Analysis of Running Biomechanics and Plantar Pressure Distributions in Subjects with Chronic Ankle Instability Morrison, KE Lateral ankle sprains are common injuries in athletic activity. Although most will resolve with conservative treatment, others develop Chronic Ankle Instability (CAI), a condition associated with persistent pain, weakness, and instability. Because of an increase in prevalence of CAI, considerable attention has been directed towards understanding the underlying causes of this pathology. Despite the amount of research conducted in this area, analysis of individuals with CAI during dynamic conditions is limited. A detailed kinematic and kinetic analysis of the stance phase of dynamic movement patterns may give greater insight into the stresses placed on the foot and ankle complex in CAI subjects and how they differ from other populations. The aims of this study are: (1) to determine if there are kinematic and kinetic differences at the foot and ankle complex in the running mechanics of subjects with CAI; (2) to determine if there are kinematic and kinetic differences at the foot and ankle complex during a forty-five degree cutting maneuver in subjects with CAI; and (3) to determine if there are differences in dynamic plantar pressure distributions at the foot during a running gait in subjects with CAI. To address these aims, a three-dimensional motion analysis and plantar pressure assessment will be conducted on 45 subjects. The subjects will be specifically recruited and divided for comparison into three groups: 15 subjects with chronic ankle instability (CAI), 15 subjects who have a previous history of only one lateral ankle sprain and never experienced recurrent symptoms (no CAI), and 15 control subjects who are without a history of a lateral ankle sprain (Control). A range of kinetic and kinematic variables will be extracted using techniques developed in previous studies. The variables will be analyzed to determine if there are differences between each subgroup during a running gait and/or a cutting maneuver. Accurately assessing foot and ankle mechanics can give insight into the pathogenesis of CAI. Once determined, future intervention studies can be performed to reduce the incidence and severity of acute and chronic lateral ankle injury.