STRENGTH Confidential I am a mother. I am a long distance swimmer. I have Multiple Sclerosis. I am not defined by my illness. I know The Diplomat Difference. Vicki Bellingham, Washington August 2014 2015 MAHP Summer Conference July 15, 2015 These materials may not be used or relied upon for any purpose other than as specifically contemplated by a written agreement with Credit Suisse AG or its Affiliates (hereafter “Credit Suisse”). Diplomat Pharmacy, Inc. Industry Trends Important note This presentation may contain “forward-looking” statements that involve risks, uncertainties and assumptions. If the risks or uncertainties ever materialize or the assumptions prove incorrect, our results may differ materially from those expressed or implied by such forwardlooking statements. All statements other than statements of historical fact could be deemed forward-looking, including, but not limited to, any projections of financial information; any statements about historical results that may suggest trends for our business and results of operations; any statements of the plans, strategies and objectives of management for future operations; any statements of expectation or belief regarding future events, health care developments, or specialty pharmaceutical industry market sizes, shares, trends or growth; and any statements of assumptions underlying any of the foregoing. Any forward-looking statements contained in this presentation are based on management's good-faith belief and reasonable judgment based on current information, and these statements are qualified by important factors, many of which are beyond our control, that could cause our actual results to differ materially from those in the forward-looking statements, including changes in global, regional or local economic, business, competitive, market, regulatory and other factors, many of which are beyond our control, including but not limited to the following risks related to our business: our ability to adapt to changes or trends within the specialty pharmacy industry; significant and increasing pricing pressure from third-party payors, our relationships with key pharmaceutical manufacturers; our limited history with integrating acquisitions; and the effects of competition. These and other risks and uncertainties associated with our business are described in the prospectus for our proposed follow-on offering, including under the heading “Risk Factors.” We assume no obligation and do not intend to update these forward-looking statements. In addition to U.S. GAAP financials, this presentation includes certain non-GAAP financial measures. These historical and forward-looking non-GAAP measures are in addition to, not a substitute for or superior to, measures of financial performance prepared in accordance with GAAP. A reconciliation between GAAP and non-GAAP measures is included in the appendix to this presentation. Diplomat is a registered trademark of Diplomat Pharmacy, Inc. This presentation also contains additional trademarks and service marks of ours and of other companies. We do not intend our use or display of other companies’ trademarks or service marks to imply a relationship with, or endorsement or sponsorship of us by, these other companies. Confidential 1 Diplomat: Largest independent specialty pharmacy Diplomat at a glance Exceptional above market revenue growth Founded: 1975; Headquarters: Flint, MI Employees: ~1,500 FY 2014 revenue: ~$2.2 billion Diversified base of marquee partners Market share ($78 billion total market size) (1) Others 20% ($ in millions) Scaled business: National footprint Springfield, MA CVS Health/ Omnicare 33% Avella 1% OptumRx/ Catamaran 8% (2) Savage, MN Flint, MI Urbandale, IA Enfield, CT Chicago, IL Ontario, CA Carlsbad, CA Woburn, MA GLDC Cincinnati, OH Greensboro, NC Scottsdale, AZ Raleigh, NC 3% Ft. Lauderdale, FL Walgreens 10% Express Scripts 25% Corporate Office Diplomat locations BioRx locations National Distribution Center (1) (2) Source: 2014 – 2015 Economic Report on Retail, Mail and Specialty Pharmacies, Drug Channel Institute and Morgan Stanley Research Based on mid-point of management’s estimate range for FY 2015 Confidential 2 Specialty pharmacy industry continues to show exceptional growth Specialty spend under pharmacy benefit to more than double(2) Specialty share of spend growing dramatically(1) 2012A 2015E 2018E 2012A 2018E Diplomat 2% 30% 58% 42% 50% 50% 70% $51million billion $51 $118 billion Traditional 58% Specialty Traditional Specialty continues to dominate top 10 drug spend(3) 2013A 6 out of top 10 2020E 9 out of top 10 Source: (1) Specialty Drug Trend Across the Pharmacy and Medical Benefit – Artemetrx 2013. (2) 2013-2014 Economic Report on Retail, Mail and Specialty Pharmacies. (3) Pembroke Consulting analysis of World Preview 2014, Outlook to 2020, EvaluatePharma. Confidential 3 Vision for specialty pharmacy • Proportion of the prescription drug spend utilized on specialty pharmaceuticals will continue to rise • Cost trend for specialty expected to continue at 15% to 25% • Pipeline: Oncology, Hepatitis C, Cystic Fibrosis, MS • Limited distribution networks • “Specialty lite” products • Continued focus on specialty spend under medical benefit in addition to pharmacy • Anticipation of biosimilars and generics – formulary opportunities and rebate opportunities • Specialty at retail and health systems – nationally leader in specialty at retail and health • 340B and Accountable Care Organization opportunities systems Journey of a specialty patient Diplomat monitors adherence and collects data Patient visits physician Patient Physician Patient receives drugs Physician writes script Patient Diplomat dispenses drug Payor Diplomat provides: Benefit verification Prior authorization Clinical intervention Payor approves script Confidential 5 Patient’s Journey Begins PROBLEM SOLUTION Education Frustration Fear PA and Appeals Coordination Funding and Co-pay Coordination 24/7 Access Anxiety Confusion Adherence Clinical Monitoring Side Effect Management Confidential 6 Communication Summary 24.19% 55.35% 20.46% 2014 Communication*/Unique Patient 33.19 Communications/Year 2.8 Communications/Month *Communication represent contact or contact attempt with the defined party •Inbound and Outbound Calls •Pharmacist, Nurse, Patient Care Coordinator •Physician Office Faxes Proprietary and Confidential of Diplomat Pharmacy Inc. 7 Unique competitive position LARGE PBM / RETAIL PHARMACY Diversification distracts from specialty pharmacy Less flexible / less nimble Singularly focused on specialty High-touch model Flexible and nimble Entrepreneurial culture National reach Scalable infrastructure SMALLER SPECIALTY PHARMACIES Limited scale Most focused on one or a few disease states Fragmented market Consolidation opportunity for Diplomat Confidential 8 Leader in Limited-Distribution Access Diplomat has access to dozens of limited-distribution drugs: Revlimid® Supprelin® LA lenalidomide histrelin acetate Tobi® Podhaler™ Nexavar® Serostim® Sylatron™ Tykerb® Zelboraf® sorafenib somatropin peginterferon alfa-2b lapatinib vemurafenib Signifor® LAR Synagis® Valstar® Zolinza® pasireotide palivizumab valrubicin vorinostat Synribo® Vantas® Zorbtive® omacetaxine mepesuccinate histrelin acetate somatropin Natpara® Actemra® Cometriq® Gazyva® Istodax® tocilizumab Cabozantinib obinutuzumab romidepsin parathyroid hormone Adcetris® Cosentyx™ Healon® Jakafi® brentuximab vedotin secukinumab sodium hyaluronate ruxolitinib Aldurazyme® Dacogen® Hizentra® Kalydeco® laronidase Decitabine immune globulin, human ivacaftor sodium nitrite, sodium thiosulfate Dysport® Pediatric Indications Only Krystexxa® Nplate® Simponi®* pegloticase romiplostim golimumab Ampyra® dalfampridine Humira® abobotulinumtoxinA Nithiodote™ Zaltrap® ziv-aflibercept tobramycin adalimumab Arzerra® Elaprase® Hycamtin® Lemtrada™ Otezla® Simponi® Aria® Tafinlar® Vidaza® Zydelig® ofatumumab idursulfase topotecan hydrochloride Alemtuzumab apremilast golimumab dabrafenib azacitidine idelalisib Aubagio® Esbriet® Lumizyme® Ozurdex® Soliris® Tarceva® Votrient® Zykadia™ teriflunomide pirfenidone Immune Globulin 10% (human) with Recombinant Human Hyaluronidase alglucosidase alfa dexamthasone eculizumab erlotinib pazopanib ceritinib Aveed® Erivedge® Ibrance® Lynparza™ Plegridy™ Soltamox® Tecfidera® Vpriv® Zytiga® testosterone undecanoate vismodegib palbociclib olaparib interferon beta-1a tamoxifen citrate dimethyl fumarate velaglucerase alfa abiraterone Pomalyst® Somatuline® Thalomid® Xalkori® pomalidomide lanreotide thalidomide crizotinib Faryak HyQvia® Makena® Bethkis® Exjade® Imbruvica® tobramycin inhalation solution deferasirox ibrutinib hydroxyprogesterone caproate Bosulif® Eylea® Inlyta® Mekinist™ Prialt® Stivarga® Thyrogen® Xtandi® Iressa bosutinib aflibercept axitinib trametinib ziconotide regorafenib thyrotropin alfa enzalutamide gefitinib Tobi® inhalation solution Yervoy® Cerezyme® Firazyr® imiglucerase icatibant Intron® A interferon alfa-2b, recombinant Myozyme® Promacta® Sutent® alglucosidase alfa eltrombopag sunitinib malate ipilimumab tobramycin * Ulcerative colitis only LAST UPDATE: 02/20/15 Proprietary and Confidential of Diplomat Pharmacy Inc. 9 Limited distribution a central and growing theme in Specialty Benefits to biotech / pharma What is limited distribution? Completely eliminate or reduce reliance on wholesaler Real-time clinical data Commercialization assistance Improves appropriate utilization Benefits to Diplomat Targeted channel strategy Provides certain specialty pharmacies with exclusive or preferred dispensing rights to certain drugs Fast-growing trend Barrier to entry Deeper, and earlier, partnerships with pharma / biotech Increased value proposition to payors Market share opportunity Traditional: Manufacturer Multiple Wholesalers 65,000 Pharmacies Limited: Manufacturer One/few pharmacies Patient Patient Portfolio of over 80 limited distribution drugs, comprising approximately 40% of revenue in 2014, and well positioned for disproportionate growth from future drug approvals Recent unique oncology limited panels…Diplomat exclusive or semi-exclusive (2012) DPLO EXCLUSIVE (2013) DPLO LARGEST OF 5 (2014) DPLO LARGEST OF 4 (2014) DPLO EXCLUSIVE The drug pipeline is projected to deliver continued new therapies, many of which will be limited distribution. Confidential 10 Unique strategic partnerships with leading retailers and health systems Needs / benefits for retail / health systems How does Diplomat support retail and health system partners? Traditional drug trend low to mid single digit growth Participate in high growth specialty without having to build expensive infrastructure internally One stop shop for patients / consumers Improve portfolio of wellness solutions Benefits to Diplomat Fee-for-service offering High margin business − Clinical and administrative support services Leverage infrastructure Improved value proposition with pharma Pharmacy of choice for limited distribution drugs − Patient engagement − Adherence programs − Integrated with retailers’ dispensing platforms − Private label programs Diplomat’s retail and health system partners Recent wins Strong pipeline of future opportunities Confidential 11 PA Navigator • Providing full delegation of prior authorization review for specialty therapies. • Diplomat can seamlessly work with all PBM’s Payor Benefits: Full transparency – all records completely auditable Improved response times for patient and provider Absolute benefit guideline compliance Customizable criteria Unlimited access to clinical expertise Automation reduces risk of delay of therapy start or missed doses Access to IROs for appeals (Independent Review Organizations) Customizable reporting Proprietary and Confidential of Diplomat Pharmacy Inc. 12 Value of True Partner Avoidable excess spend = $150,000 PBM Approved Sovaldi + Olysio combo therapy – Rx sent to Diplomat Diplomat identifies lack of clinical evidence to support approval DSP notifies payor partner 1. Patient does not have stage 3 or greater fibrosis per criteria (has liver score of 1 with normal liver function) 2. No physician confirmation of alcohol or illicit drug abstinence per criteria 3. Patient does not have any contraindications to peginterferon per criteria 1. Decision made to continue therapy to avoid risk of future relapse 2. Rationale: Patient had already initiated therapy 3. PBM required to reimburse payor cost of Sovaldi + Olysio therapy *Above data from an employer’s Q3 2014 results reported. Proprietary and Confidential of Diplomat Pharmacy Inc. 13 Hepatitis C Case Study Hepatitis C – Harvoni™ Diplomat identified a patient who received a prior authorization approval for one month of therapy. Diplomat contacted the plan to determine if approving one month of therapy was standard protocol. Medication had not been shipped yet. Client determined the authorization should not have been approved PBM internally entered approval for one month Clinical review completed previously by the plan denied the prior authorization due to patient not meeting guideline criteria Proprietary and Confidential of Diplomat Pharmacy Inc. “Just wanted to forward a sincere appraisal to you and your team for the outstanding work you do for our team and our members. It's instances such as this one that greatly highlight the attention to detail and expertise Diplomat utilizes on a day-to-day basis, inclusive to maintaining an exceptional production level. I'm grateful for the role I have and the pleasure of interacting with professionals such as yourself. Thank you for being such a wonderful partner!” Director of Pharmacy Plan with 300,000 covered lives SAVINGS TO THE PLAN 30 days of Harvoni™, $31,564 per month 14 Proper Management Minimizes Discontinuation http://www.modernhealthcare.com/article/20140917/NEWS/309179963 Proprietary and Confidential of Diplomat Pharmacy Inc. 15 Adherence Monitoring Motivational interviewing techniques identify non-adherence Nurse asks patient for number of capsules remaining and response doesn’t match patient record Patient had been hospitalized, reducing the number of capsules required with next refill Doctor contacted for new Rx Six fewer Revlimid® capsules resulted in savings of $2,858.52 *Above data from a health plans Q3 2012 results reported. Proprietary and Confidential of Diplomat Pharmacy Inc. 16 Partial-Fill Strategy Therapeutic Category Extensive Program Drug List Oncology Sutent Oncology Tafinlar Cometriq™ Oncology Tarceva Erivedge™ Oncology Targretin Gleevec Oncology Tasigna Imbruvica™ Oncology Harvoni™ Oncology Votrient Jakafi Oncology Xalkori Kalydeco™ Cystic Fibrosis Xtandi Oncology Zelboraf Olysio™ Hepatitis C Zolinza Sovaldi™ Hepatitis C Zydelig Oncology Zytiga Oncology Oncology Zykadia™ Oncology Extensive Program Drug List Afinitor Bosulif ® ® ® ® Inlyta ® Nexavar Sprycel ® ® ® Stivarga ® Therapeutic Category Program consists of a two-week supply of select specialty medications for an initial one to three months of therapy Specific medications targeted for program due to high discontinuation rate, poor response, adverse effects, and/or noncompliance Increases opportunities for clinical care for newly diagnosed patients Proven strategy to effectively manage waste Oncology ® ® ® ® ® ® ® ® ® ® ® Oncology Oncology Oncology Oncology Hepatitis C Oncology Oncology Oncology Oncology Oncology Oncology Proprietary and Confidential of Diplomat Pharmacy Inc. 17 Oncology Pathways PRM (Physician Resource Management) - comprehensive data reporting on care provided by oncologists caring for patients, alerts to treating oncologists, care coordination for oncology patients, electronic health record integration, and electronic prescribing from the oncologist office to Diplomat. CARET Portal for treating physician- full visibility to specialty pharmacy record information on a patient by patient basis. Social media Style Alerts to Practices and Physicians- daily digest emails + real time alerts for urgent matters. Care Coordination- shared protocols + care coordination guides with details on product specific recommendations on appropriateness of products under currently in use oncology protocols, recommended interventions + adjunctive therapies. EHR Integration- actively working with vendors representing the most widely utilized EHR systems within the oncology community to have interfaces in place by the end of Q1 2015. Direct Order Oral Scripts from CARET and Certain EHRs- automation of referral forms and prescriptions from within CARET to be transmitted via facsimile (for pharmacy law compliance reasons) and electronically (to prevent data entry errors) to the specialty pharmacy. 18 Proprietary and Confidential of Diplomat Pharmacy Inc. Hepatitis C Comprehensive Care Primrose Healthcare - reduce the treatment cost-per-member and deliver optimal cure rates for our health plan clients: Pre-Treatment: Optimize the health of patients who are HCV+ but are either disease free or are inappropriate for antiviral therapy, while ensuring that they obtain an optimal outcome if and when they come to treatment HCV Work Up: Determine health & family history Assess Compliance Issues: Visits, lab work & Provider recommendations Address Adherence Concerns: Review lifestyle, social & other concerns Address Clinical Morbidities: Evaluate chronic diseases & conditions Treatment: HCV- status Education & Training: Medication guidance, push alerts & notifications Adherence Checks: Daily/weekly adherence check monitoring Clinical & Lab Reminders: Appointment reminders Post-Treatment: Optimize liver function and overall patient health Outcome data: Complete review of the entire patient journey & HCV treatment Scheduled Follow up: Ongoing engagements with the patient to prevent the return of the disease Regular review of Medications: Monitor for use of unfriendly medications for the liver. Proprietary and Confidential of Diplomat Pharmacy Inc. 19 Health Plan Specialty Strategies Provider Reimbursement New contracts for ambulatory infusion – Review and renegotiate pricing for ambulatory clinics – Create preferred infusion network Site of care for drug administration – Reduce or eliminate high cost sites of care (e.g. hospital outpatient clinics) where clinically appropriate – Mandate through plan design or prior authorization – Voluntary method through lower member cost share ACO – ACOs will increase use of lower cost drugs – ACOs will encourage prescribing based on evidenced base guidelines Oncology clinical pathways – 52% of health plans surveyed by EMD Serono use third party vendors for clinical pathways1 – Palliative and end of life care are less likely to be included in current pathways – Bonus to physicians who follow guidelines and use lower cost drugs Serono Specialty Digest™, 10th Edition Managed Care Strategies for Specialty Pharmaceuticals 2014 1 EMD 20 Impact of Specialty Management Strategies Physicians • • • Payment change/reform Oncology pathways Patient engagement • • • Site of service changes Infusion networks ACO other vendor coordination Preferred products Prior authorization Outcome based formularies EMD Serono Specialty Digest™, 10th Edition Managed Care Strategies for Specialty Pharmaceuticals 2014 • • • Higher cost share Benefit design changes More participation in care Specialty Pharmacies Pharma Manufacturers • • • Patients Medical Benefit Providers • • • Partial fill Adherence programs Measuring & reporting results 21 Thank you. Confidential 22