INTEGRATIVE APPROACH CONCEPT
AND PRACTICE FOR CANCER
TREATMENT
Christo Damyanov MD, Ivan Maslev MD, Elina Dzhurenova MD
Medical center “Integrative medicine”
Sofia 2013
Medical center “Integrative medicine”
Introduction


Despite of the lack of interset and committment of
the conventional medicine towards carrying out
clinical researches on the possibilities of the Insulin
Potentiation Therapy (IPT) in tumor disease
treatment, the method is increasingly and more
widely applied in the practice of more and more
doctors and clinics.
Although the IPT efficiency is disputed by the
cancer specialists until clinical researches have
been concluded, the doctors practicing the method
have no doubt whatsoever of its low toxicity and
the improved quality of life of the patients.
Introduction

The method application in the Medical Center
“Integratve Mdicine” practice goes back to 2006 and
more than 650 patients with advanced metastatic
tumors have been treated by it, the major part of these
following the failure of preceding chemotherapy and
radiotherapy. In spite of the advanced illness and failure
of the previous treatment, there was a significant
improvement in the quality of life and remission in about
80 per cent of the patients. Our experience from the
IPT application undoubtedly allows us to accept the IPT
as a leading method in our practice.
Introduction

During the last year we used researches of the
genetic profile of circulating tumor cells in the
cases where the previous standard
chemotherapy had failed. Our preliminary results
indicate that in these cases the treatment
efficiency increased and made it possible to
avoid unnecessary medical procedures. Wider
researches allow the use of more precise and
suitable nutrients and immune modulators.
Problems Restricting our Therapeutic
Possibilities
Lack of sufficient information and cooperation
on the part of the patients
 The inability of some patients to change their life
style and carry out the prescribed treatment
within the allotted time frame
 Financial restrictions
 Limited possibility of using efficient alternative
methods of treatment, such as: ultrasound and
photodynamic therapy , hyperthermia, highly
intensive focused ultrasound (HIFU), the Coley
vaccine and others

Possibilities to Combine the IPT with
Efficient Complimentary and Alternative
Methods
1.
2.
3.
4.
The holistic approach and principles when treating cancer
leads to a great extent to improved results.
The overwhelming part of alternative and complimentary
methods applied for cancer treatment need a longer period
of impact which is insufficient in the cases with advanced
metastases.
The Insulin Potentiation Therapy is the fastest, efficient
and non toxic method for achieving remission, making it
possible at a later stage to also successfully include other
alternative methods of anti-tumor efficiency in order to
increase the final treatment results.
The complimentary therapy within the interval is an
important element of the treatment and selection of
suitable methods and is substantively important to
improving the treatment results. In the full remission cases
the complimentary therapy could successfully be used to
prevent relapses.
Possibilities to Combine the IPT with
Efficient Complimentary and Alternative
Methods
5. The complimentary methods improve the results of the
IPT application, however, the treatment as a whole
following remission also needs the application of
additional methods, such as: intravenous therapy with
high Vit. C doses , ultrasound photodynamic therapy,
hyperthermia, high-intensity focused ultrasound
(HIFU) and others.
6. Well informed and cooperative patients, their full
commitment to the treatment as well as regulating the
psycho-emotional state of the patients are important
elements of the entire treatment process.
7. Researches of the genetic profile of the circulating
tumor cells offer new possibilities to increase the
treatment efficiency.
The Medical Center Integrative Medicine
Concept for Integrative Approach in the
Treatment of Cancer
Treatment is based on the holistic approach with
leading principles:




Interaction and cooperation between doctor and patient;
Application of suitable conventional and alternative
methods helping the recuperating abilities of the body;
Not ignoring the possibilities of both the conventional
medicine and the alternative medicine and not accepting
indiscriminately the alternative methods offered;
Paying the necessary significance of factors as body,
mind and spirit in the progress and outcome of the
disease;
The Medical Center Integrative Medicine
Concept for Integrative Approach in the
Treatment of Cancer
Treatment is based on the holistic approach with
leading principles:
Optimum results from the treatment can be expected by
capable application of the scientific achievements and
openness towards new methods and possibilities;
 Application of natural non-invasive methods;
 Wide application of the integrative oncology to improve
the health of all and prevention of cancer;
 Committing those practicing integrative oncology to the
research problems in the field of CAM and the
continuous development of knowledge and abilities.

Individual Cancer Treatment Program
1.
Methods for specific therapy: Insulin Potentiation Therapy
(IPT), infusion therapy with high doses of Vit. C,
photodynamic therapy, hyperthermia combined with IPT.
2. Basic therapy:
a) reducing the impact of the risk factors for the disease
origin:

Elimination of focal infections and inflammation.

Limiting the effect of toxic environmental factors.

Diet therapy

Detoxication
b) Stimulating the immune system
c) Regulating the dysfunction of different organs and
systems.
d) Regulating the psycho-emotional state of the patient.
meditation, yoga, technique for emotional freedom anti
stress therapy.
Presentation of the Cases
First Case
I.T., a male patient of 75 y. was diagnosed
and operated in March 2011 of low
differential ductile adenocarcinoma of the
pancreas.
 Result from Surgery: when inspecting the
abdominal cavity a tumor formation was
discovered covering the head and body of the
pancreas and ductus holedohus. The case was
considered as inoperable and directed for
symptomatic treatment. A gall derivation was
performed.

Presentation of the Cases
First Case
The laboratory Test Results Before the Treatment


Hb -131 g/l ( N 120-175);; WBC- 20 G/L (N 4-10); RBC4.63 T/L (N 3,9- 6,5); PLT- 630 G/L (N 140-400); ALAT45 U/I (N up to 40); ASAT- 40U/I(N up to 40), GGT- 186
U/I(N up to 39); APH- 404 U/I (N up to 270); LDH- 114
U/I (N up to 450); BIL - total 45.4 mkmol/ l (N up to
21); Cholesterol - total 4.64 mmol/ l (N 3,33- 5,70);
Urea- 13.7 mmol/ l (N 2,8- 8,1); Creatinine- 181
mkmol/ l (N 44-110); Ferritin -272 mg/(N l20-200);
CRP- 48,5 mg/ml( N up to 5); Fibrinogen -12.6 g/l (N
2- 4,5); СЕА-132,4 4 IU/ml ( N up to 3,4), СА-19-9132,4 IU/ml (N < 39 ).
From the status –KPS-60. Symptomatic index according
to BERETTA – 45 points.
Presentation of the Cases
First Case
IPT therapy





IPT therapy (30 March 2011) with 5-FU and Gemcitabine –
one application a week.
Within the interval – antiangiogenetic therapy, anti oxidants
liver
protectors, enzyme preparations, electro-therapy and ozone
therapy.
Following the third IPT application a significant improvement
of his status was observed. The symptomatic index values
reached 19 points.
The total number of the IPT applications reached 19. The
symptomatic BERETTA index – 0 points after the 19th therapy
in January 2012.
Control CT - disease stabilization.
Presentation of the Cases
First Case
Follow up






The patient is in a remission until July 2012 (13 months).
Surgery (August 2012) - two large cysts on the pancreas were
evacuated while the cytologic test indicated the presence of
inflammatory and atypical cells.
Following the operation: antioxidants, hepatoprotectors and
enzyme preparations. The pains completely disappeared.
In December 2012 control CT - persisting tumor formation on the
pancreas head and local lymphadenomegalia was discovered.
An intravenous therapy with Vit. C-20 combined with 600 mg ALA
applied twice weekly were added to the treatment. Totally 9
applications were carried out.
The complaints decreased significantly and the patient was
stabilized.
After February 2013 the patient was lost from observation. The
total remission was over 18 months.
Presentation of the Cases
Second Case
A 64 male with pains in the lumbar area with diagnosed (April
2008) metastatic tumor of the prostate with a histological
result: adenocarcinoma-Gleason 7/2+5/.
 Hormone therapy was prescribed for one year with Goserelin
(Zoladex), Buserelin (Superfact) and biophosphates (Zometa)
as a result of which the patient is in remission until June 2009
when it was found that the ailment had progressed.
 In June 2009 a bilateral orchidectomy was performed,
however, in spite of that fact the suffering progressed. The
PSA and ALP values reached PSA-8395,0 and ALP-5264
respectively as of June 2009. The patient was offered a
painkilling treatment.
 The symptomatic index (BERETTA) before the treatment was
31 points; KPS-70.

Presentation of the Cases
Second Case
IPT therapy


In July 2009 - IPT with Insulin (0,3/kg) and Docetaxel
(8.6 mg/m2) and 20 per cent glucose i.v within 5 day
intervals. By January 2010 18 IPT applications have
been performed.
Within the interval antiangiogenetic and antioxidant
therapies were prescribed and LHRH agonist (Zoladex
3,6 mg) in monthly subcutaneous injections.
Second Case
Results







The pain syndrome went away after the 4th application. The patient
fully restored his quality of life and working capacity. The symptomatic
index following the treatment – BERETTA was 1 point. At the control
examination the biochemical indices after the 18th therapy were
within the normal values. The control PSA test following the treatment
indicated close to normal values – 3.33 ng/ml (Ref. 0.0-4,0 ng/ml).
Treatment was discontinued for four months.
Later on due to clinical and laboratory data for activation of the
suffering the patient again was accepted for treatment. The PSA–
139.50 ng/ml.
The IPT - new scheme: Epirubicin-(8.8 mg/m2), Vinkristin - ( 0.
44mg/m2), Endoxan – (240 mg/2)- 14 applications.
The patient again improved his general status and working capacity,
and PSA as of August 2011 reached 4.48 ng/ml. The BERETTA - 5
points.
The examinations that followed established a remission with a fully
restored working capacity until January 2013.
Until August 2013, the patient’s complaints were insignificant and his
working capacity was preserved. The total remission amounted to 62
months.
Conclusion




The results achieved from the treatment of more than
650 patients with highly advanced cancer, as of now,
justifies our conclusions that the presented integrative
approach with a leading IPTLD method represents a real
possibility for solving one of the most serious problem in
oncology connected with the toxicity of the standard
chemotherapy.
The case presented demonstrates serious possibilities for
achieving a long term remission even when treating
highly advanced tumors.
Undoubtedly, the merit of this approach in our opinion
together with the treatment results is the significantly
improved quality of life of the patients treated in the
prevailing number of cases.
The holistic approach and suitable selection of the
complimentary methods are the guarantee and
perspective for improved results when treating the most
serious cancer pathology.
Thank you for your attention !