Chem 331 Fall 2014
Organic Chemistry
Prof. Donald Watson
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Chem 331 Organic Chemistry
Lecture:
Section 10 M,W,F 10:10a-11:00a, Brown Lab (BRL) 101
Section 11 M,W,F 10:15a-12:05p, Brown Lab (BRL) 101
Instructor:
Professor Donald A. Watson
204 Lammot duPont
dawatson@udel.edu
Office hour:
Wednesday 9a-10a, Thursday 11a-12p
Lammont DuPont Lab (LDL) 208, or by appointment (email
please).
Website:
http://www.udel.edu/chem/dawatson/classes/Chem331_F14/
Chem331_F14-home.html
What You Need
Text:
Jones and Fleming, 5th edition
Model Set:
HGS 1003 Organic Chemistry C-Set
(or similar)
Grading
Grading:
Quizzes (6)
Problem Sets (6, done check only)
Discussion Section Attendance
Midterm Exams (2)
Final Exam
3% each (18% total)
2% each (12% total)
10%
15% each (30% total)
30%
Quizzes and Exams
Quizzes (6): Short (1 or 2 questions)
In class
Model sets may be allowed.
Closed notes and book.
Midterms:
Final:
1 hour
In class
Model sets will be allowed
Closed notes and book.
3 hour
Time and Place TBD
Model sets will be allowed
Closed notes and book.
Quizzes and Exams: No make-ups without University Approved absence.
Problem Sets
Mix of Problems from Text and Assigned Problems
Due to at beginning of class. No late problem sets accepted with
University Approved Excuse.
Grading will be “done check” only.
Percentage of the assignment completed or attempted:
% done grade ~100 % 2 ~50-­‐90% 1 < 50% 0 Discussion Sections
REQUIRED!
Attendance will be taken.
You may miss two sections without an excuse, after that unexcused
absences will result in a 10% deduction from your discussion grade per
absence.
Regrades
All requests for regrades must be
submitted in writing within 24 hours of
the material being returned. Please note,
the entire quiz or exam will be regraded – if
grading errors are found the final grades
may be higher or lower than original score.
Also note, photocopies may be made prior
to returning exams. If answers are altered,
it will be obvious and provable.
What is organic chemistry and why study it?
Organic Chemistry
•  Organic Chemistry is the study of carbon based molecules.
•  These molecules always contain at least carbon and hydrogen, and
often nitrogen and oxygen; and sometimes other elements.
Common Products in Everyday Life
Gasoline (30% octane)
Table Sugar (sucrose)
Beer (ethanol)
Coffee (caffeine)
Olive Oil (70% oleic acid)
Images: auto.howstuffworks.com, npr.org, commons.wikimedia.org, wikipedia, blog.scientificamerican.com
Medicines and Drugs
Abilify (anti depressant): $1.6 billion
Atripla (HIV): $680 million
Nexium (heartburn): $1.5 billion
Cretor (cholesterol): $1.3 billion
Alimta (cancer): $302 million
Cialis (ED): $280 million
Note: These are sales for 1st quarter, 2013!
Data taken from Wikipedia
Natural Compounds
Taxol – anticancer
Me
H
H
Me
OH
Me
O
Me
Δ-9-tetrahydrocannabinol (THC)
erythomycin - antibiotic
Understanding Biology and Biochemistry
DNA
Enzyme Structure and Function
(CYP17A1 – Enzyme Associated with Breast and Prostate Cancer)
en.wikipedia.org/wiki/DNA
publications.nigms.nih.gov/biobeat/12-02-16/
Cell Surface Markers
and Communication
Image from: Zaia, Nature Methods, 2011, 1(8), 55
Synthetic and Natural Polymers and Plastics
Images: ifestyle.howstuffworks.com, mashable.com,
en.wikipedia.org/wiki/Lego
www.soccergarage.com/balls.html, madvilla.net,
www.plasticseurope.org, www.dailytech.com/
Energy and Devices
Organic LEDs
Organic Solar Cells
Images: www.engadget.com, fibonacci-sequence21.blogspot.com/
How to Succeed Organic Chemistry
1.  Attend the lecture! Attend discussion. Read the book. Do the assigned
homework.
2.  DO NOT TRY TO CRAM. YOU WILL FAIL.
3.  Study in groups. Work and re-work the problems. Work the unassigned
problems.
4.  Understand the material, don’t try to memorize.
5.  Organic chemistry is about 10-15% memorization, and 85-90% understanding.
6.  You need to learn a remember a few basic concepts then learn how to apply
them. Look for similarities (and distinctions) in different topics.
7.  Rationalize everything… there is a clearly understood, rational reason for
(almost) everything in this course.
8.  “Clear communication comes from clear thinking. If you can’t say it in one
sentence, you don’t understand it.” – Keith Woerple
Orbitals!
Orbitals: 1s
http://winter.group.shef.ac.uk/orbitron/AOs/
Orbitals: 2s
http://winter.group.shef.ac.uk/orbitron/AOs/
Orbitals: 2p
http://winter.group.shef.ac.uk/orbitron/AOs/
Orbitals: 3s
http://winter.group.shef.ac.uk/orbitron/AOs/
Orbitals: 3p
http://winter.group.shef.ac.uk/orbitron/AOs/