The time-dependent two-echelon capacitated vehicle routing problem with environmental considerations Keeping large vehicles away from congested areas allows to reduce the environmental externalities of freight distribution (e.g., energy usage and congestion), and to improve the social consequences of such activities (e.g., traffic-related air pollution, accidents and noise). Multi-echelon distribution strategies in which freight is delivered to customers via intermediate depots rather than direct shipments from the origin can be used to alleviate burden of large vehicles on traffic. We addressed a time-dependent two echelon capacitated vehicle routing problem (2E-CVRP) that consists of a depot, and a set of satellites and customers. In two-echelon distribution systems, large trucks are used to transport freight over long-distances to satellites where consolidation takes place; afterwards, the products are transferred to destination points using small and environmentally-friendly vehicles. In our problem, time-dependent travel times are considered to account for traffic congestion effects when traveling on the defined arcs in the second-echelon. The objective of the basic 2E-CVRP is to determine two sets of first and second echelon routes that minimize total routing and satellite handling cost. Routing cost includes that of driver and fuel consumption, calculated for each arc in the network. We developed a comprehensive MILP formulation for a time-dependent 2E-CVRP that accounts for vehicle type, traveled distance, vehicle speed, load, emissions and multiple time zones that may occur during the planning horizon. To the best of our knowledge, this was the first attempt to develop a mathematical model for the time-dependent 2E-CVRP with an explicit consideration of fuel consumption through the use of a comprehensive emission function. A case study was provided to present an implementation of the proposed model on the distribution operations of a supermarket chain operating in the Netherlands. We focused on four KPIs: total distance, total time, total fuel consumption, and total cost. The proposed model was minimized over each Key Performance Indicator. Findings The resulting routes and the performances of the solutions with respect to the KPIs change according to the variation of the model. The traditional objectives of distance and time minimization did not ensure minimization of fuel consumption or cost. The comprehensive cost-minimizing objective, which breaks away from the traditional objective functions used in the 2E-CVRP by a detailed estimation of fuel consumption, could achieve average savings in total cost by 6.9%. In particular, the cost-minimizing objective outperformed the traditional approaches based on only distance or time while estimating distribution cost. The respective saving is 12% compared to the distance-minimizing objective and 4% compared to the time minimizing-objective. However, the cost minimizing objective did not guarantee the best solution in terms of emissions. 1 The use of fuel-minimizing objective could ensure the most environmentally-friendly solution by reducing total fuel consumption on average 2.5% in return for a cost increase of 10.8%. The sensitivity analyses revealed that the performances of the variations of the model on the selected KPIs changed according to the handling fee in the satellites and demand of the customers. For our case study, the most environmentally-friendly solution was obtained by the use of a two-echelon distribution system, although a single-echelon distribution system provides a solution with lower total cost. The proposed model also give users the opportunity to exploit the trade-offs among sustainability KPIs through using different objectives. 2