English Date20December2012 ExaminationNEVR2030 Therearetwotypesofquestions. SHORTANSWERQUESTIONSandTRUEorFALSEquestions. Eachshortanswerquestionrequiresonlyashortanswerandbehindeachquestionis indicatedhowmanypointsyouwillgetincaseofacorrectanswer.Simplequestions willyield1pointandahighernumberofpointsindicatethatamorecomplex and/orelaborateanswerisrequired. Trueorfalsequestionsalwaysscore1point.Youarerequiredtoclearlyindicatethe rightanswerbywritingeitherTrueorFalseonyouranswerdocument.Donotaddto theanswerinanyway,becausethatmayinfluencethemarkyouwillget. Theexamcomprisesatotalof46questions(72points)on5pages(includingthe coverpage). Youhave4hourstocompletetheexam. Useofdictionariesandothertoolsofassistance.YouareallowedONEdictionary thattranslatesstandardlanguagefromyourmothertonguetoEnglish,i.e.French‐ English,German‐Englishetc.NOSPECIALIZEDDICTIONARIESWILLBEALLOWED, suchasEnglish‐Englishdictionariesthatprovidedefinitions,ormedical dictionariesofanydescription.NativeEnglishorNorwegianspeakersarenot allowedanydictionary. 1 SHORTANSWERQUESTIONS 1. Nameoneadvantageandonedisadvantageoflesionstudiesasamethodfor mappingbrainfunctions.(2) 2. Spiralganglioncellsarebipolarcellsthatinnervateperipheralsensorycells(hair cellsintheinnerear)andsendanaxonintothe8thcranialnerve.Inwhich gangliadowefindcomparableneuronsthatmediatethetransferoftouch information?(1) 3. Besidestransmittingvibrationsfromtheeardrumtotheinnerearwhatisthe functionofthemiddleearbonesmalleus,incusandstapes?(2) 4. Whatisthelargestcommissureinthebraincalled?(1) 5. Nametwobrainregionsthataretargetedbytheolfactorytract,i.e.thepathway madeupbyaxonsofthesecondorderneurons?(2) 6. Describethestructureoftheolfactorysensoryneuron.(2) 7. Whereinthespinalsystemdowefindtheneuronsthatoriginatepartofthe parasympatheticcomponentoftheautonomicnervoussystem?(1) 8. Giveashortdefinitionofamotorunit.(1) 9. Givethenameofatleastonecranialnervethatcontrolsthemovementof theeye.(1) 10. Describethemainmechanismsthatareresponsiblefortheresting membranepotential(ca.–65mV)inneurons.(2) 11. Whydoesanactionpotentialnormallytravelonlyinonedirectionthatis awayfromthesoma?(1) 12. Theperceptualthresholdsfordetectingbitterandsweetsubstancesare substantiallydifferent.Whichoneofthesebasictasteshasthehighest threshold?(1) 13. Differenttastesessentiallyusetwodifferentprimarymechanismstoinitiate aresponseinthetastecell.Describethesetwomechanisms.(2) 14. Namethethreecranialnervesthatareinvolvedinthetransmissionoftaste informationtotheCNS.(3) 2 15. Withintheascendingpathwaysofthespinalcordthatcarrysomatosensory informationtothebrain,twodifferentcomponentsaredifferentiated.Describe themaindifferencesbetweenthesetwowithrespecttotypeofinformation carriedbythemandtheirroutesbywhichtheyreachthesomatosensorycortex. (4) 16. Namethestructureinthedevelopingbrainfromwhichtheinterneuronsinthe cortexoriginate.(1) 17. Duringtheformationoftheneuraltube,anumberofembryoniccells differentiateintotheso‐calledneuralcrest.Nametwoderivativesofneuralcrest cells.(2) 18. Theprosencephalonofthevertebratebraindifferentiatesintotwobrainparts (secondarybrainvesicles).Whatarethesetwosecondarybrainvesiclescalled? (2) 19. Describeonemainroleofthehypothalamusandthemainoutputpathway throughwhichthisismediated.(2) 20. Whatarethethreemostimportantsensorysystemsforbalancecontrol?(3) 21. Whichpartofthecentralnervoussystemischaracteristicallyaffectedin Parkinson’sdisease?(1) 22. Whichrolehasthecerebellumincontrollingmovements?(2) 23. Describebrieflythefunctionaldifferencebetweentheanteromedial(ventral)and lateralcorticospinaltracts.(2) 24. Givethenameandorigininthebrainofthreemodulatorysystems.(3) 25. Giveonepieceofevidenceforhemisphericlateralizationoflanguage.(2) 26. Giveashortdefinitionofaphasia.(1) 27. Whatisthenameofthethalamicnucleusthatdefinestheprefrontalcortex?(1) 28. DescribetwocommonsymptomsinpatientssufferingfromAlzheimer’sdisease. (2) 29. WhatistheneuralprocessunderlyingattentionaccordingtoLamme?(3) 30. Listthreebasicpositionsinthefreewilldebate.(3) 3 TRUE/FALSEQUESTIONS 1. InachemicalsynapseusingtheneurotransmitterGABA,thepostsynaptic membranepotentialisalteredbytheopeningofreceptorswhichletpassCa2+. TrueorFalse 2. Thesympatheticcellbodiesthatprovidethemajorsympatheticinnervationof theheartarelocatedinthebrainstem.TrueorFalse 3. Thecortexofthebrainisdefinedastheouterportionthatiscoveredby meningeallayers.TrueorFalse 4. Thetwovertebralarteriesarethemainbloodsupplyoftheforebrain.Trueor False 5. Theprimaryvisualcortexisinvolvedincolorperception.TrueorFalse 6. Theapexofthebasilarmembrane(thepartfurthestawayfromthecochlea)is specificallytunedtolowfrequencies.TrueorFalse 7. Tastebudsinhumansarepresentoutsideofthetongue.TrueorFalse 8. Spinalcordsegmentsatthelumbarlevelcontainneuronsthatoriginatepartof theparasympatheticnervoussystem.TrueorFalse 9. DuringthegenerationofaneuronalactionpotentialvoltagegatedK+‐channels openfirst,beforevoltageNa+‐channels.TrueorFalse 10. Evaluationoflocalization(definethedirectiontoasoundsource)isdonebythe MedialSuperiorOlive(MSO).TrueorFalse 11. Haircellsareorganizedintworows,i.e.innerandouterhaircells.TrueorFalse 12. Thehigherolfactorycentersofthehumanbrainincludetheorbitofrontalcortex. TrueorFalse 13. Olfactorysensoryneuronsprojectdirectlytotheentorhinalcortex.Trueor False 14. Inthe6layeredcortex,neuronsinlayer2aretheoldestneurons(outside‐in migration).TrueorFalse 15. Motorneuronsintheventralhornofthespinalcorddevelopfromthefloorplate. TrueorFalse 16. MostofthecasesofAlzheimer’sdiseasearecausedbyamutationinaspecific gene.TrueorFalse 4