Team Based Design of
Biomedical Devices
1R25EB012973-01
The University of Arizona
PD: Jennifer Barton, Ph.D.
Jonathan Vande Geest, Ph.D.
Associate Professor of Biomedical Engineering and
Aerospace and Mechanical Engineering
jpv1@email.arizona.edu, 520-621-2514
The University of Arizona
Tucson, AZ
ENGR
• Administration/
business
• Faculty line
support
• Space
• Access to
facilities
Dept of BME
4 Faculty complete appointment
7 Faculty split appointment
- Chemistry
- Physiology
- (3) ECE
- (2) AME
Secondary faculty from ENGR,
CoM, CALS
• Faculty line
support
• Space
• Access to
facilities
CoM/
AZCC
• Space
Bio5
Dept BME formed in the
College of Engineering in
2009, as a result of UA
transformation process (11
faculty, 8 FTE)
1st class of freshman started in Fall 2009
– 51 juniors/seniors
– 45 sophomores
Team Based Design of Biomedical Devices
The goal of this project is to educate the biomedical
engineers of the future to have
–
–
–
–
strong engineering design skills
knowledge of the clinical environment
training in translational biomedical engineering
the skills necessary to take medical devices from the
laboratory to the clinic, positively affecting human
health
Team Based Design of Biomedical Devices
• Open to all Engineering students interested in biomedical
device design
• Required coursework:
– Biomedical Instrumentation
– Clinical Rotation
– Translational Biomedical Engineering
• Clinical Immersion- 5 paid positions
• Interdisciplinary Capstone Design Project
Required Coursework
Required coursework:
– Biomedical Instrumentation (4 credit hour)
• measurements on living systems
• experimental design
• statistical analyses
– Clinical Rotation (1 credit hour)
• hospital environment (e.g., patient flow, proper attire in OR)
• observe procedure
• grand rounds lectures
– Translational Biomedical Engineering (3 credit hour)
• ethics in research
• proper use of animals in research, human subjects
• IP issues
• FDA approval procedures
Clinical Immersion
• 5 rising seniors; 10 weeks, 40 hours/week, begins
summer 2012
• Paired with physician faculty mentor for clinical research
project
– Physician pool: faculty in BME Graduate Interdisciplinary
Program, Cardiovascular BME and Biomedical Imaging and
Spectroscopy training grants (T32s): about 20 committed.
– Example planned immersion: “assessing off-loading cast
effectiveness in healing diabetic foot ulcers… The student will see
the array of diagnostic and therapeutic devices available, and will
follow patients from initial consultation, through interventions
including off-loading casts, and follow up. They would assist in
devising instrumented casts to monitor compliance.”
Clinical Immersion
Participate with medical school in acclaimed “Curriculum on
Medical Ignorance” (PD: Marlys Witte)
– Formal curriculum to explore the boundaries of ignorance
and understand the role of uncertainty in medicine
– Seminars, lectures, and clinical exercises explore the
unknown
– Provides strong existing structure, exposes students to
larger cohort of medical students
– Compliments engineering curriculum
Capstone Design
• Teams of ~5 students working on industry- and facultysponsored research projects, two semester, 6 unit
course.
– Typically 6-8 projects related to biomedical devices. More expected as
BME program advances to having seniors.
– Actively recruiting small businesses, physician faculty.
– Financially supports faculty-sponsored projects.
• Anticipate immersion students will each be assigned to a different
medical device project, to share experience with their team.
• Additional support given by physician mentor, also a clinical
engineer who discusses elements of design not covered in course.
Capstone Design - Example
• Porous biomaterial with controlled porosity and hydraulic
permeability
– control drug elution from cardiovascular devices
– enhance convective transport in combination endovascular
devices
• treatment of abdominal aortic aneurysms
[www.strokescaninc.com/aaa.htm]
Capstone Design – Polymer Cospraying
Soldani G, Panol G, Sasken HF, Goddard MB, Galletti PM. 1992. Small
diameter polyurethane-polydimethylsiloxane vascular prostheses made by a
spraying, phase-inversion process. J. Mater. Sci.: Mater. Med., 3(2): 106113.
Capstone Design – Polymer Cospraying
Capstone Design – Project Goals
• Translating and rotating target for cospraying
ppolymer=10psi pH20=10psi
• Device performance
– Porosity via traditional light
microscopy and SEM
– Hydraulic permeability
Questions?
Capstone Design - Example
Spread
Adjustment
(0-2
revolutions)
Flow Rate
Adjustment
(0-5 revolutions)
Pressure can also be
adjusted using regulator
(not pictured) with an
effective range of 2-10psi
Year 1 Fall
ENGR
102
MATH
125
CHEM
151
ENGL
101
Tier I INDV/TRAD
Intro to Engineering
Calculus with Applications I
General Chemisty I
First Year Composition I
Total
Year 1 Spring
MATH
129
CHEM
152
PHYS
141
ENGL
102
Tier I INDV/TRAD
Year 2 Fall
BME
CE
MATH
ABE
MCB
295C
214
223
284
181R/L
Year 2 Spring
ABE
205
MATH
254
PHYS
241
PSIO
201
Tier I INDV/TRAD
Calculus with Applications II
General Chemistry II
Introductory Mechanics
First Year Composition II
3
3
4
3
3
16
Total
3
4
4
3
3
17
Challenges in BME
Statics
Vector Calculus
Biosystems Thermal Engineerg
Introductory Biology I
Total
1
3
4
3
4
15
Biosys Eng Analyt Skills
Ordinary Differential Equations
Intro Elect and Mag
Human Anat Physiology I
3
3
4
4
3
17
Total
Lab
Lab
Lab
Lab
Lab
Lab
Technical Electives (21 units)
At least 12 units must be engineering
Mandatory Technical Electives for various tracks
Biomechanics
AME
AME
AME
AME
Track
302
324A
466
483
Biomaterials Track
MSE
461
ABE
486
ABE
481b
CHEM
241a
CHEM
243a
Numerical Methods
Mech Behav Eng Materials
Biomechanical Engineering
Microbiomechanics
4
3
3
3
Biological Synthetic Materials
Biomaterial Tissue Interaction
Cell and Tissue Engineering
Organic Chemistry
Organic Chemistry Lab
3
3
3
3
1
Biosensors/microtechnologies Track
AME
489a
Fab Techniques Micro Nanodevices
ABE
489b
Bio Micro/Nanotech Apps
AME
488
Micro Nano Transducer Physics
ABE
486
Biomaterial Tissue Interaction
3
3
3
3