New Yorker, Oct 9, 2000 Ergogenic aids fall into two categories: Physical / Verbal – cheering, music, altitude training, sauna and massage, psychology etc. Chemical and Pharmacological – anabolic steroids, stimulants, narcotic analgesics, beta blockers, diuretics, amino acids, vitamins etc. Ergogenic Aids: History of Use Ancient Greek Olympians ate mushrooms Aztec athletes ate human hearts In late 1800s, European cyclists took heroin, cocaine "speedballs," and ether-soaked sugar tablets Winner of 1904 Olympic marathon took strychnine and brandy during race Winner of 1920 Olympic 100-m dash drank sherry with raw egg before race In 1960 Olympics, Danish cyclist died in road race from amphetamine In 1967 Tour de France, famed British cyclist died, also from amphetamine Olympic testing began in 1968 for stimulants Ergogenic Aids: History of Use Development of Dianabol East German female swimmers of 1970s-1980s Cyclists deaths (1987-1990) Chinese female swimmers (1992-1994) 1998 Tour de France 27 Chinese athletes removed from team Bulgarian and Romanian weightlifting teams expelled USATF relinquished drug testing – alleged >12 positive tests not reported last 2 years Desire to Win by Elite Athletes A 1997 SI survey of elite US athletes asked whether they would take an illegal drug that guaranteed an Olympic gold medal. >90% would take it if assured of not being caught >50% would take it even if side effects were lethal in 5 years Ergogenic Aids: Placebo Effect Ariel & Savill, MSSE, 1972 Increasing Muscle Mass Anabolic steroids Growth hormone Protein supplements Anabolic Steroids Male hormones have anabolic effects – accelerated growth of muscle, bone, and red blood cells Anabolic steroids are synthetic relatives to testosterone – high-volume training needed for beneficial effects – inhibit protein breakdown Anabolic Steroids: Secondary Effects Androgenic effects – males: testicular atrophy, breast development, sperm count, acne – females: masculinization, facial & chest hair growth, deepening of voice, acne Additional effects – aggressiveness, mood swings, altered glucose metabolism, thyroid, lipid profiles Commonly Used Anabolic Steroids Testosterone Stanazolol Nandrolone DHEA Androstenedione DHEA and Androstenedione: Precursors of Testosterone DHEA Androstenedione DHT Testosterone Estrone (E1) Estradiol (E2) Effects of DHEA and Androstenedione After 12 Weeks of Training Wallace et al., MSSE, 1999 Protein Supplementation Research suggests that athletes have 2-3X RDA higher protein needs Typical American athletes already consume this amount Increased carbohydrate intake more important to increasing muscle mass Fatigue: Implications for Ergogenic Aids Power/Speed events – – – – muscle mass CNS & sympathetic stimulation acidosis depletion of PCr Endurance events – – – – – muscle glycogen depletion low blood [glucose] fat oxidation rate dehydration diminished O2 delivery Bicarbonate Loading Intramuscular effects of acidosis – PFK, phosphorylase – Ca2+ sensitivity – cross-bridge force output – ATP turnover – slows recovery rate Effects of bicarbonate loading – plasma pH – speeds H+ and La- transport from muscle Benefits of Bicarbonate Loading not all studies report performance benefits – dependent on dosing – benefits maximal exercise of 1-10 min – GI distress Performance After Bicarbonate Loading Costill et al., Int J Sports Med, 1984 High-Intensity Exercise Effects on Muscle Metabolites force lactate PCr ATP Endurance Training Adaptations VO2max (~15%) cardiac output (~15%) mitochondrial volume (2X) La threshold shifted to right ability to use fats (spares glycogen) Increasing O2 Delivery blood doping – RBC and blood volume – submax pH – La, HR breathing 100% O2 EPO – stimulates RBC production altitude training – live high, train low ACSM Position Stand, The use of blood doping as an ergogenic aid. MSSE, 28:i-viii, 1996. Effect of Blood Doping on VO2max and Fatigue Performance After Blood Doping Performance After Inhalation of 100% O2 What limits endurance performance? Cytochrome oxidase Pyrave-malate oxidase Palmitoyl carnitine oxidase VO2max Pyruvatemalate oxidase Palmitoyl carnitine oxidase VO2max Maximal endurance .95 .93 .74 .92 .89 .68 .89 .71 .91 .70 Davies et al., 1981, 1982 What limits endurance performance? Recovery in rats restored to normal ironintake diet. Davies et al., AJP, 1982 Increasing Energy Supply Carbohydrate availability Glucose – feeding before/during competition – enhancing fat use Creatine – important for energy production during power/speed events Increasing Fat Utilization FA availability will fat oxidation Caffeine – lipolysis? – EPI release? – blocks adenosine receptors – inhibits phosphodiesterase Ephedrine – ß-receptor agonist Increasing Fat Availability Caffeine – – – – – – – fat availability and carbohydrate use? spares carbohydrate stores? threshold for motor unit recruitment altered E-C coupling facilitated nerve transmission ion transport w/in muscle catecholamine release Other nutritional products Carbohydrate Feeding During Exercise Ivy et al., MSSE, 1979 Effect of Diet on Carbohydrate Storage and Exercise Duration CHO intake (g/24 h) 100 (15%) 280 (55%) 500 (98%) Glycogen content (mmol/kg) 53 100 205 Exercise time (min) 57 114 167 Effect of Diet on Muscle Carbohydrate Storage Costill & Miller, IJSM, 1979 Other Banned Substances Stimulants – reduces tiredness – ephedrine, cocaine, amphetamines Painkillers – narcotics Diuretics – rapid weight loss – masks steroid use Dehydration and Performance Saltin & Costill, 1988 If you were to design a new ergogenic aid for a(n), endurance athlete speed athlete power athlete what physiological mechanism(s) would be affected that result in better performances?