Ponpon’s Laboratory
EBV research group
Room: D916 (Lab) ; D908 (Office)
Department of Life Science, Tzu-Chi University
970 Hualien Taiwan
Epstein-Barr Virus (EBV)
1. Human gamaherpesvirus
2. 184 kb DNA, double strand, linear
3. EBV associated diseases
Burkitt’s Lymphoma
Hodgkin’s Disease
Nasopharyngeal Carcinoma (NPC)
Lymphoproliferative Disease
EBV
EBV infection
Cytotoxic
T cell
Downregulation
of EBV gene
Cytotoxic
T cell
B cell
infection
Persistent infection
of B cells by EBV
No SHM
Memory
B cell
GC B cell
Naive
B cell
Epithilium of oropharynx
Latent infection mediated by EBV
EBNALP
Cp Wp
EBNA2
EBNA3s
Qp
A
Orip
Latency I
Latency II
Latency III
Wp using BL
EBNA1
LMP2A/B
B C
LMP1
EBV efficiently converts human B lymphocyte
into proliferating lymphoblasts
EBV
Resting
B cell
LMP1 LMP2A
LMP2B
EBNALP
EBNA2
EBV
episomes
LCL
EBNA1
EBNA3A
EBNA3B
EBNA3C
LMP1
•Recruits TRAFs
•Activates NF-kB, JNK
•Mimics CD40 signaling
EBNA2
•Binds to RBP-Jk
•Transactivates
- EBNA Cp, LMP1
- c-Myc, CD21,
CD23
EBNALP
•Co-activates
with EBNA2
EBNA3s
•Regulators of
EBNA2 function?
Young ladies lead our group
雅琳
Miley
小尤
伶芝
冠吟
Mo
Members in Ponpon’s Lab.
PI: Pon2
pengcw@mail.tcu.edu.tw
Research Assistant: Guan-Yin Liu
cheery620@yahoo.com.tw
Graduate student:
Ling-Chih Chien
ganoderma4725@gmail.com
Undergraduate:
Fu-Yue Hsu:
93711128@stmail.tcu.edu.tw
Yi-Liy Ming
93711152@stmail.tcu.edu.tw
Yi-Ting Yu
jgiu334@yahoo.com.tw
Ya-Ling Chen
debby969@hotmail.com
Ongoing project
LMP1 vs Cp
Hsp90
Gene therapy
Gadd family
BAG family
p53
pKA and p21
EBNA1