Specialist for Enzymes and Inflammation
Welcome!
Synonyms:
• Systemic Enzyme Support = SET
• Oral Enzyme Support
Systemic Enzyme Support
The founder of SET - History
Prof. Max Wolf (1885 – 1976)
•
Physician und Scientist from Vienna
•
Developed Enzyme Therapy together
with Helen Benitez in New York
•
(Wolf-Benitez-Enzyme-Therapy)
Prof. Max Wolf and Karl Ransberger
An established
naturopathic treatment
The position of SES within naturopathy
PhytoTherapy
Substitution
at pancreatic
insufficiency
EnzymeTherapy
Physical
Therapy
Homeopathy
Systemic
Enzyme Support
Enzyme classes
Primary classes
Catalytic reaction
1. Oxidoreductases
Redox reactions
2. Transferases
Transfer of functional groups
3. Hydrolases
Hydrolytic cleavage
4. Lyases
Cleavage of functional groups with
the formation of double bonds
5. Isomerases
Transformation of isomeric
compounds
6. Ligases
Formation of new bonds during the
ATP-cleavage
Which type of enzymes
in SES?
Proteases are macromolecular proteins
• Chain of amino acids
• The three-dimensional
structure is necessary
for their biological
effectiveness
Units for proteins:
20.000 - 30.000 m.w.
Model of Chymotrypsin
Hydrolases
Amylases
Hydrolytic cleavage of sugars
Lipases
Hydrolytic cleavage of fat
Proteases
Hydrolytic cleavage of proteins
& immunological effects
Enzymes used by Mucos
Naturally, high effective substances
Bromelain
from pineapple (Ananas comosus)
Papain
from latex of unriped fruits of papaya
(Carica papaya)
Enzymes from Pancreas:
(high purification technology):
additional active substance:
•Trypsin and Chymotrypsin
•Pankreatin (mixture of
Trypsin and Chymotrypsin)
Rutosid, a bioflavonoide from
the flower bud of japanese
pagoda tree
Absorption
Absorption of enzymes is a proven fact
Conditions for effective absorption:
• Taking beyond of mealtimes
(45 min before or 1,5 hours after)
• Gastric acid resistant coating
• Dissolving in small intestine
Dosages and serum concentration
Average serum concentrations of Bromelain after oral dose of 4 x 4
respectively 4 x 8 tablets Wobenzym® N per day
(mean value from 20 test subjects)
Individuality
AUC of Bromelain after oral dose of 4 tablets
Wobenzym® N (2 subjects)
What happens after
absorption?
Linkage to Antiproteases
Proteases combine with Antiproteases
• Alpha-2-Macroglobulin (2-MG)
• Alpha-1-Antitrypsin
Results in:
• Loss of antigenetic potential of Proteases
• while maintaining the biological activity of proteases
Protease-Inhibitors
Molecular weight
Concentration mg/dl
Bonding
Function
1-antitrypsin
54.000
200 – 400
Partially reversible
Multipurpose-Serinproteases-Inhibitor
Regulatory molecule
2-macroglobuline
725.000
175 – 290
Irreversible
General proteases-inhibitor
Transport- and regulatory molecule
The key role of 2-Macroglobulin
One 2-macroglobulin
combines
two enzyme molecules
2-MG
place where the
cytokines
combines
Different Cytokine pools
INF-γ, TNF-α, IL-2, IL-6, IL-12
stimulate the immune system
IL-4, IL-5, IL-10, TGF-ß
suppress the immune system
Th1
Th2
Cytokine-imbalance leads to immune system problems
Enzyme combinations?
Different enzymes – different effects!
Effect
Bromelain
Chymotrypsin
Papain
Trypsin
+++
++
++
+++
+
-
+++
+++
+++
+
++
+
Reduction of circulating
immuncomplexes (CIC)
++
+++
-
+
Balancing of Cytokines
++
++
++
++
Regulation of Immune Function
Haemodilution
Supports Circulatory Function
Source: Modified from,Klaschka, Neue Perspektiven der Tumortherapie, Forum Medizin Verlag, 1996
Wobenzym® N
Pankreatin
Trypsin
Chymotrypsin
Bromelain
Papain
Rutosid 3 H2O
100 mg
24 mg
1 mg
45 mg
60 mg
50mg
940 F.I.P.-Units
Wobenzym® N
• Dosage
• 1. week:
• beginning 2. week:
3 x 5 tablets per day
3 x 3 tablets per day
If you have any questions ….
Please contact us by email:
mis@online.ms
Ruth Miller M.D.
or
Winfried Miller M.D. / D.V.M