sexual cells or somatic cells is an essential process to the growth of an organism as well as a species. Cell division is comprised of two processes. Division of the nucleus of the non-sexual cell is called mitosis which is immediately followed by the division of the cytoplasm and cellular content producing two daughter cells. Division and replication of the nuclei of the sex cells is called meiosis and is immediately followed by two consecutive divisions of cytoplasm and cellular content producing four daughter cells. Explain how new traits can be established by changing or manipulating genes. How new traits may arise in individuals through changes in genetic material should also be taught during the high school years. Students might misinterpret genetic changes as only detrimental. Gene or chromosome mutations or recombination of genes can increase the variations that are seen among individuals in a population. In order to understand this, the entire DNA molecule and its intricacies of replication need to be understood. An extension of this could include products of genetic engineering, natural and human produced mutations, and variations from multiple sets of genes.