Early development of heart & vessels
The primordial heart &
blood vessels developmentAngio-genesis- appear
during 3rd week. Heart
appear as paired endothelial
strands -angioblastic cordsin cardiogenic mesoderm.
(B,C)
These cords canalize to
form heart tubes, which fuse
to form one tubular heart at
the end of 3rd week.
A,Dorsal view of embryo (about 18 days).
B,C, T.S and L.S. showing relationship of
angioblastic cords in cardiogenic
mesoderm, to the pericardial coelom,
and septum transversum.
Heart starts to beat and to
function (at 22-23 days) at
the begnning of 4th week and
blood flow can be visualized
by Doppler ultrasonography.
Drawing of embryonic
cardiovascular system(26 days), at
4th week showing left vessels :
Umbilical vein.
Vitelline vein.
Cardinal veins : anterior,
posterior,& common cardinal v.
Development of veins associated
th
with the heart of 4 week embryo
Vitelline veins return poorly
oxygenated blood from yolk sac
to the sinus venosus of heart.
Umbilical veins carry welloxygenated blood from primordial
placenta to sinus venosus.
Common cardinal veins carry
poorly oxygenated blood from
body of embryo to sinus venosus
Dorsal views of the
developing heart.
A, during 4th W. showing
primordial atrium & sinus
venosus and veins draining
into them.
B, 7th W. showing venous
circulation through liver.
C, 8th W,adult derivatives of
anterior cardinal veins.
Vitelline Veins
Lie in the yolk stalk, they carry
poorly oxygenated blood from yolk
sac to sinus venosus passing through
septum transversum.
In the region of developing liver in
septum transversum, hepatic
sinusoids develop from vitelline veins,
and Hepatic veins develop from
remains of right vetilline vein.
 Proximal left vitelline vein
degenerates, but / proximal part of
right vitelline vein form hepatic part of
I.V.C.
Portal vein develops from an
anastomotic network of distal parts of
right & left vitelline veins around the
duodenum.
Umbilical Veins
They carry well-oxygenate blood
from placenta to sinus venosus.
As the liver develops, umbilical veins
lose their connection with heart.
Right umbilical vein disappears
completely.
Proximal (cranial) part of left
umbilical vein between liver & sinus
venosus degenerates.
Distal (caudal) part of left
umbilical vein persist and becomes
the umbilical vein, which carries blood
from placenta to embryo. How?
A large venous shunt- ductus venosusdevelops within liver and connects umbilical
vein with I.V.C. so blood pass directly from
placenta to heart.
Anterior Cardinal Veins
Cardinal veins constitute the main venous
drainage of the embryo.
Anterior & posterior cardinal veins drain
cranial & caudal parts of embryo
,respectively.
A,4th week, anterior & posterior cardinal
veins join the common cardinal veins, which
enter sinus venosus.
Anterior cardinal veins are
connected by anastomosis, which shunts
blood from left to right. B,7th week.
This anastomotic shunt between anterior
cardinal veins becomes left
brachiocephalic vein when caudal
part of left anterior cardinal vein
degenerates. C, 8th week.
S.V.C. develops from right anterior
cardinal vein + right common
cardinal vein. C, 8th week.
Posterior Cardinal Veins
Posterior cardinal veins
develop primarily as
vessels of mesonephroi
and disappear with
transitory kidneys.
The only adult derivatives
of posterior cardinal
veins are : root of azygos
vein + common iliac veins.
Ventral views of primordial veins of the embryos’s trunk.
A, 6 weeks. D, adult.
Subcardinal & Supracardinal Veins
Subcardinal veins appear
first, followed by supracardinal
veins to replace gradually the
posterior cardinal veins.
Subcardinal veins are
connected together through
subcardinal anastomosis and
with posterior cardinal veins
through anastomosis through
mesonephros (early kidney),
Also sub-supracardinal
anastomosis develops.
Drawings illustrating ventral views of primordial veins
of trunk : vitelline ,umbilical & cardinal veins, and also
subcardinal & supracardinal veins.
A, 6 weeks.
B, 7 weeks.
These anastomosis shunt
blood from left to right veins, as
a result, right veins enlarge
while left veins become small
and may disappear.
Fate of Subcardinal veins
Left subcardinal vein
cranial to the
anastomosis
disappears leaving
small left suprarenal
vein, while caudal to
anastomosis it becomes
left gonadal vein.
Right subcardinal
vein cranial to the
anastomosis forms the
pre-renal part of I.V.C. +
right suprarenal vein,
while caudal to the
anastomosis it develops
into right gonadal vein.
Ventral views of primordial veins of trunk’s embryo.
C, 8th week.
D, adult.
Sub-supracardinal
anastomosis forms
right & left renal veins +
renal part of I.V.C.
Fate of Supracardinal veins
They are the last pair
of vessels to develop.
The middle part of the
2 veins in the region of
kidney disappears.
Cranial part of left
supracardinal vein +
transverse
anastomosis form
Hemiazygos vein.
Cranial parts of right
supracardinal vein +
right posterior cardinal
vein form Azygos vein.
Ventral views of primordial veins of trunk’s embryo.
C, 8th week.
D, adult.
Caudal to the level of
kidney : right
supracardinal vein
forms postrenal part of
I.V.C., while
left supracardinal vein
disappears.
Development of I.V.C
Hepatic part : develops
from hepatic vein
(from proximal part of
right vitelline vein) +
hepatic sinusoids.
Prerenal part :
develops from right
subcardinal vein.
Renal part : develops
from subcardinalsupracardinal
anastomosis.
.
Postrenal part :
develops from right
supracardinal vein.