• What was your favorite thing about winter break? • What is a karyotype? • What is the purpose of a karyotype? Chapter 12 Section 1 • All of an organism’s DNA can be packaged into chromosomes • Humans - 23 pairs or 46 total chromosomes • Each pair of chromosomes contain genes with 2 alleles (1 from each parent) • Chromosome Numbers • 1-22 autosomes • Sex chromosomes “#23” • XX – Female • XY - Male • A karyotype is a picture of all chromosomes in a cell, for one organism • Karyotypes can show: • changes in chromosomes • deletion of part or loss of a chromosome • extra chromosomes Male Female • A change in a genetic trait • 1) chromosomal • 2) gene mutation • Germ cell (gametes) or somatic cell (body) • Germ cell mutations can be inherited and somatic cell mutations result in cancers • Can be lethal (even before birth) • loss of a piece of chromosome • Cri du chat • Wolf-Hirschhorn syndrome • Inversion: chromosome breaks off and reattaches in reverse • Translocation: piece breaks off and attaches to another • * No problems in an individual since all genes are intact but there are problems with crossing over during meiosis • Nondisjunction: failure of a chromosome to separate from its homologous chromosome • Trisomy - one too many chromosomes (2n=47) • EX Down Syndrome, Kleinfelter’s Syndrome (XXY) • Monosomy - only one of a homologous pair (2n=45) • EX. Turner Syndrome (X)