Nutrition in Global Health Roadmap to the world’s nutritional health: Causes, mechanisms, solutions Allan J Davison PhD, Professor, Biochemist, Faculty of Sciences, Simon Fraser University Department of Biomedical Sciences & Kinesiology June 2011 Prepared as part of an education project of the Global Health Education Consortium & collaborating partners Malnutrition overview •Inequities in distribution global hunger & starvation •One billion too hungry to live productive lives - an equal number adversely affected by overweight! •6 major deficiencies impact health through the life cycle: water, protein, iron, vitamin A, iodine, folic acid •Childbearing women & their children are hardest hit Overnutrition & inactivity risk of heart disease, cancer, strokes, osteoporosis, & diabetes everywhere Globally more are fed every year, meanwhile millions die unnecessarily Page 2 Misconceptions abound. Check yourself • As a reality check, and to create “teachable moments” for what follows, we now invite you to take a 5-minute pre-quiz • You will be offered 10 true-or-false questions to dispel some common misconceptions • Some of this misinformation is spread by those who have something to gain from it • After completing the pre-quiz, we hope you will continue this module with greater interest & clarity Page 3 Prequiz here! To get the most out of this module If you are….. • a nutritionist or student of nutrition • a student of one of the health professions • planning a project in regions with severe nutritional problems • a public health practitioner You may want to … • Pay attention to global & public health & policy implications. • Pay attention to perspectives & realities in desperate situations • Emphasize check-lists to prepare for field work & gather information to recommend/advocate for intervention • Use these slides & resources in your information / teaching sessions Page 5 Preface: Nutrition is crucial to global health • Among immediately modifiable factors that affect health … nutrition is of prime importance • At every age nutrition is a foundation for what follows • For all nations, rich & poor, nutrition determines physical health & development through the life-cycle, including • Success in childbearing, cognition, socio-economic independence, education, disease resistance, employment • Health & economic development are contingent on adequate food, nutritional resources & support Page 6 Universal limitations & health consequences • • • • We need energy for the tasks of daily life Precursors for growth, repair, and reproduction Food elements can be converted to tissues, but … We can’t survive without about 15 essential mineral elements, so they are needed in our diets, most in trace amounts • We can’t manufacture about 15 vitamins and 8 amino acids, so they to are essential dietary components Page 7 Universal limitations & health consequences In addition: We lost key metabolic abilities our evolutionary ancestors had. Thus we are vulnerable to 2 dietary risks: 1) In early life – a period of rapid growth, we are vulnerable to “kwashiorkor” (protein insufficiency) because we can’t synthesize 8 “essential” amino acids missing from our diet 2) In later life: we are vulnerable to obesity & diabetes – in part because we can make fat from carbohydrate, but we can’t easily convert stored fats back to carbohydrates Note B Page 8 Categories of nutritional status Nutritional status is assessed as one of four categories 1. Good nutritional status: All nutrients (right quantities, time & place) allow optimal, growth, maintenance, & reproduction 2. Overnutrition: An excess of a nutrients (usually calories) is being consumed, so that health is negatively impacted 3. Undernutrition: Insufficient food is consumed to allow for the energy needs of the individual. Inevitably dietary (& then body) protein is burned for energy. A secondary protein deficiency ensues – thus: "protein-energy-malnutrition" 4. Malnutrition: Energy consumption is adequate, but there is an imbalance among constituents of the diet and health is impacted Note C Page 9 Optimal health: physical & mental development reproduction, survival Good nutritional status Precursors Absence of disease Healthy diet ... food & water Access to ... ... perinatalcare ... health services # of mouths to be fed Foundations Education NB women Geography, stability, climate absence of conflict, natural resources access to markets, etc Agricultural productivity Economic development Infrastructure non-exploitive investment intellectual property The goal is to see everyone self-sufficient • People in the poverty trap live from hand to mouth, with no opportunity to put resources aside to build a better future • Such communities cannot access the ladder of economic development without external help. • The MDG promise of 0.7% of rich country GDP for aid was chosen to eliminate extreme poverty & hunger in 3 decades • But there are many nations that failed to meet this goal, including both the US and Canada • Thanks to the nations that keep their promises, widespread hunger can be eliminated, but only after 30-50 years. This not, however, cause for undiluted joy. See Note G.Note G Page 11 The “poverty trap” • Even among the richest there are some individuals so marginalized that there seems little hope for them The larger culture, if it cares, takes long-term responsibility for ensuring them the necessities of life • Globally there are communities that have been denied the resources to ever become wealthy. Often from geography, climate, invasion, or appropriation of natural resources Regardless, a world community has undertaken to provide necessities of life, & self-sufficiency to the dispossessed Note H Page 12 Nutrition in Global Context: Sections 1.Malnutrition: prevalence, causes, consequences 4 2.Major categories & measures of nutritional status4 3.Nutrition & crucial periods in the life-cycle; 4 4.Determinants of nutrition, dietary patterns & culture2 5.Nutrition and its relationship to disease4 6.Making hunger history - breaking the poverty-trap 3 7.Trends in nutrition, food security & globalization3 Page 13 Prevalence, causes, consequences On completing this section you will be able to: 1. Describe the extent of malnutrition & its impact on people of the planet, and understand how MDGs depend on nutrition 2. Analyze the factors that determine nutritional health 3. Identify nutritional problems among individuals & populations, identify causes & appropriate solutions 4. Assess risks at various stages of the life cycle & recommend strategies for diminishing risk 5. Compare competing theories accounting for the inequities 6. Predict outcomes by projecting current trends into the future & foresee a pathway toward a world without hunger Page 14 A vicious cycle: economics, hunger, health Poverty diminished access to agricultural & food resources malnutrition nutrition Physical & cognitive impairment, susceptibility to disease, early death inability to earn an income Economic marginalization inability to provide for self or family Page 15 When the only tool you have is a hammer … every problem becomes a nail Malnutrition: “spatial & temporal myopia” sees proximate, not ultimate causes It’s natural to focus on our immediate space-time: rash, diarrhea., edema. Then etiology: infection, nutrition, endocrine Meanwhile, causes further back are invisible: poverty, invasion, drought, economic Are you bored yet? You’d better not be! This module will reiterate the more enduring global causes, poverty & lack of will to change the net flow of wealth from the dispossessed to the powerful. Also the ways in which this imbalance is being overcome. Reference: Ban-Ki Moon, Noam Chomsky, The Nation Page 16 Routes to famine Being landlocked Lesotho Having resources So.Africa Nigeria, Iraq or being on a trade or pipeline route Israel, Afghanistan Bad governance To learn about the “Resource Trap” read or google Paul Collier Zimbabwe, Italy, USA Externally initiated armed conflict Dafur, Afghanistan Sometimes to overthrow a populist government (Allende, Aristide) and install a puppet, or bribable government Uncertain rainfall & drought Sahel, Palestine Blaming the bonsai tree... Yunus: The astonishing background to hunger – a world growing spectacularly rich Next slide shows century by century growth in GDP per capita For half a century we’ve had enough food to nourish everyone Yet … Why? Almost a billion are overweight while an equal number cannot get enough food to sustain life. Because the flow of wealth is overwhelmingly from the poor to the rich, & the rich are able to keep it that way BanKi Moon Page 18 World GDP $PPP per cap (est) 1500-2100 “Manifest destiny” of world - wealth 1 $10,000 China + India 2040? USA + West Europe Western Europe $5,000 China + India India to 1500 $0 1500 2000 http://ers.usda.gov/Data/Macroeconomics/ Eliminating hunger may be the main requirement for a world at peace Food is a primary human drive. Lack → social instability GW Bush Health & economic development depend on nutrition In the following vicious circle, note how malnutrition, ill health, & poverty exacerbate each other MDG 1 is elimination of extreme poverty and hunger, most if not all the others depend on this, the primary, one Page 20 We know in detail the causes of hunger & how to eliminate it We will assume you know the mechanisms in the “poverty trap” the “resource trap” Unfettered free trade favours the powerful Trickledown is overpowered by a torrent of wealth in the other direction The cures are laid out in detail in the MDGs, MVs, Grameen Foundation The chain of cause and effect, and influences are not rooted in the availability of food, nor are they an accident. You must see “starve” as a transitive verb to understand the link between extreme wealth and extreme poverty Page 21 We know what kinds of aid work and what kinds don’t Aid designed to benefit the giver rather than the recipient Fraction of the amount promised, nothing compared with warfare Promises that evaporate Page 22 Nutrition Module Sections 1.Malnutrition: prevalence, causes, consequences 4 2.Major categories & measures of nutritional status4 3.Nutrition & crucial periods in the life-cycle; 4 4.Determinants of nutrition, dietary patterns & culture2 5.Nutrition and its relationship to disease4 6.Making hunger history - breaking the poverty-trap 3 7.Trends in nutrition, food security & globalization3 Page 23 2 Categories & measures of nutritional status 4 slides: • Malnutrition, undernutrition, • Overnutrition / Overweight, Obesity • Energy requirements: calories, carboh, proteins, fats • macronutrients, micronutrients Page 24 4 Determinants of nutrition, diet & culture 2 slides: 1. Page 25 Dietary patterns across cultures 1. Hunter gatherers – the earliest category Benefits: mixed diet, well nourished in good times Risks: famine or drought, warfare & plunder, resourcedepletion through population pressure Prevalent problems: starvation, thirst, lifeexpectancy Note I Page 26 Dietary patterns across cultures 2. Peasant agriculturalists – successful small scale farmers (currently the largest group) • Benefits: close to food sources; if no punitive taxes or rents; usually well adapted to their traditional diets • Risks: single crop emphasis malnutrition, plagues (locusts, rodents), exploitation, warfare and plunder • Prevalent problems: vitamin deficiency, starvation, alcoholism Page 27 Dietary patterns across cultures 3. Indigent, landless crop planters Benefits: Community, share with family, neighbors, income is typically less than a dollar a day Risks: Crop failure, drought or famine, erosion, soilexhaustion, pestilence, economic exploitation (by landlords, seed providers, loan-sharks), displacement, forced migration, civil unrest or foreign invasion Problems: multiple vitamin deficiencies, kwashiorkor (protein malnutrition), infectious disease epidemics. Too poor, powerless to help themselves, most ofPage 28 Dietary patterns across cultures 4. Urban slum dwellers – fastest growing group Benefits: hope for jobs, escape from drought or crop failure Risks: overcrowding, poverty, poor hygiene, limited food choice, social disruption loss of traditional diets, crime Prevalent problems: deficiencies of essential nutrients, alcoholism, obesity, kwashiorkor, Page 29 Dietary patterns across cultures 5. Affluent urbanites – most recent category Benefits: many food choices (appropriate and inappropriate) Risks: inactivity along with high fat, sugar, alcohol intakes Prevalent problems: overnutrition, obese babies and adults diabetes (carbohydrates), cholesterol, atheroma (lipid), strokes, heart disease diabetes, gout (uric acid - meat sources) Note J Page 30 Under- & over-nutrition occur in all cultures • Disparities in income, nutrition & health care are increasing between countries & within groups in the same country In addition, in low and middle income countries diseases of overnutrition are increasingly common • Obesity related disorders, including diabetes, are now as important in some lower to middle income Page 31 countries as in North America and the European Also, under-nutrition occurs in many rich nations • In rich nations, enormous wealth for some has left others ravaged by health costs, unemployment, foreclosures • Developed countries have marginalized cultural groups. Hunger is common in N & S America, China & E Europe • For example, ~49% of US children (and over 80% of black children) require food-aid at some time during childhood • Scandinavia & few western European countries are almost the only exceptions Page 32 Overnutrition is no longer limited to rich countries Obesity is a growing problem worldwide, particularly among those who lack resources for a wide range of food choices. • All too often, the cheapest foods are high calorie, poor in nutrients, rich in sugar, salt, fat, & trans-fats • The predominant cause of obesity is underexercising rather than overeating. On average, overweight people eat slightly fewer calories than lean people, but are much less active • Obesity increases risk of many disorders, most Page 33 Overnutrition is no longer limited to rich countries • Previously, the poorest were almost immune to diabetes, hypertension, gout, & atherosclerosis & heart disease • No longer. These are growing problems, impacting health worldwide. In the next few slides we’ll consider prevention. • Diabetes has reached epidemic proportions threatening, vision, kidney function, mobility, heart-health & life itself. • A cluster of symptoms, hypertension, hyperlipidemia, and hyperglycemia is sometimes called “metabolic syndrome” • Each of them increases risk of heart disease, and together the risk is greatly amplified. Read on….. Page 34 Nutrition Module Sections 1.Malnutrition: prevalence, causes, consequences 4 2.Major categories & measures of nutritional status4 3.Nutrition & crucial periods in the life-cycle; 4 4.Determinants of nutrition, dietary patterns & culture2 5.Nutrition and its relationship to disease4 6.Making hunger history - breaking the poverty-trap 3 7.Trends in nutrition, food security & globalization3 Page 35 3 Critical periods: nutrition in the life-cycle 4 slides: 1. Perinatal nutrition: 0-6 mo: Breast vs. formula 1st 5 y Weaning & infancy –intellectual develop 2. School years; ability to learn 3. Work performance 4. Elderly Page 36 Nutrition through the life-cycle Stage Risks associated with malnutrition birth defects, birth weight, infant and peri-natal mortality, high maternal death rate cognitive & physical development, bone malformation blindness, impaired immune response, risk of infections, faster progress of HIV, in protein-energy malnutrition, early death from causes the well-nourished would survive Adolescence risk of infection, anemia, diabetes, problems with heart, lungs, vision, & adult life risk of all cancers, anemia, blindness, beriberi, pellagra This stage of life lays a foundation for later good or ill health, osteoporosis, greatly diminished life-expectancy Old age few chronically malnourished persons survive to old age. Those who do survive poor lifestyle and nutrition, often endure a very low quality of life Prenatal & (pregnancy) Infancy & early life Page 37 Factors in perinatal nutrition (see also Acute malnutrition module) • Nutritional health begins in the womb – a healthy outcome to a pregnancy requires that mother be well nourished; good feeding must initiated early • The most common birth defects result from a deficiency of folic acid in the diet of the pregnant mother, Best outcomes require folic acid supplementation before conception! Page 38 Factors in perinatal nutrition (see also Module on Acute malnutrition) • Delaying clamping the umbilical cord until it stops pulsing iron stores see: www.naturalchildbirth.org/natural/resources/labor/labor04.htm http://apps.who.int/rhl/pregnancy_childbirth/childbirth/3rd_stage/jcco m/en/index.html • Ideally, babies should receive vitamins E & K injections at birth • A baby who’s healthy at birth may experience "failure to thrive" (or "growth faltering") in the first year of life. So ….. • Good infant feeding behaviors must start early. Most importantly, breastfeeding should be initiated within an hour of birth & maintained exclusively for 6 months. • Breastfeeding could prevent 1.3 million deaths each year http://www2.unicef.org/nutrition/index_22657.html • Page 39 Perinatal nutrition requires attention1 • Malnutrition in pregnancy birth defects & low birth-weight • Failure to thrive is an early danger sign, requiring investigation • Nutrition in infancy to early life impacts physical & cognitive development. It determines immediate & future risks of blindness, thyroid function, bone development, & more • Under-nutrition or deficiencies of many micronutrients can cause failure to thrive“ Page 40 Malnutrition in early childhood • Children are at special need because they are at the fastest-growing stage of life. Problems an adult could survive can be lethal to a child • This is the most vulnerable period – a child is developing physically & mentally. Damage can be permanent • Most importantly, they are unable to fend for themselves & depend on others (parents, others) for health & survival • They are the planet’s future. We owe it to them & to ourselves to ensure that they grow well, with a Page 41 Nutrition through the life cycle - adolescence Adolescence carries risks for both poor & affluent • Adolescent & adult patterns of food consumption & activity massively impact immediate & future health risks • Adolescents are notoriously careless about health. Their eating patterns can lead quickly to obesity or anorexia. Page 42 Nutrition through the life cycle - adolescence Adolescence carries risks for both poor & affluent • Dieting can lead to deficiencies of vit. C, protein, folic acid in a sedentary person. Even if a good mix of foods is consumed, total food intake may be insufficient. • A pattern of healthy eating in adolescence sets a pattern that can promote lifelong health • A foundation for healthy bones is set by exercise, calcium, & vitamin D. After early adult life, bones go slowly downhill Page 43 Nutrition through the life cycle – adult life Nutrition & acute & infectious diseases • Malnutrition depletes immunity leading to increased risk & severity of infections & parasites: AIDS, malaria, etc. • Flagrant deficiencies of specific micronutrients can put at risk the life & health of the mother in pregnancy & lactation • Nutritional anaemias, pellagra, blindness, skin disorders beriberi, scurvy, etc, can range in severity from mild to fatal Page 44 Adult life - degenerative diseases • In late life, risk of breast, prostatic, & most other cancers are predicted by diet, obesity, inactivity or smoking in adult life • Also heart disease, strokes, osteoporosis, diabetes • Cancers and diabetes are now leading causes of death & disability in low- and middle-income countries (see Lancet August 13, 2009) • Nearly two-thirds of the world’s 7.6 million cancerrelated deaths now occur in developing nations. Page 45 Differential nutritional vulnerability of females • Women are much more prone to nutritional anaemias since they need to replace red cells lost in menstruation • Women are the majority of elders, increasingly so in Asia and Africa. Osteoporosis is more common in the elderly • Osteoporosis is a major cause of illness, disability and death. The annual number of hip fractures Page 46 Differential nutritional vulnerability of females • Women suffer 80% of hip fractures; lifetime risk 30 - 40% compared with 13% for men. • Osteoporosis prevention (exercise, calcium, & vitamin D) must start well before age 30 when bones still respond. • Negative calcium balance in later life is not very responsive to nutritional measures. Page 47 Prevention of heart attacks and strokes • Risk factors : hypertension, hyperlipidemias (LDL / “bad” cholesterol), inactivity & diabetes. All correlated with obesity • Smoking is the most life-shortening risk factor of all • These risks can be changed earlier or later, by modification of diet & other life-style changes or medication Page 48 Prevention of heart attacks and strokes • There is no easy solution to obesity. In a typical study: <10% of people dieting, <10% of those exercising, and <15% of those exercising & dieting, lost weight. • However, over 80% of those who underwent stomach stapling or banding lost weight! • Not very encouraging, for lifestyle treatment. Many argue that surgery to control weight should be done more often Page 49 Measures to diminish cardiovascular risks Lifestyle measures: have greatest impact in older people! • Increasing consumption of fruit & vegetables by one to two servings can cut cardiovascular risk by 30% • Reduction of blood pressure by 6 mm Hg reduces stroke risk by 40% & heart attack by 15%. Hydrochlorthiazides (diuretics) are inexpensive and effective Page 50 Measures to diminish cardiovascular risks • Modest cutbacks in saturated fat & salt improve blood pressure & lipids; & diminish risk of cardiovascular disease • Lifestyle measures are, optimally, combined with pharmaceutical intervention • Best practices in the area of diabetes & cardiovascular disease are a moving target. Anyone teaching or practicing in this area needs skills in finding evidence-based information in an ocean of misinformation. Page 51 Nutrition in later life and old age • Worldwide, the proportion of people over 60 is increasing. By 2025, the world will have more than 1.2 billion older persons – two-thirds of them in low income countries • The foundation laid in earlier life determines risk of diabetes, heart disease, hypertension, strokes, osteoporosis, cancer, etc. All these bring special nutritional concerns. Page 52 Nutrition in later life and old age • Old age can be cut short by many kinds of malnutrition • Deficiencies of calcium, iron, water, vit. B12 can severely compromise old age • Loss of taste and smell can render the elderly at risk for food poisoning from spoiled food • Loss of thirst sensitivity in this age group makes dehydration (inadequate water intake) a common cause of confusion, headache, & occasionally kidney stones • Prevention is better than cure, & symptomatic treatments that are effective ,are often unavailable to the aged in LMICs Page 53 Nutrition in Global Health Causes, mechanisms, solutions Nutrition is crucial to global health & MDGs 1. 2. 3. 4. 5. 6. Overview of nutrition across humankind Human nutrition fundamentals in global context Top Six nutrition problems, & their solutions Nutrition across the life cycle in rich & poor nations Cause & effect in population nutrition Overview and where we are now Bridge to Part 2, Roadmap to a world without hunger Page 55 Human Nutrition Fundamentals in Global Context The next set of slides covers the critical skill set needed for understanding nutritional issues in the context of global health They are not a substitute for nutritional training, but rather a catalog of nutritional tools applicable to problems a health practitioner might encounter in the field From this you can learn when to call in a nutritional expert, what kind, & what to you might reasonably ask for & receive If you have learned nutrition in a developed country, this may help you to expand your knowledge of nutrition and public health in the context of 3rd world health problems Page 56 Dietary patterns across cultures 1. Hunter gatherers – the earliest category Benefits: mixed diet, well nourished in good times Risks: famine or drought, warfare & plunder, resourcedepletion through population pressure Prevalent problems: starvation, thirst, lifeexpectancy Note I Page 57 Dietary patterns across cultures 2. Peasant agriculturalists – successful small scale farmers (currently the largest group) • Benefits: close to food sources; if no punitive taxes or rents; usually well adapted to their traditional diets • Risks: single crop emphasis malnutrition, plagues (locusts, rodents), exploitation, warfare and plunder • Prevalent problems: vitamin deficiency, starvation, alcoholism Page 58 Dietary patterns across cultures 3. Indigent, landless crop planters Benefits: Community, share with family, neighbors, income is typically less than a dollar a day Risks: Crop failure, drought or famine, erosion, soilexhaustion, pestilence, economic exploitation (by landlords, seed providers, loan-sharks), displacement, forced migration, civil unrest or foreign invasion Problems: multiple vitamin deficiencies, kwashiorkor (protein malnutrition), infectious disease epidemics. Too poor, powerless to help themselves, most ofPage 59 Dietary patterns across cultures 4. Urban slum dwellers – fastest growing group Benefits: hope for jobs, escape from drought or crop failure Risks: overcrowding, poverty, poor hygiene, limited food choice, social disruption loss of traditional diets, crime Prevalent problems: deficiencies of essential nutrients, alcoholism, obesity, kwashiorkor, Page 60 Dietary patterns across cultures 5. Affluent urbanites – most recent category Benefits: many food choices (appropriate and inappropriate) Risks: inactivity along with high fat, sugar, alcohol intakes Prevalent problems: overnutrition, obese babies and adults diabetes (carbohydrates), cholesterol, atheroma (lipid), strokes, heart disease diabetes, gout (uric acid - meat sources) Note J Page 61 Nutrition Module Sections 1.Malnutrition: prevalence, causes, consequences 4 2.Major categories & measures of nutritional status4 3.Nutrition & crucial periods in the life-cycle; 4 4.Determinants of nutrition, dietary patterns & culture2 5.Nutrition and its relationship to disease4 6.Making hunger history - breaking the poverty-trap 3 7.Trends in nutrition, food security & globalization3 Page 62 5 Nutrition & disease cause vs effect 4 slides: • Acute and chronic malnutrition; • Socio-cultural determinants of malnutrition • Undernutrition as contributor to much childhood mortality / morbidity • Micronutrient deficiencies: Iron, Vitamin A, iodine, calcium, etc. • Nutrition &major diseases: CV, strokes, diabetes • Over-nutrition, obesity Page 63 Some communities subsist in the “poverty trap” • Even among the richest there are some individuals so marginalized that there seems little hope for them The larger culture, if it is compassionate, takes long-term responsibility for ensuring them the necessities of life • Globally there are communities that have been denied the resources to ever become wealthy. Often from geography, climate, invasion, or appropriation of their natural resources Note H Regardless, a world community of compassion can Page 64 Money? Useless - no nearby shops • It’s hard to imagine a malnourished community and you may want to experience field conditions in advance No commerce! Try it at a Medecins sans Frontieres site: http://www.starvedforattention.org/ • No shops to spend money in, no one to employ anyone, no one to sell things to • Hungry children are all too visible, and those who didn’t survive are in tiny unmarked graves Their needs are much more immediate than money Page 65 If they don’t need money – what do they need? • Short term they likely need emergency rations, safe water In conflict zones, shelter & safety to live, plant, harvest • Medium term they need to become self-sufficient, with: good seeds, fertilizer, usable water, sanitation, low technology agricultural info & resources, health services, mosquito nets, pharmaceuticals • Long term they need the prerequisites of sustainable economic development - tools for development – see Part 2 • Kids need particular attention – see note below & later slides Note F Page 66 Top 6 global manifestations of malnutrition We begin with a perspective, then we take each of the 6 in turn 1) Water is a food (“food” is the material we eat & drink”) In hot climates, we can die in a few hours from a lack of it 2) Protein-energy malnutrition • The machinery of life, sculpted from 20 different The material in this section is well reviewed at: http://www.pitt.edu/~super1/lecture/lec0141/index.htm amino acids Iron, vitamin A, iodine – check the latest information at: http://www.micronutrient.org/English/view.asp?x=1 • Deficiency is most serious in children (time of fastest growth): "failure to thrive", stunted growth Page 67 Top 6 global manifestations of malnutrition (cont.) 3) Iron deficiency - prevalent in Africa and Asia • Women & children are the most seriously affected • In parts of Africa 60% of children have blood iron • About a quarter of these have symptoms of anaemia 4) Vitamin A deficiency Over 100 million children under 5 suffer vitamin A deficiency •In high deficiency areas vit. A tabs child mortality by 23 % & child blindness by 80%. Night-blindness is an early sign Page 68 Top 6 global manifestations of malnutrition (cont.) 5) Don’t underestimate iodine deficiency disorders • WHO 2003: “1.6 billion people don’t get enough iodine”. This is the major cause of preventable brain damage. • Thanks to MDG programmes the problem is shrinking! http://www.who.int/vmnis/iodine/status/en/index.html In addition nutrition determines chronic disease risk • Heart disease, osteoporosis, cancer, diabetes, strokes, etc. We’ll go through these one at a time in the following slides and Note K lists categories of at risk people across countries Note K Page 69 Top 6 global manifestations of malnutrition (cont.) 6) Folic Acid is required for healthy babies • A deficiency causes spina-bifida – a common birth defect • Supplements are recommended before start of pregnancy • 50% of pregnancies are unintentional! Women who might become pregnant, need advice More details on these nutrients in the ensuing slides Page 70 Water: one of our most important foods • Adequate safe water is most important dietary component • 9 million worldwide have water-borne diseases • In India, contaminated water kills 300,000 children annually • Problems relating to water supply & safety have simple, relatively inexpensive solutions • Water “ownership” is, however, contentious & usually follows military power (e.g. in Middle East) http://www.who.int/water_sanitation_health/mdg1/en/index.html • In hot humid conditions workers may need over Page 5 l 71/ The special importance of proteins • Proteins are the machinery of life. We have no storage form. If we must use protein “stores”, tissues lose function • Plasma, liver and kidney lose function first. Their proteins are the most “labile”. Then, digestive tract, muscle & heart • Proteins are made up of 20 amino acids. 12 are nonessential and can be made from other dietary components • 8 amino acids are “essential”. If even one is missing, no protein can be synthesized. A protein lacking any one essential amino acid has zero “biological value Page 72 Dietary deficiency of proteins is deadly • When any essential amino acid is missing, all the rest are burned & no protein synthesis can occur – zero! • All essential aa’s must be there at the same time. Meeting an amino acid need 1 day later is useless • A diet previously adequate in essential amino acids becomes inadequate if non-essential amino acids are removed. Because, although the body can make missing non-essential aa, it uses up essential amino acids to do so • Protein complementarity, de-emphasized in nutrition courses, can be vital where protein intake is compromised Page 73 Humans adapt to low protein intakes ... ... otherwise impact of protein deficiency would be even higher Endocrine changes improve the recycling of proteins. As tissues repair, the released amino acids are reused more efficiently •In the African presentation of kwashiorkor, a child is exposed to a protein deficient diet (ages 1 to 5) & adapts successfully •Then a 1-week lack of protein (parent loses job, baby is fed glucose-water only, or a gastro-intestinal infection) kwash •Child is treated for kwash, sent back to home to same diet, & reaches adolescence, usually without recurrence. Page 74 Protein & energy nutrition are inseparable • When the diet lacks carbohydrates, it uses some amino acids to make glucose for brain, muscle, etc. • When a diet lacks total calories, proteins are co-opted, first dietary, then plasma, liver, kidney, etc. • For these reasons, a diet previously adequate in essential amino acids becomes inadequate if carbohydrate or calories are removed. • Do an internet search on “protein-sparing effects of carbohydrates” if you want to understand this further Page 75 Protein-energy malnutrition - in adults Tissues are raided, with the following consequences: • Loss of plasma proteins oedema* • Loss of liver & kidney function diminished inactivation & excretion of carcinogens and toxins • Loss of immune function gastro-intestinal infections • Loss of digestive tract / liver function amino acids can’t be utilized for proteins. No treatment can prevent death • Loss of muscle and heart tissue weakness, heart failure *Oedema or edema = abnormal accumulation of fluid beneath the skin or in body cavities Page 76 Hungry kids – difficulties in diagnosis • Marasmic babies may not seem undernourished until a check for “pitting oedema” reveals that what appear to be strong arms and legs, are in reality oedematous • Another diagnostic complication is that most deficiencies are combined, as in protein energy malnutrition (“PEM”) with multiple vitamin deficiencies • The distinctions are crucial both in determining treatment, and in determining if the underlying problem in the community is scarcity of food, a protein, or many nutrients Page 77 Protein malnutrition is different • In uncomplicated kwashiorkor, only protein is lacking “Malnourished, not undernourished” • The risk of death or permanently retarded development is great, and the risk is increased because its easier to miss the diagnosis • Kwashiorkor babies may have more than adequate calories in their diets. They may be chubby, with substantial subcutaneous fat • Kwashiorkor may go unnoticed even when urgent hospitalization is needed, or when death is imminent Page 78 Protein malnutrition: diagnosis When there are many sick kids in a community, but none look undernourished, be sure to look for protein deficiency. Why? • It’s important not to miss the diagnosis. Kwashiorkor has a high fatality rate even with hospitalization • The 1st symptom to present is often diarrhoea, or oedema • The child may be treated for a gastrointestinal infection while the underlying cause, kwashiorkor, goes undiagnosed • Oedema is an early symptom, and may be mistaken for chubby limbs, so test if nutrition may be compromised Page 79 Tracking protein-energy malnutrition in kids Failure to thrive may be an early warning of flagrant PEM in an individual child or a community. Always investigate the cause • Growth charts give weight for stature / length across age. They provide criteria to estimate severity. Proper use requires training! • Change in position on a chart shows effectiveness of treatment & probability of survival • If many children in a community show up at risk on growth charts, authorities must be alerted to endemic problems Page 80 What saves lives after PEM diagnosis • Treatment is urgent - hospitalization is preferred • Oral rehydration solutes “ORS” have saved millions with diarrhoea (usually the case) • Ready-to-use foods “RTUF” rebuild wasted tissues • Delayed physical growth is often restored in catchup growth when a good diet is provided • Prolonged cognitive disabilities may be irreversible Note L Page 81 Early measures required on PEM diagnosis • Both RTUF and ORS can be given at home in a bottle (Wikipedia). World production of ORS is around 500 million sachets / year. Improvisation of ORS is described at http://rehydrate.org/ors/made-at-home.htm#recipes • Powdered milk protein in boiled water can be very helpful as an emergency measure • Acute fatality rate IS 10-25% even with prompt treatment Page 82 Iron deficiency affects 500 million globally • Iron deficiency is best diagnosed in the preclinical stage, by measurement of transferrin saturation • Females > males due to iron loss at menstruation ->50% of pregnant women are affected in the developing world – 3 times as many as in developed countries • 25% of men also are deficient in iron in the developing world Page 83 Iron deficiency affects 500 million globally http://www.micronutrient.org/English/view.asp?x=579 • Causes: insufficient availability of dietary iron, or increased iron requirements to meet reproductive demands, haemmorhage, parasitic infections (often concurrently). • The result is an increasingly severe anaemia, reduced work productivity → poverty, diminished learning ability, increased susceptibility to infection Note M For more on consequences of iron deficiency, see Page 84 Treatment of iron deficiency: rebuilding iron reserves • Iron tablets are effective within weeks, but noncompliance is common. Check compliance! • Increase iron intake through combining iron-rich foods with agents that iron absorption (vit C) • Encourage availability & use of iron-fortified foods Page 85 Treatment of iron deficiency: rebuilding iron reserves • Weekly / daily supplementation is recommended for vulnerable groups in areas with widespread iron deficiency • Treat causes of diminished iron reserves: haemorrhage, parasites (including malaria), and hemolytic conditions. • Be alert! Iron may be lethal in some inherited anaemias (thalassemias, sickle cell, or Hb M) common in Africa & Asia Page 86 Iron excess - dangerous to some • Those with haemolytic anaemias: (eg thalassaemia – common in people of African or Asian descent). Iron should not be prescribed until the cause of an anaemia is known • Where iron pots are used for cooking or beer: Siderosis: iron deposition in liver, kidney, heart, pancreas organ failure • Children: Parents' iron pills are attractive to kids in developed countries. The most common of fatal childhood poisonings • Those with familial haemochromatosis: This common inherited disease has symptoms similar to siderosis (above) The first sign of this disease is often inoperable liver cancer Note N Page 87 Vitamin A deficiency in public health • Vit. A deficiency is a public health problem in over 70 countries, especially in Africa, SE Asia & the W Pacific where it affects 250 million mostly aged 04 years • Night blindness may predict vitamin A deficiency, with risk of permanent total blindness if it progresses • There is also increased risk of severe illness and death from infections such as diarrhoeal disease and measles Page 88 Vitamin A deficiency & perinatal health • Vit. A is crucial for maternal & child survival, supplements in high-risk areas can dramatically decrease maternal mortality* • In pregnant women Vit. A deficiency is seen in the last trimester when demands by unborn child & mother are highest • Partnerships for progress in vitamin A nutrition In 1998 WHO, UNICEF, CIDA, USAID (ia) launched a global initiative in 40 countries that has *This issue is under active investigation. For the status at time of writing see Lancet, Volume 376, 9744,million p 873 - 874, 11 September 2010 to date avertedIssue 1.25 deaths, by giving Page 89 vitamin A to kids at clinics Vitamin A deficiency & perinatal health • Night blindness in pregnant women - an early danger sign • In children, the cost-effective prevention is breast-feeding • Genetically engineered high Vit. A rice crops could help Caution: Vit. A supplements as retinol are controversial. It can be toxic & teratogenic ( birth defects). However, given as carotene, vitamin A supplements are safe, leading only to an orange tinge in skin colour. Page 90 Iodine deficiency disorders • The world’s major cause of preventable brain damage In 1990: 1.6 billion people were at risk in over 100 countries, mainly in parts of Africa and Asia where soil is iodine-deficient • 38 Million children have mental impairment from lack of iodine For latest data, see: http://www.micronutrient.org/english/View.asp?x=578 Page 91 Iodine deficiency disorders • Consequences start before birth and continue afterward – In utero, spontaneous abortion, congenital abnormalities & retarded foetal development – In early childhood and progress toward adolescence iodine deficiency causes cretinism, an irreversible retardation. Impacts home, school, & work – Today we are on the verge of eliminating iron deficiency --- a major public health triumph like getting rid of smallpox & polio Page 92 Toward iodine sufficiency – iodized salt • A cost-effective low-tech therapy, iodized salt costs just $0.05 per person per year • UNICEF, ICCIDD (International Council for Control of IDD), & the salt industry have set up iodization programmes. Globally, 66% of households have access to iodized salt. • As of 2009 the number of at risk countries has been halved! Page 93 6 Making hunger history - breaking the vicious cycle of the poverty-trap To find the remedy, we must know the causes Poverty trap Resource trap Then we’ll understand what “remedies” don’t work what is working dramatically why hunger will become history in this century Page 94 Page 95 Worldwide distribution of malnutrition Over 20 million children suffer from acute malnutrition WHO. Scientific American, Sept 2007 Page 96 Worldwide, nutritional inequities follow poverty (as do health inequities & life expectancy) • Globally, there is plenty of food for everyone but …those who have more than they need find reasons not to share • The result – in the time you spend on this module over 1000 children will have died of hunger • Each day 1500 children go forever blind from lack of vitamin A • The poorest are 50-200x more likely to die in pregnancy (more than half these deaths are attributable to iron deficiency). Note D Page 97 “The bottom billion” (title of a book by Paul Collier ) “The poorest of the poor” - Public health nutritionists identify a subclass of the hungry those who try to survive on resources worth less than $1 per day • We define this subclass as people who don't get enough to meet the ordinary demands of life • They lack the resources to earn a living, or obtain what’s needed for normal, growth, maintenance & reproduction Page 98 “The bottom billion” (title of a book by Paul Collier ) • Their lack of access to resources is such that a significant fraction will be unable to stay alive • They live mostly in isolated rural areas and most are subsistence farmers This means that what they eat this month is what they can take out of the ground from last month's planting Page 99 7 Malnutrition & MDGs: cause, effect, cure 3 slides: 1. Trends in nutrition, food security & globalization 2. Agricultural trends 3. Nutritional inequities - Cause & consequence 4. Food security; Prospects for having enough food Page 100 Unhelpful misconceptions about aid False: “Most aid money goes into the Swiss bank accounts of corrupt African dictators” “Aid creates dependence & impedes self-sufficiency” “Despite all the aid $, the problems are only getting worse” The truth is: Overwhelmingly African leaders are not corrupt. When they are, most bribes come from the West Well planned aid builds capacity & self-sufficiency Overall, hunger worldwide is diminishing. MDGs go forward because of the countries that honour their pledges! Note E Page 101 Page 102 Case study • Note to authors : You could pose the case on a PowerPoint slide, ask the student to address the question, and then provide a supplementary note that reviews how the case resolved, or could resolve. Several considerations: – What actually happened? – What factors should be considered, and their relative importance? – Or how would you, the expert, approach answering the case? If you opt for this response you can acknowledge that yours is just one answer of many, that every situation is different, and that there is no perfect answer Page 103 Supplementary note Note to authors : A “note” supplements the information provided on a slide. It allows the author to provide additional text, graphics , case studies, or other resources about a topic without filling the module with content likely to be of interest only to the more advanced or curious learner. This slide and the next several slides are blank pages, without special formatting. To provide a supplementary note scroll through the next several slides to see a demonstration of how to provide a note. You can then select and erase these slides or insert blank slides to provide a note. Do the following: 1) Prepare the slide to which you wish to append a supplementary note. 2) Immediately after that slide provide the note. Either draft the note text yourself or go to a source for your note, select and copy it, and then paste it into a box on an otherwise blank slide. If your note is large, paste it, select the entire note and reduce the font size so that it fits and then bring in the box margins so that the note is contained on the slide. Add pictures or graphics as desired. When GHEC converts your PowerPoint file into the module platform the note layout and font size will be formatted appropriately. If the note is very long you can also provide it in a Word file, making it clear through letter codes, A, B, C, etc., the PowerPoint slide to which it relates. 3) In processing the file GHEC will link the note to the appropriate slide and provide buttons for accessing the note and returning to its reference slide. The following slides give examples of what can be done. Page 104 Maternal mortality (Demonstration index slide for a note) • Maternal health refers to the health of women during pregnancy, childbirth and the postpartum period. While motherhood is often a positive and fulfilling experience, for too many women it is associated with suffering, ill-health and even death. • The major direct causes of maternal morbidity and mortality include hemorrhage, infection, high blood pressure, unsafe abortion, and obstructed labor. A click on the note button takes viewer to the note Note button Page 105 Supplementary note to the preceding slide Every day, 1500 women die from pregnancy- or childbirthrelated complications. In 2005, there were an estimated 536 000 maternal deaths worldwide. Most of these deaths occurred in developing countries, and most were avoidable. (1) Improving maternal health is one of the eight Millennium Development Goals adopted by the international community at the United Nations Millennium Summit in 2000. In Millennium Development Goal 5 (MDG5), countries have committed to reducing the maternal mortality ratio by three quarters between 1990 and 2015. However, between 1990 and 2005 the maternal mortality ratio declined by only 5%. Achieving Millennium Development Goal 5 requires accelerating progress. Maternal mortality in 2005: estimates developed by WHO, UNICEF, UNFPA and the World Bank. Geneva, World Health Organization, 2007 (http://www. who.int/reproductivehealth/publications/maternal_mortality_2005/index.html, accessed 14 August 2008). Photo credits Source: http://www.who.int/making_pregnancy_safer/topics/maternal_mortality/en/index.html Page 106 Supplementary note to the preceding slide Source: http://www.who.int/making_pregnancy_safer/topics/maternal_mortality/en/index.html Page 107 Supplementary note to a preceding slide Why do mothers die? Women die from a wide range of complications in pregnancy, childbirth or the postpartum period. Most of these complications develop because of their pregnant status and some because pregnancy aggravated an existing disease. The four major killers are: severe bleeding (mostly bleeding postpartum), infections (also mostly soon after delivery), hypertensive disorders in pregnancy (eclampsia) and obstructed labour. Complications after unsafe abortion cause 13% of maternal deaths. Globally, about 80% of maternal deaths are due to these causes. Among the indirect causes (20%) of maternal death are diseases that complicate pregnancy or are aggravated by pregnancy, such as malaria, anaemia and HIV.(2) Women also die because of poor health at conception and a lack of adequate care needed for the healthy outcome of the pregnancy for themselves and their babies. Page 108 Supplementary note to a preceding slide Semmelweis's observations conflicted with the established scientific and medical opinions of the time. The theory of diseases was highly influenced by ideas of an imbalance of the basic "four humours" in the body, a theory known as dyscrasia, for which the main treatment was bloodlettings. Medical texts at the time emphasized that each case of disease was unique, the result of a personal imbalance, and the main difficulty of the medical profession was to establish precisely each patient's unique situation, case by case. The findings from autopsies of deceased women also showed a confusing multitude of various physical signs, which emphasised the belief that puerperal fever was not one, but many different, yet unidentified, diseases. Semmelweis's main finding — that all instances of puerperal fever could be traced back to only one single cause: lack of cleanliness — was simply unacceptable. His findings also ran against the conventional wisdom that diseases spread in the form of "bad air", also known as miasmas or vaguely as "unfavourable atmospheric-cosmic-terrestrial influences". Semmelweis's groundbreaking idea was contrary to all established medical understanding. As a result, his ideas were rejected by the medical community. Other more subtle factors may also have played a role. Some doctors, for instance, were offended at the suggestion that they should wash their hands; they felt that their social status as gentlemen was inconsistent with the idea that their hands could be unclean.[6]:9[Note 7] Specifically, Semmelweis's claims were thought to lack scientific basis, since he could offer no acceptable explanation for his findings. Such a scientific explanation was made possible only some decades later, when the germ theory of disease was developed by Louis Pasteur, Joseph Lister, and others. During 1848, Semmelweis widened the scope of his washing protocol to include all instruments coming in contact with patients in labor, and used mortality-rate time series to document his success in virtually eliminating puerperal fever from the hospital ward. Note to authors: This page provides an example of a long note associated with a picture. The font and picture can be made as small as necessary to fit on the slide. They will be enlarged as necessary on the processed note. Page 109 Supplementary note -- Example of extensive text Author note: You can copy/paste and reduce font size to put text in a slide. It will later be converted by GHEC into a supplementary note At a conference of German physicians and natural scientists, most of the speakers rejected his doctrine, including the celebrated Rudolf Virchow, who was a scientist of the highest authority of his time. Virchow’s great authority in medical circles potently contributed to the lack of recognition of the Semmelweis doctrine for a long time.[13] It has been contended that Semmelweis could have had an even greater impact if he had managed to communicate his findings more effectively and avoid antagonising the medical establishment, even given the opposition from entrenched viewpoints.[18] Page 110 Thought or discussion questions • Note to authors: These can be very useful and may be used at multiple locations. Two varieties: – Thought question: This is a “stop and think” question that invites the learner, before proceeding to the next slide, to think about the question and perhaps provide a short answer. For example: “Before going to the next slide take one minute to write down words or terms that indicate the kinds of factors a donor organization will want to consider when responding to a request for funding support by a potential recipient.” – Discussion question: This can be a more general question, especially suitable for use when the module has been assigned prior to a class. Page 111 Special features • Note to authors: We hope authors will make use of some of the special features allowed in PowerPoint and the following sections illustrate several of them. – Voiceovers – Video and YouTube clips – Hotlinks to other resources • If you would like to use one or another of such features but need assistance please let us know. Page 112 Audio voiceover • This slide describes, and the following slide demonstrates, an audio voiceover. You’ll need a microphone (low cost) plugged into your computer. – Click on the loudspeaker and hear brief text. • Voiceovers allow you to comment or expand on a slide and, in the process, ‘humanize’ your presence to the learner. Clicking on the loudspeaker initiates the recording. • Both the 2003 and 2007 versions of PowerPoint allow voiceovers though the procedures are somewhat different. Review the instructions and experiment a bit until you master the technique. If you encounter problems we may be able to help. Page 113 Box 1 Five common shortcomings of health-care delivery Demonstration voiceover; click on the loud speaker The sound reproduction in this example is not good. It was done on the microphone of a laptop. If you can’t get good reproduction then either don’t use a voiceover or ask your university’s IT staff for help. Inverse care. People with the most means – whose needs for health care are often less – consume the most care, whereas those with the least means and greatest health problems consume the least10. Public spending on health services most often benefits the rich more than the poor11 in high- and low income countries alike12,13. Impoverishing care. Wherever people lack social protection and payment for care is largely out-of-pocket at the point of service, they can be confronted with catastrophic expenses. Over 100 million people annually fall into poverty because they have to pay for health care14. Fragmented and fragmenting care. The excessive specialization of health-care providers and the narrow focus of many disease control programmes discourage a holistic approach to the individuals and the families they deal with and do not appreciate the need for continuity in care15. Health services for poor and marginalized groups are often highly fragmented and severely under-resourced16, while development aid often adds to the fragmentation17. Unsafe care. Poor system design that is unable to ensure safety and hygiene standards leads to high rates of hospital-acquired infections, along with medication errors and other avoidable adverse effects that are an underestimated cause of death and ill-health18. Misdirected care. Resource allocation clusters around curative services at great cost, neglecting the potential of primary prevention and health promotion to prevent up to 70% of the disease burden19,20. At the same time, the health sector lacks the expertise to mitigate the adverse effects on health from other sectors and make the Page 114 Quiz, format options – Author note The next slides demonstrate six types of question options that you can use as “pop ups” or as section and final quizzes. Please provide your questions on individual slides inserted in the location where you want the questions to appear. For each question indicate the desired option style if not readily apparent. Indicate which answer(s) are correct, and provide short feedback answers that you want to appear when a student’s response is not correct. Do not be concerned with formatting; we will handle that at the time of assembling your module. Page 115 Quiz, format option 1 How many women die each year due to pregnancy-related conditions? a. b. c. d. e. abc -- incorrect; correct answer is…. def -- incorrect; correct answer is…. ghi -- correct jkl -- incorrect; correct answer is…. mno -- incorrect; correct answer is…. Page 116 Quiz, format option 2 Which two of the following answers are major risk factors for pregnancy-related morbidity? a. b. c. d. e. abc -- incorrect; correct answers are…. def -- incorrect; correct answers are…. ghi -- correct jkl -- incorrect; correct answers are…. mno -- correct Page 117 Quiz, format option 3 Which word or phrase best fills in the blank? _________ would be the most effective single measure to reduce maternal morbidity due to hemorrhage? a. b. c. d. e. abc -- incorrect; correct answer is…. def -- incorrect; correct answer is…. ghi -- incorrect; correct answer is…. jkl -- incorrect; correct answer is…. mno -- correct Page 118 Quiz, format option 4 Match each item on the left with the appropriate line on the right • • • • • • Abc Def Ghi Jkl Mno Pqr • • • • • • 123 456 789 987 654 321 Note: Be sure to indicate which items are linked Page 119 Quiz option 5 – ranking Rank the below answers starting from most important to least important • • • • • • Abc Def Ghi Jkl Mno Pqr Note: Be sure to show the correct ranking Page 120 Quiz option 6 – true/false Indicate whether each answer is true or false. (When response is incorrect a brief explanation as to why it is incorrect should be provided) • • • • • • Abc [true] Def [false] Ghi [false] Jkl [true] Mno [true] Pqr [false] Page 121 Quiz • Now we invite you to take the module quiz and test your recent learning. • This module quiz includes: – [Add a brief reference to the respective module quiz. How many questions, the type and scope of questions, and any other information and instruction for the students.] • After completing your quiz, come back for the summary of this module presentation. Summary • [Add content to your summary slide(s) ] • [State what has been learned and if appropriate, ways to apply the learning ] • [Make sure you cover the most important points in your module objectives…] Page 123 Further readings & other resources • Note to authors: Provide a listing, briefly annotated if useful, of additional resources relevant to the module’s topic. Especially useful are recent journal reviews and good online material • Source abc • Source def • Source ghi • Source, etc. Page 124 Acknowledgments • Note to authors: This slide is for acknowledging help received from persons and organizations that were especially useful in preparating the module. Named authors will not be listed on the “Credits” slide Page 125 Credits [for named authors; you can include contact information if desired] • [Add author 1 information] • [Add author 2 information] • [Add … ] End of module [Reserved for GHEC notes and acknowledgment of donor organizations] Structural elements & instructions to authors Page 128 Module parts (Delete this slide when no longer necessary) • Author note: This file provides a PowerPoint template for your module. Duplicate each of the below template forms as necessary and replace the illustrative text and figures with your own content. The template forms are: – Title page – Module goals – List of module sections – Learning objectives – Section content – Case study – Supplementary note – Thought or discussion questions – Special features (voiceovers, video clips, etc.) – Quiz (including several quiz options) – Section or Module summary – Further readings and other resources – Acknowledgements – Credits Page 129 Module overview (Delete this slide when no longer necessary) • Formatting. Template defaults are Tahoma 32 font for slide titles and Arial 28, 24, and 20 fonts for lower levels of text. Please use these defaults wherever possible but you may deviate from them in individual slides as appropriate. • Components. If your topic can be logically divided into several major subtopics we suggest that each subtopic have its own learning objectives, content, and if useful, case study, quiz, and/or summary. Some of these components may not be appropriate or would unduly complicate or clutter your module and hence may be omitted or modified to meet you needs. Page 130 Module processing procedure (Delete this slide when no longer necessary) • Module submission. Send draft module to Tom Hall (thall@epi.ucsf.edu) and to Glenn Nordehn (gnordehn@gmail.com) for review. Use placeholder slides, inserted immediately before the slides to which they refer, to provide instructions for the use of special eLearning features. Examples of such features are given later in this file. GHEC will initiate the review process and arrange for clarification of any questions that arise. • Processing and posting. On completion of the initial review and revision the module will be sent to an IT specialist for processing your module into the appropriate application platform and then posting on GHEC’s website. Page 131 Module features (Delete this slide when no longer necessary) • Your module can accommodate these features: – PowerPoint-like slides with text, graphics and buttons that will take viewers to supplementary notes & resources – Ability to highlight by arrows, circles, colors or other means selected features of any slide – Voiceovers, in which you give audio explanations or commentary of selected slides. Voiceovers allow you to expand on a slide without using a lot of text. – Video and YouTube clips. We can provide you with help in how to add these features – Pop quizzes and end-of-module quizzes that provide answers, feedback and tabulation of correct answers – Links to any URLs on the internet Page 132