Dean’s Workshop on
Biomedical Engineering
Biomedical Engineering at Yale:
Collaborations and Translational
Partnerships
W. Mark Saltzman
Where did we come from?
Who are we now?
Where do we want to be?
My perspective on today’s
program
Groundwork
Prior to 1996: Separate faculty research activity
1996-99: Whitaker Foundation Special Opportunity Award
1996: Program in BME formed
Foundation
1999: First full class of B.S. BME graduates
1999-2000: Provost/ Dean of Medicine task force on BME;
President Levin allocates 6 new BME faculty positions
2000: PhD Specialization in BME approved by Graduate School
Growth
2001-2002: Mark Saltzman and Erin Lavik hired to develop
biomolecular engineering effort
2002: Bioimaging faculty secure $7M Image-Guided Neurosurgery
Grant (first out of new NIH- NIBIB institute)
2003: Department of BME officially begins
2004: Richard Carson and Michael Levene hired to lead molecular
imaging effort
2005: Tarek Fahmy hired to bridge drug delivery/molecular imaging
Where did we come from?
Who are we now?
Where do we want to be?
My perspective on today’s
program
Biomedical Engineering at Yale:
Research and Educational Strengths
Bioimaging
Biomolecular
engineering
Biomechanics
Richard Carson, PET imaging and modeling
Todd Constable, MR imaging
James Duncan, Image analysis/processing
Fahmeed Hyder, MR spectroscopy
Michael Levene, Biophotonics/optical microscopy
Douglas Rothman, MR spectroscopy
Lawrence Staib, Image analysis/processing
Steven Zucker, Computer vision
Jacek Cholewicki, Spine biomechanics
Tarek Fahmy, Targeted drug delivery
Erin Lavik, Tissue engineering
Mark Saltzman, Drug delivery/tissue engineering
Hemant Tagare, Diagnostic Radiology
Xenios Papademetris, Diagnostic Radiology
Robin deGraaf, Diagnostic Radiology
Steven Segal, Physiology/Pierce
Themis Kyriakides , Pathology
Fred Sigworth, Physiology
Mark Laubach, Neurobiology/Pierce
Laura Niklason, Anesthesiology
Francesco d’Errico, Diagnostic Radiology
Biomedical Engineering at Yale:
Research and Educational Strengths
e.g. Molecular
imaging
Bioimaging
e.g. In vivo
tissue
function
Biomolecular
engineering
Biomechanics
e.g. Functional
tissue
engineering
Where did we come from?
Who are we now?
Where do we want to be?
My perspective on today’s
program
System/Disease-Oriented
Clusters
Technology-Oriented
Clusters
Neuroengineering
Biomaterials/Biomechanics
RC, TC, JD, FH, EL, ML, DR, MS, LS, SZ
JC, EL, MS, TF
KEY Person: Paul van Tassel
Vascular Engineering
Bioimaging
JD, TF, EL, MS
RC, TC, JD, FH, ML, DR, LS, SZ
KEY Person: Jordan Pober/VBT
KEY Person: Jim Duncan
Cancer Diagnostics/Therapeutics Biomolecular Engineering:
JD, MS, TF
Drug Delivery
RC, ML, EL, MS, TF
Immunotherapy
MS, TF
Biomolecular Engineering:
Tissue Engineering
EL, MS
KEY Person: Themis Kyriakides
Where did we come from?
Who are we now?
Where do we want to be?
My perspective on today’s
program
#1
Imaging is central to
Biomedical Engineering
research
Biomedical Imaging
at Yale
fMRI
MRS
Image-guided neurosurgery for epilepsy
Jim Duncan, Dennis Spencer et al.
fMRI
Left hand (red/yellow) & right
hand (blue) motor cortex
activation
MRS
QuickTime™ and a
Cinepak decompressor
are needed to see this picture.
Multiphoton in situ histology, Michael Levene
Liver
Ovary
Lung
Breast
Francesco d’Errico, Dept Diagnostic Radiology
Microemulsions for ultrasound-controlled drug release
(A)
Concept of image-guided
drug release with ultrasound
sensitive microemulsions
(B)
Doppler imaging of rabbit kidney
whereby the vaporization of droplets in
the renal artery reduces the blood flow
Perflurocarbon droplets with
oil inclusions containing a
water-insoluble drug
The blood flow is gradually restored when
bubbles dissolve in the blood-stream
#2
Biomolecular
Engineering provides
new opportunities for
basic and translational
research
Nanoparticles for Controlled Release of Curcumin
Margaret Cartiera, Mark Saltzman, Marie Egan, Michael Caplan
Isoproterenol Response
Magnitude of hyperpolarization (mV)
8
6
4
2
No Treatment
Curcumin
0
89F
2M
18M
-2
-4
-6
-8
Mouse #
78M
NanoCurcumin
Nanoparticles: particles as
small as a virus, but
engineered from safe
synthetic polymers and
loaded with high
concentrations of drugs
Microengineered Scaffolds to
Guide Cell Development to
Tissues
#3
Collaboration and
translation
One biomedical engineer’s experience at Yale
Neurobiology/Neurosurgery
Rick Matthews, Joe Piepmaier
Surgery
Christopher Breuer
Convection-enhanced delivery of nanoparticles
Tissue engineering of large vessels
Cancer Center/Dermatology
Rick Edelson, Doug Hanlon
Diagnostic Radiology
Todd Constable, Francesco d’Errico
Vascular Biology & Transplantation Medicine/ Gastroenterology
Jordan Pober, Themis Kyriakides
Chuhan Chung
Physiology/Pediatrics
Marie Egan, Michael Caplan
Therapeutic Radiology
Sarah Rockwell
Obstetrics and Gynecology
Hugh Taylor, Gil Mor
Laboratory Medicine
Diane Krause
Ophthalmology
Colin Barnstable
Comparative Medicine
Martha Harding, Janet Brandsma
Genetics
Dan DiMaio
Epidemiology and Public Health
Diane McMahon-Pratt
Opening Remarks
Carolyn W. Slayman, Ph.D.
Deputy Dean for Academic and Scientific Affairs
1:30-2:00 PM
BIOMEDICAL ENGINEERING AT YALE:
COLLABORATIONS AND TRANSLATIONAL PARTNERSHIPS
W. Mark Saltzman, Ph.D.
Goizueta Foundation Professor of Chemical and Biomedical Engineering and of Cellular and Molecular
Physiology
2:00-2:30 PM
TOWARDS THE CONSTRUCTION OF NEW GENERATION VACCINE SYSTEMS BASED ON BIOLOGICALDRIVEN DESIGNS
Tarek Fahmy, Ph.D.
Assistant Professor of Biomedical Engineering
Ira S. Mellman, Ph.D.
Sterling Professor of Cell Biology and Professor of Immunobiology
2:30-3:00 PM
BRINGING MULTIPHOTON MICROSCOPY TO THE CLINIC: ASSESSMENT OF WOUND HEALING WITH
ARTIFICIAL SKIN GRAFTS AND OTHER APPLICATIONS
Michael J. Levene, Ph.D.
Assistant Professor of Biomedical Engineering
Jordan S. Pober, M.D., Ph.D.
Professor of Pathology, Immunobiology and Dermatology
3:00-3:30 PM
ARCHITECTURAL HYDROGELS: SCAFFOLDS FOR VASCULAR AND NEURAL PROGENITOR CELL
CONSTRUCTS FOR THE NERVOUS SYSTEM
Erin Lavik, Sc.D.
Assistant Professor of Biomedical Engineering
Joseph A. Madri, M.D., Ph.D.
Professor of Pathology and of Molecular, Cellular and Developmental Biology