Western Illinois University College of Arts and Sciences Department of Chemistry Syllabus 1. PRELIMINARY INFORMATION COURSE TITLE & NUMBER: COURSE CREDIT: Introduction to Pharmacology, CHEM 263 (STARS 83829) Three semester hours LECTURE TIME & PLACE: 2:00 - 3:15 pm Tues. and Thurs. in Currens 202 INSTRUCTOR: Dr. Mai-Lei Chen OFFICE NUMBER: 519 B Currens Hall OFFICE HOURS: Mon. 9:00 am – 12:00 noon, Wed. 9:00 am – 12:00 noon OFFICE TEL No. 309/298-2578 FAX No. 309/298-2180 email: M-chen2@wiu.edu Required Textbook Goodman & Gilman’s Manual of Pharmacology and Therapeutics , 1st Ed., McGraw Hill ISBN 978-0-07-144343-2 Note: 2. Data Storage devices other than a simple scientific calculator (such as graphing calculators, cell phones, IPods, IPads, MP3 players, and laptops) are not allowed to be used on any exam and during lectures. COURSE GOALS AND OBJECTIVES To provide students an understanding of the basic concepts of pharmacology, including the mechanism of action of broad categories of pharmaceutical agents. To prepare students to utilize web sites to find accurate, viable information of pharmaceutical agents, vitamins, and nutritional supplements. 1 3. PERFORMANCE AND GRADING SCALE Four hour exams (each worth 100 points, ten take-home quizzes (each worth 20 points), and a final exam (not comprehensive) worth 100 points will be given. Exams and quizzes will be multiple-choice formats Outside work requirement: Students are expected to review, study and learn all material discussed in lecture, as well as read assigned chapters in the textbook, and to work assigned practice problems/questions/terms listed in class or on Western Online. Chemistry Help Center: Currens 515. Free tutoring and/or help is provided by the department through the Chemistry Help Center. Hours are 8:00 am – 5:00 pm on Mon.Thurs, and 8:00 am – 1:00 pm on Fri. Attendance Policy: You are expected to attend class regularly and punctually. All students are responsible for all information given in class, starting on the first day of classes, (regardless of when you register whether present or not.) Roll will be taken every day. Excessive absences will be reported to the financial aid office. Any student who arrives 20 minutes late for an exam may not be allowed to take the exam. Students are responsible for all material presented in class whether present or not. New material is presented during each class lecture. It is the student’s responsibility to get class notes from their classmates for any class missed. It not the instructor’s responsibility to provide class notes for absent students. Students are expected to memorize/learn the material outside of class by studying a minimum of 2-3 hrs outside of class for each lecture period In order to accommodate absences due to illness, and other excused absences, take-home quizzes will be posted on Western Online and can be FAXed to the Department of Chemistry (309-298-2180) by the due date, and a comprehensive make-up exam (which can be substituted for one missed exam) will be given. No other make up exams will be given. If you miss more than one exam it is recommended that you to drop the course. Seating will be assigned by the instructor during the exams and/or any other time deemed necessary. The exam will not begin until all students are properly seated. Simple scientific calculators only (example TI-30XA) may be used on exams, however no other data storage device, such as graphing calculators, cell phones, laptops, MP3 players, IPADs or IPODs are permitted to be used on any exam. Exam and quiz due dates are announced in advance during lecture periods and on Western Onine. 2 A single comprehensive make up exam will be given at the end of the semester and may count as one missed exam (due to an excused absence)*. *Students who are called away from campus to participate in University sponsored trips, such as athletics or professional meetings (not sorority/frat.or other clubs) may be allowed to make up exams, if the student provides a signed memo from the faculty sponsor at least 7 days before the expected absence. NO EXCEPTIONS TO THE SEVEN DAY WRITTEN NOTICE Methods of Assessment of Performance: 4 lecture Exams = 400 pts 10 Take Home Quizzes = 200 pts Final Exam = 100 pts ___________________________________ Total possible = 700 pts Grading Scale: Grades are assigned based on total points achieved after the final exam scores have been posted: Total points 630 - 700 602 - 629 574 - 601 546 - 573 518 - 546 490 - 517 462 - 489 434 - 461 406 - 432 378 - 405 350 - 377 0 - 349 points points points points points points points points points points points points Grade = A = A= B+ = B = B= C+ = C = C= D+ = D = D= F 90% 86% 82% 78% 74% 70% 66% 62% 58% 54% 50% Exam grades are based on the total number of correct answers, and all grades are final. No curve will be applied to exam grades, and no “retakes” will be allowed. No “extra point” assignments will be made or applied to grades. Students can view their individual quiz and exam scores on Western OnLine (WIU ECom is required for login). CLASSROOM POLICIES: Any student convicted of academic dishonesty, can receive a failing grade and may be subject to further academic penalties. (See academic dishonesty policy http://www.wiu.edu/policies/acintegrity.shtml. ) Data 3 storage devices other than a simple calculator (TI-30XA) such as cell phones, lap tops computers, IPODs, IPADs, MP3 players, video games, etc. are not to be used on any lecture exam. Cell phones must be put away (turned off or placed on vibrate mode and stowed out of sight) during all classroom activities. Use of headphones, blue-tooth, ear phones, etc. is not permitted during an exam. All hats, caps, and hoods that cover your ears are not allowed to be worn during an exam. The instructor reserves the right to assign seating for the students during exams and/or any other time deemed necessary. Simple scientific calculators may be used on quizzes and exams, however no graphing calculators are permitted. COURSE POLICY: No incomplete will be given to a student with a failing grade in the course. No incomplete will be given in this course unless the student experiences a documented emergency that takes him/her away from the university for at least two consecutive weeks and/or causes him/her to miss the final exam. The student must notify the instructor of this emergency before the final exam (Tuesday, December 10, 2013 at 3:00 pm). Any student convicted of academic dishonesty, (including plagiarism) may receive a failing grade and may be subject to further academic penalties, such as possible expulsion from the university. (See academic dishonesty policy http://www.wiu.edu/policies/acintegrity.shtml.) The instructor reserves the right to assign seating for the students during exams and/or any other time deemed necessary. Simple scientific calculators may be used on lecture exams, however no graphing calculators are permitted. WIU Policies: It is the policy of Western Illinois University to accommodate individuals with disabilities pursuant to federal law and the University's commitment to equal educational opportunities. It is the responsibility of the student to inform the instructor of any necessary accommodations at the beginning of the course. Any student with a disability requiring accommodations should contact the Office of Disability Support Services. In accordance with University policy and the Americans with Disabilities Act (ADA), academic accommodations may be made for any student who notifies the instructor of the need for an accommodation. It is imperative that you take the initiative to bring such needs to the instructor’s attention, as he/she is not legally permitted to inquire about such particular needs of students. Students who may require special assistance in emergency evacuations (i.e. fire, tornado, etc.) should contact the instructor as to the most appropriate procedures to follow in such an emergency. Contact Disability Support Services at 298-2512 for additional services. Please find the web address for Student Rights and Responsibilities: http://www.wiu.edu/provost/students/php 4 The following action is prohibited under the Student Conduct Code: 1. Disorderly Conduct: Any behavior which disrupts the regular or normal functions of the University community, including behavior which breaches the peace or violates the rights of others. Web address for Academic Integrity Policy (http://www.wiu.edu/policies/acintegrity.php) Emergency Preparedness: The WIU Office of Risk Management and Emergency Preparedness provides resources on how to respond to emergency situations. Please view the video resources at www.wiu.edu/rmep/ (Click “Resources” on the right side of the page). If the fire alarms sound and/or students are asked to evacuate the building all students should proceed immediately to the nearest exit and gather at the southwest corner of the Higgins parking lot (near the fence) until the “all clear” is given. IMPORTANT DATES: First Day of Class Thanksgiving Classes Resume Comprehensive Make up exam FINAL EXAM Tues. Aug. 20, 2013 Mon-Fri, Nov. 25-29, 2013 Tue., Dec. 03, 2013 Thur. Dec.05, 2013 3:00-4:50 pm Tues. Dec.10, 2013 ADDITIONAL READING LIST: Physician's Desk Reference (PDR) 2011 Addition 65, Thomson Healthcare Publishing. PDR for Nutritional Supplements 2009 (second edition) Thomson Healthcare Publishing. PDR for Herbal Medicines 2008, 4th Edition, Thomson Healthcare Publishing Pharmacology for Chemists, 2010 by Joseph G. Cannon, Oxford publishing. Principles of Medical Pharmacology, 8th edition by Harold Kalant and Walter Roschlau, 2007, Oxford Publishing. Hansten & Horn's Drug Interactions, Analysis and Management: Facts & Comparisons by Philip D. Hansten & John Horn, 2008, PP Publishing. 5 Stability Indicating HPLC Methods of Drug Analysis, 3rd Edition, by Quanyun Xu and Lawrence Trissel, 2008, PP Publishing. Clarke's Analysis of Drugs and Poisons, 3rd edition, by Anthony Moffat, David Osselton, , Brian Widdop, and Lauret Y. Galichet, 2004, P.P. Publishing. Handbook of Forensic Drug Analysis by Fred Smith and Jay A. Siegel, 2004, P.P. Publishing. Pharmacology DeMystified. by Mary Kamienski and Jim Keogh 2006, McGraw Hill Drugs and the Human Body, 6th Edition by Ken Liska 2000, Prentice Hall. Medical Terminology by Nina Thierer and Lisa Breitbard, 2006, McGraw Hill Goodman and Gilman’s The Pharmacological Basis of Therapeutics 12 Ed. Laurence Brunton, Bruce Chabner abd Bjorn Knollman, 2011, Mc Graw Hill 6 CHEM263 Fall 2013 Tentative Lecture Schedule Date Lecture topic 08-20 L01: General Principles 08-22 L02: General Principles 08-27 08-29 09-03 L03: Neurotransmission: The Autonomic and Somatic Motor Nervous System L04: Muscarinic Receptor Agonists and Antagonists Acetylcholinesterase Inhibitors Dr. ML Chen Chapter 1-5 1-5 6 7 8 09-05 L05 Agents Acting at the Neuromuscular Junction and Autonomic 9 Ganglia L06: Adrenergic Agonists and Antagonists 10 09-10 Exam 1 (L01-L06) 09-12 L07: Diuretics 28 09-17 L08: Treatment of Myocardial Ischemia Pharmacotherapy of Congestive Heart Failure 31 33 09-19 L09: Vasopressin, Renin and Angiotensin 29-30 09-24 L10: Therapy of Hypertension 32 09-26 L11: Drug Therapy for Hypercholesterolemia and Dyslipidemia 35 10-01 Exam 2 (L07-L11) 10-03 L12: Neurotransmission and the Central Nervous System 12 10-08 L13: Hypnotics and Sedatives 16 10-10 L14: Drug Therapy of Depression and Anxiety Disorders 17 10-15 L15: Pharmacotherapy of the epilepsies 10-17 L16: Treatment of CNS degenerative Disorders 10-22 Exam 3 (L12-L15) 10-24 L17: Adrenocorticotropic Hormone 59 10-29 L18: Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas 60 10-31 L19: Histamine, Bradykinin, and their Antagonist Pharmacology of Athmas 24 27 11-05 L20: Analgesic-Antipyretic and Anti-inflammatory Agents; Pharmacotherapy of Gout L21: Opioid Analgesics 26 11-07 7 21 11-12 Exam 4 (L17-21) 11-14 L22: Blood Coagulation and Anticoagulant, Thrombolytic, and antiplatelet Drugs 54 11-19 L23: Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophagel Reflux Disease L24: Antineoplastic Agents 36 11-21 45 11-26 Thanksgiving Holiday (No Class) 11-28 Thanksgiving Holiday (No Class) 12-03 L25: Natural and Herbal Products (*APhA’s Complete Review for Pharmacy) 12-05 Review/Comprehensive makeup Exam. 12-10 3:00 pm – 4:50 pm, Final Exam (L22-L25) THIS SYLLABUS IS SUBJECT TO CHANGE UPON NOTIFICATION BY INSTRUCTOR. 8