A Revolutionary Approach to Clear
Heavy Metals & Toxins
• All of us are carrying around a
LIFETIME of accumulated
TOXINS!!!
• There is now a simple, scientific
and very effective means for
substantially reducing your risk of
Toxic Induced Chronic
Degenerative Diseases!!!
“A growing body of literature suggests an association between
toxicant exposure and the etiology of a number of chronic
Conditions.”
The Role of Detoxification in the Prevention of Chronic Degenerative Diseases BY DEANN J. LISKA, PH.D.
• Abnormal pregnancy outcomes • Joint pain
• Atherosclerosis
• Kidney dysfunction
of Chronic Degenerative Diseases
BY DEANN J. LISKA, PH.D.
• Broad mood swings
• Learning disorders
• Cancer
• Memory loss
• Chronic fatigue syndrome
• Mineral imbalances (particularly zinc and
calcium)
• Chronic immune system depression
• Multiple chemical sensitivities
• Contact dermatitis
• Muscle pain and weakness
• Fatigue
• Nonresponsive or recurrent yeast infections
• Fertility problems
• Panic attacks
• Fibromyalgia
• Parkinson's disease
• Headaches
• Tinnitus
• Unusual responses to medications or
• History of increasing sensitivity tosupplements
exogenous exposures, odors,
or medications
•Worsening of symptoms after anesthesia or
pregnancy
TOXIC EFFECTS OF
GENETICALLY MODIFIED ORGANISMS
“GMO” OR “GM” FOOD
We are confronted with
what is undoubtedly the
single most potent
technology the world has
ever known - more
powerful even than
atomic energy. Yet it is
being released
throughout our
environment and
deployed with superficial
or no risk assessments as if no one needs to
worry an iota about its
unparalleled powers to
harm life as we know it and for all future
generations.
Nathan Batalion, ND
www.rawwisdom.com/genetically%20modi
“statins are nothing more than isolated
poisons derived from the fungus known as
red yeast rice”
“Nowhere in the
History of man has an
acknowledged poison
been touted as a daily
vitamin for every man
woman and child.”
Reuter Health News
Wednesday,
May 23, 2007
Non- GMP certified supplements
can be toxic!!!
•
•
•
“Of the 21 brands of
multivitamins on the market in
the US and Canada, selected
by ConsumerLab.com and
tested by by independent
laboratories, just 10 met the
stated claims on their labels or
satisfied other quality
standards.”
“In the report, test showed that
the Vitamin Shoope womens
product conatined 15.3
micrograms of lead per daily
serving of two daily tablets.
This amount of lead is more
than 10 times the amount
permitted wothout a warning in
California.”
www.msnbc.msn.com/id/16655
168/below
WebMD with AOL
Health
• In a study of
newborn blood
released by the
Environmental
Working group, an
average of 200
industrial chemicals
and pollutants were
found in umbilical
cord...
• Eighteen different
forms of dioxin were
also found in the
samples
•
www.my.webmd.com/content/ar
ticle/10/8/109035.htm
Scientist have found
TOXIC compounds
planet wide, in polar
bears in the Artic,
cormorants in
England and killer
whales in the Pacific.
Dangers of Visceral Adipose Tissue
Belly Fat
“Fat is a major
source of silent
inflammation. It is
a toxic waste
dump full of
Arachidonic Acid
and Toxins.”
Barry Sears, Ph.D.
Research published in the International Journal of Obesity
indicates that liver toxicity can often lead to excess body fat
accumulation, and moderately obese people frequently suffer from
liver dysfunction
“Due to the
overwhelming evidence
linking excess body fat
to an overstressed liver
cleansing and
supporting your
liver may be your
ticket to a healthier
metabolism.”
Brad J. King, MS, MFS, is a
nutritional researcher and
author
Toxins from the environment and diet
usually can lead bodily stress and dis-ease
Continuous exposure to dietary and environmental toxins may
lead to an impairment in the ability of patients to metabolize and
clear damage causing compounds from their body
Exposure to heavy metal toxicants is
almost unavoidable in today’s world
We are routinely exposed to heavy metal toxins through
food, ground water, industrial waste and exposure to
industrial environments.
Elevated toxic burden is related to a
number of different chronic conditions
“There were striking dose-response relations between
serum concentrations of six selected POP’s (persistent
organic pollutants) and the prevalence of type 2 diabetes.
The strong association could offer a compelling
challenge to future toxicological studies.”
Diabetes Care 2006; 29: 1638-43.
PCB production was banned in the 1970s due to the
high toxicity of most PCB congeners and mixtures.
PCBs are classified as persistent organic pollutants
which bioaccumulate in animals.
Many POPs are currently or were in the past used
as pesticides. Others are used in industrial
processes and in the production of a range of
goods such as solvents, polyvinyl chloride,
and pharmaceuticals.[1]
Elevated toxic metal burden affects all
organ systems
Toxicity, Heavy Metals
Soghoian S, MD, et al
Department of Emergency Medicine, State University of New York Downstate Medical Center
Background: Heavy metal toxicity represents an uncommon, yet clinically significant, medical condition. If unrecognized or
inappropriately treated, heavy metal toxicity can result in significant morbidity and mortality. The periodic table contains 105
elements, of which 80 are considered metals. Toxic effects in humans have been described for less than 30 of these. Many
metals are essential to biochemical processes, and others have found therapeutic uses in medicine. Iatrogenic metal toxicity
may occur with bismuth, gold, gallium, lithium, and aluminum species. Intentional or unintentional ingestion of arsenic has been
notorious as a means of suicide and homicide. However, occupational exposure to heavy metals has accounted for the vast
majority of poisonings throughout human history. Hippocrates described abdominal colic in a man who extracted metals, and
the pernicious effects of arsenic and mercury among smelters were known even to Theophrastus of Erebus (370-287 BC).
The classic acute occupational heavy metal toxicity is metal fume fever (MFF), a self-limiting inhalation syndrome seen in
workers exposed to metal oxide fumes. MFF, or “brass founders ague,” “zinc shakes,” “Monday morning fever” as it is variously
known, is characterized by fever, headache, fatigue, dyspnea, cough, and a metallic taste occurring within 3-10 hours after
exposure. The usual culprit is zinc oxide, but MFF may occur with magnesium, cobalt, and copper oxide fumes as well. A
neutrophil alveolitis ensues, with hypoxia, reduced vital capacity, and diffuse bilateral infiltrates seen on radiographs.
The pathophysiology of MFF appears to be a direct toxic irritation. Treatment is supportive and effects generally resolve within
24 hours. The diagnosis of MFF is based on a history of exposure and must be clearly differentiated from the true chemical
pneumonitis that occurs after exposure to metal fumes from cadmium, manganese, mercury, and nickel. These exposures are
clinically indistinguishable from MFF in the early stages but tend to progress to ARDS and cause significantly more morbidity
and mortality.
Toxic effects from chronic exposure to heavy metals are far more common than acute poisonings. Chronic exposure may lead
to a variety of conditions depending on the route of exposure and the metabolism and storage of the specific element in
question. For example, chronic exposure to cobalt dust has been associated with the development of pulmonary fibrosis that
can lead to cor pulmonale. This hard metal pneumoconiosis has been described for other metal dusts. Chronic inhalation of
high levels of cadmium also causes both fibrotic and emphysematous lung damage, but it also has major effects in bone and
“Nearly all organ systems are involved in heavy metal
toxicity; however, the most commonly involved organ
systems include the central nervous system, peripheral
nervous system, gastrointestinal, hematopoietic, renal,
and cardiovascular.”
http://www.emedicine.com/EMERG/topic237.htm
How do you recognize the symptoms of
elevated toxicity in your body?
Some EARLY warning signs are:
– Generalized muscle aches
– Chronic fatigue
– Fibromyalgia
– Food allergies or chemical sensitivities
Additional indications that may be linked to
elevated heavy metal burden
Some EARLY warning signs of heavy
metal toxicity are:
– Difficulty concentrating, irritability, headache
– Lethargy, fatigue, weakness (#1 physical complaint)
– Abdominal pain, tremors,
– Kidney distress, elevated liver enzymes
Simple in-office surveys and tools that help
us help identify patients in need
Simple diagnostics to evaluate toxicity in our patients
– Detoxification Questionnaire
– Bio Impedance Analysis
• (Phase Angle and ICW Vs. ECW)
– Urinary pH testing
– Hair analysis
Use the detoxification questionnaire to
qualify your patients’ needs
Detoxification Questionnaire
– Quantifies patient symptoms (MSQ)
– Identifies Toxicant Tolerability (XTT)
– Simple metric to track patient improvement
Use the established MSQ to quantify
symptoms
Medical Symptoms Questionnaire
(MSQ)
–Identifies symptoms in most body
systems
- Quantifies patient’s level of
symptoms
- Provides a simple metric to track
patient improvement
pH testing aids in identifying our patients that
may benefit from increased urinary alkalinity
• Increased urinary alkalinity has been
associated with increased rates of toxin
We
always
recommend
alkalizing
excretion
support for patients with urinary pH
• Screen patients that may need additional
below 6.6
support to excrete toxins
By far the majority of toxins and toxic drugs
are lipid soluble:
Therefore, to be efficiently and safely removed
via urine must be converted to a non-toxic watersoluble molecule during metabolism
Liver - The Detox Machine
• Filters 2 quarts of blood every minute
– Removes and alters substances
– Prepares them for elimination
Specific nutrients are required to support
all three phases of detoxification
Metabolic detoxification improves the process of biotransformation and
an alkaline urinary pH supports clearance of toxins
Phase III
Phase I
Phase II
Increased alkalinity
supports excretion
Helps to balance clearance enzymes
Phase I enzymes activate toxins in
preparation for biotransformation
L-Cysteine, Magnesium and other nutrients support proper
expression of Phase I CYP450 enzymes
Phase I
Cytochrome P450
enzymes add
reactive functional
groups to fat-soluble
toxins
Reactive
Toxin
Intermediary
Phase I
Functionalization
Phase II
Conjugation
Phase II enzymes neutralize the activated
toxin in preparation for elimination
Glycine, taurine, sodium sulfate and glutathione precursors
support the creation of Phase II enzymes
Phase II
Neutralized
Reactive
Intermediary
Toxin
Phase I
Functionalization
Phase II
Conjugation
The functional groups
are then reacted with
conjugation molecules
to neutralize the toxins
and make them water
soluble
Elimination of toxins is supported by an
alkaline urinary pH
Potassium citrate increases urinary alkalinity which supports
excretion of biotransformed toxins
Neutralized
Toxin
Neutralized
Toxin
Phase III
Phase I
Functionalization
Phase II
Conjugation
Alkaline urine supports
excretion
There is a demonstrated need for a safer, more
convenient method of removing heavy metals
Intravenous Chelation Therapy
• EDTA
– Typically heavy metals and atherosclerosis
– Has not been shown effective in oral dosing
Side effects: Depletion of vitamins and minerals, including
B vitamins, vitamin C, and magnesium.
Other side effects that have been reported include low
blood sugar, diminished calcium levels, headache,
nausea, dangerously low blood pressure, kidney failure,
organ damage, irregular heartbeat, and seizures.
A new approach: stimulate the body’s natural
ability to remove heavy metals
Metallothionein
• One of the most important detoxification proteins
in all species
• In absence of heavy metals, its primary role is
to transport zinc and copper
• Protection against and elimination of toxic metals
by metallothionein is well-described in literature
Andrews GK. Regulation of metallothionein gene expression by oxidative stress and
metal ions. Biochem Pharmacol 2000;59(1):95-104. Lichtlen et al.. Bioessays.
2001;23(11):1010-7.
Natural proteins designed to transport and
eliminate metals from cells
Metallothioneins
• Known to efficiently bind several toxic
metals (particularly Cadmium and
Mercury) and act as a transporter of
toxic metals to the liver or kidneys for
conjugation and excretion
• Prevents reaction of toxic metals with
other biomolecules, thus attenuating
their toxicity
Sources of heavy metals include seafood, groundwater, smoking,
dental amalgams, pesticides and industrial exposure
Andrews GK. Regulation of metallothionein gene expression by oxidative stress and
metal ions. Biochem Pharmacol 2000;59(1):95-104. Lichtlen et al.. Bioessays.
2001;23(11):1010-7.
We can expect exceptional regenerative
outcomes with a nutrigenomic approach
A complete system for
detoxification
(Direct)
Diet & Medical Food
Metabolism
Gene Expression
Key Nutritional
Support for
liver and kidneys
Cellular Expression
(Indirect)
SKRMS: Modulate cell signals
A revolutionary mechanism for heavy
metal detoxification
The excretion of toxic metals is governed by a complex chain of
interwoven activities:
– Phytonutrients up-regulates expression of MTF-1
(Metal-activated transcription factor-1)
– MTF-1 induces creation of metallothionein (MT) in messenger
RNA
– Induced metallothionein (MT) bind to metals within the cell
– Once metal is mobilized by MT, it is transported through the cell
membrane and transported to the liver for Phase II detoxification
and excretion through urine or feces
Study patients experienced a significant
increase in the excretion of metals
• All patients began with mercury levels below
Elimination
of lead
arsenic
increased
increased
200%
124%
detectable limits
• Two patients experienced a significant increase in
Increase
of Urine Excretion of Clinically Relevant Metals
mercury
excretion
250%
Mercury Elimination Through Urine
% Imrovement
150%
Arsenic
Day 0
Day 10
Patients 1-3
dl >
dl >
Patient 4
dl >
Significant Increase
Cadmium
Cobalt
Patients 5-8
dl >
dl >
Aluminum
200%
100%
Lead
Barium
Lithium
50%
Metabolism
of essential
was
not significantly
Patient
9
dl > minerals
Significant
Increase
Molybdenum
0%
impacted
in study patients*
Increase
baseline
dl over
> = Below
Detectable limit
*manganese was the one exception, consider additional supplementation during program.
No significant side effects were seen in
study patients
• No changes in basic labs including
hematology, electrolytes, and liver and kidney
function tests
• Two subjects had minor symptoms:
– One subject with history of migraines
experienced a migraine and GI upset
– One subject experienced mild headache
Conclusions from study and clinical
guidelines
Combination of Polyphenol-rich hops,
andrographis, curcumin and zinc
– Resulted in a significant increase in the
expression of metallothionein
– Increases excretion of clinically relevant toxic
metals (with minimal effect on nutrient compounds)
Research indicates this clinical
breakthrough achieves dramatic results
Metagenics Functional Medicine Research Center dosage guidelines
3 tablets
twice dailyapproach
for 30 to 60
days
This
revolutionary
has
shown clinically
to support and eliminate the following symptoms
of heavy
metal toxicity:
Other
considerations:
•
–
•
•
•–
Fatigue, lethargy, muscle weakness
Can be used to compliment a comprehensive
Difficulty concentrating, irritability, headache
metabolic detoxification program
Kidney distress, elevated liver enzymes
Some patients
mayanalysis
experience
mild metals
headache
Positive
lab or hair
for heavy
– Additional manganese supplementation may be
needed
The Intestinal Tract
• A Natural Barrier to Toxic Substances
• “Leaky Gut Syndrome” - passage of toxic
substances into the body
Strategies to Prevent “Leaky Gut”
•
•
•
•
Balance microflora (“good” bacteria)
Limit use of NSAIDs
Enlist nutritional support
Minimize use of alcohol, caffeine, processed
foods and additives
• Manage stress
Promote Balanced Microflora
• Probiotics
– Lactobacillus acidophilus
– Bifidobacterium
• Prebiotics
– Fructooligosaccharides – honey, onions,
bananas, oats
Foods for Detoxification
• Cruciferous vegetables
– Broccoli, cabbage, bok choy, arugula,
cauliflower
• Limonene-containing fruits
– Orange, tangerine, lemon (not grapefruit)
Nutrients for Detoxification
• Magnesium
• Copper
• Zinc
• Vitamin C
• Vitamin B family
• Protein
Core Protocols for Comprehensive
Detoxification
Metabolic Detoxification
Alkalizing support for detoxification
• 2 scoops twice daily as recommended in Quick Start guide
• Choose 10 or 28 day program based upon need
• Some people may need to be introduced to the Medical
Food slowly
Heavy Metal Detoxification
Polyphenol-rich hops, Andrographis, Curcumin, Zinc
• 3 tablets twice daily
• Continue therapy for 30 to 60 days
• Use in conjunction with a comprehensive metabolic
detoxification program, or as a stand-alone therapy
You can expect increased NRG and a
dramatic increase in health with a clinically
proven approach to detoxification
Significant improvement in patients’ condition in just
Research
Summary
four weeks۰
– 17 Years
of clinical testing with tensPatient
of Case
thousands
of
Study #1505
Patient Case Study #1504
patients
70
60
– Published
clinical studies demonstrating efficacy
50
MSQ
40
– Numerous
case studies establishing effectiveness in
Symptom
30
Score
20
treating
toxic-related symptoms
10
0
– Significant
reduction
in patient symptoms is typical
Before
Week 1
week 4
45
40
35
30
MSQ
25
Symptom
20
Score
15
10
5
0
Program
Fibromyalgia
Case Studies: MET1504, MET1505
Before
Program
Week 1
Week 2
Week 4
Fibromyalgia, Peripheral Neuropathy, and Insomnia