国外著名有机化学家简介
讲演人
化学02班
谢鑫
002429
化学02班
白楠
002432
Stuart L. Schreiber
POZITION
Director, Harvard Institute of
Chemistry & Cell Biology
Investigator, Howard Hughes
Medical Institute
Morris Loeb Professor and
Chair, Chemistry & Chemical
Biology
Director, Bauer Center of
Genomics Research
Honors And Awards
RECEIVED 30 AWARDS BETWEEN 1985-2000
Some main prize
 NSF presidential young investigator award, 1985;
 Thieme-IUPAC award in synthetic organic
chemistry, 1992;
 Eli Lilly award in biological chemistry, ACS, 1993;
 Dupont Merck young investigator award of the
protein society, 1995;
 Tetrahedron prize for creativity in organic
chemistry, 1997;
 Derek Barton medal, 1999;
 Alfred Bader award in bioorganic and bioinorganic
chemistry, ACS, 2000;
Thieme-IUPAC Award
in Synthetic Organic Chemistry
The Thieme-IUPAC Prize is
awarded every two years on the
occasion of IUPAC's
International Conference on
Organic Synthesis (ICOS) to a
scientist under 40 years of age,
whose research has had a major
impact on the field of synthetic
organic chemistry. The Prize is
sponsored jointly by Georg
Thieme Verlag, IUPAC, and
the Editors of Synthesis,
Synlett, Science of Synthesis,
and Houben-Weyl.
Thieme-IUPAC
Prize
in
Synthetic
Oraganic
Chemistry
Schreiber’s Research
Biologists study pathways and networks by perturbing
them and observing the result. Whereas these
perturbations most often result from mutations in
genetic investigations, they can also result from small
organic molecules. Numerous examples exist of small
molecules being used to explore immunology, yet
these examples have been brought to light generally
on a case-by-case basis. Rather than using small
molecules on an ad hoc basis, Stuart Schreiber's
laboratory is attempting to use them in a systematic
way, so that virtually any area of biology can be
examined with small molecules.
Schreiber’s Research
Beginning in the mid-1980‘s, Schreiber and his co-workers
studied the molecular mechanisms of the immunosuppressive
agents cyclosporin（环孢菌素）, FK506 and rapamycin（雷伯
酶素）, which led to new insights into two signaling networks
central to hematopoietic cell function. Using a synthetic analog
of FK506, they were able to show that these
immunosuppressants “bridge” two proteins. Both the complex
of cyclosporin （环孢菌素） with its receptor, cyclophilin（亲环
蛋白）, and the complex of FK506 with its receptor, FKBP12,
bind the same protein, the protein phosphatase calcineurin（磷
酸酶神经储钙蛋白）. This discovery, together with Gerald
Crabtree's discovery of NFAT proteins, now known to be
essential for immune function, heart development, and the
acquisition of memory in the hippocampus.
Schreiber’s Research
Combining synthetic organic chemistry and cell
biology, Schreiber and co-workers co-discovered the
mammalian protein FRAP, the target of the complex
between FKBP12 and rapamycin, and unraveled its
role as a metabolic sensor and a regulator of cell's
response to nutrients. FRAP and its yeast orthologs
Tor1p/2p are now recognized as the founding
members of a family of proteins called the PIKrelated kinases (ATM, ATR, DNA-PK), which act as
intracellular sensors monitoring a number of
different cellular pathways.
Papers & Publications
1."Chemistry and Biology of the Immunophilins
and Their Immunosuppressive Ligands" S. L.
Schreiber, Science 1991, 251, 283-287.
2."Three-Part Inventions: Intracellular Signaling
and Induced Proximity" Gerald R. Crabtree and
Stuart L. Schreiber, TIBS 1996, 21, 418-422
3."Chemical Genetics Resulting from a Passion
for Synthetic Organic Chemistry" Stuart L.
Schreiber, BioMed Chem. 1998, 6, 1127-1152.
4."Target-Oriented & Diversity-Oriented Organic
Synthesis" S L Schreiber Science 2000, 287,
1964-69.
Picnic
Connection
Tel: 617-495-5318
Fax: 617-495-0571
E-mail:sls@slsiris.harvard.edu
Group Website
http://www-schreiber.chem.harvard.edu/
Dieter Seebach
Dieter Seebach has been Full Professor
at the Organic Chemistry Laboratory of
the ETH Zurich since 1977.
Dieter Seebach was born in 1937 in
Karlsruhe（卡尔斯鲁厄）, Germany.
He has studied chemistry at the
University of Karlsruhe and Harvard
University.
Dieter Seebach
He returned to Karlsruhe and earned
habilitation in 1969 with a thesis on S
and Se stabilized carbanion and
carbene derivatives.
In 1971 he was called to the Justus
Liebig University in Giessen and in 1977
to the ETH Zurich.
He has been a guest professor at the
Universities of Madison, Strasbourg,
Munich (TU), Kaiserslautern, Frankfurt
and at Caltech, Pasadena, as well as at
the Max Planck Institute in Mulheim.
Dieter Seebach
Prof. Seebach is a member of the New
Swiss Chemical Society and comparable
associations in Germany, Great Britain,
Japan and the USA.
He also belongs to the German Academy
of Natural Science Research Leopoldina
and is a corresponding member of the
Academy of Sciences and Literature in
Mainz, and is an elected member of the
Schweizerische Akademie der
Technischen Wissenschaften.
Honors And Awards
1984–FRSC Fellow of the Royal Society of Chemistry, U.K.
Visiting Professorship:
1974– California Institute of Technology, Pasadena, USA
1980-Imperial College, London, U.K.
1981-Max-Planck-Institut
Lectureship:
1981-University of Minnesota, Minneapolis, USA
1982-University of Illinois, Urbana-Champaign, USA
1982-Princeton University, Princeton, USA
1984-University of Manchester, U.K.
1986-University of Chicago, USA
1986-University of Michigan, Ann Arbor, USA
Honors And Awards
1986-The University of California, Berkeley, USA
1988-University of North Carolina at Chapel Hill, USA
1988-The University of Wisconsin, Madison, USA
1989-Massachusetts Institute of Technology, Cambridge, USA
1990-Harvard University, Cambridge, USA
1990-Ohio State University, Columbus, USA
1990-University of California, Irvine, USA
1990-Columbia University, New York, USA
1992-Duke University, Durham, NC, USA
University of Cambridge, Cambridge, U.K.
Yale University, New Haven, USA
1996-Kansas University, Lawrence, USA
1997-Cornell University, Ithaca, NY, USA
2002-Stanford University, Stanford, CA, USA
Seebach’s Research
His work focuses on the development of
new synthesis methods; production and
secondary structure examination of beta
peptides; the synthesis of oligomers in (R)3 hydroxybutyric acid（羟丁酸） and the
respective biopolymers as well as their
application possibilities; the synthesis of
chiral dendrimers（树枝状大分子） and the
use of chiral titanates in organic synthesis.
Seebach’s Research
Synthesis, Structural Investigations and
Biological Evaluation of Oligomers of
Beta-Amino Acids
Investigations of the Biopolymer PHB and
of related Oligo(3-hydroxyalkanoates)
Enantioselective Reactions（对映选择性
反应）Using Transition Metal Complexes
Connection
Prof. Dr. Dieter Seebach
Laboratory of organic chemistry
ETH Hoenggerberg, HCI
CH-8093 Zuerich, Switzerland
Tel : +41-1-632 2990
Fax: +41-1-632 1144
E-ail :mailto:seebach@org.Chem.ethz.Ch
David Evans
David Albert Evans was born in
Washington D.C. in 1941.
He received his A.B. degree from
Oberlin College in 1963. He
obtained his Ph.D. at the California
Institute of Technology in 1967.In
that year he joined the faculty at
the University of California, Los
Angeles.
David Evans
In 1973 he was promoted to the
rank of Full Professor and shortly
thereafter returned to Caltech where
he remained until 1983.
In 1983 he joined the Faculty at
Harvard University and in 1990 he
was appointed as the Abbott and
James Lawrence Professor of
Chemistry. In July of 1998 he
completed his three-year term as
chair of the Harvard Department of
Chemistry and Chemical Biology.
Honors And Awards
Professor Evans is a recipient of numerous honors
such as the ACS Award for Creative Work in
Synthetic Organic Chemistry (1982), and the Arthur
C. Cope Scholar Award (1988), the Yamada Prize
(1997), the Tetrahedron Prize (1998), the Robert
Robinson Award (1998), the Prelog Medal (1999),
and the Arthur C. Cope Award (2000).
He was elected into the National Academy of
Sciences in 1984, the American Academy of Arts and
Sciences in 1988 and the Royal Society of Chemistry
in 2001.
Honors And Awards
He is currently a consultant with Merck
Research Laboratories and with Oxford
Asymmetry. He has been on the Advisory
Boards of The Journal of the American
Chemical Society, Tetrahedron, Tetrahedron
Letters, and Topics in Stereochemistry.
Currently, he is on the Advisory Boards of
Organic Letters and Current Opinion in Bioorganic Chemistry, London, UK
Evans’ Research
Evans has made fundamental
advances in the design of
stereoselective reactions and the
applications of these reactions to
natural products synthesis.
Significant Advances in
Reaction Methodology
In the area of synthesis design, Evans was the first
to achieve the de novo synthesis of complex
natural products through the exclusive use of
chiral auxiliaries to control stereochemical
relationships. This represented a dramatic
departure from the more prevalent reliance on the
"chiral pool" for the origins of absolute
stereocontrol within the target structure. Evans'
chiral auxiliaries and chiral catalysts for
enantioselective bond constructions are widely
used in both industrial and academic laboratories
throughout the world.