Genetic Engineering Ray Bohlin, Ph.D. Probe Ministries rbohlin@probe.org www.probe.org Biblical Principles • Genesis 1:26-28 • Created in God’s Image • Therefore we are distinct from the animals • We are fallen creatures. • Our imperfections are used by God. • Exhortation to be fruitful and multiply Naturalistic/Evolutionar y Principles • An organism’s sole purpose is to survive and reproduce • We are just another animal species • We are defined by our genes and how they interact with the environment. • The species persists through time. • We are just a vehicle for the reproduction of DNA. What is a Gene? • The gene is the basic unit of heredity. Genes determine our hair, eye and skin color. • A gene is a stretch of DNA which codes for a specific protein. • Proteins perform, regulate, or influence all our bodily functions. What is the Human Genome Project? • An organism’s genome consists of all its genes. • The Human Genome Project is a multinational research project to determine the sequence of all 3 x 109 base pairs and hence all human genes. What is genetic engineering? • GE is defined as the manipulation or alteration of the genetic structure of a single cell or organism. • This refers to the deliberate addition, deletion, or intentional mutation of an organism’s DNA sequence to produce a desired result. What is genetic engineering? • More commonly it involves the transfer of a gene from one organism to another. • This is neither good nor evil, the nature of the experiments themselves will determine the moral content. Are we playing God? • Difficult phrase to understand. • Some are simply expressing awe and wonder at our power. • For some it means taking over “God Only” activity. • Often used to express fear and ignorance Are we playing God? • Being good stewards of God’s creation requires knowledge of His creation. • Part of being created in God’s image is our creativity. • In this sense we “Play God” by imitating Him. Is it wrong to combine genes from different species? • One gene does not define a species. DNA is not alive. • We have created many “new” creatures by selective breeding and artificial selection such as dogs, cattle, mules, wheat and corn. Is it wrong to combine genes from different species? • What is different with GE is the precision with which the changes can be made. But the change is also more limited. • Creating crops that are naturally and safely resistant to disease and pests is a worthy goal. • One case at a time. Is it wrong to combine genes from different species? • However, intentionally manipulating genes to produce a new and more virulent bacterium or virus is a hideous evil. • Proper tests must be carried out before using genetically engineered organisms. Is it wrong to place human genes in an animal? • Once again, one gene does not a human make. A gene is a molecule of DNA. • Transgenic pigs have been made to produce human Factor VIII, a bloodclotting agent needed by hemophiliacs. • But human/chimp transgenic organisms designed to begin deciphering the difference between humans and chimps is a different story. Is it OK to use animals to produce human organs? • In Genesis 3:21 the Lord used animals skins to make clothes for Adam and Eve. • In Gen. 9:3 He gave permission to use animals for food. • We’ve used spleens of pigs for insulin for diabetics. • Seems no difference in using animals for organs. Should GE be used for curing genetic diseases? • Curing genetic diseases should be approached cautiously. • The Church has traditionally been about the business of healing. • At first, only lethal conditions should be researched for complications. • Must approach with humility and sensitivity towards those already affected by these diseases. • We will always have some imperfections, but . . . . Could GE produce a dangerous superbug? • In the early 70s molecular biologists imposed a moratorium and guidelines to guide GE. • Fears of unexpected consequences proved groundless. • A superbug could be produced intentionally. What about producing superhumans or subhumans? • The knowledge and techniques are lacking. • The genetic factors surrounding athletic ability, intelligence, appearance, and personality are still a mystery. • But what about 50-100 years from now? • The importance of worldview! • Wilson and sociobiology. Should I be able to determine the sex of my child? • Not a simple yes or no answer. • If the determination is made after fertilization, a negative result is only rectified by abortion. • But we can separate “y” sperm from “x” sperm. • Not much wrong , but little good about it, even if preventing a sexlinked disease. Is it ever OK to engineer desired traits? • Public opinion is currently against this procedure. • We live in a culture where personal choice is idolized. • We allow facelifts and tummy tucks don’t we? • Trying to limit GE to curing disease is not as easy as it sounds. Is it ever OK to engineer desired traits? • There will be hard cases and choices. • GATTACA • A single gene in mice allows them to learn faster, remember longer and possess greater curiosity. • But this same protein plays a role in the consequences of strokes and sensitizes the brain to heroin and cocaine. Do we have the right to change our genetic make-up in any way? • Our physical bodies do not define the image of God. • Correcting a genetic mutation does not alter God’s image. • However, transfer of sets of genes designed to alter our physical, emotional, intellectual, and spiritual capacities are another story. We Can No Longer Afford to Be Ignorant of Genetic Technologies • While within Christian worldview we are compelled to alleviate and relieve suffering, we must do so with humility. • The effects of the Fall cannot be completely reversed. • Solving one problem often creates another. • Those still suffering from genetic diseases cannot be made to feel less than human.