Western Illinois University
College of Arts and Sciences
Department of Chemistry
CHEM463G Syllabus, Spring 2016
1.
PRELIMINARY INFORMATION
COURSE TITLE & NUMBER:
COURSE CREDIT:
CHEM 463G:Advanced Pharmacology
(STARS 18376)
Three semester hours
LECTURE TIME & PLACE:
MWF, 9:00 am - 9:50 am, in Currens 202
INSTRUCTOR:
Dr. Mai-Lei Chen
OFFICE NUMBER:
Currens Hall 519 B
OFFICE HOURS:
Mon. and Wed. 12:00 pm – 1:30 pm;
Fri. 12:00 pm – 1:00 pm, or by appointments
OFFICE TEL No.
309/298-2578
FAX No.
309/298-2180
email:
M-chen2@wiu.edu
Required Textbook: Basic & Clinical Pharmacology by Bertram G. Katzung,
McGraw-Hill, 12th edition,
ISBN 978-0-07-176401-8; MHID 0-07-176401-1
Note:
Data Storage devices other than a simple scientific calculator (such as
graphing calculators, cell phones, IPods, IPads, MP3 players, and laptops)
are NOT allowed to be used on any exam and during lectures.
2.
COURSE GOALS AND OBJECTIVES
This course introduces the students to the chemical aspects of drug-receptor interactions,
pharmacokinetics, and pharmacodynamics of major categories of pharmacologic agents. Not
open to students who have credit for PSY 444.
Prerequisites: CHEM 421 and either ZOOL 331 or ZOOL 430; or NURS 310 and permission of
the instructor.
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3.
PERFORMANCE AND GRADING SCALE
Four hour exams (each worth 100 points, Eight take-home quizzes (each worth 20 points), and a
final exam (not comprehensive) worth 100 points will be given. Exams and quizzes will be
multiple-choice or short-answer formats
Outside work requirement: Students are expected to review, study and learn all material
discussed in lecture, as well as read assigned chapters in the textbook, and to work assigned
practice problems/questions/terms listed in class or on Western Online.
Chemistry Resource Center: Currens 107. Free tutoring and/or help is provided by the
department through the Chemistry Resource Center
Attendance Policy: You are expected to attend class regularly and punctually. All students are
responsible for all information given in class, starting on the first day of classes, (regardless of
when you register whether present or not.)
Attendance will be taken each class period. Students need to sign in on the lecture signup sheet
before the lecture. If students have more than three excused or non-excused absences, 5 points
will be deducted from their grade points for each absence, after three absences. Excessive
absences will also be reported to the financial aid office.
Any student who arrives 20 minutes late for an exam may not be allowed to take the exam.
Students are responsible for all material presented in class whether present or not. New material
is presented during each class lecture. It is the student’s responsibility to get class notes from
their classmates for any class missed. It not the instructor’s responsibility to provide class
notes for absent students. Students are expected to memorize/learn the material outside of
class by studying a minimum of 2-3 hrs outside of class for each lecture period
In order to accommodate absences due to illness, and other excused absences, take-home
quizzes will be posted on Western Online and can be emailed to me by the due date, and a
comprehensive make-up exam (which can be substituted for one missed exam) will be
given. No other make up exams will be given. If you miss more than one exam it is
recommended that you to drop the course.
Seating will be assigned by the instructor during the exams and/or any other time deemed
necessary. The exam will not begin until all students are properly seated. Simple scientific
calculators only (example TI-30XA) may be used on exams, however no other data storage
device, such as graphing calculators, cell phones, laptops, MP3 players, IPADs or IPODs
are permitted to be used on any exam. Exam and quiz due dates are announced in advance
during lecture periods and on WesternOnine.
A single comprehensive make up exam will be given at the end of the semester and may
count as one missed exam (due to an excused absence)*.
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*Students who are called away from campus to participate in University sponsored trips,
such as athletics or professional meetings (not sorority/frat.or other clubs) may be allowed
to make up exams, if the student provides a signed memo from the faculty sponsor at least
7 days before the expected absence. NO EXCEPTIONS TO THE SEVEN DAY WRITTEN
NOTICE
Methods of Assessment of Performance: (Students without the graduate project)
3 lecture Exams
=
300 pts
7 Take Home Quizzes (40 points each)
=
280 pts
Final Exam
=
100 pts
_________________________________
Total possible
=
680 pts
Grading Scale:
Grades are assigned based on total points achieved after the final
exam scores have been posted:
Total points
598 - 680 points
571 - 597 points
544 - 570 points
516 - 543 points
489 - 515 points
462 - 488 points
435 - 461 points
408 - 434 points
380 - 407 points
353 - 379 points
326 - 352 points
0 - 325 points
Grade
= A 88%
= A- 84%
= B+ 80%
= B 76%
= B- 72%
= C+ 68%
= C 64%
= C- 60%
= D+ 56%
= D 52%
= D- 48%
= F
Exam grades are based on the total number of correct answers, and all grades are final. No curve
will be applied to exam grades, and no “retakes” will be allowed. No “extra point” assignments
will be made or applied to grades. Students can view their individual quiz and exam scores on
WesternOnline (WIU ECom is required for login).
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For students who want to do the graduate project:
The graduate project will consist of (1) four case studies, (2) a written report as compilation
of the case studies, and (3) an oral class presentation describing the case studies and their
resolution.
Graduate Project grade will be calculated as follows:
Four case studies
=
Compilation report
=
Oral class presentation
=
Graduate project total
=
60 points
20 points
20 points
100 points
For each case study, the student receives a patient history (with age, gender, race, medical
history, current medications, and a list of allergies) as well as the diagnosis of ailment to be
treated. The student who wishes to receive graduate credit for the course is expected to research
available drugs, potential side effects, and drug interactions for treatment of the patient's
diagnosed condition. The student must select a drug (or drug combination) to be prescribed for
the patient's diagnosed ailment, and write a through justification of the drug of choice, including
why other drugs were not chosen. A complete drug regiment based on the patient's age, race,
gender, weight, etc. should be also proposed. The student must also select a second choice drug
to be used if the patient were found not to respond to, or not to tolerate well, the first choice
drug. Justification for the second choice drug should be provided. The individual case study
write ups will be due (about every 3 to 4 weeks) during the semester, and are independent of the
compilation report.
The written compilation summary report should be typewritten, 10 – 20 pages (including a
title page), single spaced in size12 font, and should list at least five references for each case
study. The report is due at the time and day of the student's scheduled oral presentation (during
the last two weeks of class). Two points per day will be deducted for late reports.
Class presentation: The student will be expected to make a 10 to 15 minute oral class
presentation of his/her four case studies to the class during the last two weeks of class. The
student should see the course instructor to schedule a date for oral presentation of his/her case
study.
Methods of Assessment of Performance: (Students with the graduate project)
3 lecture Exams
=
300 pts
7 Take Home Quizzes (40 point each)
=
280 pts
Final Exam
=
100 pts
Graduate Project
=
100 pts
_________________________________
Total possible
=
780 pts
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Grading Scale:
Grades are assigned based on total points achieved after the final
exam scores have been posted:
Total points
686 - 780
655 - 685
624 - 654
592 - 623
561 - 591
530 - 560
499 - 529
468 - 498
436 - 467
405 - 435
374 - 404
0 - 373
points
points
points
points
points
points
points
points
points
points
points
points
Grade
= A 88%
= A- 84%
= B+ 80%
= B 76%
= B- 72%
= C+ 68%
= C 64%
= C- 60%
= D+ 56%
= D 52%
= D- 48%
= F
Exam grades are based on the total number of correct answers, and all grades are final. No curve
will be applied to exam grades, and no “retakes” will be allowed. No “extra point” assignments
will be made or applied to grades. Students can view their individual quiz and exam scores on
Western OnLine (WIU ECom is required for login).
CLASSROOM POLICIES: Any student convicted of academic dishonesty, can receive a
failing grade and may be subject to further academic penalties. (See academic dishonesty
policy http://www.wiu.edu/policies/acintegrity.shtml. ) Data storage devices other than a
simple calculator (TI-30XA) such as cell phones, lap tops computers, IPODs, IPADs, MP3
players, video games, etc. are not to be used on any lecture exam. Cell phones must be put
away (turned off or placed on vibrate mode and stowed out of sight) during all classroom
activities. Use of headphones, blue-tooth, ear phones, etc. is not permitted during an exam.
All hats, caps, and hoods that cover your ears are not allowed to be worn during an exam. The
instructor reserves the right to assign seating for the students during exams and/or any other time
deemed necessary. Simple scientific calculators may be used on quizzes and exams, however no
graphing calculators are permitted.
COURSE POLICY: No incomplete will be given to a student with a failing grade in the
course. No incomplete will be given in this course unless the student experiences a documented
emergency that takes him/her away from the university for at least two consecutive weeks and/or
causes him/her to miss the final exam. The student must notify the instructor of this emergency
before the final exam (Wednesday, May 11, 2016, 8:00 am – 9:50 am).
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Any student convicted of academic dishonesty, (including plagiarism) may receive a failing
grade and may be subject to further academic penalties, such as possible expulsion from
the university. (See academic dishonesty policy
http://www.wiu.edu/policies/acintegrity.shtml.)
The instructor reserves the right to assign seating for the students during exams and/or any other
time deemed necessary. Simple scientific calculators may be used on lecture exams, however no
graphing calculators are permitted.
WIU Policies: It is the policy of Western Illinois University to accommodate individuals with
disabilities pursuant to federal law and the University's commitment to equal educational
opportunities. It is the responsibility of the student to inform the instructor of any necessary
accommodations at the beginning of the course. Any student with a disability requiring
accommodations should contact the Office of Disability Support Services.
In accordance with University policy and the Americans with Disabilities Act (ADA), academic
accommodations may be made for any student who notifies the instructor of the need for an
accommodation. It is imperative that you take the initiative to bring such needs to the instructor’s
attention, as he/she is not legally permitted to inquire about such particular needs of students.
Students who may require special assistance in emergency evacuations (i.e. fire, tornado, etc.)
should contact the instructor as to the most appropriate procedures to follow in such an
emergency. Contact Disability Support Services at 298-2512 for additional services.
Please find the web address for Student Rights and Responsibilities:
http://www.wiu.edu/provost/students/php
The following action is prohibited under the Student Conduct Code:
1. Disorderly Conduct: Any behavior which disrupts the regular or normal functions of the
University community, including behavior which breaches the peace or violates the
rights of others. Web address for Academic Integrity Policy
(http://www.wiu.edu/policies/acintegrity.php)
Emergency Preparedness: The WIU Office of Risk Management and Emergency
Preparedness provides resources on how to respond to emergency situations. Please view the
video resources at www.wiu.edu/rmep/ (Click “Resources” on the right side of the page). If
the fire alarms sound and/or students are asked to evacuate the building all students should
proceed immediately to the nearest exit and gather at the southwest corner of the Higgins
parking lot (near the fence) until the “all clear” is given.
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IMPORTANT DATES:
First Day of Class
Exam 1
Exam 2
Spring Break
Exam 3
Comprehensive Make up exam
FINAL EXAM
Wed. Jan. 20, 2016
Fri. Feb. 26
Fri. Mar. 11
Mar. 14-18
Fri. Apr. 8
Wed. May 4
Wed. May 11, 8:00-9:50 am
ADDITIONAL READING LIST:
Physician's Desk Reference (PDR) 2009 Addition 63, Thomson Healthcare Publishing.
PDR for Nutritional Supplements 2008, 2nd edition, Thomson Healthcare Publishing.
PDR for Herbal Medicines 2008, 4th Edition, Thomson Healthcare Publishing
Pharmacology for Chemists, by Joseph G. Cannon, Oxford publishing.
Principles of Medical Pharmacology, 8th edition by Harold Kalant and Walter Roschlau, 2007,
Oxford Publishing.
Hansten & Horn's Drug Interactions, Analysis and Management: Facts & Comparisons by Philip
D. Hansten & John Horn, 2008, PP Publishing.
Stability Indicating HPLC Methods of Drug Analysis, 3rd Edition, by Quanyun Xu and Lawrence
Trissel, 2008, PP Publishing.
Clarke's Analysis of Drugs and Poisons, 3rd edition, by Anthony Moffat, David Osselton, , Brian
Widdop, and Lauret Y. Galichet, 2004, P.P. Publishing.
Handbook of Forensic Drug Analysis by Fred Smith and Jay A. Siegel, 2004, P.P. Publishing.
Pharmacology DeMystified. by Mary Kamienski and Jim Keogh 2006, McGraw Hill
Drugs and the Human Body, 6th Edition by Ken Liska 2000, Prentice Hall.
Medical Terminology by Nina Thierer and Lisa Breitbard, 2006, McGraw Hill
*Goodman and Gilman’s The pharmacological Basis of Therapeutics by Laurence Brunton,
Bruce Chabner and Bjorn Knollman, 12 Ed., 2012, McGraw Hill
* Goodman and Gilman’s Manual of Pharmacology and Therapeutics by Laurence Brunton,
Keith Parker, Donald Blumenthal and Iain Buxton, 2007, McGraw Hill
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CHEM463G Spring 2016 Tentative Lecture Schedule
Week Date
Lecture topic
1
01-18 Dr. Martin Luther King Day (No class)
01-20 Syllabus
L01: Basic principles of pharmacology
01-22 L02: Basic principles of pharmacology
Dr. Mai-Lei Chen
Chapter
1-5
1-5
2
01-25 L03: Basic principles of pharmacology
01-27 L04: Basic principles of pharmacology
01-29 L05: Basic principles of pharmacology
1-5
1-5
1-5
3
02-01 L06: Basic principles of pharmacology
02-03 L07: Basic principles of pharmacology
Autonomic drugs
02-05 L08: Autonomic drugs
1-5
1-5
6-10
6-10
4
02-08 L09: Autonomic drugs Quiz 1 (L01-06) Due
02-10 L10: Autonomic drugs
02-12 Lincoln’s Birthday (No Class)
6-10
6-10
6-10
5
02-15 L11: Autonomic drugs
02-17 L12: Autonomic drugs
02-19 L13: Autonomic drugs
Cardiovascular – renal drugs
6-10
6-10
6-10
11-15
6
02-22 L14: Cardiovascular – renal drugs Quiz 2 (L07-13) Due
02-24 L15: Cardiovascular – renal drugs
02-26 Exam 1 (L01-13)
11-15
11-15
7
02-29 L16: Cardiovascular – renal drugs
03-02 L17: Cardiovascular – renal drugs
03-04 L18: Cardiovascular – renal drugs
11-15
11-15
11-15
8
03-07 L19: Drugs that act in the CNS
03-09 L20: Drugs that act in the CNS
03-11 Exam 2 (L12-L18)
21-32
21-32
21-32
9
03-14 Spring Break (No Class)
03-16 Spring Break (No Class)
03-18 Spring Break (No Class)
10
03-21 L21: Drugs that act in the CNS
03-23 L22: Drugs that act in the CNS
03-25 L23: Drugs that act in the CNS
Endocrine drugs
Quiz 3 (L12-18) Due
21-32
21-32
21-32
37-42
8
Week Date
Lecture topic
Chapter
11
03-28 L24: Endocrine drugs
03-30 L25: Endocrine drugs
04-01 L26: Endocrine drugs
Quiz 4 (L19-23) Due
12
04-04 L27: Chemotherapeutic drugs Quiz 5 (L23-26) Due
04-06 L28: Chemotherapeutic drugs
04-08 Exam 3 (L19-26)
43-55
43-55
13
04-11 L29: Chemotherapeutic drugs
04-13 L30: Chemotherapeutic drugs
04-15 L31: Chemotherapeutic drugs
43-55
43-55
43-55
14
04-18 L32: Special Topics
04-20 L33: Special Topics
04-22 L34: Special Topics
34,35, 60
34,35, 60
34,35, 60
15
04-25 L35: Special Topics
04-27 L36: Special Topics
04-29 Presentation
16
05-02 Presentation
05-04 Presentation
05-06 Presentation
17
05-11 Final Exam (L29-L36), at 8:00 am – 9:50 am
Quiz 6 (L27-31) Due
37-41
37-41
37-41
34,35, 60
34,35, 60
Quiz 7 (L32-36) Due
Comprehensive Lecture Makeup Exam
THIS SYLLABUS IS SUBJECT TO CHANGE UPON NOTIFICATION BY INSTRUCTOR.
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