Pre-AP Karyotyping Activity
Open Internet Explorer and go to the following website:
http://www.biology.arizona.edu/Human_Bio/activities/karyotyping/karyotyping.html
Open your journal up to the next clean page. Title it “Karyotyping Journal Activity” and put
today’s date.
Write all answers in COMPLETE SENTENCES or points will be taken off!
Introduction
1. This exercise is a simulation of human karyotyping using digital images of
___________________from actual human genetic studies.
2. What does karyotyping analysis involve?
3. What does Giemsa Dye do?
4. What do the thinnest bands on a chromosome represent?
5. What three features of a chromosome are compared in a karyotype?
Click on Patient Histories
Click on ‘Complete Patient A’s Karyotype’
Match up the chromosomes for Patient A, including the extra chromosome.
Interpreting the Karyotype
6. How many chromosomes in a normal human karyotype?
7. How many autosomes (non sex chromosomes) in a normal human karyotype?
8. How many sex chromosomes (X or Y) in a normal human karyotype?
9. What sex chromosomes would you find in a male?
10. What sex chromosomes would you find in a female?
11. What notation would you use to characterize a normal human karyotype?
12. What notation would you use to characterize Patient A’s karyotype?
13. Using the chart at the bottom of the page, how would you diagnose Patient A?
Patient B
14. What notation would you use to characterize Patient B’s karyotype?
15. What is Patient B’s diagnosis?
Patient C
16. What notation would you use to characterize Patient C’s karyotype?
17. What is Patient C’s diagnosis?
Notation
18. What does the # represent?
19. What do the letters represent?
20. What does that + # represent?