Abdominal Fat Reduction by Injection
Participants will receive weekly injections to the abdomen for 8 weeks and must
return for a 1 week follow-up visit. Participants must be willing to have 3 MRIs
done at an offsite location (MRI is done to measure fat).
Inclusion Criteria:
 Healthy male & female patients at least 18 years of age
 You must be able to make ALL visits and phone contacts for the full study
period
 You are willing to have 20 injections of the study drug or placebo with a
needle under the skin of your belly once a week for 8 weeks.
 BMI cannot be greater than 30
 You have a history of stable diet and exercise routine over the last 3
months
Exclusion Criteria:
 You cannot have any metals in the body that would interfere with MRI
scans (ex: cardiac pacemakers, defibrillators or valves, metallic dental
implants, IUDs, orthopedic rods, plates, nails or screws)
 You have claustrophobia that would interfere with completing the MRI
procedure
 You have excessive skin wrinkles, loose skin or folds in your belly area
 You have had any treatment of the fat around your abdomen, including
surgical procedures
 You have any skin diseases, extensive tattoos, extensive stretch marks, or
scars anywhere on the abdomen
 You are planning to start a weight loss or exercise program other than your
normal routine
 Any diseases that would compromise your participation in the study (ex:
diabetes, heart disease, anemia, COPD & asthma)
 You have any kidney or liver problems
 You have had major surgery in the past 30 days or are planning a major
surgery during the study
 You have an allergy to Salmeterol Xinofoate (active study drug that is
widely used for the treatment of asthma)
 You have participated in another investigational clinical trial in the past 30
days
 You have used any corticosteroids or immunomodulators in the past 28
days
 You have used any tricyclic antidepressants or monoamine oxidase
inhibitors in the past 14 days
 You have used any anticoagulants or aspirin in the past 5 days
 You are breastfeeding, pregnant or have had a baby within the past 12
months