`
DNA Structure and Function 12.1 Function and structure of DNA `
`
`
`
`
`
`
`
`
What does DNA do? Codes for proteins How this was discovered `
Griffith’s transformation experiment How did viruses confirm this? Hershey and Chase experiment `
Used bacteriophage Review: What is DNA made of? Nucleotide `
Recall three parts Types `
`
Purines Pyrimidines Chargaff’s experiment `
Complementary base pairing `
`
`
`
`
`
`
`
Review: What is the structure of DNA? Watson and Crick model `
`
Double helix Rosalind Franklin What are the specifics of DNA structure? 5’ vs. 3’ Sugar‐phosphate background Hydrogen bonding of bases Covalent bonding of sugar‐phosphate DNA Structure and Function 12.2 DNA Replication `
`
`
What are the basics of DNA replication? Semiconservative replication Three stages to replication `
`
`
`
`
`
`
Unwinding `
helicase Complementary base pairing `
`
DNA polymerase Leading vs. lagging (see next slide) Joining `
ligase How do the leading and lagging strands differ? Leading strand Lagging strand `
Okazaki fragments DNA Structure and Function 12.3 Replication in cells and mutations `
`
`
`
`
`
How does DNA replicate in prokaryotes? Prokaryotic DNA is circular Eukaryotic DNA is _______ What happens if there is an error in replication? Mutation `
`
Proofreading If not corrected Æ cancer (eventually) DNA repair enzymes `
Thymine dimers