Overview of the Chemical Threat Laboratory of Texas William Edgemond, Ph.D. Texas Department of State Health Services October 2013 Course Objectives Introduction and Background Who We Are What We Can Do What We Want You to Do Chemical Threats Laboratory Response Network International network of laboratories to respond quickly to high priority public health emergencies, such as biological, chemical, and radiological threats, through training, rapid testing, timely notification and secure messaging of laboratory results. LRN-C Structure CDC Level 1 • 10 Labs • Level 2 & Level 3 Activities • National Surge Capacity • Core Methods & Add’l Methods •Additional Personal & Instruments Level 2 • 34 Labs • Level 3 Activities • Core Methods • State/Local Response Capacity Level 3 • 9 Labs • Competency in collecting and shipping clinical samples • Comprehensive response plan US Chemical Threat Labs Level 1 Level 2 Level 3 Course Objectives Introduction and Background Who We Are What We Can Do What We Want You to Do Personnel Dr. Bill Edgemond Team Lead/Chemical Threat Coordinator Jim Barnes Chemist Jocelyn Hover-Jeansonne Chemist How We Will Respond Can easily handle a large number of samples utilizing Lab Check-in personnel and space Types of Samples Clinical Samples Blood Urine Environmental/White Powders Clincal Methods CAP/CLIA Accredited Lab 11 Methods Developed by CDC 3 GC/MS Methods 4 LC-MS/MS Methods 3 ICP-MS Methods 1 LC-ICP-MS Methods Instrumentation & Capabilities Biosafety L2 Hood Chemical Hoods Automated Liquid Handler Bar Code Reader LIMS GC-MS Cyanide in Blood Volatile Organic Compounds in Blood Tetramine in Urine ICP-MS Cadmium, Lead, & Mercury in Blood Trace Elements in Urine (Be, Co, Mo, Cd, Sb, Cs, Ba, W, Pt, Tl, Pb, U) Arsenic & Selenium LC-MS-ICP Lewisite (Chlorovinyl arsonous acid) LC-MS/MS Abrine/Ricinine Organophosphorous Nerve Agent Metabolites Tetranitromethane Metabolite (HNPAA) Monofluoroacetate/ Monchloroacetate Unknowns/White Powders Typical submitted by FBI Cleared by Bio Threat Classify type of compound Texas CT Lab Know we’re here. Know what we can do. Share that with labs, hospitals and first responders across the state. Unknowns/White Powders FT-IR FT-IR Microscope XRF Geiger Counter Volatiles Detector Wet Chemistry Tools CT Lab Contact Info 512-458-7270—Direct Lab Phone. 512-689-9945—24-hour Emergency Phone. William.edgemond@dshs.state.tx.us – Chemical Threat Coordinator http://www.dshs.state.tx.us/lab/epr.shtm -DSHS Chemical Emergency Website http://emergency.cdc.gov/chemical/lab.asp -CDC Chemical Emergency Website Texas CT Lab Questions