Online Appendix for the following JACC article
TITLE: Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope
AUTHORS: Martin Huth Ruwald, MD, Morten Lock Hansen, MD, PHD, Morten Lamberts, MD,
Carolina Malta Hansen, MD, Michael Vinther Højgaard, MD, PHD, Lars Køber, MD, DMSc,
Christian Torp-Pedersen, MD, DMSc, Jim Hansen, MD, DMSc, Gunnar Hilmar Gislason, MD,
PHD
Two classes of antihypertensive treatment as defined by: α adrenergic blockers (C02A, C02B,
C02C), non-loop diuretics (C02DA, C02L, C03A, C03B, C03D, C03E, C03X, C07C, C07D, C08G,
C09BA, C09DA, C09XA52), vasodilators (C02DB, C02DD, C02DG, C04, C05), β blockers (C07),
calcium channel blockers (C07F, C08, C09BB, C09DB), and renin-angiotensin system inhibitors
(C09).
Selected pharmacotherapy of importance is defined by records of claimed prescriptions 180 days
prior to admission for any of the following drugs: beta-blockers (C07), angiotensin converting
enzyme inhibitors (C09), loop diuretics (C03C), spironolactone (C03D), thiazides (C03A), calcium
channel blockers (C08), digoxin (C01A), class I antiarrhythmic drugs (C01BC), class III
antiarrhythmic drugs (C01BD and (C07AA) class IV antiarrhythmic drugs (C08DA), morphine
(N02AA), glucose lowering medication (A10), clopidogrel (B01AC04), (B01AA0), vitamin K
antagonists (B01AA0, antipsychotic agents (N05A) and bronchodilators (R04).
Table A
Secondary diagnoses given to 6,202 patients of the 37,017 patients, in groups of diseases and
presented in terms of relevancy to syncope and the overall frequency.
Diagnosis
ICD-10 coding
Frequency
Percentage of total
secondary diagnoses
1
Diarrhea and
A08, A09, K52
206
2.7%
E86, E87
229
3.0%
D50,D51,D52,D53,D6
163
2.1%
gastroenteritis
Volume depletion and
other electrolyte
disturbances
Anemia
2,D64
Hypoglycemia
E15
41
0.5%
High cholesterol
E78
83
1.1%
Alcoholism or
F10
558
7.2%
Depression
F32, F33
83
1.1%
Parkinson’s Disease
G20
64
0.8%
Epilepsy or cramps
G40, R56
231
3.0%
Migraine and Horton’s
G43, G44
108
1.4%
Hypertension
I10
288
3.7%
Cardiac Ischemia or AMI
I20, I22, I23, I24, I25
19
0.2%
Aortic stenosis
I35
83
1.1%
Heart block or conduction
I44,I45
33
0.4%
Heart failure
I50, I42
4
0.1%
Cerebral infarction or
I60-I69
21
0.3%
Arrhythmias
I47-I49
59
0.8%
COPD
J42, J44
8
0.1%
Hypotension and
I95
57
0.7%
J03, J06, J11, J20
94
1.2%
M54, M62
136
1.8%
intoxication
headache
disorder
hemorrhage
orthostatic hypotension
Upper airway tract
infection
Back pain or muscle
2
tensions
Cystitis
N30, N39
167
2.2%
Abnormal heart rhythm or
R00
90
1.2%
Hyperventilation
R06
76
1.0%
Vertigo
R42
94
1.2%
Head neck or throat
S00-S09, S10-S19
841
10.8%
S20-S29, S30-S39
83
1.1%
S40-S49, S50-S59,
189
2.4%
154
2.0%
815
10.5%
bradycardia
trauma
Thorax or abdominal
trauma
Upper extremities trauma
S60-S69
Lower extremities trauma
S70-79, S80-S89, S90S99
Observation for medical
Z03
diseases
3