Main Idea: DNA Replication – Process of making a copy of the DNA molecule • Remember - for you to grow, repair wounds or replace dead cells, your cells must go through mitosis • And in order to sexually reproduce, sex cells must be made through meiosis. • Before either of these processes occur, DNA must be copied DNA is copied during the Interphase’s “S” stage • At the origin of replication DNA helicase enzymes “unzip” the DNA molecule by breaking the hydrogen bonds between base pairs Each strand serves as a template or pattern that complementary nucleotides attach to following the base pairing rules DNA polymerase enzyme joins nucleotides together so that hydrogen bonds can form between the base pairs to hold the 2 strands together. DNA polymerase also “Proofreads” the new DNA strand for accuracy and corrects errors. The base pair sequence of the 2 new DNA molecules is identical to the original DNA molecule. The new DNA molecule is “semiconservative” It is made of one strand of the original molecule (which served as the template) and one newly made strand. There are many origins of replication along a DNA molecule so that the process can be completed quickly DNA replication begins at many sites along the long DNA molecule of a chromosome Replication Bubbles 13 of 8 © Boardworks Ltd 2010 The Amoeba Sister’s DNA REPLICATION 15 of 8 © Boardworks Ltd 2010 DNA replication 16 of 8 © Boardworks Ltd 2010 DNA replication enzymes 17 of 8 © Boardworks Ltd 2010 DNA replication 18 of 8 © Boardworks Ltd 2010 19 of 8 © Boardworks Ltd 2010