Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Due Date:
Candidate Number: 002171-
Student Name:
Blog resource: http://tinyurl.com/6cu7yvh
This workbook is printed for the Making ATP unit.
ATP
1. Draw and annotate a molecule of ATP to show how it stores and releases energy.
2. List six cellular process that use ATP as a source of energy.
3.7 Cell Respiration
3. Define cell respiration.
The ______________________ release of ________________ in the form of _____________
from _______________________________ in cells.
4. State the word and symbol equations for the process of cell respiration.
Word:
Symbol:
5. Identify two organic molecules, other than glucose, which could be used for respiration.
6. Identify the two components of the cell in which respiration takes place.
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Due Date:
Candidate Number: 002171-
Student Name:
7. Distinguish between aerobic and anaerobic in terms of cell respiration.
8. Label the diagram of aerobic cell respiration below.
9.
Label the diagram of anaerobic cell respiration below.
10. Complete the table below, comparing aerobic and anaerobic respiration.
Aerobic
Anaerobic
Hexose sugar input in both types of respiration
Oxygen in
2 ATP produced
Pyruvate as an intermediate compound in both types of respiration
Yeast
Animals
Carbon dioxide produced
Water produced
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Due Date:
Candidate Number: 002171-
Student Name:
11. Complete the table below summarizing the events of aerobic cell respiration.
Reaction
Location
Purpose
ATP yield
Glycolysis
2
Matrix of the
mitochondrion
Convert pyruvate (3C)
to acetyl CoA (2C)
0
Krebs Cycle
Inner mitochondrial
membrane
Oxidative
phosphorylation
12. Label the diagram below with the correct processes, locations and compounds:
13. Explain how end-product inhibition controls the rate of ATP production.
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Student Name:
Due Date:
Candidate Number: 002171-
8.1/C3 Cell Respiration (AHL/Option content)
14. Many reactions in living things can be classified as either oxidation or reduction reactions.
These are particularly important in cell respiration and photosynthesis.
Complete the table below to compare oxidation and reduction reactions.
OXIDATION
Electrons are…
REDUCTION
lost
Oxygen is…
Hydrogen is…
15. Define phosphorylation.
16. List two ways in which phosphorylation is used in cell respiration.


17. In the space below, draw a diagram to show the process of glycolysis.
Include phosporylation, lysis, oxidation and ATP formation.
18. Explain the link reaction, including oxidative decarboxylation and conversion of pyruvate to
acetyl CoA and CO2.
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Due Date:
Candidate Number: 002171-
Student Name:
19. The link reaction produces Acetyl CoA (2C) from the input substrate (usually pyruvate).
The extra carbon is released as carbon dioxide. Acetyl CoA can also be produced from
fatty acids. When the fatty acid chain contains an even number of carbons, no CO2 is
released. How many Acetyl CoA molecules can be produced with the following fatty acids?
a. 23C
b. 18C
c. 31C
20. Draw and label a diagram showing the structure of the mitochondrion as seen in a TEM image.
Include the inner and outer mitochondrial membranes, matrix, christae, mitochondrial DNA and ribosomes
and a scale bar.
21. Complete the table below with the functions of the structures of the mitochondrion.
How is each structure adapted to help maximize efficiency of respiration?
Structure:
Function:
Adapted to increase efficiency by:
Outer membrane
Inner membrane
(including christae)
Matrix
Mitochondrial DNA and
ribosomes
Inter-membrane space
22. What is an electron carrier?
23. List two electron carriers that are used in cell respiration.


Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Student Name:
Due Date:
Candidate Number: 002171-
24. State the final destination of electron carriers produced in the Krebs Cycle.
25. In the space below, draw a diagram of the Krebs cycle.
Include formation of citrate, oxidation, decarboxylation, substrate-level phosphorylation (ATP
formation) and production of electron carriers.
26. Identify compounds in cell respiration that contain:
Six carbons
Four carbons
Three carbons
Two carbons
One carbons
Zero carbons
27. Annotate the diagram below with the stages of the electron transport chain and oxidative
phosphorylation. Include generation of a H+ concentration gradient in the inter-membrane
space, movement of electrons, oxidative phosphorylation by ATP synthase, use of O2 as the
terminal electron acceptor
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Student Name:
Due Date:
Candidate Number: 002171-
28. In the space below, using the term ‘chemiosmosis’, describe how ATP synthase works.
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Student Name:
Due Date:
Candidate Number: 002171-
29. Name (with reasons) three tissues in the body that contain high numbers of mitochondria.
Tissue
Reason
Muscle
30. Explain why high levels of lactic acid might be found in an athlete’s blood test, post-exercise.
31. Explain why ATP yield in aerobic cell respiration is so much higher than in anaerobic
respiration. (Long answer question – think about knock-on effects of reduced O2). 8 marks
Link question:
32. Draw and annotate sketch graphs of the effects of the following variables on rate of
respiration – temperature, CoA concentration, pH.
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com
Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Due Date:
Candidate Number: 002171-
Student Name:
Sample exam questions:
Practice these in your own time.

Describe the role of Acetyl CoA in the metabolism of lipids. (2 marks)

Explain chemiosmosis as it occurs in respiration. (2 marks)

Explain the process of aerobic respiration, including oxidative phosphorylation (8
marks)

Compare aerobic and anaerobic respiration, including yield of ATP. (8 marks)
Interesting reading:
 Nobel prizewinners: Krebs and Lipmann:
http://nobelprize.org/nobel_prizes/medicine/laureates/1953/
Sample data analysis question (from IB QuestionBank)
At the start of glycolysis, glucose is phosphorylated to produce glucose 6-phosphate, which is converted into
fructose 6-phosphate. A second phosphorylation reaction is then carried out, in which fructose 6-phosphate
is converted into fructose 1,6-bisphosphate. This reaction is catalyzed by the enzyme phosphofructokinase.
Biochemists measured the enzyme activity of phosphofructokinase (the rate at which it catalyzed the
reaction) at different concentrations of fructose 6-phosphate. The enzyme activity was measured with a low
concentration of ATP and a high concentration of ATP in the reaction mixture. The graph below shows the
results.
Low ATP concentration
Enzyme activity
High ATP concentration
Stephen Taylor
Bandung International
School
Fructose 6-phosphate
http://sciencevideos.wordpress.com
concentration
Essential Biology: 3.7 8.1 C3 Respiration Core & AHL
Student Name:
(a)
(i)
Due Date:
Candidate Number: 002171-
Using only the data in the above graph, outline the effect of increasing
fructose 6-phosphate concentration on the activity of phosphofructokinase, at
a low ATP concentration.
...............................................................................................................................
...............................................................................................................................
...............................................................................................................................
(2)
(ii)
Explain how increases in fructose 6-phosphate concentration affect the activity
of the enzyme.
...............................................................................................................................
........................................................................................................................
...............................................................................................................................
...............................................................................................................................
(2)
(b)
(i)
Outline the effect of increasing the ATP concentration on the activity of
phosphofructokinase.
...............................................................................................................................
...............................................................................................................................
...............................................................................................................................
...............................................................................................................................
(2)
(ii)
Suggest an advantage to living organisms of the effect of ATP on
phosphofructokinase.
...............................................................................................................................
...............................................................................................................................
(1)
(Total 7 marks)
Stephen Taylor
Bandung International School
http://sciencevideos.wordpress.com