Histology Lab -10- Shorooq Wessam Peripheral nervous system The peripheral nervous system (PNS) consists of neurons , nerves and axons that are located outside the CNS . these include cranial nerves from the brain and spinal nerves from the spinal cord , along with their associated ganglia . Ganglia (singular , ganglion) are small accumulations of neurons that are located outside the CNS and are surrounded by a connective tissue capsule . the nerves of the PNS contain both sensory and motor axons . these axons transmit information between the peripheral organs and the CNS . the neurons of the peripheral nerves are located either within or outside the CNS in different ganglia. Connective tissue layers in the PNS A peripheral nerve is composed of numerous axons of various sizes surrounded by several layers of connective tissue that partition the nerve into several nerve (axon) bundles or fascicles . the outermost connective tissue layer is the epinerium , which consists of dense irregular connective tissue that completely surrounds the peripheral nerve . a thinner connective tissue layer , Called the perineurium , extends into several and surrounds numerous nerve fascicles . within each fascicle are individual axon and their supporting cells , the neurolemmocytes (Schwann cells) . each exon is surrounded by a loose connective tissue layer of thin reticular fibers , called the endonerium . Supporting cells in the PNS The supportive cells in the PNS are the myeline – forming neurolemmocytes (Schwann cells) and the satellite cells . satellite cells are small cells that surround the neuronal cells in paravertebral and peripheral ganglia . paravertebral ganglia are an interconnected chain of ganglia that are located parallel to the vertebral column , near the junction of the dorsal and ventral roots of the spinal nerves . peripheral ganglia are located distally from the vertebral column , near various visceral organs . 1 2