Influenza Vaccine Production and Immunization Update
November 2007
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• Sanofi pasteur and its customers share common goals
• Raise immunization rates and improve access to vaccine
• Maintain consistent communication regarding influenza vaccine
• In pursuit of our common goals, sanofi pasteur:
• Closely coordinates with the Centers for Disease Control and Prevention
(CDC) and other medical and public health authorities
• Manages all aspects of influenza vaccine order fulfillment
• Proactively seeks to provide broad access to all customer segments
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• Current production plan is 50M doses
• Additional doses are contingent on production yields and demand throughout the full immunization season
• For example, in 2006 sanofi pasteur produced 54M doses
• Investing $150M in a new facility that will double capacity for influenza vaccine production
• 100M dose production capacity
• Planned increase for single-dose presentation
• This new facility is expected to come on-line for the 2008-2009 influenza season
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Doses Produced Doses Distributed
140
120
100
80
60
40
20
0
1980 1990 1995 2000 2001 2002 2003 2004 2005 2006
Vaccine Supply & Assurance Branch

(millions of doses)
Manfacturer sanofi pasteur
Other Companies
Total
2006
54
66
120
2007
50
97
147
2008
50
120
170
*Based on data presented at the 2/21/07 Advisory Committee on Immunization Practices meeting and sanofi pasteur estimates
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• Provide broad access across all customer segments
• Increase immunization rates in line with the CDC’s Healthy People
2010 goals
• Reach all market segments as equitably as possible
• High-risk patients are served across multiple access points
• Support the CDC’s annual influenza recommendations
• Fully implement last year’s 6-59 month of age immunization recommendation
• Educate market on the revised ACIP recommendation* for 2 doses in naive or partially immunized patients 9 years of age and younger
• Prepare market for expected supply growth
*ACIP released 2007-2008 recommendations later in 2007
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2006-2007 Direct and Indirect Sales*
(% of doses committed)
CIP
†
/VNAA
32%
Private Office-Based
Providers
8%
Long-Term Care
Facilities/Institutions
5%
30%
Public Health
‡
•
Vaccines for Children Program
• State and Local Public Health
Departments
• US Veterans Administration
• US Military
Retail Pharmacies
‡
* Source: sanofi pasteur internal estimates of 2006-2007 shipping results
†
Community Immunization Provider
Historically, Public Health administers approximately 22% of the overall influenza market supply
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• Shipping began as soon as vaccine was released by the FDA in
August
• Virtually no inventory is stored during peak demand periods
• Shipping notifications are sent one to two weeks prior to shipment to inform customer of delivery window
• Typically occurs prior to final product release, which prevents the identification of an exact delivery date
• To identify an exact delivery date, inventory would need to be built which would only delay shipment
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• Two to three partial shipments per customer are planned to ensure that we provide broad access to all customer segments throughout the entire immunization season
• Supported by the CDC as a “best demonstrated practice”
• More costly for sanofi pasteur, but supports the public need
• Full shipments would limit the number of customers receiving early season doses
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:

Faces of Influenza
• Situational analysis of upcoming influenza season
• What is the Faces of Influenza ?
• 2006 program success
• Activities for 2007-2008 influenza season
• Benefits to the community
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• Influenza immunization recommendations apply to 218M
Americans
• Moving towards universal recommendations for 300M Americans
• US supply to surpass demand
• A record 120M doses supplied in 2006, however later than expected
• Between 130-170M doses may be available in the next few years
• Consumer awareness regarding the seriousness of Influenza and the safety of the vaccine is low
• It will be extremely challenging to immunize 130-170M people during the current 2-3 month immunization season
• Need to utilize the entire influenza season
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Faces of Influenza
Faces
• Faces of Influenza is a consumer awareness campaign developed through a collaboration between the American Lung
Association and sanofi pasteur
• Goal of the campaign: put a “face” on influenza illness and help
Americans understand need for annual vaccination
• Help people personally identify with influenza
• See themselves and loved ones among Centers for Disease Control and Prevention (CDC) recommended groups for immunization
• Stress seriousness of influenza throughout full immunization season
• Stress the safety of influenza vaccine
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Faces of Influenza
Campaign Results:
• More than 550 million total media impressions
• Public service announcements ranked in top 12% of campaigns
• Six regional events in Phoenix, Detroit, Minneapolis/St. Paul,
Philadelphia, Seattle, and Houston, secured significant media coverage for local Lung Associations:
• 36 million media impressions
• Activities in December and January fueled coverage of full season utilization
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Faces of Influenza
• Comprehensive national campaign
• Six targeted regional campaigns
• Regional grassroots campaigns
• Local partnerships to promote influenza immunization
• Opportunity to reach more consumers with an important public health message in our local market
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Faces of Influenza
• Celebrity-driven consumer awareness campaign featuring Jennifer
Garner
• Television and radio public service announcements
• National media event in New York City - November
• Updated program materials including website
• “Are you a Face of Influenza ?” quiz
• Augmented media outreach vehicles
• Television and radio satellite media tour (SMT)
• Audio News Release (ANR) for radio
• Mat release - newspaper ready article
• Extensive media outreach to print and broadcast outlets, including morning shows and entertainment programs
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Faces of Influenza
• Conduct six celebrity-supported consumer awareness campaigns over a 4-6 week period in November and December
• 4-week media outreach blitz in each market
• Peaks with event in high traffic location
• Planned promotional activities include:
• Conduct media relations and controlled advertising to saturate market and drive influenza vaccination messages
• In addition to national celebrity, partner with local celebrity and physician
• Conduct media events at a high-traffic location in local market
• Post-event controlled promotion and media in each market
• Coalition will serve as an in-market resource to media
• Locations – Detroit, Houston, Minneapolis/St. Paul, Philadelphia,
Phoenix, and Seattle
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Faces of Influenza
Mission:
• Provide a new platform to speak about influenza to consumers and health-care providers
• Proven, creative, and “media sexy” consumer campaign
• Increase immunization rates at the local level throughout the full immunization season
• Put a “face” on influenza illness and help your local audience understand need for annual vaccination
• Research conducted during the 2006-2007 campaign found immunization rates increased in regional markets using the campaign
• Provide consistent messages to the public
• Combat challenges faced in previous influenza seasons and education efforts
• Assist stakeholders and coalitions in their public health advocacy
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Faces of Influenza
• Building collaboration within our community
• Consumer education materials
• Media outreach materials
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Faces of Influenza
Building a collaboration within our communities:
• How-to guide for the toolkit and campaign in a binder
• Internet instructions for all materials, available via LungNet
• A Faces of Influenza presentation designed specifically for potential partners
• Timeline and key milestones for campaign
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Faces of Influenza
Consumer education materials:
• Faces of Influenza Portrait Book
• Faces of Influenza brochures
• Faces of influenza poster
• “Are you a Face of Influenza ?” quiz
• Various fact sheets
• Template graphics and text to link to the Faces of Influenza
Web site www.facesofinfluenza.org
• An influenza background presentation for partners to use
• Communication templates – newsletter article, Web article, patient and consumer letter, physician letter, elected official, heath official, school, office on aging
• Advertising Template – newspaper, Web, radio and TV scripts
• Influenza and immunization talking points and Q&A
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Faces of Influenza
Media outreach materials:
• Press release templates
• General awareness
• Clinic announcement
• Educational event announcement
• “Outbreak” alert
• Letter-to-the-editor and Op-Ed
• Various extend the season announcements
• Disease backgrounder for media outlets
• Influenza talking points and Q&A
• Copies of the TV and radio PSA for distribution to local media
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Faces of Influenza
• Working together we can successfully:
• Improve influenza immunization rates and reduce influenza mortality and illness
• Take a leadership role in the prevention of influenza within our communities
• Minimize the confusion of mixed messages
• Leverage the power of a high profile national consumer awareness campaign
• Magnify the power of the “one voice” concept
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How do we move forward?
• Convene working group to determine how the campaign materials can be utilized by your group to increase consumer awareness
• Lung Association/sanofi pasteur to deliver resources to partners
• Lung Association/sanofi pasteur to work with your group to implement campaign
APR MAY JUNE JULY AUG SEPT OCT NOV DEC JAN
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• Questions?
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