Original Article (Supplementary Information)
Quantitative Proteomic Analysis of Meningiomas for the Identification of
Surrogate Protein Markers
Samridhi Sharma1†, Sandipan Ray 1†, Aliasgar Moiyadi 2, Epari Sridhar 3
and Sanjeeva Srivastava1*
1
Wadhwani Research Center for Biosciences and Bioengineering, Department of Biosciences
and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
2
Department of Neurosurgery, Advanced Center for Treatment Research and Education in
Cancer, Tata Memorial Center, Kharghar, Navi Mumbai 410210, India
3
Department of Pathology, Tata Memorial Hospital, Mumbai 400012, India.
†
Both authors contributed equally to the preparation of this manuscript
*
Correspondence: Dr. Sanjeeva Srivastava, Department of Biosciences and Bioengineering,
IIT Bombay, Mumbai 400 076, India: E-mail: sanjeeva@iitb.ac.in
Phone: +91-22-2576-7779, Fax: +91-22-2572-3480
Running Title: Proteomic Analysis of Different Grades of Meningioma
1
A
2
3
B
4
5
Figure S1. (A) Representative 2D- DIGE image (Cy3 and Cy5 channel overlap) and trends of
differentially expressed proteins in meningioma grade I (compared to healthy controls) visualized in 2DDIGE. (B) Representative 2D- DIGE image (Cy3 and Cy5 channel overlap) Trends of differentially
expressed proteins in meningioma grade II (compared to healthy controls) visualized in 2D-DIGE.
6
157 proteins
157 proteins
157 proteins
Figure S2. The distribution of the differentially expressed proteins in different grades of meningiomas;
grade I (A), II (B) and III (C) identified in iTRAQ.
7
B. Complement pathways
8
B. Complement pathways
9
B. Complement pathways
Continued…
10
C. PPAR Signaling Pathway
Continued…
11
D. ECM signalling
Figure S3. Different biological pathways modulated in meningiomas obtained in DAVID analysis.
12
A
13
B
Figure S4. Cellular and molecular sub-trees associated with the differentially expressed proteins
identified in meningiomas.
14
Figure S5. Equal loading of protein samples during western blot experiment. Representative CBB
stained SDS-PAGE gel (A) and Ponceau stained blot (B) containing the resolved proteins depicting
equal loading (50 µg) of the samples (meningioma patients and healthy subjects) in every lane during
western blot experiment.
15
Figure S6. Frequency distribution of serum concentrations of Apo E, HPX, Apo A1 and RBP4 in
healthy controls and different grades of meningioma patients measured by ELISA.
16
Figure S7. Receiver operating characteristic (ROC) curves depicting accuracy of 4 classifier proteins;
Apo E, HPX, Apo A1 and RBP4 for prediction of grade I and grade II meningiomas
17
Figure S8. Comparison of the fold changes of the differentially expressed proteins identified from iTRAQ data with
proteins reported in published literature in tissue and CSF samples. Differential expression of proteins in tissue and CSF
samples are obtained from reference number 17 and 20 respectively.
18
Supplementary Tables
Table S1. Demographics and clinical details of the meningioma patients and healthy subjects
Sl.No.
Patient ID
Diagnosis
Grade
Age
Sex
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
CJ 14742
CJ4231
CH 30545
CF 4450
CH 24953
CJ 20717
CJ 20619
CJ 29822
CJ 29452
CJ 29583
CJ 9179
CJ 26538
CK 726
CK 985
CJ 15491
CJ 15753
CH 17967
CJ 3577
CK 7710
CJ6540
Meningothelial Meningioma
Transitional Meningioma
Transitional meningioma
MeningothelialMeningioma
Transitional meningioma
MeningothelialMeningioma
MeningothelialMeningioma
Transitional meningioma
Transitional meningioma
Meningothelial meningioma
Transitional meningioma
Lipomatous meningioma
MeningothelialMeningioma
Angiomatous meningioma
Atypical meningioma
Atypical meningiom
Atypical meningioma
Atypical meningioma
Atypical meningioma
Pappalary Meningioma
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. I
Gr. II
Gr. II
Gr. II
Gr. II
Gr. II
Gr. III
29
35
17
55
41
39
41
50
42
44
57
45
56
55
67
46
58
43
55
61
M
F
M
F
F
F
F
F
F
F
F
F
F
F
M
F
M
F
F
M
19
Table S2. Details of all statistically significant (p < 0.05) differentially expressed protein spots
in meningioma grade I (compared to healthy controls) visualized in 2D-DIGE
Sl. No.
Master No.
Appearance
T-test
Av. Ratio
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
684
441
263
277
262
264
707
1312
653
677
758
1009
261
214
657
436
1054
58
1011
1553
1016
322
266
56
510
210
43
1595
590
319
177
1394
36
459
48
59
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
0.00039
0.00089
0.0011
0.0011
0.0013
0.0019
0.0036
0.0054
0.0084
0.012
0.012
0.012
0.013
0.019
0.019
0.02
0.021
0.028
0.035
0.00042
0.0011
0.0015
0.0045
0.0057
0.0075
0.018
0.019
0.021
0.022
0.027
0.032
0.032
0.034
0.034
0.037
0.037
-6.23
4.42
-3.88
-4.04
-3.76
-3.4
2.98
2.84
2.42
-2.67
2.37
1.63
-2.02
1.86
-2.7
2.08
1.6
1.56
1.76
5.49
3.2
-1.4
-2.55
-2.31
-6.23
-3.95
-1.62
6.57
3.08
-1.63
-2.93
2.52
-4.13
1.56
-3.46
-2.73
20
37
38
39
40
41
81
38
73
970
258
6 (9)
6 (9)
6 (9)
6 (9)
6 (9)
21
0.037
0.043
0.044
0.046
0.047
-3.99
3.96
4.17
2.43
2.99
Table S3. Details of all statistically significant (p < 0.05) differentially expressed protein
spots in meningioma grade II (compared to healthy controls) visualized in 2D-DIGE
Sl. No.
Master No.
Appearance
T-test
Av. Ratio
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
1084
632
1340
1483
1435
636
612
641
861
945
1194
682
928
724
915
697
492
901
582
251
651
993
921
587
9 (9)
6 (9)
9 (9)
9 (9)
9 (9)
9 (9)
9 (9)
6 (9)
9 (9)
9 (9)
9 (9)
6 (9)
9 (9)
9 (9)
9 (9)
6 (9)
6 (9)
9 (9)
6 (9)
6 (9)
9 (9)
6 (9)
9 (9)
9 (9)
0.00067
0.0039
0.0071
0.0083
0.011
0.012
0.016
0.019
0.019
0.024
0.024
0.025
0.027
0.029
0.029
0.031
0.033
0.035
0.037
0.042
0.042
0.042
0.049
0.05
1.74
1.49
6.19
-2.01
-2.23
2.06
-3.16
-1.50
3.83
-2.62
-1.9
1.82
1.55
2.83
1.86
1.65
-1.71
1.53
1.47
2.09
-2.62
-1.52
1.62
-2.02
22
Table S4. Master tables for all MALDI-TOF/TOF identified proteins in meningioma grade I
visualized in 2D-DIGE#
[Analysis Type: Combined (MS+MS/MS); Database: SwissProt; Taxonomy: Human]
Sl
No.
Mast
er
ID
Foldchange
Name of protein with
UniProt
accession number
MW
(kDa)
Protein
score
No. of
matched
peptides
1
210
-3.95
(P02768) Serum albumin
69.32
456
30
2
459
1.56
(P00738) Haptoglobin
45.17
217
13
3
1016
3.2
(P02647) Apolipoprotein AI (Apo-AI)
30.75
486
20
23
Peptide sequence
CCKADDK
YLYEIAR
LCTVATLR
DDNPNLPR
LKCASLQK
FQNALLVR
LVNEVTEFAK
FKDLGEENFK
HPDYSVVLLLR
AVMDDFAAFVEK
RHPDYSVVLLLR
CCAAADPHECYAK
DVFLGMFLYEYAR
KVPQVSTPTLVEVSR
QEPERNECFLQHK
HPYFYAPELLFFAK
RHPYFYAPELLFFAK
HPYFYAPELLFFAKR
RPCFSALEVDETYVPK
VFDEFKPLVEEPQNLIK
EFNAETFTFHADICTLSEK
ALVLIAFAQYLQQCPFEDHVK
TCVADESAENCDKSLHTLFGDK
MPCAEDYLSVVLNQLCVLHEK
EFNAETFTFHADICTLSEKER
QNCELFEQLGEYKFQNALLVR
RMPCAEDYLSVVLNQLCVLHEK
LVRPEVDVMCTAFHDNEETFLK
RMPCAEDYLSVVLNQLCVLHEK
LVRPEVDVMCTAFHDNEETFLKK
DYAEVGR
QLVEIEK
GSFPWQAK
ILGGHLDAK
VGYVSGWGR
VMPICLPSK
VTSIQDWVQK
DIAPTLTLYVGK
SCAVAEYGVYVK
YVMLPVADQDQCIR
VSVNERVMPICLPSK
VMPICLPSKDYAEVGR
SPVGVQPILNEHTFCAGMSK
QKVEPLR
AELQEGAR
LHELQEK
AKPALEDLR
LSPLGEEMR
QKLHELQEK
4
1011
1.76
(P02753) Plasma retinolbinding protein (RBP4)
23.02
637
11
5
262
-3.76
(P04217) Alpha-1Bglycoprotein precursor
(Alpha-1-BN glycoprotein)
54.3
900
16
6
1312
2.84
(P02790) Hemopexin
precursor (Beta-1Bglycoprotein)
51.64
239
14
7
1054
1.6
(P02743) Serum amyloid Pcomponent precursor (SAP)
25.37
179
7
24
QGLLPVLESFK
DLATVYVDVLK
VQPYLDDFQK
WQEEMELYR
THLAPYSDELR
LSPLGEEMRDR
VQPYLDDFQKK
VSFLSALEEYTK
DYVSQFEGSALGK
KWQEEMELYR
VEPLRAELQEGAR
LLDNWDSVTSTFSK
DSGRDYVSQFEGSALGK
LREQLGPVTQEFWDNLEK
QEELCLAR
FSGTWYAMAK
DPNGLPPEAQK
YWGVASFLQK
QRQEELCLAR
LIVHNGYCDGR
LLNLDGTCADSYSFVFSR
LLNNWDVCADMVGTFTDTEDPAK
GNDDHWIVDTDYDTYAVQYSCR
*DPEGLFLQDNIVAEFSVDETGQMSATA
K*
*KDPEGLFLQDNIVAEFSVDETGQMSAT
AK*
GVTFLLR
LLELTGPK
CLAPLEGAR
ATWSGAVLAGR
LETPDFQLFK
SGLSTGWTQLSK
HQFLLTGDTQGR
CEGPIPDVTFELLR
NGVAQEPVHLDSPAIK
LELHVDGPPPRPQLR
VTLTCVAPLSGVDFQLR
IFFHLNAVALGDGGHYTCR
SLPAPWLSMAPVSWITPGLK
TPGAAANLELIFVGPQHAGNYR
SWVPHTFESELSDPVELLVAES
*LHDNQNGWSGDSAPVELILSDETLPAP
EFSPEPESGR*
LHIMAGR
LWWLDLK
RLWWLDLK
DYFMPCPGR
VWVYPPEKK
FDPVRGEVPPR
YYCFQGNQFLR
GECQAEGVLFFQGDR
ALPQPQNVTSLLGCTH
LYLVQGTQVYVFLTK
SGAQATWTELPWPHEK
LLQDEFPGIPSPLDAAVECHR
EVGTPHGIILDSVDAAFICPGSSR
*SLGPNSCSANGPGLYLIHGPNLYCYSD
VEK*
AYSDLSR
VGEYSLYIGR
QGYFVEAQPK
GYVIIKPLVWV
IVLGQEQDSYGGK
AYSLFSYNTQGR
IVLGQEQDSYGGKFDR
8
758
2.37
(P01023) Alpha-2macroglobulin
163.17
318
39
9
707
2.98
(P00450) Ceruloplasmin
122.13
460
36
25
YGAATFTR
FQVDNNNR
QGIPFFGQVR
LPPNVVEESAR
YDVENCLANK
AIGYLNTGYQR
VGFYESDVMGR
VTAAPQSVCALR
NALFCLESAWK
HYDGSYSTFGER
NQGNTWLTAFVLK
LVHVEEPHTETVR
ALLAYAFALAGNQDK
IAQWQSFQLEGGLK
DNSVHWERPQKPK
TEHPFTVEEFVLPK
SSSNEEVMFLTVQVK
ALLAYAFALAGNQDKR
AHTSFQISLSVSYTGSR
LLIYAVLPTGDVIGDSAK
QFSFPLSSEPFQGSYK
VSVQLEASPAFLAVPVEK
GHFSISIPVKSDIAPVAR
FSGQLNSHGCFYQQVK
GNRIAQWQSFQLEGGLK
AFQPFFVELTMPYSVIR
LLLQQVSLPELPGEYSMK
VDLSFSPSQSLPASHAHLR
AFQPFFVELTMPYSVIR
MCPQLQQYEMHGPEGLR
AGAFCLSEDAGLGISSTASLR
MCPQLQQYEMHGPEGLR
LHTEAQIQEEGTVVELTGR
QQNAQGGFSSTQDTVVALHALSK
SLFTDLEAENDVLHCVAFAVPK
NALFCLESAWKTAQEGDHGSHVYTK
VVSMDENFHPLNELIPLVYIQDPK
*YDVENCLANKVDLSFSPSQSLPASHAH
LR*
*SPCYGYQWVSEEHEEAHHTAYLVFSPS
K*
KGSLHANGR
QYTDSTFR
EYTDASFTNR
EYTDASFTNRK
GAYPLSIEPIGVR
EVGPTNADPVCLAK
QSEDSTFYLGER
DIASGLIGPLIICK
ALYLQYTDETFR
VNKDDEEFIESNK
DLYSGLIGPLIVCR
RQSEDSTFYLGER
QYTDSTFRVPVER
KALYLQYTDETFR
NNEGTYYSPNYNPQSR
TTIEKPVWLGFLGPIIK
TYYIAAVEVEWDYSPQR
NLASRPYTFHSHGITYYK
LISVDTEHSNIYLQNGPDR
MHSMNGFMYGNQPGLTMCK
KAEEEHLGILGPQLHADVGDK
FNKNNEGTYYSPNYNPQSR
KLISVDTEHSNIYLQNGPDR
MYYSAVDPTKDIFTGLIGPMK
HYYIGIIETTWDYASDHGEK
MYSVNGYTFGSLPGLSMCAEDR
MFTTAPDQVDKEDEDFQESNK
GPEEEHLGILGPVIWAEVGDTIR
SGAGTEDSACIPWAYYSTVDQVK
HYYIGIIETTWDYASDHGEKK
SVPPSASHVAPTETFTYEWTVPK
GVYSSDVFDIFPGTYQTLEMFPR
ERGPEEEHLGILGPVIWAEVGDTIR
WYLFGMGNEVDVHAAFFHGQALTNK
*ADDKVYPGEQYTYMLLATEEQSPGEG
DGNCVTR*
*NMATRPYSIHAHGVQTESSTVTPTLPG
ETLTYVWK*
10
214
1.86
(P10909) Clusterin
precursor (Complementassociated protein SP-40)
52.46
151
8
11
1553
5.49
(P02750) Leucine-rich
alpha-2-glycoprotein (LRG)
38.15
637
10
12
970
2.43
(P02790) Hemopexin
precursor (Beta-1Bglycoprotein)
52.38
207
9
13
322
-1.4
(P02774) Vitamin D
Binding protein
199
3
14
653
2.42
(P01009) Alpha-1antitrypsin
46.87
355
5
15
1394
2.52
(P01024) Complement C3
188.56
275
8
16
258
2.99
(P02649) Apolipoprotein E
precursor
36.24
234
6
54.52
26
VCRSGSGLVGR
EGDDDRTVCR
ELDESLQVAER
NPKFMETVAEK
ASSIIDELFQDR
EILSVDCSTNNPSQAK
LFDSDPITVTVPVEVSR
VTTVASHTSDSDVPSGVTEVVVK
GPLQLER
DCQVFR
VAAGAFQGLR
ALGHLDLSGNR
DLLLPQPDLR
ENQLEVLEVSWLHGLK
TLDLGENQLETLPPDLLR
NALTGLPPGLFQASATLDTLVLK
DGFDISGNPWICDQNLSDLYR
LQELHLSSNGLESLSPEFLRPVPQLR
RLWWLDLK
DYFMPCPGR
DYFM*PCPGR
NFPSPVDAAFR
FDPVRGEVPPR
YYCFQGNQFLR
GECQAEGVLFFQGDR
LLQDEFPGIPSPLDAAVECHR
EVGTPHGIILDSVDAAFICPGSSR
SCESNSPFPVHPGTAECCTK
EVVSLTEACCAEGADPDCYDTR
HQPQEFPTYVEPTNDEICEAFR
GKWERPFEVK
ITPNLAEFAFSLYR
FNKPFVFLMIEQNTK
ELDRDTVFALVNYIFFK
LYHSEAFTVNFGDTEEAKK
GYTQQLAFR
DFDFVPPVVR
KGYTQQLAFR
AGDFLEANYM*NLQR
SYTVAIAGYALAQMGR
SYTVAIAGYALAQMGR
ILLQGTPVAQMTEDAVDAER
EGVQKEDIPPADLSDQVPDTESETR
LAVYQAGAR
LGPLVEQGR
LQAEAFQAR
AKLEEQAQQIR
17
319
-1.63
(P02768) Serum albumin
precursor
69.32
663
26
18
436
2.08
(P00738) Haptoglobin
precursor
45.17
248
12
19
441
4.42
(P00738) Haptoglobin
precursor
45.17
713
14
20
1009
1.63
(P10909) Clusterin
precursor (Complementassociated protein SP-40)
52.46
179
8
21
261
-2.02
(P02768) Serum albumin
precursor
69.3
674
23
27
AATVGSLAGQPLQER
SELEEQLTPVAEETR
CCKADDK
YLYEIAR D
DNPNLPR FQNALLVR
CASLQKFGER
HPDYSVVLLLR
AVMDDFAAFVEK
RHPDYSVVLLLR
CCAAADPHECYAK
DVFLGMFLYEYAR
KVPQVSTPTLVEVSR
QNCELFEQLGEYK
QEPERNECFLQHK
HPYFYAPELLFFAK
RPCFSALEVDETYVPK
NECFLQHKDDNPNLPR
VFDEFKPLVEEPQNLIK
VHTECCHGDLLECADDR
EFNAETFTFHADICTLSEK
MPCAEDYLSVVLNQLCVLHEK
EFNAETFTFHADICTLSEKER
VHTECCHGDLLECADDRADLAK
LVRPEVDVMCTAFHDNEETFLK
RMPCAEDYLSVVLNQLCVLHEK
LVRPEVDVMCTAFHDNEETFLKK
CCTESLVNRRPCFSALEVDETYVPK
NYYKLR
NPANPVQR
VMPICLPSK
YQCKNYYK
LPECEAVCGKPK
TEGDGVYTLNDKK
LRTEGDGVYTLNDK
YVMLPVADQDQCIR
LRTEGDGVYTLNNEK
AVGDKLPECEAVCGKPK
LPECEADDGCPKPPEIAHGYVEHSVR
*AVGDKLPECEADDGCPKPPEIAHGYVE
HSVR*
DYAEVGR
GSFPWQAK
VGYVSGWGR
VTSIQDWVQK
DIAPTLTLYVGK
TEGDGVYTLNDK
SCAVAEYGVYVK
YVMLPVADQDQCIR
VSVNERVMPICLPSK
VVLHPNYSQVDIGLIK
VMPICLPSKDYAEVGR
SPVGVQPILNEHTFCAGMSK
YVMLPVADQDQCIRHYEGSTVPEK
*YQEDTCYGDAGSAFAVHDLEEDTWY
ATGILSFDK*
IDSLLENDR
RPHFFFPK
QTCMKFYAR
TLLSNLEEAKK
NPKFMETVAEK
ASSIIDELFQDR
QQTHMLDVMQDHFSR
EPQDTYHYLPFSLPHR
YLYEIAR
FQNALLVR
QTALVELVK
CASLQKFGER
ECCEKPLLEK
HPDYSVVLLLR
AVMDDFAAFVEK
RHPDYSVVLLLR
CCAAADPHECYAK
VPQVSTPTLVEVSR
DVFLGMFLYEYAR
YICENQDSISSKLK
KVPQVSTPTLVEVSR
QNCELFEQLGEYK
QEPERNECFLQHK
RPCFSALEVDETYVPK
VPQVSTPTLVEVSRNLGK
SLHTLFGDKLCTVATLR
AAFTECCQAADKAACLLPK
VFDEFKPLVEEPQNLIK
EFNAETFTFHADICTLSEK
MPCAEDYLSVVLNQLCVLHEK
RMPCAEDYLSVVLNQLCVLHEK
# Alterations in protein expression levels in MG I patients were measured using healthy subjects as controls
* Indicates the continuation of peptide sequence in the next line
28
Table S5. Master tables for all MALDI-TOF/TOF identified proteins in meningioma grade II
visualized in 2D-DIGE #
[Analysis Type: Combined (MS+MS/MS); Database: SwissProt; Taxonomy: Human]
Sl
No.
Mast
er
ID
Foldchange
Name of protein with
UniProt accession
number
MW
(kDa)
Protein
score
No. of
matched
peptide
s
Peptide sequence
1
636
2.06
(P00738) Haptoglobin
45.17
713
14
2
641
-1.50
(P00751) Complement
factor B precursor (EC
3.4.21.47)
85.4
717
26
3
651
-2.62
(P02787) Serotransferrin
precursor (Transferrin)
76.99
1160
42
DYAEVGR
GSFPWQAK
VGYVSGWGR
VTSIQDWVQK
DIAPTLTLYVGK
TEGDGVYTLNDK
SCAVAEYGVYVK
YVMLPVADQDQCIR
VSVNERVMPICLPSK
VVLHPNYSQVDIGLIK
VMPICLPSKDYAEVR
SPVGVQPILNEHTFCAGMSK
YVMLPVADQDQCIRHYEGSTVPK
*YQEDTCYGDAGSAFAVHDLEEDTWYA
TGILSFDK*
ISVIRPSK
STGSWSTLK
VASYGVKPR
DISEVVTPR
EELLPAQDIK
ALFVSEEEKK
VKDISEVVTPR
YGLVTYATYPK
LPPTTTCQQQK
EKLQDEDLGFL
LEDSVTYHCSR
QLNEINYEDHK
DFHINLFQVLPWLK
FIQVGVISWGVVDVCK
EAGIPEFYDYDVALIK
FLCTGGVSPYADPNTCR
KEAGIPEFYDYDVALIK
SRFIQVGVISWGVVDVK
DLEIEVVLFHPNYNINGK
YGQTIRPICLPCTEGTTR
AIHCPRPHDFENGEYWPR
LPPTTTCQQQKEELLPAQDIK
WSGQTAICDNGAGYCSNPGIPIGTR
LLQEGQALEYVCPSGFYPYPVQTR
EDYLDVYVFGVGPLVNQVNINALASK
*GHESCMGAVVSEYFVLTAAHCFTVD
D KEHSIK*
NPDPWAK
SCHTAVGR
APNHAVVTR
ASYLDCIR
YLGEEYVK
KASYLDCIR
WCALSHHER
DSGFQMNQLR
SASDLTWDNK
HSTIFENLANK
EFQLFSSPHGK
EGYYGYTGAR
WCAVSEHEAT
K
29
4
1084
1.74
(P00738) Haptoglobin
45.17
306
9
5
697
1.65
(P02790) Hemopexin (Beta1B-glycoprotein)
51.64
596
21
6
682
1.82
(P01876) Ig alpha-1 chain C
region
37.63
491
14
30
KDSGFQMNQLR
DYELLCLDGTR
KSASDLTWDNLK
SVIPSDGPSVACVK
MYLGYEYVTAIR
SKEFQLFSSPHGK
LKCDEWSVNSVGK
CSTSSLLEACTFR
DQYELLCLDNTR
DLLFRDDTVCLAK
FDEFFSEGCAPGSK
TAGWNIPMGLLYNK
KPVEEYANCHLAR
EDPQTFYYAVAVVK
KCSTSSLLEACTFR
DCHLAQVPSHTVVAR
FDEFFSEGCAPGSKK
IECVSAETTEDCIAK
EGTCPEAPTDECKPVK
WCAVSEHEATKCQSFR
ADRDQYELLCLDNTR
NLNEKDYELLCLDGTR
EDLIWELLNQAQEHFGK
SDNCEDTPEAGYFAVAVVK
SAGWNIPIGLLYCDLPEPR
NLREGTCPEAPTDECKPVK
KPVDEYKDCHLAQVPSHTVVAR
LCMGSGLNLCEPNNKEGYYGYTGAFR
*AIAANEADAVTLDAGLVYDAYLAPNN
LKPVVAEFYGSK*
DYAEVGR
NYYKLR
GSFPWQAK
VGYVSGWGR
VMPICLPSK
YQCKNYYK
VTSIQDWVQK
SCAVAEYGVYVK
YVMLPVADQDQCIR
LHIMAGR
LWWLDLK
GEVPPRYPR
RLWWLDLK
DYFMPCPGR
VWVYPPEKK
FDPVRGEVPPR
GDKVWVYPPEK
SWPAVGNCSSALR
YYCFQGNQFLR
EWFWDLATGTMK
GECQAEGVLFFQGDR
LYLVQGTQVYVFLTK
SGAQATWTELPWPHEK
SWPAVGNCSSALRWLGR
LLQDEFPGIPSPLDAAVECHR
EVGTPHGIILDSVDAAFICPGSSR
CSPHLVLSALTSDNHGATYAFSGTHYWR
GECQAEGVLFFQGDREWFWDLATGTM
K
*DGWHSWPIAHQWPQGPSAVDAAFSWE
EK*
*SLGPNSCSANGPGLYLIHGPNLYCYSDV
EK*
VAAEDWK
YLTWASR
SAVQGPPER
EKYLTWASR
WLQGSQELPR
TFTCTAAYPESK
7
612
-3.16
(P02768) Serum albumin
69.3
1410
26
8
861
3.83
(P02647) Apolipoprotein AI (Apo-AI)
30.75
486
20
9
587
-2.02
(P02768) Serum albumin
69.32
456
30
31
DASGVTFTWTPSSGK
QEPSQGTTTFAVTSILR
GDTFSCMVGHEALPLAFTQK
TFTCTAAYPESKTPLTATLSK
KGDTFSCMVGHEALPLAFTQK
DLCGCYSVSSVLPGCAEPWNHGK
*NFPPSQDASGDLYTTSSQLTLPATQCLA
GK*
*SGNTFRPEVHLLPPPSEELALNELVTLT
CLAR*
YLYEIAR
LCTVATLR
DDNPNLPR
FQNALLVR
NECFLQHK
CCTESLVNR
LVNEVTEFAK
ECCEKPLLEK
HPDYSVVLLLR
AVMDDFAAFVEK
AAFTECCQAADK
RHPDYSVVLLLR
CCAAADPHECYAK
VPQVSTPTLVEVSR
DVFLGMFLYEYAR
KVPQVSTPTLVEVSR
QNCELFEQLGEYK
HPYFYAPELLFFAK
RPCFSALEVDETYVPK
VHTECCHGDLLECADDR
VFDEFKPLVEEPQNLIK
EFNAETFTFHADICTLSEK
ALVLIAFAQYLQQCPFEDHVK
MPCAEDYLSVVLNQLCVLHEK
LVRPEVDVMCTAFHDNEETFLK
SHCIAEVENDEMPADLPSLAADFVESK
QKVEPLR
AELQEGAR
LHELQEK
AKPALEDLR
LSPLGEEMR
QKLHELQEK
QGLLPVLESFK
DLATVYVDVLK
VQPYLDDFQK
WQEEMELYR
THLAPYSDELR
LSPLGEEMRDR
VQPYLDDFQKK
VSFLSALEEYTK
DYVSQFEGSALGK
KWQEEMELYR
VEPLRAELQEGAR
LLDNWDSVTSTFSK
DSGRDYVSQFEGSALGK
LREQLGPVTQEFWDNLEK
CCKADDK
YLYEIAR
LCTVATLR
DDNPNLPR
LKCASLQK
FQNALLVR
LVNEVTEFAK
FKDLGEENFK
HPDYSVVLLLR
AVMDDFAAFVEK
RHPDYSVVLLLR
CCAAADPHECYAK
DVFLGMFLYEYAR
10
945
-2.62
(P02765) Alpha-2-HSglycoprotein
39.29
495
10
KVPQVSTPTLVEVSR
QEPERNECFLQHK
HPYFYAPELLFFAK
RHPYFYAPELLFFAK
HPYFYAPELLFFAKR
RPCFSALEVDETYVPK
VFDEFKPLVEEPQNLIK
EFNAETFTFHADICTLSEK
ALVLIAFAQYLQQCPFEDHVK
TCVADESAENCDKSLHTLFGDK
MPCAEDYLSVVLNQLCVLHEK
EFNAETFTFHADICTLSEKER
QNCELFEQLGEYKFQNALLVR
RMPCAEDYLSVVLNQLCVLHEK
LVRPEVDVMCTAFHDNEETFLK
RMPCAEDYLSVVLNQLCVLHEK
LVRPEVDVMCTAFHDNEETFLKK
QYGFCK
FSVVYAK
HTLNQIDEVK
CDSSPDSAEDVRK
EHAVEGDCDFQLLK
HTFMGVVSLGSPSGEVSHPR
HTFMGVVSLGSPSGEVSHPRK
AQLVPLPPSTYVEFTVSGTDCVAK
*QPNCDDPETEEAALVAIDYINQNLPWG
YK*
*VWPQQPSGELFEIEIDTLETTCHVLDPTP
VAR*
# Alterations in protein expression levels in MG II patients were measured using healthy subjects as controls
* Indicates the continuation of peptide sequence in the next line
32
Table S6. Complete details of protein identification and quantitative iTRAQ data for different
grades of meningiomas.
Gr
ou
p
N
u
m
Nu
m
Sp
ect
ra
Nu
m
Pe
ps
Un
iq
ue
Sc
or
e
Un
iq
ue
%
Cov
era
ge
log2_iTRAQ
_115_114_m
edian
Fo
ldch
an
ge
(H
C
vs.
M
G1
)
log2_iTRAQ
_116_114_m
edian
Fo
ldch
an
ge
(H
C
vs.
M
G2
)
log2_iTRAQ
_117_114_m
edian
Fo
ldch
an
ge
(H
C
vs.
M
G3
)
Accessi
on_num
ber
Protein_n
ame
Peptide sequence
1
320
100
179
7.2
8
32.7
0.843
1.7
9
1.895
3.7
2
2.718
6.5
8
P04114.
2
Apolipopr
otein B100
AALTELSLGSAYQA
MILGVDSK
ADSVVDLLSYNVQG
SGETTYDHK
AEPLAFTFSHDYK
AHLDIAGSLEGHLR
ALVEQGFTVPEIK
AQNLYQELLTQEGQ
ASFQGLK
ATFQTPDFIVPLTDLR
ATGVLYDYVNK
ATVAVYLESLQDTK
AVSMPSFSILGSDVR
DAVEKPQEFTIVAFV
K
DFSLWEK
DKAQNLYQELLTQE
GQASFQGLK
DKDQEVLLQTFLDD
ASPGDKR
DLKVEDIPLAR
DNVFDGLVR
EELCTMFIR
EFNLQNMGLPDFHIP
ENLFLK
EFQVPTFTIPK
ESQLPTVMDFR
EVGTVLSQVYSK
EVYGFNPEGK
EYSGTIASEANTYLN
SK
FDHTNSLNIAGLSLD
FSSK
FPEVDVLTK
FSDEGTHESQISFTIE
GPLTSFGLSNK
GFEPTLEALFGK
GIISALLVPPETEEAK
GMALFGEGK
HSITNPLAVLCEFISQ
SIK
IADFELPTIIVPEQTIEI
PSIK
IAELSATAQEIIK
IDDIWNLEVK
IEFEWNTGTNVDTK
IEGNLIFDPNNYLPK
IEIPLPFGGK
IGQDGISTSATTNLK
ILGEELGFASLHDLQ
LLGK
INCKVELEVPQLCSFI
LK
ITENDIQIALDDAK
ITLPDFR
IVQILPWEQNEQVK
KMTSNFPVDLSDYPK
33
KYTYNYEAESSSGVP
GTADSR
LDFSSQADLR
LEIQSQVDSQHVGHS
VLTAK
LELELRPTGEIEQYSV
SATYELQR
LELELRPTGEIEQYSV
SATYELQREDR
LIDVISMYR
LLLQMDSSATAYGST
VSK
LNDLNSVLVMPTFH
VPFTDLQVPSCK
LNTDIAGLASAIDMS
TNYNSDSLHFSNVFR
LPQQANDYLNSFNW
ER
LPYTIITTPPLKDFSL
WEK
LSLESLTSYFSIESSTK
LSLESLTSYFSIESSTK
GDVK
LSLPDFK
LSNDMMGSYAEMK
LTLDIQNK
LVGFIDDAVK
MGLAFESTK
MTSNFPVDLSDYPK
MYQMDIQQELQR
NFVASHIANILNSEEL
DIQDLK
NFVASHIANILNSEEL
DIQDLKK
NIQEYLSILTDPDGK
NLQDLLQFIFQLIEDN
IK
NLQNNAEWVYQGAI
R
NLTDFAEQYSIQDWA
K
NSLFFSAQPFEITAST
NNEGNLK
QTIIVVLENVQR
QVFLYPEKDEPTYIL
NIKR
SGSSTASWIQNVDTK
SLWDFLK
SVSDGIAALDLNAVA
NK
SVSLPSLDPASAK
TEHGSEMLFFGNAIE
GK
TEVIPPLIENR
TFQIPGYTVPVVNVE
VSPFTIEMSAFGYVFP
K
TIHDLHLFIENIDFNK
TILGTMPAFEVSLQA
LQK
TLADLTLLDSPIK
TLADLTLLDSPIKVPL
LLSEPINIIDALEMR
TLQGIPQMIGEVIR
TSSFALNLPTLPEVK
VEDIPLAR
VELEVPQLCSFILK
VHANPLLIDVVTYLV
ALIPEPSAQQLREIFN
MAR
VIGNMGQTMEQLTP
ELK
VLLDQLGTTISFER
VNWEEEAASGLLTSL
K
VNWEEEAASGLLTSL
34
KDNVPK
VPLLLSEPINIIDALE
MR
VPQTDMTFR
VPSYTLILPSLELPVL
HVPR
VSALLTPAEQTGTW
K
YDKNQDVHSINLPFF
ETLQEYFER
YENYELTLK
YSQPEDSLIPFFEITVP
ESQLTVSQFTLPK
YTYNYEAESSSGVPG
TADSR
35
2
393
75
134
4.3
6
54.9
0.316
1.2
4
1.323
2.5
0
36
1.591
3.0
1
P01024.
2
Complem
ent C3
ACEPGVDYVYK
ACEPGVDYVYKTR
ADIGCTPGSGKDYAG
VFSDAGLTFTSSSGQ
QTAQR
AEDLVGKSLYVSAT
VILHSGSDMVQAER
AGDFLEANYMNLQR
APSTWLTAYVVKVF
SLAVNLIAIDSQVLC
GAVK
AYYENSPQQVFSTEF
EVK
DAPDHQELNLDVSL
QLPSR
DFDFVPPVVR
DICEEQVNSLPGSITK
DSCVGSLVVK
DSITTWEILAVSMSD
K
DSITTWEILAVSMSD
KK
DYAGVFSDAGLTFTS
SSGQQTAQR
ENEGFTVTAEGK
EPGQDLVVLPLSITTD
FIPSFR
EVVADSVWVDVK
EVVADSVWVDVKDS
CVGSLVVK
EYVLPSFEVIVEPTEK
FISLGEACK
FVTVQATFGTQVVE
K
FYYIYNEK
GLEVTITAR
ILLQGTPVAQMTEDA
VDAER
IPIEDGSGEVVLSR
ISLPESLK
KQELSEAEQATR
KVEGTAFVIFGIQDG
EQR
KVFLDCCNYITELR
KVLLDGVQNPRAED
LVGK
LDKACEPGVDYVYK
LDKACEPGVDYVYK
TR
LESEETMVLEAHDA
QGDVPVTVTVHDFP
GK
LESEETMVLEAHDA
QGDVPVTVTVHDFP
GKK
NNNEKDMALTAFVLI
SLQEAK
NTLIIYLDK
NTMILEICTR
QDSLSSQNQLGVLPL
SWDIPELVNMGQWK
QGALELIK
QKPDGVFQEDAPVIH
QEMIGGLR
QLYNVEATSYALLAL
LQLKDFDFVPPVVR
QVREPGQDLVVLPLS
ITTDFIPSFR
RIPIEDGSGEVVLSR
SDDKVTLEERLDK
SEETKENEGFTVTAE
GK
SEETKENEGFTVTAE
GKGQGTLSVVTMYH
AK
SEFPESWLWNVEDL
K
SEFPESWLWNVEDL
KEPPK
SGIPIVTSPYQIHFTK
SGQSEDRQPVPGQQ
MTLK
SGQSEDRQPVPGQQ
MTLKIEGDHGAR
SLYVSATVILHSGSD
MVQAER
SNLDEDIIAEENIVSR
SSLSVPYVIVPLK
SSLSVPYVIVPLKTGL
QEVEVK
TELRPGETLNVNFLL
R
TGLQEVEVKAAVYH
HFISDGVR
TKKQELSEAEQATR
TVMVNIENPEGIPVK
VELLHNPAFCSLATT
K
VFLDCCNYITELR
VFLDCCNYITELRR
VHQYFNVELIQPGAV
K
VLLDGVQNPR
VLLDGVQNPRAEDL
VGK
VPVAVQGEDTVQSL
TQGDGVAK
VQLSNDFDEYIMAIE
QTIK
VQLSNDFDEYImAIE
QTIK
VQLSNDFDEYIMAIE
QTIKSGSDEVQVGQQ
R
VSHSEDDCLAFK
VTIKPAPETEK
VVLVAVDK
VYAYYNLEESCTR
WLILEK
YFKPGMPFDLMVFV
TNPDGSPAYR
YISKYELDK
37
3
317
52
954
.16
47.8
0.54
1.4
5
1.788
3.4
5
38
1.641
3.1
2
P01023.
3
Alpha-2macroglob
ulin
AFQPFFVELTMPYSVI
R
AFQPFFVELTmPYSVI
R
AGAFCLSEDAGLGIS
STASLR
ALLAYAFALAGNQD
K
AVDQSVLLMKPDAE
LSASSVYNLLPEK
AYIFIDEAHITQALIW
LSQR
DMYSFLEDMGLK
DTVIKPLLVEPEGLE
K
EEFPFALGVQTLPQT
CDEPK
ETTFNSLLCPSGGEVS
EELSLK
ETTFNSLLCPSGGEVS
EELSLKLPPNVVEES
AR
FEVQVTVPK
GGVEDEVTLSAYITI
ALLEIPLTVTHPVVR
HNVYINGITYTPVSST
NEK
HNVYINGITYTPVSST
NEKDMYSFLEDMGL
K
HYDGSYSTFGER
IAQWQSFQLEGGLK
IAQWQSFQLEGGLKQ
FSFPLSSEPFQGSYK
KDTVIKPLLVEPEGL
EK
KYSDASDCHGEDSQ
AFCEK
LHTEAQIQEEGTVVE
LTGR
LLIYAVLPTGDVIGDS
AK
LLLQQVSLPELPGEY
SMK
LPPNVVEESAR
LVHVEEPHTETVR
MCPQLQQYEMHGPE
GLR
NALFCLESAWK
NEDSLVFVQTDK
QFSFPLSSEPFQGSYK
QGIPFFGQVR
QQNAQGGFSSTQDT
VVALHALSK
QTVSWAVTPK
SASNMAIVDVK
SGGRTEHPFTVEEFV
LPK
SGGRTEHPFTVEEFV
LPKFEVQVTVPK
SLFTDLEAENDVLHC
VAFAVPK
SPCYGYQWVSEEHE
EAHHTAYLVFSPSK
SSSNEEVMFLTVQVK
TEHPFTVEEFVLPK
TEVSSNHVLIYLDK
TTVMVKNEDSLVFV
QTDK
VDLSFSPSQSLPASHA
HLR
VGFYESDVMGR
VSVQLEASPAFLAVP
VEK
VTAAPQSVCALR
VTGEGCVYLQTSLK
VVSMDENFHPLNELI
PLVYIQDPK
VVSMDENFHPLNELI
PLVYIQDPKGNR
VYDYYETDEFAIAEY
NAPCSK
YDVENCLANK
YDVENCLANKVDLS
FSPSQSLPASHAHLR
YNILPEKEEFPFALGV
QTLPQTCDEPK
YSDASDCHGEDSQAF
CEK
39
4
382
46
887
.4
59.1
-0.573
0.6
7
0.095
1.0
7
40
0.332
1.2
6
P02787.
3
Serotransf
errin
ADRDQYELLCLDNT
R
ASYLDCIR
CDEWSVNSVGK
CLKDGAGDVAFVK
CLVEKGDVAFVK
CSTSSLLEACTFR
DGAGDVAFVK
DLLFK
DLLFKDSAHGFLK
DLLFRDDTVCLAK
DSGFQMNQLR
EDLIWELLNQAQEHF
GK
EDLIWELLNQAQEHF
GKDK
EDPQTFYYAVAVVK
EDPQTFYYAVAVVK
K
EFQLFSSPHGK
EGTCPEAPTDECKPV
K
EGTCPEAPTDECKPV
KWCALSHHER
EGYYGYTGAFR
FDEFFSEGCAPGSK
FDEFFSEGCAPGSKK
GDVAFVK
HSTIFENLANK
HSTIFENLANKADRD
QYELLCLDNTR
IECVSAETTEDCIAK
INHCRFDEFFSEGCAP
GSK
KPVDEYKDCHLAQV
PSHTVVAR
KPVEEYANCHLAR
KSASDLTWDNLK
LCMGSGLNLCEPNN
K
LCMGSGLNLCEPNN
KEGYYGYTGAFR
LKCDEWSVNSVGK
LKCDEWSVNSVGKIE
CVSAETTEDCIAK
MYLGYEYVTAIR
mYLGYEYVTAIR
NLNEKDYELLCLDGT
R
NLNEKDYELLCLDGT
RKPVEEYANCHLAR
SAGWNIPIGLLYCDL
PEPR
SASDLTWDNLK
SASDLTWDNLKGK
SETKDLLFRDDTVCL
AK
SMGGKEDLIWELLN
QAQEHFGK
SmGGKEDLIWELLNQ
AQEHFGK
SMGGKEDLIWELLN
QAQEHFGKDK
SmGGKEDLIWELLNQ
AQEHFGKDK
SVIPSDGPSVACVK
TAGWNIPMGLLYNK
WCAVSEHEATK
YLGEEYVK
5
186
42
774
.94
31
0.245
1.1
9
0.67
1.5
9
41
0.727
1.6
6
P0C0L5
.1
Complem
ent C4-B
AEFQDALEK
AEFQDALEKLNMGIT
DLQGLR
AEMADQASAWLTR
DFALLSLQVPLK
DFALLSLQVPLKDAK
DSSTWLTAFVLK
ECVGFEAVQEVPVGL
VQPASATLYDYYNPE
R
ECVGFEAVQEVPVGL
VQPASATLYDYYNPE
RR
EELVYELNPLDHR
EMSGSPASGIPVK
EPFLSCCQFAESLR
FGLLDEDGK
FGLLDEDGKK
FGLLDEDGKKTFFR
GLEEELQFSLGSK
GPEVQLVAHSPWLK
GSFEFPVGDAVSK
ITPGKPYILTVPGHLD
EMQLDIQAR
KEVYMPSSIFQDDFVI
PDISEPGTWK
KKEVYMPSSIFQDDF
VIPDISEPGTWK
LELSVDGAK
LHLETDSLALVALGA
LDTALYAAGSK
LLATLCSAEVCQCAE
GK
LNMGITDLQGLR
LQETSNWLLSQQQA
DGSFQDLSPVIHR
LTVAAPPSGGPGFLSI
ERPDSRPPR
SFFPENWLWR
STQDTVIALDALSAY
WIASHTTEER
TEQWSTLPPETK
VDFTLSSER
VDFTLSSERDFALLSL
QVPLKDAK
VDVQAGACEGK
VEYGFQVK
VGDTLNLNLR
VLQIEKEGAIHREEL
VYELNPLDHR
VLSLAQEQVGGSPEK
VQQPDCREPFLSCCQ
FAESLR
VQQPDCREPFLSCCQ
FAESLRK
VTASDPLDTLGSEGA
LSPGGVASLLR
YLDKTEQWSTLPPET
K
YVLPNFEVK
YVSHFETEGPHVLLY
FDSVPTSR
6
108
30
615
.64
67.4
-0.659
0.6
3
0.075
1.0
5
42
-0.723
0.6
1
P02768.
2
Serum
albumin
ADDKETCFAEEGKK
AEFAEVSKLVTDLTK
ALVLIAFAQYLQQCP
FEDHVK
AVMDDFAAFVEK
DVFLGMFLYEYAR
EFNAETFTFHADICTL
SEK
EFNAETFTFHADICTL
SEKER
KVPQVSTPTLVEVSR
LKECCEKPLLEK
LVAASQAALGL
LVNEVTEFAK
LVRPEVDVMCTAFH
DNEETFLK
LVRPEVDVMCTAFH
DNEETFLKK
LVTDLTK
MPCAEDYLSVVLNQ
LCVLHEK
MPCAEDYLSVVLNQ
LCVLHEKTPVSDR
NYAEAKDVFLGMFL
YEYAR
QNCELFEQLGEYK
QTALVELVK
RMPCAEDYLSVVLN
QLCVLHEK
RMPCAEDYLSVVLN
QLCVLHEKTPVSDR
RPCFSALEVDETYVP
K
SHCIAEVENDEMPAD
LPSLAADFVESK
SHCIAEVENDEMPAD
LPSLAADFVESKDVC
K
VFDEFKPLVEEPQNLI
K
VHTECCHGDLLECA
DDR
VHTECCHGDLLECA
DDRADLAK
VPQVSTPTLVEVSR
YICENQDSISSK
YLYEIAR
7
197
29
539
.32
70.4
1.19
2.2
8
2.825
7.0
9
43
3.729
13.
26
P02647.
1
Apolipopr
otein A-I
AKPALEDLR
AKVQPYLDDFQK
ATEHLSTLSEK
ATEHLSTLSEKAKPA
LEDLR
DLATVYVDVLK
DLATVYVDVLKDSG
RDYVSQFEGSALGK
DLEEVK
DSGRDYVSQFEGSAL
GK
DYVSQFEGSALGK
EQLGPVTQEFWDNL
EK
EQLGPVTQEFWDNL
EKETEGLR
KWQEEMELYR
LLDNWDSVTSTFSK
LLDNWDSVTSTFSKL
R
LREQLGPVTQEFWD
NLEK
LREQLGPVTQEFWD
NLEKETEGLR
LSPLGEEMR
LSPLGEEMRDR
QGLLPVLESFK
QGLLPVLESFKVSFLS
ALEEYTK
QKVEPLRAELQEGAR
THLAPYSDELR
VEPLRAELQEGAR
VKDLATVYVDVLK
VKDLATVYVDVLKD
SGR
VQPYLDDFQK
VQPYLDDFQKKWQE
EMELYR
VSFLSALEEYTK
WQEEMELYR
8
152
27
564
.51
37.8
0.048
1.0
3
1.028
2.0
4
44
0.52
1.4
3
P00450.
1
Ceruloplas
min
ADDKVYPGEQYTYM
LLATEEQSPGEGDGN
CVTR
AEEEHLGILGPQLHA
DVGDK
AGLQAFFQVQECNK
ALYLQYTDETFR
DIASGLIGPLIICK
DIFTGLIGPMK
DLYSGLIGPLIVCR
ERGPEEEHLGILGPVI
WAEVGDTIR
EVGPTNADPVCLAK
GAYPLSIEPIGVR
GPEEEHLGILGPVIW
AEVGDTIR
GVYSSDVFDIFPGTY
QTLEMFPR
HYYIAAEEIIWNYAP
SGIDIFTK
HYYIGIIETTWDYAS
DHGEKK
KAEEEHLGILGPQLH
ADVGDK
KAEEEHLGILGPQLH
ADVGDKVK
KERGPEEEHLGILGP
VIWAEVGDTIR
MFTTAPDQVDKEDE
DFQESNK
MYYSAVDPTK
MYYSAVDPTKDIFTG
LIGPMK
NNEGTYYSPNYNPQS
R
QKDVDKEFYLFPTVF
DENESLLLEDNIR
SGAGTEDSACIPWAY
YSTVDQVK
SVPPSASHVAPTETFT
YEWTVPK
TYCSEPEKVDKDNED
FQESNR
VNKDDEEFIESNK
VYPGEQYTYMLLAT
EEQSPGEGDGNCVTR
9
153
27
485
.96
32.8
-0.147
0.9
0
0.2
1.1
5
-0.034
0.9
8
P08603.
4
Complem
ent factor
H
10
126
23
392
.79
53.1
0.761
1.6
9
2.641
6.2
4
2.874
7.3
3
P01009.
3
Alpha-1antitrypsin
45
AGEQVTYTCATYYK
AVYTCNEGYQLLGEI
NYR
CFEGFGIDGPAIAK
CTLKPCDYPDIK
DGEKVSVLCQENYLI
QEGEEITCKDGR
DGWSAQPTCIK
DTSCVNPPTVQNAYI
VSR
EIMENYNIALR
EKTKEEYGHSEVVEY
YCNPR
GDAVCTESGWRPLPS
CEEK
IDVHLVPDR
IVSSAMEPDREYHFG
QAVR
LGYVTADGETSGSIT
CGK
LSYTCEGGFR
NTEILTGSWSDQTYP
EGTQAIYK
RPCGHPGDTPFGTFT
LTGGNVFEYGVK
SCDIPVFMNAR
SIDVACHPGYALPK
SITCIHGVWTQLPQC
VAIDK
SSNLIILEEHLK
TDCLSLPSFENAIPMG
EK
TGESVEFVCK
TKEEYGHSEVVEYY
CNPR
VSVLCQENYLIQEGE
EITCK
VSVLCQENYLIQEGE
EITCKDGR
WQSIPLCVEK
WSSPPQCEGLPCK
AVLTIDEK
AVLTIDEKGTEAAGA
MFLEAIPMSIPPEVK
DTEEEDFHVDQVTTV
K
DTEEEDFHVDQVTTV
KVPMMK
ELDRDTVFALVNYIF
FK
FLEDVK
GTEAAGAMFLEAIPM
SIPPEVK
ITPNLAEFAFSLYR
IVDLVK
IVDLVKELDRDTVFA
LVNYIFFK
KLYHSEAFTVNFGDT
EEAK
KLYHSEAFTVNFGDT
EEAKK
LGMFNIQHCK
LQHLENELTHDIITK
LSITGTYDLK
LVDKFLEDVK
LVDKFLEDVKK
LYHSEAFTVNFGDTE
EAK
QINDYVEK
SPLFMGK
SVLGQLGITK
TDTSHHDQDHPTFNK
ITPNLAEFAFSLYR
WERPFEVK
11
83
22
400
.36
18.2
-0.143
0.9
1
0.507
1.4
2
1.168
2.2
5
P02751.
4
Fibronecti
n
12
182
22
389
.03
48.2
-0.28
1.6
7
0.133
2.1
0
-0.212
1.8
7
P00738.
1
Haptoglob
in
46
DDKESVPISDTIIPAV
PPPTDLR
DLEVVAATPTSLLIS
WDAPAVTVR
DLQFVEVTDVK
EESPLLIGQQSTVSDV
PR
EINLAPDSSSVVVSGL
MVATK
EYLGAICSCTCFGGQ
R
GEWTCIAYSQLR
GFNCESKPEAEETCF
DK
ITYGETGGNSPVQEF
TVPGSK
NLQPASEYTVSLVAI
K
NTFAEVTGLSPGVTY
YFK
QDGHLWCSTTSNYE
QDQK
RPGGEPSPEGTTGQS
YNQYSQR
SSPVVIDASTAIDAPS
NLR
SYTITGLQPGTDYK
TDELPQLVTLPHPNL
HGPEILDVPSTVQK
TNTNVNCPIECFMPL
DVQADREDSRE
VDVIPVNLPGEHGQR
VTIMWTPPESAVTGY
R
VTWAPPPSIDLTNFL
VR
VVTPLSPPTNLHLEA
NPDTGVLTVSWER
WCGTTQNYDADQK
AVGDKLPECEADDG
CPKPPEIAHGYVEHS
VR
AVGDKLPECEAVCG
KPK
DIAPTLTLYVGK
DYAEVGR
GSFPWQAK
LPECEADDGCPKPPEI
AHGYVEHSVR
LPECEAVCGKPK
LRTEGDGVYTLNDK
LRTEGDGVYTLNDK
K
LRTEGDGVYTLNNE
K
LRTEGDGVYTLNNE
KQWINK
QLVEIEK
SCAVAEYGVYVK
SPVGVQPILNEHTFC
AGMSK
TEGDGVYTLNDKKQ
WINK
TEGDGVYTLNNEK
TEGDGVYTLNNEKQ
WINK
VGYVSGWGR
VMPICLPSK
VMPICLPSKDYAEVG
R
VTSIQDWVQK
YVMLPVADQDQCIR
13
65
22
382
.45
50.6
-0.237
0.8
5
0.264
1.2
0
-0.357
0.7
8
P02774.
1
Vitamin
D-binding
protein
14
95
22
372
.13
51.2
-0.112
0.9
3
0.742
1.6
7
1.521
2.8
7
P01008.
1
Antithrom
bin-III
47
EDFTSLSLVLYSR
EFSHLGKEDFTSLSL
VLYSR
ELPEHTVK
ELSSFIDK
ELSSFIDKGQELCAD
YSENTFTEYK
ELSSFIDKGQELCAD
YSENTFTEYKK
EYANQFMWEYSTNY
GQAPLSLLVSYTK
GQELCADYSENTFTE
YK
HQPQEFPTYVEPTND
EICEAFR
HQPQEFPTYVEPTND
EICEAFRK
HQPQEFPTYVEPTND
EICEAFRKDPK
KELSSFIDKGQELCA
DYSENTFTEYK
LAQKVPTADLEDVLP
LAEDITNILSK
SCESNSPFPVHPGTAE
CCTK
SLGECCDVEDSTTCF
NAK
TAMDVFVCTYFMPA
AQLPELPDVELPTNK
THLPEVFLSK
VCSQYAAYGEK
VLEPTLK
VMDKYTFELSR
VPTADLEDVLPLAED
ITNILSK
YTFELSR
ADGESCSASMMYQE
GK
AFLEVNEEGSEAAAS
TAVVIAGR
DDLYVSDAFHK
DIPMNPMCIYR
ELFYKADGESCSASM
MYQEGK
ELTPEVLQEWLDELE
EMMLVVHMPR
EQLQDMGLVDLFSPE
K
EVPLNTIIFMGR
FRIEDGFSLKEQLQD
MGLVDLFSPEK
GDDITMVLILPKPEK
IEDGFSLK
ITDVIPSEAINELTVL
VLVNTIYFK
LPGIVAEGRDDLYVS
DAFHK
LQPLDFK
LQPLDFKENAEQSR
NDNDNIFLSPLSISTA
FAMTK
RVAEGTQVLELPFKG
DDITMVLILPKPEK
SKLPGIVAEGRDDLY
VSDAFHK
VAEGTQVLELPFK
VAEGTQVLELPFKGD
DITMVLILPKPEK
VEKELTPEVLQEWLD
ELEEMMLVVHMPR
VWELSK
15
64
21
368
.56
43
-0.131
0.9
1
0.17
1.1
3
0.262
1.2
0
P00734.
2
Prothromb
in
16
161
19
365
.85
46.7
0.203
1.1
5
1.627
3.0
9
1.794
3.4
7
P02790.
2
Hemopexi
n
48
DKLAACLEGNCAEG
LGTNYR
ELLESYIDGR
ENLDRDIALMK
HQDFNSAVQLVENF
CR
ISMLEK
ITDNMFCAGYKPDEG
K
ITDNMFCAGYKPDEG
KR
IVEGSDAEIGMSPWQ
VMLFR
KPVAFSDYIHPVCLP
DRETAASLLQAGYK
KSPQELLCGASLISDR
LAACLEGNCAEGLG
TNYR
NPDSSTTGPWCYTTD
PTVR
RQECSIPVCGQDQVT
VAMTPR
SEGSSVNLSPPLEQC
VPDR
SEGSSVNLSPPLEQC
VPDRGQQYQGR
SGIECQLWR
SPQELLCGASLISDR
TATSEYQTFFNPR
TFGSGEADCGLRPLF
EK
WYQMGIVSWGEGCD
R
WYQMGIVSWGEGCD
RDGK
DGWHSWPIAHQWPQ
GPSAVDAAFSWEEK
DVRDYFMPCPGR
DYFMPCPGR
EVGTPHGIILDSVDA
AFICPGSSR
EWFWDLATGTMK
FDPVRGEVPPR
GECQAEGVLFFQGD
R
GECQAEGVLFFQGD
REWFWDLATGTMK
GECQAEGVLFFQGD
REWFWDLATGTMKE
R
GEFVWK
LEKEVGTPHGIILDSV
DAAFICPGSSR
LLQDEFPGIPSPLDAA
VECHR
LWWLDLK
NFPSPVDAAFR
RLEKEVGTPHGIILDS
VDAAFICPGSSR
SGAQATWTELPWPH
EK
SGAQATWTELPWPH
EKVDGALCMEK
VDGALCMEK
VWVYPPEK
17
71
19
336
.5
39.8
-0.285
0.8
2
0.728
1.6
6
0.892
1.8
6
P00747.
2
Plasminog
en
18
72
17
320
.84
31.1
0.759
1.6
9
1.643
3.1
2
1.909
3.7
6
Q14624.
4
Interalphatrypsin
inhibitor
heavy
chain H4
49
ATTVTGTPCQDWAA
QEPHR
DVVLFEK
EAQLPVIENK
FGMHFCGGTLISPEW
VLTAAHCLEK
FSPATHPSEGLEENY
CR
FVTWIEGVMR
KLYDYCDVPQCAAP
SFDCGKPQVEPK
LFLEPTR
LSSPAVITDK
NPDADKGPWCFTTD
PSVR
NPDGDVGGPWCYTT
NPR
NPDNDPQGPWCYTT
DPEKR
TECFITGWGETQGTF
GAGLLK
TMSGLECQAWDSQS
PHAHGYIPSK
TPENYPNAGLTMNY
CR
VILGAHQEVNLEPHV
QEIEVSR
VIPACLPSPNYVVAD
R
VQSTELCAGHLAGG
TDSCQGDSGGPLVCF
EK
WELCDIPR
ATTVTGTPCQDWAA
QEPHR
DVVLFEK
EAQLPVIENK
FGMHFCGGTLISPEW
VLTAAHCLEK
FSPATHPSEGLEENY
CR
FVTWIEGVMR
KLYDYCDVPQCAAP
SFDCGKPQVEPK
LFLEPTR
LSSPAVITDK
NPDADKGPWCFTTD
PSVR
NPDGDVGGPWCYTT
NPR
NPDNDPQGPWCYTT
DPEKR
TECFITGWGETQGTF
GAGLLK
TMSGLECQAWDSQS
PHAHGYIPSK
TPENYPNAGLTMNY
CR
VILGAHQEVNLEPHV
QEIEVSR
VIPACLPSPNYVVAD
R
VQSTELCAGHLAGG
TDSCQGDSGGPLVCF
EK
WELCDIPR
19
53
17
274
.73
36.4
0.075
1.0
5
0.979
1.9
7
1.42
2.6
8
P01011.
2
Alpha-1antichymo
trypsin
20
45
16
254
.97
45.4
-0.095
0.9
4
0.686
1.6
1
1.318
2.4
9
P06727.
3
Apolipopr
otein A-IV
21
53
15
250
.09
36.3
-0.547
0.6
8
-0.227
0.8
5
-0.725
0.6
0
P04003.
2
C4bbinding
protein
alpha
chain
50
ADLSGITGAR
AKWEMPFDPQDTHQ
SR
AVLDVFEEGTEASAA
TAVK
AVLDVFEEGTEASAA
TAVKITLLSALVETR
DEELSCTVVELK
EIGELYLPK
EQLSLLDR
EQLSLLDRFTEDAK
GTHVDLGLASANVD
FAFSLYK
ITLLSALVETR
LINDYVK
LYGSEAFATDFQDSA
AAK
LYGSEAFATDFQDSA
AAKK
MEEVEAMLLPETLK
MEEVEAMLLPETLK
R
RLYGSEAFATDFQDS
AAAK
WEMPFDPQDTHQSR
ALVQQMEQLR
ENADSLQASLRPHAD
ELK
IDQNVEELK
IDQTVEELR
LAPLAEDVR
LEPYADQLR
LGEVNTYAGDLQK
LKEEIGKELEELR
LTPYADEFK
LTPYADEFKVK
LVPFATELHER
RVEPYGENFNKALV
QQMEQLR
SELTQQLNALFQDK
SLAELGGHLDQQVEE
FR
SLAELGGHLDQQVEE
FRR
SLAPYAQDTQEKLN
HQLEGLTFQMK
CEWETPEGCEQVLTG
K
EDVYVVGTVLR
FSAICQGDGTWSPR
GVGWSHPLPQCEIVK
KPDVSHGEMVSGFG
PIYNYKDTIVFK
LMQCLPNPEDVK
LSLEIEQLELQR
MALEVYK
MALEVYKLSLEIEQL
ELQR
QSSSYSFFKEEIIYEC
DK
SHSTQTLTCNSDGEW
VYNTFCIYK
SRPANHCVYFYGDEI
SFSCHETSR
TPSCGDICNFPPK
TWYPEVPKCEWETP
EGCEQVLTGKR
WTPYQGCEALCCPEP
K
22
23
14
241
.85
14
1.381
2.6
0
2.044
4.1
2
2.917
7.5
5
P01031.
4
Complem
ent C5
AFTECCVVASQLR
ALVEGVDQLFTDYQI
K
DGHVILQLNSIPSSDF
LCVR
DVFLEMNIPYSVVR
FSDASYQSINIPVTQN
MVPSSR
IDTQDIEASHYR
IPLDLVPK
LSMDIDVSYK
MSAVEGICTSESPVID
HQGTK
MVETTAYALLTSLNL
K
QLPGGQNPVSYVYLE
VVSK
SYFPESWLWEVHLVP
R
TSTSEEVCSFYLK
VSITSITVENVFVK
23
179
14
259
.83
56.6
0.125
1.0
9
0.165
1.1
2
-0.868
0.5
5
P01876.
2
Ig alpha-1
chain C
region
DASGVTFTWTPSSGK
DLCGCYSVSSVLPGC
AEPWNHGK
GDTFSCMVGHEALPL
AFTQK
KGDTFSCMVGHEAL
PLAFTQK
LAGKPTHVNVSVVM
AEVDGTCY
NFPPSQDASGDLYTT
SSQLTLPATQCLAGK
QEPSQGTTTFAVTSIL
R
SGNTFRPEVHLLPPPS
EELALNELVTLTCLA
R
TFTCTAAYPESK
TPLTATLSK
VAAEDWK
VAAEDWKKGDTFSC
MVGHEALPLAFTQK
WLQGSQELPR
WLQGSQELPREK
24
41
13
246
.37
25.9
-0.507
0.7
0
-1.449
0.3
7
-0.932
0.5
2
P00751.
2
Complem
ent factor
B
ALFVSEEEK
DAQYAPGYDKVKDI
SEVVTPR
EAGIPEFYDYDVALI
K
EELLPAQDIK
EKLQDEDLGFL
FLCTGGVSPYADPNT
CR
HVIILMTDGLHNMG
GDPITVIDEIR
KEAGIPEFYDYDVAL
IK
LLQEGQALEYVCPSG
FYPYPVQTR
QLNEINYEDHKLK
VKDISEVVTPR
VSEADSSNADWVTK
WSGQTAICDNGAGY
CSNPGIPIGTR
51
25
35
13
236
.8
44.9
0.472
1.3
9
1.611
3.0
5
1.783
3.4
4
P25311.
2
Zincalpha-2glycoprote
in
AGEVQEPELR
AYLEEECPATLR
DYIEFNK
EDIFMETLK
EIPAWVPFDPAAQIT
K
HVEDVPAFQALGSLN
DLQFFR
NILDRQDPPSVVVTS
HQAPGEK
QDPPSVVVTSHQAPG
EK
QKWEAEPVYVQR
QVEGMEDWK
QVEGMEDWKQDSQL
QK
WEAEPVYVQR
YYYDGKDYIEFNK
26
55
12
212
.34
23.8
-0.245
0.8
4
-0.446
0.7
3
0.278
1.2
1
P19823.
2
Interalphatrypsin
inhibitor
heavy
chain H2
27
34
12
205
.15
20.9
0.38
1.3
0
0.389
1.3
1
0.624
1.5
4
P19827.
3
Interalphatrypsin
inhibitor
heavy
chain H1
28
73
11
199
.84
36.5
-1.059
0.4
8
0.678
1.6
0
0.322
1.2
5
P01871.
3
Ig mu
chain C
region
AEDHFSVIDFNQNIR
ETAVDGELVVLYDV
KREEK
FLHVPDTFEGHFDGV
PVISK
HLEVDVWVIEPQGLR
IQPSGGTNINEALLR
MLADAPPQDPSCCSG
ALYYGSK
NVQFNYPHTSVTDVT
QNNFHNYFGGSEIVV
AGK
SILQMSLDHHIVTPLT
SLVIENEAGDER
SLPGESEEMMEEVDQ
VTLYSYKVQSTITSR
SSALDMENFR
TILDDLR
TILDDLRAEDHFSVID
FNQNIR
ADVQAHGEGQEFSIT
CLVDEEEMK
ADVQAHGEGQEFSIT
CLVDEEEMKK
EVAFDLEIPK
GMADQDGLKPTIDK
PSEDSPPLEMLGPR
GSLVQASEANLQAA
QDFVR
LDAQASFLPK
LWAYLTIQELLAK
QAVDTAVDGVFIR
QLVHHFEIDVDIFEPQ
GISK
QYYEGSEIVVAGR
TAFISDFAVTADGNA
FIGDIKDKVTAWK
VTFQLTYEEVLK
DVMQGTDEHVVCK
EGKQVGSGVTTDQV
QAEAK
ESATITCLVTGFSPAD
VFVQWMQR
FTCTVTHTDLPSPLK
GQPLSPEKYVTSAPM
PEPQAPGR
GVALHRPDVYLLPPA
R
NVPLPVIAELPPK
QVGSGVTTDQVQAE
AK
STGKPTLYNVSLVMS
DTAGTCY
YAATSQVLLPSKDV
MQGTDEHVVCK
YVTSAPMPEPQAPGR
52
29
49
11
184
.25
21.1
-0.317
0.8
0
0.306
1.2
4
0.19
1.1
4
P01042.
2
Kininogen
-1
DFVQPPTK
DIPTNSPELEETLTHTI
TK
ENFLFLTPDCK
FKLDDDLEHQGGHV
LDHGHK
IASFSQNCDIYPGKDF
VQPPTK
LGQSLDCNAEVYVV
PWEK
TVGSDTFYSFK
TVGSDTFYSFKYEIK
TWQDCEYKDAAK
YEIKEGDCPVQSGK
YFIDFVAR
30
16
11
156
.93
16.7
0.145
1.1
1
1.876
3.6
7
1.754
3.3
7
P04264.
6
Keratin,
type II
cytoskelet
al 1
DYQELMNTK
IEISELNR
NMQDMVEDYR
QISNLQQSISDAEQR
SKAEAESLYQSK
SKAEAESLYQSKYEE
LQITAGR
SLDLDSIIAEVK
SLDLDSIIAEVKAQYE
DIAQK
TNAENEFVTIK
WELLQQVDTSTR
YEELQITAGR
31
72
10
204
.75
78.2
1.339
2.5
3
4.294
19.
62
3.083
8.4
7
P68871.
2
Hemoglob
in subunit
beta
32
25
10
189
.08
26.7
-0.989
0.5
0
-1.061
0.4
8
-0.561
0.6
8
P06396.
1
Gelsolin
EFTPPVQAAYQK
FFESFGDLSTPDAVM
GNPK
FFESFGDLSTPDAVm
GNPK
GTFATLSELHCDK
GTFATLSELHCDKLH
VDPENFR
LHVDPENFR
LLVVYPWTQR
SAVTALWGK
VLGAFSDGLAHLDN
LK
VNVDEVGGEALGR
VVAGVANALAHKYH
AQPVQVAEGSEPDGF
WEALGGK
DSQEEEKTEALTSAK
EVQGFESATFLGYFK
NWRDPDQTDGLGLS
YLSSHIANVER
QTQVSVLPEGGETPL
FK
SEDCFILDHGK
TPSAAYLWVGTGAS
EAEK
VHVSEEGTEPEAMLQ
VLGPKPALPAGTEDT
AK
VPEARPNSMVVEHPE
FLK
VPFDAATLHTSTAM
AAQHGMDDDGTGQ
K
53
33
23
9
169
.19
21
0.722
1.6
5
0.873
1.8
3
1.682
3.2
1
P43652.
1
Afamin
34
19
9
154
.97
31.7
0.528
1.4
4
1.256
2.3
9
1.746
3.3
5
P08697.
3
Alpha-2antiplasmi
n
35
37
8
164
.39
34.8
-0.721
0.6
1
-0.451
0.7
3
-0.717
0.6
1
P02765.
1
Alpha-2HSglycoprote
in
36
20
8
153
.51
20.4
0.08
1.0
6
0.422
1.3
4
0.632
1.5
5
P10643.
2
Complem
ent
componen
t C7
37
30
8
156
.9
36.8
-0.053
0.9
6
2.741
6.6
9
2.19
4.5
6
P02763.
1
Alpha-1acid
glycoprote
in 1
/orosomuc
oid 1
54
AESPEVCFNEESPK
ESLLNHFLYEVAR
HELTDEELQSLFTNF
ANVVDK
HPDLSIPELLR
IAPQLSTEELVSLGEK
KSDVGFLPPFPTLDPE
EK
LKHELTDEELQSLFT
NFANVVDK
SDVGFLPPFPTLDPEE
K
TYVPPPFSQDLFTFH
ADMCQSQNEELQR
DSFHLDEQFTVPVEM
MQAR
ELKEQQDSPGNKDFL
QSLK
EQQDSPGNKDFLQSL
K
GFPIKEDFLEQSEQLF
GAKPVSLTGK
HQMDLVATLSQLGL
QELFQAPDLR
IQEFLSGLPEDTVLLL
LNAIHFQGFWR
LCQDLGPGAFR
QEDDLANINQWVK
WFLLEQPEIQVAHFP
FK
AQLVPLPPSTYVEFT
VSGTDCVAK
EHAVEGDCDFQLLK
EHAVEGDCDFQLLK
LDGK
HTFMGVVSLGSPSGE
VSHPR
TVVQPSVGAAAGPV
VPPCPGR
VWPQQPSGELFEIEID
TLETTCHVLDPTPVA
R
ELSHLPSLYDYSAYR
GGGAGFISGLSYLEL
DNPAGNKR
LLEPHCFPLSLVPTEF
CPSPPALK
LTPLYELVK
SCVGETTESTQCEDE
ELEHLR
SVAVYGQYGGQPCV
GNAFETQSCEPTR
VLFYVDSEK
VTVSCSGGMSLEGPS
AFLCGSSLK
EQLGEFYEALDCLR
NWGLSVYADKPETT
K
SDVVYTDWK
SDVVYTDWKK
TEDTIFLR
TYMLAFDVNDEK
TYMLAFDVNDEKNW
GLSVYADKPETTK
YVGGQEHFAHLLILR
38
23
8
143
.68
35.6
1.318
2.4
9
0.562
1.4
8
1.019
2.0
3
P02649.
1
Apolipopr
otein E
39
22
8
143
.1
30.8
-0.857
0.5
5
-0.4
0.7
6
-0.68
0.6
2
O43866.
1
CD5
antigenlike
40
14
8
134
.58
22.4
0.099
1.0
7
0.982
1.9
8
1.68
3.2
0
P36955.
4
Pigment
epithelium
-derived
factor
41
42
8
133
.48
31.8
0.066
1.0
5
0.375
1.3
0
0.436
1.3
5
P02749.
3
Beta-2glycoprote
in 1
42
25
8
129
.38
23.6
0.119
1.0
9
0.238
1.1
8
0.839
1.7
9
P10909.
1
Clusterin
43
48
7
152
.35
72.7
0.207
1.1
5
0.509
1.4
2
0.892
1.8
6
P02766.
1
Transthyre
tin
55
AATVGSLAGQPLQER
ALMDETMKELK
AYKSELEEQLTPVAE
ETR
FWDYLR
GEVQAMLGQSTEEL
R
SWFEPLVEDMQR
VQAAVGTSAAPVPS
DNH
WVQTLSEQVQEELLS
SQVTQELR
EATLQDCPSGPWGK
ELGCGAASGTPSGIL
YEPPAEK
ELGCGAASGTPSGIL
YEPPAEKEQK
FWGFHDCTHQEDVA
VICSG
GQWGTVCDDGWDIK
GQWGTVCDDGWDIK
DVAVLCR
GVWGSVCDDNWGE
KEDQVVCK
IWLDNVR
ALYYDLISSPDIHGTY
K
ALYYDLISSPDIHGTY
KELLDTVTAPQK
EIPDEISILLLGVAHF
K
ELLDTVTAPQK
KTSLEDFYLDEER
LAAAVSNFGYDLYR
LQSLFDSPDFSK
YGLDSDLSCK
ATFGCHDGYSLDGPE
EIECTK
CSYTEDAQCIDGTIE
VPK
CTEEGKWSPELPVCA
PIICPPPSIPTFATLR
DKATFGCHDGYSLD
GPEEIECTK
KCSYTEDAQCIDGTI
EVPK
TCPKPDDLPFSTVVP
LK
TFYEPGEEITYSCKPG
YVSR
WSPELPVCAPIICPPP
SIPTFATLR
ASSIIDELFQDR
EILSVDCSTNNPSQA
K
KTLLSNLEEAK
LFDSDPITVTVPVEVS
R
QQTHMLDVMQDHFS
R
RELDESLQVAER
TLLSNLEEAK
VTTVASHTSDSDVPS
GVTEVVVK
AADDTWEPFASGK
ALGISPFHEHAEVVF
TANDSGPR
GSPAINVAVHVFR
KAADDTWEPFASGK
TSESGELHGLTTEEEF
VEGIYK
TSESGELHGLTTEEEF
VEGIYKVEIDTK
YTIAALLSPYSYSTTA
VVTNPKE
44
34
7
128
.73
23.8
-0.213
0.8
6
0.175
1.1
3
0.022
1.0
2
P04217.
4
Alpha-1Bglycoprote
in
45
20
7
120
.08
13.8
0.698
1.6
2
2.23
4.6
9
2.817
7.0
5
P05155.
2
Plasma
protease
C1
inhibitor
46
50
7
112
.67
85.8
0.356
1.2
8
1.266
2.4
0
0.362
1.2
9
P0CG05
.1
Ig lambda2 chain C
regions
47
12
7
111
.61
11.5
-0.227
0.8
5
1.483
2.8
0
1.061
2.0
9
P13671.
3
Complem
ent
componen
t C6
48
27
7
108
.78
19.2
-0.396
0.7
6
-0.19
0.8
8
0.219
1.1
6
P04004.
1
Vitronecti
n
49
26
7
105
.71
49.2
0.778
1.7
1
2.857
7.2
5
1.029
2.0
4
P69905.
2
Hemoglob
in subunit
alpha
56
CEGPIPDVTFELLR
LELHVDGPPPRPQLR
LLELTGPK
SLPAPWLSMAPVSWI
TPGLK
SWVPHTFESELSDPV
ELLVAES
TPGAAANLELIFVGP
QHAGNYR
VTLTCVAPLSGVDFQ
LR
GVTSVSQIFHSPDLAI
R
IKVTTSQDMLSIMEK
LEDMEQALSPSVFK
LLDSLPSDTR
TNLESILSYPK
VTTSQDMLSIMEK
AAPSVTLFPPSSEELQ
ANK
ADSSPVKAGVETTTP
SK
AGVETTTPSK
AGVETTTPSKQSNNK
YAASSYLSLTPEQWK
ATLVCLISDFYPGAV
TVAWK
SYSCQVTHEGSTVEK
YAASSYLSLTPEQWK
DLTSLGHNENQQGSF
SSQGGSSFSVPIFYSS
K
IGESIELTCPK
SEYGAALAWEK
TECIKPVVQEVLTITP
FQR
TFSEWLESVK
VPANLENVGFEVQT
AEDDLK
VPANLENVGFEVQT
AEDDLKTDFYK
DWHGVPGQVDAAM
AGR
GQYCYELDEK
LIRDVWGIEGPIDAAF
TR
MDWLVPATCEPIQSV
FFFSGDK
RVDTVDPPYPR
SIAQYWLGCPAPGHL
VDTVDPPYPR
KVADALTNAVAHVD
DMPNALSALSDLHA
HK
KVADALTNAVAHVD
DMPNALSALSDLHA
HKLR
TYFPHFDLSHGSAQV
K
VADALTNAVAHVDD
MPNALSALSDLHAH
K
VADALTNAVAHVDD
MPNALSALSDLHAH
KLR
VDPVNFK
VGAHAGEYGAEALE
R
50
22
6
114
.22
30.3
0.563
1.4
8
3.444
10.
88
3.097
8.5
6
P19652.
2
Alpha-1acid
glycoprote
in 2
51
23
6
110
.95
21.5
-0.121
0.9
2
0.276
1.2
1
0.334
1.2
6
P02760.
1
Protein
AMBP
52
12
6
92.
51
26.4
-0.779
0.5
8
-0.471
0.7
2
0.414
1.3
3
P27169.
3
Serum
paraoxona
se/aryleste
rase 1
53
52
5
93.
68
79.2
0.006
1.0
0
1.529
2.8
9
0.753
1.6
9
P01834.
1
Ig kappa
chain C
region
54
9
5
85.
93
14
-0.264
0.8
3
0.869
1.8
3
-0.298
0.8
1
P07357.
2
Complem
ent
componen
t C8 alpha
chain
55
12
5
72.
06
10.2
-0.211
0.8
6
0.308
1.2
4
0.186
1.1
4
P05156.
2
Complem
ent factor
I
AQLGDLPWQVAIK
GLETSLAECTFTK
IVIEYVDR
TMGYQDFADVVCYT
QK
VFSLQWGEVK
56
9
5
71.
22
10.5
-0.022
0.9
8
-0.283
0.8
2
0.613
1.5
3
P06681.
2
Complem
ent C2
57
7
5
69.
93
13.7
1.051
2.0
7
1.987
3.9
6
1.562
2.9
5
P08670.
2
Vimentin
precursor
AVISPGFDVFAK
KNQGILEFYGDDIAL
LK
LDVDWR
LLGMETMAWQEIR
QPYSYDFPEDVAPAL
GTSFSHMLGATNPTQ
K
MSTRSVSSSS
EEMLQREEAE
RKLLEGEESR
ISLPLPNFSS
TLLIKTVETR
57
EQLGEFYEALDCLCI
PR
NWGLSFYADKPETT
K
SDVMYTDWK
TEDTIFLR
TLMFGSYLDDEK
TLMFGSYLDDEKNW
GLSFYADKPETTK
AFIQLWAFDAVK
EDSCQLGYSAGPCM
GMTSR
ETLLQDFR
GECVPGEQEPEPILIP
R
KEDSCQLGYSAGPC
MGMTSR
VVAQGVGIPEDSIFT
MADR
EVQPVELPNCNLVK
FDVSSFNPHGISTFTD
EDNAMYLLVVNHPD
AK
GIETGSEDLEILPNGL
AFISSGLKYPGIK
IFFYDSENPPASEVLR
ILLMDLNEEDPTVLE
LGITGSK
IQNILTEEPK
DSTYSLSSTLTLSK
SGTASVVCLLNNFYP
R
TVAAPSVFIFPPSDEQ
LK
VDNALQSGNSQESVT
EQDSK
VYACEVTHQGLSSPV
TK
ALDQYLMEFNACR
AMAVEDIISR
FGGTICSGDIWDQAS
CSSSTTCVR
LGSLGAACEQTQTEG
AK
YNPVVIDFEMQPIHE
VLR
58
7
5
69.
14
14.6
1.098
2.1
4
2.895
7.4
4
3.015
8.0
8
P05546.
3
Heparin
cofactor 2
GGETAQSADPQWEQ
LNNK
HQGTITVNEEGTQAT
TVTTVGFMPLSTQVR
IAIDLFK
NYNLVESLK
QFPILLDFK
59
36
5
73.
15
37.3
0.216
1.1
6
0.759
1.6
9
1.834
3.5
7
P02656.
1
Apolipopr
otein C-III
60
32
4
89.
49
9.8
0.117
1.0
8
1.82
3.5
3
2.138
4.4
0
P01019.
1
Angiotens
inogen
DALSSVQESQVAQQ
AR
DYWSTVK
GWVTDGFSSLK
GWVTDGFSSLKDYW
STVK
TAKDALSSVQESQVA
QQAR
ALQDQLVLVAAK
DPTFIPAPIQAK
SLDFTELDVAAEK
SLDFTELDVAAEKID
R
61
22
4
76.
36
12.3
1.212
2.3
2
1.145
2.2
1
0.544
1.4
6
P04196.
1
Histidinerich
glycoprote
in
DGYLFQLLR
GEVLPLPEANFPSFPL
PHHK
GGEGTGYFVDFSVR
YKEENDDFASFRVDR
62
5
4
71.
51
11.7
-0.061
0.9
6
1.442
2.7
2
1.427
2.6
9
P35908.
2
Keratin,
type II
cytoskelet
al 2
epidermal
IEISELNR
NLDLDSIIAEVK
SKEEAEALYHSKYEE
LQVTVGR
VDLLNQEIEFLK
63
42
4
71.
67
42
0.95
1.9
3
3.061
8.3
5
3.757
13.
52
P02652.
1
Apolipopr
otein A-II
64
9
4
71.
13
14.4
-0.588
0.6
7
-1.253
0.4
2
-0.359
0.7
8
Q96PD5
.1
Nacetylmur
amoyl-Lalanine
amidase
65
11
4
69.
71
17.7
0.279
1.2
1
1.562
2.9
5
2.39
5.2
4
P08185.
1
Corticoste
roidbinding
globulin
EPCVESLVSQYFQTV
TDYGK
EPCVESLVSQYFQTV
TDYGKDLMEK
EPCVESLVSQYFQTV
TDYGKDLmEK
EQLTPLIK
SPELQAEAK
EFTEAFLGCPAIHPR
EGKEYGVVLAPDGS
TVAVEPLLAGLEAGL
QGR
GCPDVQASLPDAK
GSQTQSHPDLGTEGC
WDQLSAPR
GTWTQPFDLASTR
HYYESEVLAMNFQD
WATASR
IVDLFSGLDSPAILVL
VNYIFFK
WSAGLTSSQVDLYIP
K
66
8
4
68.
08
9.7
0.486
1.4
0
2.058
4.1
6
2.259
4.7
9
P13645.
6
Keratin,
type I
cytoskelet
al 10
IEISELNR
NLDLDSIIAEVK
SKEEAEALYHSKYEE
LQVTVGR
VDLLNQEIEFLK
67
8
4
66.
79
23.2
-0.295
0.8
2
0.641
1.5
6
1.573
2.9
8
P05090.
1
Apolipopr
otein D
CPNPPVQENFDVNK
MTVTDQVNCPK
NPNLPPETVDSLK
WYEIEK
58
68
8
4
65.
72
43.5
0.582
1.5
0
0.618
1.5
3
1.72
3.2
9
P02655.
1
Apolipopr
otein C-II
ESLSSYWESAK
STAAMSTYTGIFTDQ
VLSVLK
STAAMSTYTGIFTDQ
VLSVLKGEE
TYLPAVDEK
69
10
3
68.
38
14.4
-0.056
0.9
6
0.839
1.7
9
1.445
2.7
2
P35527.
3
Keratin,
type I
cytoskelet
al 9
MTLDDFR
SDLEMQYETLQEEL
MALK
TLLDIDNTR
70
7
3
61.
94
11.6
0.233
1.1
8
-0.402
0.7
6
0.018
1.0
1
P02748.
2
Complem
ent
componen
t C9
AIEDYINEFSVR
FEGIACEISK
RQCVPTEPCEDAEDD
CGNDFQCSTGR
71
7
3
54.
01
16.8
-0.514
0.7
0
-0.74
0.6
0
-0.604
0.6
6
P07360.
3
72
6
3
51.
01
8.2
-0.094
0.9
4
0.36
1.2
8
0.782
1.7
2
P07358.
3
VQEAHLTEDQIFYFP
K
YGFCEAADQFHVLD
EVR
YGFCEAADQFHVLD
EVRR
DTMVEDLVVLVR
IPGIFELGISSQSDR
VKVEPLYELVTATDF
AYSSTVR
73
5
3
50.
09
14.8
-1.661
0.3
2
-0.514
0.7
0
-1.986
0.2
5
P01880.
2
Complem
ent
componen
t C8
gamma
chain
Complem
ent
componen
t C8 beta
chain
Ig delta
chain C
region
74
4
3
49.
63
8.1
-0.145
0.9
0
-0.237
0.8
5
0.724
1.6
5
P09871.
1
Complem
ent C1s
subcompo
nent
LLEVPEGR
MGPTVSPICLPGTSSD
YNLMDGDLGLISGW
GR
SNALDIIFQTDLTGQK
75
5
3
48.
97
13.6
-0.486
0.7
1
-0.024
0.9
8
0.426
1.3
4
P51884.
2
Lumican
NIPTVNENLENYYLE
VNQLEK
SLEDLQLTHNK
SLEYLDLSFNQIAR
76
3
3
46.
74
5.6
-0.455
0.7
3
0.587
1.5
0
0.876
1.8
4
P07225.
1
Vitamin
Kdependent
protein S
FSAEFDFR
NIPGDFECECPEGYR
SQDILLSVENTVIYR
77
5
3
44.
46
6.1
0.288
1.2
2
-0.01
0.9
9
0.103
1.0
7
P03952.
1
Plasma
kallikrein
GGDVASMYTPNAQY
CQMR
VAEYMDWILEK
VLTPDAFVCR
78
3
3
44.
16
9.1
0.459
1.3
7
1.226
2.3
4
1.276
2.4
2
P00748.
3
Coagulati
on factor
XII
AEEHTVVLTVTGEPC
HFPFQYHR
LHEAFSPVSYQHDLA
LLR
NPDNDIRPWCFVLNR
79
3
3
39.
68
8.3
-0.46
0.7
3
-0.065
0.9
6
0.874
1.8
3
P05154.
3
Plasma
serine
protease
inhibitor
ADFTFDLYR
GFQQLLQELNQPR
MQILEGLGLNLQK
80
5
3
34.
62
17.8
0.89
1.8
5
1.503
2.8
3
0.264
1.2
0
P20851.
1
C4bbinding
protein
beta chain
EVEGQILGTYVCIK
NLCEAMENFMQQLK
SQCLEDHTWAPPFPI
CK
59
DSYYMTSSQLSTPLQ
QWR
TPECPSHTQPLGVYL
LTPAVQDLWLR
VPTGGVEEGLLER
81
8
2
69.
93
12.8
0.121
1.0
9
0.73
1.6
6
0.649
1.5
7
P05160.
3
Coagulati
on factor
XIII B
chain
Complem
ent factor
H-related
protein 2
Ig kappa
chain VIII region
GOL
Ficolin-3
GDTYPAELYITGSILR
WSSPPVCLEPCTVNV
DYMNR
82
8
2
49.
53
17.4
0.155
1.1
1
0.649
1.5
7
0.482
1.4
0
P36980.
1
83
14
2
41.
95
30.2
-0.459
0.7
3
-0.079
0.9
5
-0.326
0.8
0
P04206.
1
84
6
2
40.
28
13.7
-0.296
0.8
1
-0.831
0.5
6
0.79
1.7
3
O75636.
2
85
7
2
40.
02
7.1
0.303
1.2
3
-2.501
0.1
8
-1.798
0.2
9
P02743.
2
Serum
amyloid
Pcomponen
t
Ig kappa
chain V-II
region
TEW
IVLGQEQDSYGGK
IVLGQEQDSYGGKFD
R
86
8
2
38.
38
31.8
-1.137
0.4
5
0.201
1.1
5
-0.192
0.8
8
P01617.
1
87
4
2
35.
37
10.9
-1.378
0.3
8
-0.897
0.5
4
-0.822
0.5
7
P01857.
1
Ig gamma1 chain C
region
2.4
7
P05543.
2
Thyroxine
-binding
globulin
TPEVTCVVVDVSHED
PEVK
TTPPVLDSDGSFFLYS
K
EGQMESVEAAMSSK
GTEAAAVPEVELSDQ
PENTFLHPIIQIDR
88
5
2
34.
94
10.3
0.108
1.0
8
1.05
2.0
7
1.304
89
3
2
32.
73
7
0.362
1.2
9
1.105
2.1
5
1.99
3.9
7
P29622.
3
Kallistatin
EIEEVLTPEMLMR
VPMMLQDQEHHWY
LHDR
90
4
2
30.
17
6.5
0.27
1.2
1
-0.58
0.6
7
0.363
1.2
9
O14791.
5
Apolipopr
otein L1
VNEPSILEMSR
VTEPISAESGEQVER
91
2
2
29.
91
5.7
-0.626
0.6
5
-0.994
0.5
0
-0.959
0.5
1
Q9BXR
6.1
Complem
ent factor
H-related
protein 5
EIMENYNIALR
ITCTEEGWSPTPK
YKPFSQVPTGEVFYY
SCEYNFVSPSK
92
3
2
28.
95
7.1
0.658
1.5
8
0.94
1.9
2
1.342
2.5
4
Q14520.
1
Plasma
hyalurona
n-binding
protein
NPDADEKPWCFIK
TVCLPDGSFPSGSEC
HISGWGVTETGK
93
4
2
27.
77
18.7
0.134
1.1
0
-0.338
0.7
9
0.397
1.3
2
P02775.
3
GKEESLDSDLYAELR
ICLDPDAPR
-0.002
1.0
0
0.063
1.0
4
0.605
1.5
2
P35858.
1
Platelet
basic
protein
Insulinlike
growth
factorbinding
protein
complex
acid labile
subunit
94
2
2
27.
67
4.6
60
TGDIVEFVCK
YKPFSQVPTGEVFYY
SCEYNFVSPSK
EIVLTQSPGTLSLSPG
ER
FSGSGSGTDFTLTISR
ALPVFCDMDTEGGG
WLVFQR
ELLSQGATLSGWYH
LCLPEGR
DIVMTQSPLSLPVTP
GEPASISCR
FSGSGSGTDFTLK
DLHFLEELQLGHNR
LAELPADALGPLQR
95
4
2
27.
28
4.7
-0.618
0.6
5
0.087
1.0
6
0.173
1.1
3
P22792.
3
Carboxyp
eptidase N
subunit 2
AGGSWDLAVQER
DHLGFQVTWPDESK
96
5
2
25.
48
8.8
0.369
1.2
9
1.276
2.4
2
1.551
2.9
3
P22352.
2
FLVGPDGIPIMR
MDILSYMR
97
5
1
32.
08
7.4
1.574
2.9
8
3.349
10.
19
2.292
4.9
0
P02750.
2
98
3
1
28.
77
4.9
-0.662
0.6
3
-0.354
0.7
8
-0.007
1.0
0
Q06033.
2
99
3
1
25
5.7
0.297
1.2
3
-0.413
0.7
5
0.302
1.2
3
Q96KN
2.4
10
0
12
1
23.
86
15
0.485
1.4
0
0.12
1.0
9
-0.172
0.8
9
P01766.
1
10
1
4
1
22.
6
15.7
-0.303
0.8
1
-0.294
0.8
2
-0.46
0.7
3
P01598.
1
10
2
6
1
20.
6
15.7
-0.303
0.8
1
-0.017
0.9
9
-0.511
0.7
0
P01593.
1
10
3
1
1
20.
58
2.9
-0.997
0.5
0
-0.01
0.9
9
1.064
2.0
9
P80108.
3
10
4
1
1
20.
35
2.3
0.24
1.1
8
0.751
1.6
8
0.047
1.0
3
P02671.
2
10
5
1
1
20.
17
15.7
-0.466
0.7
2
0.175
1.1
3
-0.303
0.8
1
P01611.
1
10
6
10
7
10
8
2
1
0.2
-0.779
3.4
-1.914
6
1
15.1
-0.452
1.0
6
0.8
2
1.5
2
-1.914
1
0.5
8
0.2
7
0.7
3
0.078
1
19.
01
18.
97
18.
57
0.2
7
0.5
5
0.9
2
P08519.
1
P06276.
1
P01774.
1
10
9
2
1
18.
3
14.9
-2.438
0.1
8
-0.424
0.7
5
-0.6
0.6
6
P01625.
2
11
0
5
1
17.
59
9.4
-0.465
0.7
2
-0.294
0.8
2
-0.165
0.8
9
P01591.
4
11
1
2
1
17.
31
15.7
0.32
1.2
5
-1.093
0.4
7
0.113
1.0
8
P01714.
1
11
2
1
1
16.
92
3.9
0
1.0
0
0
1.0
0
0
1.0
0
P01854.
1
11
3
11
4
2
1
10.8
0.593
16.8
1.542
39.
84
0.5
8
5.85
1
1.5
1
2.9
1
5.316
3
16.
69
16.
17
57.
68
0.8
2
P02654.
1
P01717.
1
Glutathion
e
peroxidase
3
Leucinerich alpha2glycoprote
in
Interalphatrypsin
inhibitor
heavy
chain H3
Beta-AlaHis
dipeptidas
e
Ig heavy
chain VIII region
BRO
Ig kappa
chain V-I
region EU
Ig kappa
chain V-I
region AG
Phosphati
dylinositol
-glycanspecific
phospholi
pase D
Fibrinoge
n alpha
chain
Ig kappa
chain V-I
region
Wes
Apolipopr
otein(a)
Cholineste
rase
Ig heavy
chain VIII region
POM
Ig kappa
chain VIV region
Len
Immunogl
obulin J
chain
Ig lambda
chain VIII region
SH
Ig epsilon
chain C
region
Apolipopr
otein C-I
Ig lambda
chain VIV region
-0.28
0.608
-0.776
61
-0.859
-0.115
-0.286
DLLLPQPDLR
STSIVIMLTDGDANV
GESRPEK
AIHLDLEEYR
EVQLVESGGGLVQP
GGSLR
DIQMTQSPSTLSASV
GDR
DIQMTQSPSSLSASV
GDR
FGGVLHLSDLDDDG
LDEIIMAAPLR
TFPGFFSPMLGEFVSE
TESR
DIQMTQSPSSVSASV
GDR
EWFSETFQK
AILQSGSFNAPWAVT
SLYEAR
EVQLLESGGGLVQPG
GSL
DIVMTQSPDSLAVSL
GER
CYTAVVPLVYGGET
K
SELTQDPAVSVALGQ
TVR
AAPEVYAFATPEWP
GS
WIYHLTEGSTDLR
SYELTQPPSVSVSPG
QTAR
Hil
11
5
2
1
16.
03
4.8
-0.731
0.6
0
-0.426
0.7
4
0.059
1.0
4
P15169.
1
11
6
2
1
15.
76
16.3
1.213
2.3
2
1.303
2.4
7
1.018
2.0
3
P0DJI8.
1
11
7
2
1
15.
68
3.7
-0.355
0.7
8
0.782
1.7
2
0.888
1.8
5
Q96IY4
.2
11
8
1
1
15.
59
7.8
-0.601
0.6
6
-0.353
0.7
8
-1.48
0.3
6
P04433.
1
11
9
1
1
15.
46
20.5
-3.216
0.1
1
-3.216
0.1
1
0
1.0
0
P01616.
1
12
0
12
1
12
2
1
1
1
-0.79
3.6
-0.633
1
1
5.1
-0.768
0.4
6
1.1
9
1.1
3
-1.058
1
0.5
8
0.6
4
0.5
9
-1.11
2
15.
22
15.
18
14.
72
0.4
8
1.6
0
2.6
2
P07996.
2
P27918.
2
P01861.
1
12
3
1
1
14
5.2
-1.191
0.4
4
-0.393
0.7
6
-2.173
0.2
2
P01859.
2
12
4
12
5
12
6
1
1
11.8
1.079
10.8
-0.316
1
1
11.5
0.476
1.7
5
3.1
3
0.2
5
1.519
1
2.1
1
0.8
0
1.3
9
0.809
1
13.
71
13.
49
13.
47
2.8
7
4.4
1
0.3
1
P05109.
1
P31151.
4
P35542.
2
12
7
4
1
13.
33
4.5
-1.809
0.2
9
-4.079
0.0
6
-4.277
0.0
5
P50897.
1
12
8
2
1
13.
27
7.7
1.182
2.2
7
3.267
9.6
3
2.284
4.8
7
P01781.
1
12
9
3
1
13.
05
2.7
-0.041
0.9
7
2.091
4.2
6
3.573
11.
90
P50213.
1
13
0
13
1
2
1
6.9
-0.502
15.7
-0.377
2.2
0
0.3
1
1.853
1
0.7
1
0.7
7
1.137
1
12.
97
12.
74
3.6
1
0.2
2
O95445.
2
P04430.
1
13
2
1
1
12.
6
7.5
-0.26
0.8
4
-1.288
0.4
1
0.82
1.7
7
P04070.
1
13
3
13
4
1
1
13.1
1.091
0.6
-1.459
22.
75
0.3
5
4.485
1
2.1
3
0.3
6
4.508
1
12.
39
12.
32
22.
39
0.4
6
P06702.
1
Q5XPI4
.1
13
5
1
1
11.
84
4.5
-0.161
1.0
1
P00742.
2
0.8
9
0.248
0.173
1.645
-1.972
-1.688
-1.528
-1.043
0.4
9
62
0.675
1.389
2.141
-1.698
-2.158
-1.132
0.017
Carboxyp
eptidase N
catalytic
chain
Serum
amyloid
A-1
protein
Carboxyp
eptidase
B2
Ig kappa
chain VIII region
VG
Ig kappa
chain V-II
region
MIL
Thrombos
pondin-1
Properdin
Ig gamma4 chain C
region
Ig gamma2 chain C
region
Protein
S100-A8
Protein
S100-A7
Serum
amyloid
A-4
protein
Palmitoylprotein
thioesteras
e1
Ig heavy
chain VIII region
GAL
Isocitrate
dehydroge
nase
[NAD]
subunit
alpha,
mitochond
rial
Apolipopr
otein M
Ig kappa
chain V-I
region
BAN
Vitamin
Kdependent
protein C
Protein
S100-A9
E3
ubiquitinprotein
ligase
RNF123
Coagulati
on factor
HLYVLEFSDHPGIHE
PLEPEV
FFGHGAEDSLADQA
ANEWG
*
DIQMTQSPSSLSASV
GDR
DIVLTQSPLSLPVTPG
EPASISCR
FVFGTTPEDILR
*
TTPPVLDSDGSFFLYS
R
TTPPMLDSDGSFFLY
SK
LLETECPQYIR
GTNYLADVFEK
SFFKEALQGVGDMG
R
CPGESSHICDFIRK
GLEWVANIK
IAEFAFEYAR
WIYHLTEGSTDLR
DIQLTQSPSSLSASVG
DR
STTDNDIALLHLAQP
ATLSQTIVPICLPDSG
LAER
LLETECPQYIR
FLQENASGR
ITVVAGEHNIEETEHT
EQKR
X
13
6
13
7
1
1
11.
6
11.
49
2.3
-0.465
1
1
13
8
13
9
2
1
1
1
14
0
1
14
1
0.7
2
0.5
8
7.2
6
0.2
8
P43251.
2
P00740.
2
4.3
-0.789
11.
36
11.
26
1.5
0.306
1.3
1
0.9
8
O15265.
1
Q7Z353
.1
3.9
-0.606
1
11.
23
2.4
1.952
3.8
7
-1.295
0.4
1
2.614
6.1
2
P01833.
4
2
1
11.
16
10.9
-1.142
0.4
5
-3.046
0.1
2
-4.978
0.0
3
Q6ZN0
3.1
14
2
1
1
11.
14
0.4
0.117
1.0
8
0
1.0
0
-1.596
0.3
3
Q96M8
6.2
14
3
1
1
11.
13
4.7
-0.191
0.8
8
-2.062
0.2
4
-1.817
0.2
8
Q8N336
.3
14
4
14
5
2
1
5.2
0.039
1
1
11.
12
10.
91
1.0
3
0.6
2
1.466
2.7
6
0.5
7
1.978
3.9
4
0.6
8
P09486.
1
Q04756.
1
2.9
-0.682
14
6
1
1
10.
89
11
2.137
4.4
0
3.163
8.9
6
0.979
1.9
7
P02745.
2
14
7
1
1
10.
69
2
0.828
1.7
8
3.24
9.4
5
3.489
11.
23
Q9C0A
0.3
14
8
1
1
10.
54
4.5
2.535
5.8
0
5.277
38.
77
3.418
10.
69
P00915.
2
14
9
1
1
10.
51
0.7
-0.839
0.5
6
-0.232
0.8
5
-0.346
0.7
9
Q9P2R6
.2
15
0
15
1
1
1
1
1
10.
47
10.
3
6.9
0
0
1.345
1.0
0
1.3
2
0
11.8
1.0
0
2.5
4
1.0
0
1.0
0
P05452.
3
Q16514.
1
15
2
1
1
10.
27
6.4
0.952
1.9
3
1.558
2.9
4
1.605
3.0
4
Q9HBK
9.3
15
3
2
1
10.
21
1.3
0.085
1.0
6
-3.562
0.0
8
-4.584
0.0
4
Q8WV
M7.3
15
4
1
1
10.
21
0.6
-0.74
0.6
0
-0.598
0.6
6
-0.877
0.5
4
Q9P1Q0
.2
1.2
4
0.6
6
2.534
-2.115
0.67
0.643
-0.815
0.399
5.7
9
0.2
3
1.5
9
1.5
6
63
2.859
-1.821
0.39
-0.032
-0.56
0
Biotinidas
e
Coagulati
on factor
IX
Ataxin-7
Highly
divergent
homeobox
Polymeric
immunogl
obulin
receptor
Uncharact
erized
protein
encoded
by
LINC0032
2
Dynein
heavy
chain
domaincontaining
protein 1
ELMO
domaincontaining
protein 1
SPARC
Hepatocyt
e growth
factor
activator
Complem
ent C1q
subcompo
nent
subunit A
Contactinassociated
proteinlike 4
Carbonic
anhydrase
1
Arginineglutamic
acid
dipeptide
repeats
protein
Tetranecti
n
Transcript
ion
initiation
factor
TFIID
subunit 12
Arsenite
methyltran
sferase
Cohesin
subunit
SA-1
Vacuolar
protein
sorting-
VDLITFDTPFAGR
ITVVAGEHNIEETEHT
EQKR
IPPVPSTTSPISTR
KNYGNSSVQASEMT
VPQKPSVCHRPCK
NADLQVLKPEPELVY
EDLR
*
*
GMGLLGLYNLQYFA
ER
YIPPCLDSELTEFPLR
VQLSPDLLATLPEPA
SPGR
GLFQVVSGGMVLQL
QQGDQVWVEKDPK
RSENVDSAEAVLKSE
LNIQNAVNENQK
ADGLAVIGVLMK
TDLYFMPLAGSK
NWETEITAQPDGGK
*
YGFQASNVTFIHGYI
EKLGEAGIK
CLKALQSLYTNRELF
PK
*
15
5
1
1
10.
2
4.7
0.526
1.4
4
-0.657
0.6
3
-0.765
0.5
9
Q08380.
1
15
6
1
1
10.
18
15.7
0
1.0
0
0
1.0
0
0
1.0
0
P01763.
1
15
7
1
1
10.
12
0
-0.445
0.7
3
1.795
3.4
7
1.804
3.4
9
Q8WZ4
2.4
64
associated
protein 54
Galectin3-binding
protein
Ig heavy
chain VIII region
WEA
Titin
AAFGQGSGPIMLDEV
QCTGTEASLADCK
QVQLVDSGGGLVEP
GGSLR
NTADLKWTVPEKDG
GSPITNYIVEK
Table S7. Complete details of protein identification and label-free MS data for differentially
expressed proteins in meningioma grade I (compared to healthy controls).
Sl
No
.
Nu
m
Spe
ctr
a
Uni
que
Pep
tide
s
Sco
re
1
415
75
118
8.1
9
2
695
67
109
1.3
6
3
389
60
982
.32
Seq
uenc
e
Cov
erag
e
(%)
52.9
HC
I
(Set
1)
HC
I
(Set
2)
HC
(Set
3)
Aver
age
MG
I
(Set
1)
MG
I
(Set
2)
MG
I
(Set
3)
Aver
age
Fol
dcha
nge
7.83
E+0
7
8.14
E+0
7
9.94
E+0
7
8636
6667
1.78
E+0
8
2.09
E+0
8
2.26
E+0
8
2043
3333
3
2.3
7
P010
24.2
74
3.23
E+0
8
3.52
E+0
8
4.20
E+0
8
3650
0000
0
6.00
E+0
8
7.29
E+0
8
7.63
E+0
8
6973
3333
3
1.9
1
P027
87.3
50
4.32
E+0
7
4.16
E+0
7
4.72
E+0
7
4400
0000
2.39
E+0
8
2.95
E+0
8
3.03
E+0
8
2790
0000
0
6.3
4
A5A6
I6.1
65
Protein Name
Acces
sion
num
ber
RecName:
Full=Complement C3:
AltName: Full=C3 and PZPlike alpha-2-macroglobulin
domain-containing protein
1: Contains: RecName:
Full=Complement C3 beta
chain: Contains: RecName:
Full=Complement C3 alpha
chain: Contains: RecName:
Full=C3a anaphylatoxin:
Contains: RecName:
Full=Acylation stimulating
protein: Short=ASP:
AltName: Full=C3adesArg:
Contains: RecName:
Full=Complement C3b
alpha' chain: Contains:
RecName:
Full=Complement C3c
alpha' chain fragment 1:
Contains: RecName:
Full=Complement C3dg
fragment: Contains:
RecName:
Full=Complement C3g
fragment: Contains:
RecName:
Full=Complement C3d
fragment: Contains:
RecName:
Full=Complement C3f
fragment: Contains:
RecName:
Full=Complement C3c
alpha' chain fragment 2:
Flags: Precursor
RecName:
Full=Serotransferrin:
Short=Transferrin:
AltName: Full=Beta-1
metal-binding globulin:
AltName:
Full=Siderophilin: Flags:
Precursor
RecName:
Full=Serotransferrin:
Short=Transferrin:
AltName: Full=Beta-1
metal-binding globulin:
AltName:
Full=Siderophilin: Flags:
Precursor
4
269
36
600
.5
74.5
4.29
E+0
7
5.12
E+0
7
5.44
E+0
7
4950
0000
1.73
E+0
8
2.06
E+0
8
2.13
E+0
8
1973
3333
3
3.9
9
P010
23.3
5
294
33
501
.32
71.9
1.56
E+0
7
1.43
E+0
8
1.22
E+0
8
9353
3333
9.86
E+0
7
1.59
E+0
8
3.01
E+0
8
1862
0000
0
1.9
9
P026
47.1
6
237
30
448
.76
56.6
2.31
E+0
8
1.77
E+0
8
1.92
E+0
8
2000
0000
0
2.81
E+0
8
3.64
E+0
8
5.50
E+0
8
3983
3333
3
1.9
9
P0DJ
G1.1
7
108
29
439
.72
26.8
1.61
E+0
7
1.07
E+0
7
1.07
E+0
7
1250
0000
4.63
E+0
7
4.79
E+0
7
3.98
E+0
7
4466
6667
3.5
7
P007
38.1
8
153
26
416
.22
48.7
48
1.04
E+0
8
7.00
E+0
7
1.04
E+0
8
9.71
E+0
7
P007
39.2
362
.25
7.00
E+0
7
6.07
E+0
7
6.9
8
21
1.47
E+0
7
5.70
E+0
7
9266
6667
159
1.12
E+0
7
7.18
E+0
7
1326
6667
9
1.39
E+0
7
5.23
E+0
7
7593
3333
1.2
6
P010
09.3
6036
6667
66
RecName: Full=Alpha-2macroglobulin:
Short=Alpha-2-M:
AltName: Full=C3 and PZPlike alpha-2-macroglobulin
domain-containing protein
5: Flags: Precursor
RecName:
Full=Apolipoprotein A-I:
Short=Apo-AI:
Short=ApoA-I: AltName:
Full=Apolipoprotein A1:
Contains: RecName:
Full=Truncated
apolipoprotein A-I:
AltName:
Full=Apolipoprotein A-I(1242): Flags:
Precursorgi|380876859|sp|G
3QY98.1|APOA1_GORGO
RecName:
Full=Apolipoprotein A-I:
Short=Apo-AI:
Short=ApoA-I: AltName:
Full=Apolipoprotein A1:
Contains: RecName:
Full=Truncated
apolipoprotein A-I: Flags:
Precursorgi|385178604|sp|P
0DJG0.1|APOA1_PANTR
RecName:
Full=Apolipoprotein A-I:
Short=Apo-AI:
Short=ApoA-I: AltName:
Full=Apolipoprotein A1:
Contains: RecName:
Full=Truncated
apolipoprotein A-I: Flags:
Precursor
RecName:
Full=Apolipoprotein A-I:
Short=Apo-AI:
Short=ApoA-I: AltName:
Full=Apolipoprotein A1:
Contains: RecName:
Full=Truncated
apolipoprotein A-I: Flags:
Precursor
RecName:
Full=Haptoglobin:
AltName: Full=Zonulin:
Contains: RecName:
Full=Haptoglobin alpha
chain: Contains: RecName:
Full=Haptoglobin beta
chain: Flags: Precursor
RecName:
Full=Haptoglobin-related
protein: Flags: Precursor
RecName: Full=Alpha-1antitrypsin: AltName:
Full=Alpha-1 protease
inhibitor: AltName:
Full=Alpha-1antiproteinase: AltName:
Full=Serpin A1: Contains:
RecName: Full=Short
peptide from AAT:
Short=SPAAT: Flags:
Precursor
10
210
20
335
.36
59.7
8.36
E+0
7
9.92
E+0
7
9.28
E+0
7
9186
6667
1.67
E+0
8
1.97
E+0
8
2.82
E+0
8
2153
3333
3
2.3
4
Q5R
CW5.
1
11
76
18
303
.55
30.6
1.81
E+0
7
8.96
E+0
6
1.02
E+0
7
1242
0000
3.17
E+0
7
3.27
E+0
7
3.18
E+0
7
3206
6667
2.5
8
P0C0
L4.1
12
117
18
302
.11
45.6
48.1
6.2
4
P018
71.3
RecName: Full=Ig mu chain
C region
130
17
278
.6
57.9
P042
20.1
111
16
218
.42
32.7
1246
6666
7
8476
6667
2.4
1
15
2.0
3
P018
76.2
RecName: Full=Ig mu
heavy chain disease protein:
AltName: Full=BOT
RecName: Full=Ig alpha-1
chain C region
16
57
15
197
.1
20.3
5666
666.7
1.3
5
P018
77.3
RecName: Full=Ig alpha-2
chain C region
17
109
14
243
.23
49.3
8.22
E+0
7
7.27
E+0
7
1.39
E+0
8
1.38
E+0
8
4.31
E+0
6
6.74
E+0
7
6720
0000
14
7.58
E+0
7
5.86
E+0
7
1.19
E+0
8
6.70
E+0
7
3.52
E+0
6
5.22
E+0
7
P027
68.2
271
.11
6.34
E+0
7
7.03
E+0
7
1.16
E+0
8
4.93
E+0
7
9.17
E+0
6
3.48
E+0
7
4.3
6
18
2.27
E+0
7
6.46
E+0
6
5.26
E+0
7
4.55
E+0
7
4.89
E+0
6
5.23
E+0
7
7380
0000
100
1.25
E+0
7
9.17
E+0
6
6.11
E+0
7
4.43
E+0
7
4.01
E+0
6
5.42
E+0
7
1693
3333
13
1.56
E+0
7
1.67
E+0
7
4.17
E+0
7
3.52
E+0
7
3.67
E+0
6
5.14
E+0
7
RecName: Full=Alpha-1antitrypsin: AltName:
Full=Alpha-1 protease
inhibitor: AltName:
Full=Alpha-1antiproteinase: AltName:
Full=Serpin A1: Flags:
Precursor
RecName:
Full=Complement C4-A:
AltName: Full=Acidic
complement C4: AltName:
Full=C3 and PZP-like
alpha-2-macroglobulin
domain-containing protein
2: Contains: RecName:
Full=Complement C4 beta
chain: Contains: RecName:
Full=Complement C4-A
alpha chain: Contains:
RecName: Full=C4a
anaphylatoxin: Contains:
RecName: Full=C4b-A:
Contains: RecName:
Full=C4d-A: Contains:
RecName:
Full=Complement C4
gamma chain: Flags:
Precursor
RecName: Full=Serum
albumin: Flags: Precursor
5146
6667
0.9
8
P004
50.1
18
82
14
232
.59
44.6
1.41
E+0
7
1.04
E+0
7
7.95
E+0
6
1081
6667
2.56
E+0
7
1.70
E+0
7
2.09
E+0
7
2116
6667
1.9
6
P027
90.2
19
142
13
207
.07
35.1
4.70
E+0
7
4.59
E+0
7
3.80
E+0
7
4363
3333
3.91
E+0
7
4.66
E+0
7
5.79
E+0
7
4786
6667
1.1
0
P027
74.1
RecName:
Full=Ceruloplasmin:
AltName: Full=Ferroxidase:
Flags: Precursor
RecName:
Full=Hemopexin: AltName:
Full=Beta-1B-glycoprotein:
Flags: Precursor
RecName: Full=Vitamin Dbinding protein:
Short=DBP: Short=VDB:
AltName: Full=Gc-globulin:
AltName: Full=Groupspecific component: Flags:
1077
6667
5180
0000
4166
6667
4190
000
5263
3333
67
Precursor
20
123
12
225
.55
77.5
7.46
E+0
7
9.03
E+0
7
7.47
E+0
7
7986
6667
5.89
E+0
7
7.16
E+0
7
8.74
E+0
7
7263
3333
0.9
1
P086
03.4
21
83
12
194
.08
49.5
1.97
E+0
7
3.09
E+0
7
3.69
E+0
7
2916
6667
4.89
E+0
7
7.29
E+0
7
1.05
E+0
8
7560
0000
2.5
9
P010
08.1
22
31
12
133
.57
19.7
3.22
E+0
6
1.73
E+0
6
1.84
E+0
6
2263
333.3
5.88
E+0
6
8.03
E+0
6
7.99
E+0
6
7300
000
3.2
3
P042
17.4
23
30
11
168
.91
24.7
2.79
E+0
6
4.37
E+0
6
1.51
E+0
6
2890
000
1.44
E+0
7
1.91
E+0
7
2.06
E+0
7
1803
3333
6.2
4
P027
66.1
24
42
11
159
.52
4.5
6.53
E+0
5
1.31
E+0
6
1.08
E+0
6
1014
333.3
4.64
E+0
6
4.54
E+0
6
3.07
E+0
6
4083
333.3
4.0
3
P027
65.1
25
120
9
155
.12
92.4
3.41
E+0
7
4.64
E+0
7
4.60
E+0
7
4216
6667
6.89
E+0
7
9.70
E+0
7
8.10
E+0
7
8230
0000
1.9
5
Q9N2
D0.1
26
90
9
150
.39
74
6.31
E+0
7
7.04
E+0
7
4.29
E+0
7
5880
0000
1.74
E+0
8
1.90
E+0
8
1.77
E+0
8
1803
3333
3
3.0
7
P010
42.2
68
RecName:
Full=Complement factor H:
AltName: Full=H factor 1:
Flags: Precursor
RecName:
Full=Antithrombin-III:
Short=ATIII: AltName:
Full=Serpin C1: Flags:
Precursor
RecName: Full=Alpha-1Bglycoprotein: AltName:
Full=Alpha-1-B
glycoprotein: Flags:
Precursor
RecName:
Full=Transthyretin:
AltName: Full=ATTR:
AltName: Full=Prealbumin:
AltName: Full=TBPA:
Flags: Precursor
RecName: Full=Alpha-2HS-glycoprotein: AltName:
Full=Alpha-2-Z-globulin:
AltName: Full=Ba-alpha-2glycoprotein: AltName:
Full=Fetuin-A: Contains:
RecName: Full=Alpha-2HS-glycoprotein chain A:
Contains: RecName:
Full=Alpha-2-HSglycoprotein chain B: Flags:
Precursor
RecName: Full=Alpha-2HS-glycoprotein: AltName:
Full=Fetuin-A: Contains:
RecName: Full=Alpha-2HS-glycoprotein chain A:
Contains: RecName:
Full=Alpha-2-HSglycoprotein chain B: Flags:
Precursor
RecName: Full=Kininogen1: AltName: Full=Alpha-2thiol proteinase inhibitor:
AltName: Full=Fitzgerald
factor: AltName: Full=High
molecular weight kininogen:
Short=HMWK: AltName:
Full=Williams-FitzgeraldFlaujeac factor: Contains:
RecName: Full=Kininogen1 heavy chain: Contains:
RecName: Full=T-kinin:
AltName: Full=Ile-SerBradykinin: Contains:
RecName: Full=Bradykinin:
AltName: Full=Kallidin I:
Contains: RecName:
Full=Lysyl-bradykinin:
AltName: Full=Kallidin II:
Contains: RecName:
Full=Kininogen-1 light
chain: Contains: RecName:
Full=Low molecular weight
growth-promoting factor:
Flags: Precursor
27
51
7
128
.7
59.1
1.38
E+0
7
2.29
E+0
7
2.65
E+0
7
2106
6667
1.13
E+0
7
2.31
E+0
6
4.79
E+0
6
6133
333.3
0.2
9
P007
51.2
28
21
7
110
.17
17.5
8.27
E+0
5
3.09
E+0
6
4.38
E+0
6
2765
666.7
2.80
E+0
6
4.58
E+0
6
1.23
E+0
6
2870
000
1.0
4
P041
14.2
29
35
7
108
.84
37.3
16
1.89
E+0
7
1.77
E+0
6
2.06
E+0
7
3.66
E+0
6
P018
34.1
105
.07
1.44
E+0
7
1.05
E+0
6
1.0
9
7
1.34
E+0
7
2.39
E+0
5
1796
6667
17
1.94
E+0
7
8.54
E+0
5
1650
0000
30
1.67
E+0
7
4.77
E+0
5
2160
000
4.1
3
P026
52.1
5233
33.33
69
RecName:
Full=Complement factor B:
AltName: Full=C3/C5
convertase: AltName:
Full=Glycine-rich beta
glycoprotein: Short=GBG:
AltName: Full=PBF2:
AltName: Full=Properdin
factor B: Contains:
RecName:
Full=Complement factor B
Ba fragment: Contains:
RecName:
Full=Complement factor B
Bb fragment: Flags:
Precursor
RecName:
Full=Apolipoprotein B-100:
Short=Apo B-100:
Contains: RecName:
Full=Apolipoprotein B-48:
Short=Apo B-48: Flags:
Precursor
RecName: Full=Ig kappa
chain C region
RecName:
Full=Apolipoprotein A-II:
Short=Apo-AII:
Short=ApoA-II: AltName:
Full=Apolipoprotein A2:
Contains: RecName:
Full=Truncated
apolipoprotein A-II:
AltName:
Full=Apolipoprotein A-II(176): Flags:
Precursorgi|385178606|sp|P
0DJG2.1|APOA2_GORGO
RecName:
Full=Apolipoprotein A-II:
Short=Apo-AII:
Short=ApoA-II: AltName:
Full=Apolipoprotein A2:
Contains: RecName:
Full=Truncated
apolipoprotein A-II: Flags:
Precursor
31
44
7
96.
93
16.7
1.14
E+0
7
6.57
E+0
6
8.33
E+0
6
8766
666.7
5.52
E+0
6
5.30
E+0
6
2.04
E+0
7
1040
6667
1.1
9
P688
71.2
32
18
7
82.
89
12.2
1.95
E+0
6
1.13
E+0
6
1.85
E+0
6
1643
333.3
1.17
E+0
6
8.22
E+0
5
1.50
E+0
6
1164
000
0.7
1
P040
04.1
33
16
7
81.
46
5.8
0.00
E+0
0
2.52
E+0
5
1.99
E+0
5
1503
33.33
3.74
E+0
6
4.67
E+0
6
4.54
E+0
6
4316
666.7
28.
71
P027
63.1
34
20
6
80.
1
22.8
1.32
E+0
6
0.00
E+0
0
1.11
E+0
6
8100
00
4.00
E+0
6
5.97
E+0
6
1.13
E+0
7
7090
000
8.7
5
P196
52.2
35
37
6
102
.86
31.3
9.30
E+0
6
1.21
E+0
7
7.83
E+0
6
9743
333.3
7.88
E+0
6
7.87
E+0
6
1.33
E+0
7
9683
333.3
0.9
9
P040
03.2
70
RecName:
Full=Hemoglobin subunit
beta: AltName: Full=Betaglobin: AltName:
Full=Hemoglobin beta
chain: Contains: RecName:
Full=LVV-hemorphin7gi|56749857|sp|P68872.2|H
BB_PANPA RecName:
Full=Hemoglobin subunit
beta: AltName: Full=Betaglobin: AltName:
Full=Hemoglobin beta
chaingi|56749858|sp|P68873
.2|HBB_PANTR RecName:
Full=Hemoglobin subunit
beta: AltName: Full=Betaglobin: AltName:
Full=Hemoglobin beta chain
RecName: Full=Vitronectin:
Short=VN: AltName:
Full=S-protein: AltName:
Full=Serum-spreading
factor: AltName: Full=V75:
Contains: RecName:
Full=Vitronectin V65
subunit: Contains:
RecName: Full=Vitronectin
V10 subunit: Contains:
RecName:
Full=Somatomedin-B:
Flags: Precursor
RecName: Full=Alpha-1acid glycoprotein 1:
Short=AGP 1: AltName:
Full=Orosomucoid-1:
Short=OMD 1: Flags:
Precursor
RecName: Full=Alpha-1acid glycoprotein 2:
Short=AGP 2: AltName:
Full=Orosomucoid-2:
Short=OMD 2: Flags:
Precursor
RecName: Full=C4bbinding protein alpha chain:
Short=C4bp: AltName:
Full=Proline-rich protein:
Short=PRP: Flags:
Precursor
36
84
6
100
.97
79.2
4.34
E+0
7
5.29
E+0
7
4.92
E+0
7
4850
0000
3.57
E+0
7
7.80
E+0
7
5.89
E+0
7
5753
3333
1.1
9
P109
09.1
37
20
6
98.
79
28.1
6.67
E+0
5
1.25
E+0
6
1.81
E+0
6
1242
333.3
3.32
E+0
6
2.23
E+0
6
2.76
E+0
6
2770
000
2.2
3
Q146
24.4
38
19
6
95.
94
14.6
6.59
E+0
5
6.93
E+0
5
7.32
E+0
5
6946
66.67
4.41
E+0
6
2.60
E+0
6
1.11
E+0
7
6036
666.7
8.6
9
P027
51.4
71
RecName: Full=Clusterin:
AltName: Full=Agingassociated gene 4 protein:
AltName:
Full=Apolipoprotein J:
Short=Apo-J: AltName:
Full=Complement cytolysis
inhibitor: Short=CLI:
AltName:
Full=Complementassociated protein SP-40,40:
AltName: Full=Ku70binding protein 1: AltName:
Full=NA1/NA2: AltName:
Full=Testosterone-repressed
prostate message 2:
Short=TRPM-2: Contains:
RecName: Full=Clusterin
beta chain: AltName:
Full=ApoJalpha: AltName:
Full=Complement cytolysis
inhibitor a chain: Contains:
RecName: Full=Clusterin
alpha chain: AltName:
Full=ApoJbeta: AltName:
Full=Complement cytolysis
inhibitor b chain: Flags:
Precursor
RecName: Full=Inter-alphatrypsin inhibitor heavy chain
H4: Short=ITI heavy chain
H4: Short=ITI-HC4:
Short=Inter-alpha-inhibitor
heavy chain 4: AltName:
Full=Inter-alpha-trypsin
inhibitor family heavy
chain-related protein:
Short=IHRP: AltName:
Full=Plasma kallikrein
sensitive glycoprotein 120:
Short=Gp120: Short=PK120: Contains: RecName:
Full=70 kDa inter-alphatrypsin inhibitor heavy chain
H4: Contains: RecName:
Full=35 kDa inter-alphatrypsin inhibitor heavy chain
H4: Flags: Precursor
RecName: Full=Fibronectin:
Short=FN: AltName:
Full=Cold-insoluble
globulin: Short=CIG:
Contains: RecName:
Full=Anastellin: Contains:
RecName: Full=Ugl-Y1:
Contains: RecName:
Full=Ugl-Y2: Contains:
RecName: Full=Ugl-Y3:
Flags: Precursor
39
36
6
95.
42
19.2
4.68
E+0
6
1.98
E+0
6
1.60
E+0
7
7553
333.3
1.34
E+0
7
1.70
E+0
7
2.90
E+0
7
1980
0000
2.6
2
P027
49.3
40
10
6
87.
92
15.9
11.5
4.17
E+0
6
5.69
E+0
6
4.08
E+0
6
5.36
E+0
6
P0CG
05.1
75.
86
5.32
E+0
5
6.50
E+0
6
57.
78
6
1.52
E+0
5
0.00
E+0
0
2927
333.3
18
0.00
E+0
0
0.00
E+0
0
5066
6.667
41
0.00
E+0
0
6.22
E+0
5
5850
000
28.
22
P253
11.2
42
15
6
73.
75
14.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
3.44
E+0
6
4.06
E+0
6
3.06
E+0
6
3520
000
#DI
V/0
!
P051
55.2
43
38
5
73.
61
49.2
1.68
E+0
7
1.48
E+0
7
1.43
E+0
7
1530
0000
2.75
E+0
6
1.73
E+0
6
3.49
E+0
6
2656
666.7
0.1
7
P007
34.2
44
23
4
71.
38
8
3.80
E+0
6
2.69
E+0
6
2.32
E+0
6
2936
666.7
1.25
E+0
7
1.17
E+0
7
1.42
E+0
7
1280
0000
4.3
6
P067
27.3
45
13
4
70.
74
10.4
4.55
E+0
5
3.38
E+0
6
1.62
E+0
6
1818
333.3
4.28
E+0
6
4.48
E+0
6
1.67
E+0
7
8486
666.7
4.6
7
P063
96.1
46
16
4
52.
19
11
1.48
E+0
6
8.83
E+0
5
3.41
E+0
5
9013
33.33
2.76
E+0
6
9.73
E+0
5
3.21
E+0
6
2314
333.3
2.5
7
P010
11.2
2073
33.33
72
RecName: Full=Beta-2glycoprotein 1: AltName:
Full=APC inhibitor:
AltName: Full=Activated
protein C-binding protein:
AltName:
Full=Anticardiolipin
cofactor: AltName:
Full=Apolipoprotein H:
Short=Apo-H: AltName:
Full=Beta-2-glycoprotein I:
Short=B2GPI:
Short=Beta(2)GPI: Flags:
Precursor
RecName: Full=Ig lambda-2
chain C regions
RecName: Full=Zinc-alpha2-glycoprotein: Short=Znalpha-2-GP: Short=Znalpha-2-glycoprotein: Flags:
Precursor
RecName: Full=Plasma
protease C1 inhibitor:
Short=C1 Inh: Short=C1Inh:
AltName: Full=C1 esterase
inhibitor: AltName:
Full=C1-inhibiting factor:
AltName: Full=Serpin G1:
Flags: Precursor
RecName:
Full=Prothrombin:
AltName: Full=Coagulation
factor II: Contains:
RecName: Full=Activation
peptide fragment 1:
Contains: RecName:
Full=Activation peptide
fragment 2: Contains:
RecName: Full=Thrombin
light chain: Contains:
RecName: Full=Thrombin
heavy chain: Flags:
Precursor
RecName:
Full=Apolipoprotein A-IV:
Short=Apo-AIV:
Short=ApoA-IV: AltName:
Full=Apolipoprotein A4:
Flags: Precursor
RecName: Full=Gelsolin:
AltName: Full=AGEL:
AltName: Full=Actindepolymerizing factor:
Short=ADF: AltName:
Full=Brevin: Flags:
Precursor
RecName: Full=Alpha-1antichymotrypsin:
Short=ACT: AltName:
Full=Cell growth-inhibiting
gene 24/25 protein:
AltName: Full=Serpin A3:
Contains: RecName:
Full=Alpha-1antichymotrypsin His-Pro-
less: Flags: Precursor
47
3
3
20.
06
10.4
5.76
E+0
5
1.26
E+0
6
0.00
E+0
0
6120
00
1.73
E+0
8
2.06
E+0
8
0.00
E+0
0
1263
3333
3
206
.43
P699
05.2
48
15
3
59.
38
16.7
2.56
E+0
6
4.83
E+0
6
2.94
E+0
6
3443
333.3
3.98
E+0
6
2.78
E+0
6
7.89
E+0
5
2516
333.3
0.7
3
P198
23.2
49
9
3
43.
69
24
1.04
E+0
6
7.15
E+0
5
0.00
E+0
0
5850
00
1.47
E+0
6
5.62
E+0
5
4.97
E+0
5
8430
00
1.4
4
P007
47.2
50
5
3
42.
86
8.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
6.26
E+0
5
2.51
E+0
6
2.28
E+0
5
1121
333.3
#DI
V/0
!
P041
96.1
73
RecName:
Full=Hemoglobin subunit
alpha: AltName:
Full=Alpha-globin:
AltName: Full=Hemoglobin
alpha
chaingi|57013851|sp|P69906
.2|HBA_PANPA RecName:
Full=Hemoglobin subunit
alpha: AltName:
Full=Alpha-globin:
AltName: Full=Hemoglobin
alpha
chaingi|57013852|sp|P69907
.2|HBA_PANTR RecName:
Full=Hemoglobin subunit
alpha: AltName:
Full=Alpha-globin:
AltName: Full=Hemoglobin
alpha chain
RecName: Full=Inter-alphatrypsin inhibitor heavy chain
H2: Short=ITI heavy chain
H2: Short=ITI-HC2:
Short=Inter-alpha-inhibitor
heavy chain 2: AltName:
Full=Inter-alpha-trypsin
inhibitor complex
component II: AltName:
Full=Serum-derived
hyaluronan-associated
protein: Short=SHAP:
Flags: Precursor
RecName:
Full=Plasminogen:
Contains: RecName:
Full=Plasmin heavy chain
A: Contains: RecName:
Full=Activation peptide:
Contains: RecName:
Full=Angiostatin: Contains:
RecName: Full=Plasmin
heavy chain A, short form:
Contains: RecName:
Full=Plasmin light chain B:
Flags: Precursor
RecName: Full=Histidinerich glycoprotein: AltName:
Full=Histidine-proline-rich
glycoprotein: Short=HPRG:
Flags: Precursor
51
5
3
37.
97
18.2
9.41
E+0
5
0.00
E+0
0
5.99
E+0
5
5133
33.33
1.64
E+0
5
0.00
E+0
0
7.83
E+0
5
3156
66.67
0.6
1
P027
60.1
52
6
2
30.
2
22.8
25.
33
12.1
1.30
E+0
6
9.33
E+0
6
8.10
E+0
5
6.79
E+0
7
0.00
E+0
0
4.79
E+0
7
4171
0000
#DI
V/0
!
2.0
5
P181
36.2
2
0.00
E+0
0
2.16
E+0
7
7033
33.33
8
0.00
E+0
0
1.94
E+0
7
0
53
0.00
E+0
0
2.00
E+0
7
54
4
2
24.
91
1.9
24.
13
19.1
P016
25.2
2
19.
45
2.4
7300
0
0.6
5
P007
61.1
RecName: Full=Trypsin:
Flags: Precursor
57
3
2
18.
25
5.7
1.28
E+0
5
4.65
E+0
6
2.19
E+0
5
1.26
E+0
6
8.2
0
2
1.38
E+0
5
2.36
E+0
5
0.00
E+0
0
0.00
E+0
0
3008
666.7
56
1.06
E+0
5
4.14
E+0
6
0.00
E+0
0
0.00
E+0
0
P015
91.4
2
6.09
E+0
4
5.92
E+0
5
0.00
E+0
0
5.20
E+0
5
6.1
1
10
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
4.47
E+0
5
1240
00
55
0.00
E+0
0
5.09
E+0
5
3.37
E+0
5
0.00
E+0
0
RecName: Full=Protein
AMBP: Contains:
RecName: Full=Alpha-1microglobulin:
Short=Protein HC:
AltName: Full=Alpha-1
microglycoprotein:
AltName: Full=Complexforming glycoprotein
heterogeneous in charge:
Contains: RecName:
Full=Inter-alpha-trypsin
inhibitor light chain:
Short=ITI-LC: AltName:
Full=Bikunin: AltName:
Full=EDC1: AltName:
Full=HI-30: AltName:
Full=Uronic-acid-rich
protein: Contains:
RecName: Full=Trypstatin:
Flags: Precursor
RecName: Full=Ig kappa
chain V-III region HIC:
Flags: Precursor
RecName: Full=Afamin:
AltName: Full=Alphaalbumin: Short=Alpha-Alb:
Flags: Precursor
RecName:
Full=Immunoglobulin J
chain: Flags: Precursor
RecName: Full=Ig kappa
chain V-IV region Len
4200
00
1.3
0
P010
31.4
58
3
2
15.
39
11.6
14.
31
0.6
3.17
E+0
4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
P017
66.1
2
0.00
E+0
0
3.84
E+0
5
0.0
2
2
7.15
E+0
5
0.00
E+0
0
1056
6.667
59
7.94
E+0
5
0.00
E+0
0
RecName:
Full=Complement C5:
AltName: Full=C3 and PZPlike alpha-2-macroglobulin
domain-containing protein
4: Contains: RecName:
Full=Complement C5 beta
chain: Contains: RecName:
Full=Complement C5 alpha
chain: Contains: RecName:
Full=C5a anaphylatoxin:
Contains: RecName:
Full=Complement C5 alpha'
chain: Flags: Precursor
RecName: Full=Ig heavy
chain V-III region BRO
0
0.0
0
P051
56.2
2033
3333
2030
0
3670
00
1123
33.33
3223
33.33
5030
00
1280
00
74
P436
52.1
RecName:
Full=Complement factor I:
AltName: Full=C3B/C4B
inactivator: Contains:
RecName:
Full=Complement factor I
heavy chain: Contains:
RecName:
Full=Complement factor I
light chain: Flags: Precursor
60
3
2
12.
62
7.1
0.00
E+0
0
0.00
E+0
0
8.39
E+0
5
2796
66.67
8.65
E+0
5
0.00
E+0
0
2.77
E+0
6
1211
666.7
4.3
3
O438
66.1
61
2
2
11.
96
4.7
0.00
E+0
0
0.00
E+0
0
5.69
E+0
5
1896
66.67
1.31
E+0
7
0.00
E+0
0
0.00
E+0
0
4366
666.7
23.
02
P042
07.2
62
1
1
8.7
7
2.2
5.3
8
2.6
0.00
E+0
0
2.34
E+0
6
3.16
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
O750
37.2
1
0.00
E+0
0
0.00
E+0
0
1053
33.33
1
0.00
E+0
0
0.00
E+0
0
0
63
0.00
E+0
0
0.00
E+0
0
64
1
1
8.4
4
5.7
1
24.
82
38.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
9.69
E+0
7
4.00
E+0
4
9.14
E+0
6
0.00
E+0
0
0.00
E+0
0
1333
3.333
5
0.00
E+0
0
0.00
E+0
0
0
65
0.00
E+0
0
0.00
E+0
0
66
5
1
22.
18
39.3
1
18.
89
4.9
0.00
E+0
0
1.31
E+0
6
4.88
E+0
7
8.95
E+0
5
0.00
E+0
0
1.21
E+0
6
0.00
E+0
0
5.52
E+0
6
1626
6667
7
0.00
E+0
0
1.31
E+0
6
0
67
0.00
E+0
0
1.55
E+0
6
68
8
1
18.
77
7
1.74
E+0
6
7.49
E+0
5
3.80
E+0
6
2096
333.3
0.00
E+0
0
2.15
E+0
6
69
1
1
18.
4
3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.54
E+0
5
70
7
1
17.
46
4.7
1.94
E+0
6
1.05
E+0
6
2.37
E+0
6
1786
666.7
71
5
1
16.
14
1.2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
72
1
1
15.
79
3.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
7800
00
Q3S
V33.1
#DI
V/0
!
#DI
V/0
!
Q86V
V4.2
P517
77.1
2541
666.7
#DI
V/0
!
1.8
3
0.00
E+0
0
7166
66.67
0.3
4
P189
78.1
0.00
E+0
0
0.00
E+0
0
8466
6.667
#DI
V/0
!
Q5R
AD0.
1
2.53
E+0
5
0.00
E+0
0
0.00
E+0
0
8433
3.333
0.0
5
P074
15.1
0
6.10
E+0
5
7.10
E+0
5
4.22
E+0
5
5806
66.67
#DI
V/0
!
P010
29.3
0
8.34
E+0
5
0.00
E+0
0
0.00
E+0
0
2780
00
#DI
V/0
!
P191
34.4
0
1390
000
75
3534
6667
P320
81.1
P274
85.2
RecName: Full=CD5
antigen-like: AltName:
Full=CT-2: AltName:
Full=IgM-associated
peptide: AltName: Full=SPalpha: Flags: Precursor
RecName: Full=Ig kappa
chain V-III region CLL:
AltName: Full=Rheumatoid
factor: Flags: Precursor
RecName: Full=Kinesinlike protein KIF21B
RecName: Full=Sulfite
reductase [NADPH]
hemoprotein betacomponent: Short=SiR-HP:
Short=SiRHP
RecName: Full=Ranbinding protein 3-like
RecName: Full=Cold shock
protein CspB: AltName:
Full=Major cold shock
protein
RecName: Full=Cold shock
protein CspD
RecName: Full=Retinolbinding protein 4: AltName:
Full=Plasma retinol-binding
protein: Short=PRBP:
Short=RBP: Flags:
Precursor
RecName:
Full=Hemoglobin subunit
alpha: AltName:
Full=Alpha-globin:
AltName: Full=Hemoglobin
alpha chain
RecName:
Full=Complement
component C7: Flags:
Precursor
RecName:
Full=Hemoglobin subunit
beta: AltName: Full=Betaglobin: AltName:
Full=Hemoglobin beta chain
RecName:
Full=Complement C4-B:
Contains: RecName:
Full=Complement C4 beta
chain: Contains: RecName:
Full=Complement C4 alpha
chain: Contains: RecName:
Full=C4a anaphylatoxin:
Contains: RecName:
Full=Complement C4
gamma chain: Flags:
Precursor
RecName:
Full=Serotransferrin:
Short=Transferrin:
AltName: Full=Beta-1
metal-binding globulin:
AltName:
Full=Siderophilin: Flags:
Precursor
73
1
1
14.
86
2.7
3.71
E+0
5
0.00
E+0
0
0.00
E+0
0
1236
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q9C6
M5.1
74
2
1
14.
65
3.8
4.71
E+0
5
0.00
E+0
0
0.00
E+0
0
1570
00
1.45
E+0
6
0.00
E+0
0
0.00
E+0
0
4833
33.33
3.0
8
P086
97.3
75
1
1
12.
99
9.7
12.
92
7.2
1
12.
87
6.9
1.29
E+0
6
9.16
E+0
5
6.50
E+0
5
1198
666.7
2
0.00
E+0
0
2.68
E+0
6
0.00
E+0
0
#DI
V/0
!
6.8
9
77
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
P063
10.1
1
0.00
E+0
0
3.42
E+0
5
0.00
E+0
0
4300
00
6
0.00
E+0
0
1.80
E+0
5
0.00
E+0
0
0
76
0.00
E+0
0
0.00
E+0
0
1.01
E+0
5
2166
66.67
6.4
4
P355
42.2
78
9
1
12.
71
16.1
4.60
E+0
6
2.72
E+0
6
4.27
E+0
6
3863
333.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P026
56.1
79
3
1
12.
39
0.9
0.00
E+0
0
1.73
E+0
6
1.83
E+0
6
1186
666.7
2.20
E+0
6
0.00
E+0
0
0.00
E+0
0
7333
33.33
0.6
2
O948
04.1
80
1
1
11.
67
11.6
11.
53
3.4
3.86
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
0.0
0
P017
00.1
1
0.00
E+0
0
0.00
E+0
0
1286
66.67
1
0.00
E+0
0
0.00
E+0
0
0
81
0.00
E+0
0
8.07
E+0
6
A7HJ
X5.1
82
4
1
11.
45
1.7
3.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
Q28H
X4.1
11.
21
9.73
E+0
5
0.00
E+0
0
0.4
0
1
7.65
E+0
5
8.98
E+0
6
3243
33.33
7
7.39
E+0
5
4.87
E+0
6
8153
33.33
83
9.42
E+0
5
4.86
E+0
6
0
0.0
0
Q625
58.2
84
4
1
11.
07
0
3.69
E+0
5
4.61
E+0
5
6.08
E+0
5
4793
33.33
3.95
E+0
5
0.00
E+0
0
0.00
E+0
0
1316
66.67
0.2
7
Q9I7
U4.3
1740
00
3366
6.667
2690
000
6236
666.7
76
0
P807
48.1
RecName: Full=AP2/ERF
and B3 domain-containing
transcription repressor
TEM1: AltName:
Full=Protein
TEMPRANILLO 1:
AltName: Full=RAV1-like
ethylene-responsive
transcription factor TEM1
RecName: Full=Alpha-2antiplasmin: Short=Alpha-2AP: AltName: Full=Alpha2-plasmin inhibitor:
Short=Alpha-2-PI:
AltName: Full=Serpin F2:
Flags: Precursor
RecName: Full=Ig kappa
chain V-II region RPMI
6410: Flags: Precursor
RecName: Full=Ig lambda
chain V-III region LOI
RecName: Full=Serum
amyloid A-4 protein:
AltName:
Full=Constitutively
expressed serum amyloid A
protein: Short=C-SAA:
Flags: Precursor
RecName:
Full=Apolipoprotein C-III:
Short=Apo-CIII:
Short=ApoC-III: AltName:
Full=Apolipoprotein C3:
Flags: Precursor
RecName:
Full=Serine/threonineprotein kinase 10: AltName:
Full=Lymphocyte-oriented
kinase
RecName: Full=Ig lambda
chain V-I region HA
RecName: Full=Valine-tRNA ligase: AltName:
Full=Valyl-tRNA
synthetase: Short=ValRS
RecName:
Full=Intraflagellar transport
protein 57 homolog
RecName:
Full=Haptoglobin:
AltName: Full=Zonulin:
Contains: RecName:
Full=Haptoglobin alpha
chain: Contains: RecName:
Full=Haptoglobin beta
chain: Flags: Precursor
RecName: Full=Titin:
AltName: Full=D-Titin:
AltName: Full=Kettin
85
1
1
10.
48
8.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
5.01
E+0
4
1670
0
#DI
V/0
!
C1D
RQ7.
1
86
1
1
10.
43
13.2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
3.39
E+0
5
0.00
E+0
0
0.00
E+0
0
1130
00
#DI
V/0
!
P590
93.1
87
1
1
10.
39
1.1
0.00
E+0
0
0.00
E+0
0
5.77
E+0
5
1923
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
A3P
GJ0.1
88
1
1
10.
31
4.5
10.
07
0.5
0.0
0
1
10.
02
2.3
0
0.0
0
Q0P5
E6.1
91
1
1
10
13.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
Q0A
BG0.
1
P286
85.1
90
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
4.14
E+0
5
0.0
0
1
0.00
E+0
0
3.11
E+0
6
0.00
E+0
0
0.00
E+0
0
0
3
1.65
E+0
6
1.45
E+0
6
2.57
E+0
6
0.00
E+0
0
5500
00
89
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1380
00
#DI
V/0
!
B4U6
R8.1
92
1
1
9.8
9
0.6
0.00
E+0
0
4.71
E+0
5
0.00
E+0
0
1570
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q076
30.1
93
3
1
9.8
8
7.8
1.7
9.7
8
1
1
9.6
4
0.5
1.72
E+0
6
1.78
E+0
7
0.00
E+0
0
6816
666.7
95
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
B7VI
S1.1
9.7
7
7.01
E+0
5
2.65
E+0
6
0.00
E+0
0
5.5
3
1
0.00
E+0
0
0.00
E+0
0
6.61
E+0
5
8070
00
4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1460
00
94
4.38
E+0
5
2.09
E+0
6
0.00
E+0
0
0
0.0
0
A6N
DB9.
2
O515
68.1
96
1
1
9.6
2
2.9
0.00
E+0
0
0.00
E+0
0
5.99
E+0
5
1996
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q92B
Q6.1
97
1
1
9.5
4
15.8
0.00
E+0
0
0.00
E+0
0
2.57
E+0
5
8566
6.667
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
B2HI
J2.1
1520
000
8566
66.67
0
6966
66.67
2203
33.33
77
RecName:
Full=Methylthioribose-1phosphate isomerase:
Short=M1Pi: Short=MTR-1P isomerase: AltName:
Full=S-methyl-5-thioribose1-phosphate isomerase
RecName:
Full=Uncharacterized
protein C21orf99: AltName:
Full=Cancer/testis antigen
85: Short=CT85
RecName: Full=DNAdirected RNA polymerase
subunit beta': Short=RNAP
subunit beta': AltName:
Full=RNA polymerase
subunit beta': AltName:
Full=Transcriptase subunit
beta'
RecName: Full=50S
ribosomal protein L6
RecName: Full=Contactin2: AltName: Full=Axonin-1:
Flags: Precursor
RecName: Full=Alpha-1syntrophin
RecName:
Full=Deoxyuridine 5'triphosphate
nucleotidohydrolase:
Short=dUTPase: AltName:
Full=dUTP pyrophosphatase
RecName: Full=RNA
replication protein:
AltName: Full=165 kDa
protein: AltName:
Full=ORF1 protein:
Includes: RecName:
Full=RNA-directed RNA
polymerase: Includes:
RecName: Full=Helicase
RecName: Full=UPF0325
protein VS_2356
RecName:
Full=Paralemmin-3: Flags:
Precursor
RecName:
Full=Transcription-repaircoupling factor:
Short=TRCF: AltName:
Full=ATP-dependent
helicase mfd
RecName: Full=RNA
polymerase sigma factor
RpoD: AltName:
Full=Sigma-43
RecName: Full=UracilDNA glycosylase:
Short=UDG
98
3
1
9.5
4
3.7
6.91
E+0
5
0.00
E+0
0
0.00
E+0
0
2303
33.33
0.00
E+0
0
0.00
E+0
0
1.44
E+0
6
4800
00
2.0
8
P050
90.1
99
1
1
9.4
4
7.7
9.2
0.2
10
1
1
1
9.1
7
1.9
2.76
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
3.83
E+0
6
2.47
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
#DI
V/0
!
Q9HI
R2.1
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
9200
00
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
10
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
10
2
5
1
9.1
5
14.9
4.00
E+0
6
0.00
E+0
0
0.00
E+0
0
1333
333.3
1.01
E+0
7
1.04
E+0
7
1.20
E+0
7
1083
3333
8.1
3
A9G
UX6.
1
10
3
1
1
9.1
1
3.1
9.1
2.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
4.94
E+0
6
4.10
E+0
3
2.18
E+0
6
#DI
V/0
!
#DI
V/0
!
Q5G
H72.1
1
0.00
E+0
0
0.00
E+0
0
1366.
6667
3
0.00
E+0
0
0.00
E+0
0
0
10
4
0.00
E+0
0
0.00
E+0
0
10
5
2
1
9.0
3
1
4.35
E+0
5
0.00
E+0
0
6.52
E+0
5
3623
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
O433
45.1
10
6
1
1
8.8
6
3.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.54
E+0
5
0.00
E+0
0
0.00
E+0
0
8466
6.667
#DI
V/0
!
O433
74.2
10
7
5
1
8.8
1
14.2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
7.58
E+0
6
7.33
E+0
6
2.09
E+0
6
5666
666.7
#DI
V/0
!
Q8R
BK6.
1
0
0
0
78
1276
666.7
8233
33.33
2373
333.3
Q54I
X3.1
A1B4
95.1
P0AC
P6.1
RecName:
Full=Apolipoprotein D:
Short=Apo-D: Short=ApoD:
Flags: Precursor
RecName: Full=50S
ribosomal protein L2P
RecName: Full=Probable
polyketide synthase 26:
Short=dipks26
RecName: Full=NADHquinone oxidoreductase
subunit D: AltName:
Full=NADH dehydrogenase
I, subunit 4: AltName:
Full=NADH dehydrogenase
I, subunit D: AltName:
Full=NADH-quinone
oxidoreductase subunit 4:
Short=NQO4: AltName:
Full=NDH-1, subunit 4:
AltName: Full=NDH-1,
subunit D
RecName: Full=NADHquinone oxidoreductase
subunit B 1: AltName:
Full=NADH dehydrogenase
I subunit B 1: AltName:
Full=NDH-1 subunit B 1
RecName: Full=XK-related
protein 7
RecName: Full=HTH-type
transcriptional regulator
GntR: AltName:
Full=Gluconate utilization
system GNT-I
transcriptional
repressorgi|82581670|sp|P0
ACP5.1|GNTR_ECOLI
RecName: Full=HTH-type
transcriptional regulator
GntR: AltName:
Full=Gluconate utilization
system GNT-I
transcriptional repressor
RecName: Full=Zinc finger
protein 208: AltName:
Full=Zinc finger protein 91like
RecName: Full=Ras
GTPase-activating protein
4: AltName: Full=Calciumpromoted Ras inactivator:
AltName: Full=Ras p21
protein activator 4:
AltName: Full=RasGAPactivating-like protein 2
RecName:
Full=Phosphoribosylformyl
glycinamidine synthase 1:
AltName:
Full=Phosphoribosylformyl
glycinamidine synthase I:
Short=FGAM synthase I
10
8
2
1
8.7
5
2.3
0.00
E+0
0
0.00
E+0
0
7.84
E+0
5
2613
33.33
6.23
E+0
5
0.00
E+0
0
0.00
E+0
0
2076
66.67
0.7
9
D2N
T89.2
10
9
1
1
8.7
4
18.6
8.7
1
2.7
4.26
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
4.27
E+0
6
#DI
V/0
!
#DI
V/0
!
O070
06.1
1
0.00
E+0
0
0.00
E+0
0
1420
00
1
0.00
E+0
0
0.00
E+0
0
0
11
0
0.00
E+0
0
0.00
E+0
0
11
1
1
1
8.6
8
5.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
4.61
E+0
6
1536
666.7
#DI
V/0
!
Q8V
V84.1
11
2
2
1
8.6
4
0.4
8.6
1
3
5
1
8.5
8
10.9
1.37
E+0
6
0.00
E+0
0
2.71
E+0
6
2.70
E+0
6
1.47
E+0
5
2.79
E+0
6
1833
333.3
#DI
V/0
!
#DI
V/0
!
0.6
0
Q5RF
M4.3
11
4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
Q8IY
W2.3
1
0.00
E+0
0
0.00
E+0
0
2.72
E+0
6
1356
666.7
1
0.00
E+0
0
0.00
E+0
0
3.04
E+0
6
0
11
3
0.00
E+0
0
0.00
E+0
0
3.39
E+0
6
11
5
2
1
8.5
7
63
5.4
0.00
E+0
0
8.44
E+0
6
4.74
E+0
6
1.57
E+0
7
P015
42.2
8.5
7
0.00
E+0
0
0.00
E+0
0
0.5
3
1
8.98
E+0
6
7.96
E+0
6
1580
000
4
0.00
E+0
0
8.65
E+0
6
2993
333.3
11
6
0.00
E+0
0
0.00
E+0
0
8046
666.7
1.4
5
P622
58.1
11
7
3
1
8.5
6
1.2
5.30
E+0
5
0.00
E+0
0
0.00
E+0
0
1766
66.67
0.00
E+0
0
1.04
E+0
6
1.27
E+0
6
7700
00
4.3
6
O744
58.1
11
8
1
1
8.5
6
3.9
0.00
E+0
0.00
E+0
0.00
E+0
0
0.00
E+0
8.65
E+0
0.00
E+0
2883.
3333
#DI
V/0
P465
57.1
0
0
3050
000
5536
666.7
79
1423
333.3
4900
0
Q5H
PJ0.1
O578
18.1
RecName: Full=AAA
ATPase forming ringshaped complexes:
Short=ARC
RecName: Full=Phenolic
acid decarboxylase PadC:
Short=PAD
RecName: Full=Aconitate
hydratase: Short=Aconitase:
AltName: Full=Citrate
hydro-lyase
RecName: Full=60 kDa
chaperonin: AltName:
Full=GroEL protein:
AltName: Full=Protein
Cpn60
RecName:
Full=Tetratricopeptide
repeat protein 40
RecName:
Full=Centromere/kinetochor
e protein zw10 homolog
RecName:
Full=Uncharacterized HTHtype transcriptional
regulator PH0045
RecName: Full=Crambin
RecName: Full=14-3-3
protein epsilon: Short=14-33Egi|60391192|sp|P62259.1|
1433E_MOUSE RecName:
Full=14-3-3 protein epsilon:
Short=14-33Egi|61216932|sp|P62260.1|
1433E_RAT RecName:
Full=14-3-3 protein epsilon:
Short=14-3-3E: AltName:
Full=Mitochondrial import
stimulation factor L subunit:
Short=MSF
Lgi|71153779|sp|P62261.1|1
433E_BOVIN RecName:
Full=14-3-3 protein epsilon:
Short=14-33Egi|71153780|sp|P62262.1|
1433E_SHEEP RecName:
Full=14-3-3 protein epsilon:
Short=14-3-3E: AltName:
Full=Protein kinase C
inhibitor protein 1:
Short=KCIP1gi|82197924|sp|Q5ZMT0.1
|1433E_CHICK RecName:
Full=14-3-3 protein epsilon:
Short=14-3-3E
RecName:
Full=Transcription factor
tau subunit sfc4: AltName:
Full=TFIIIC subunit sfc4:
AltName:
Full=Transcription factor C
subunit 4
RecName: Full=Matrix nonpeptidase homolog 1: Flags:
0
0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0
3
0
3.57
E+0
5
2.20
E+0
6
1.35
E+0
5
0.00
E+0
0
7.60
E+0
4
0.00
E+0
0
1893
33.33
11
9
3
1
8.5
6
18.2
12
0
1
1
8.5
8.9
12
1
1
1
8.4
9
5.2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.46
E+0
5
0.00
E+0
0
0.00
E+0
0
12
2
1
1
8.4
5
2.3
0.00
E+0
0
1.05
E+0
6
0.00
E+0
0
3500
00
0.00
E+0
0
0.00
E+0
0
12
3
1
1
8.4
4
0.5
1
1
8.4
1
0.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1220
00
12
4
3.66
E+0
5
0.00
E+0
0
0.00
E+0
0
5.13
E+0
6
12
5
1
1
8.3
8
2.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
12
6
6
1
8.3
1
34.8
1
1
8.3
1
1.3
12
8
3
1
8.2
9
0.3
12
9
2
1
8.2
8
8.7
13
0
1
1
8.2
1
3
2.64
E+0
6
0.00
E+0
0
0.00
E+0
0
6.84
E+0
5
0.00
E+0
0
6.14
E+0
6
0.00
E+0
0
0.00
E+0
0
7.74
E+0
5
0.00
E+0
0
3606
666.7
12
7
2.04
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
13
1
2
1
8.1
7
0.3
1
1
8.1
5
2.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
13
2
0.00
E+0
0
2.40
E+0
5
0
0
0
0
4860
00
0
8000
0
!
Precursor
#DI
V/0
!
#DI
V/0
!
Q9B
YA7.
2
Q7TT
U9.1
8200
0
#DI
V/0
!
Q1M
PL6.1
0.00
E+0
0
0
0.0
0
Q9UJ
X2.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P553
83.1
1710
000
#DI
V/0
!
Q135
23.3
0.00
E+0
0
0.00
E+0
0
3.47
E+0
5
1156
66.67
#DI
V/0
!
Q87R
J4.1
7.16
E+0
6
1.51
E+0
6
7.81
E+0
5
0.00
E+0
0
0.00
E+0
0
6.70
E+0
6
0.00
E+0
0
1.35
E+0
6
0.00
E+0
0
0.00
E+0
0
6.70
E+0
6
0.00
E+0
0
2.26
E+0
6
0.00
E+0
0
4.67
E+0
4
6853
333.3
1.9
0
C4L2
G6.1
5033
33.33
#DI
V/0
!
#DI
V/0
!
0.0
0
Q7T
Q07.2
1556
6.667
#DI
V/0
!
Q9Y4
D2.3
3.56
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
2.06
E+0
6
0.00
E+0
0
8053
33.33
#DI
V/0
!
0.0
0
P527
46.4
80
7333
33.33
1463
666.7
0
0
Q6B
NL1.
2
P553
61.1
P427
68.4
RecName: Full=Putative
proline dehydrogenase-like
protein
RecName:
Full=Tryptophan--tRNA
ligase: AltName:
Full=Tryptophanyl-tRNA
synthetase: Short=TrpRS
RecName:
Full=Aspartyl/glutamyltRNA(Asn/Gln)
amidotransferase subunit B:
Short=Asp/Glu-ADT
subunit B
RecName: Full=Cell
division cycle protein 23
homolog: AltName:
Full=Anaphase-promoting
complex subunit 8:
Short=APC8: AltName:
Full=Cyclosome subunit 8
RecName:
Full=Uncharacterized
protein y4cA
RecName:
Full=Serine/threonineprotein kinase PRP4
homolog: AltName:
Full=PRP4 kinase:
AltName: Full=PRP4 premRNA-processing factor 4
homolog
RecName: Full=DNA
ligase: AltName:
Full=Polydeoxyribonucleoti
de synthase [NAD(+)]
RecName: Full=Putative
membrane protein insertion
efficiency factor
RecName: Full=DNA
polymerase nu
RecName: Full=Actin
cytoskeleton-regulatory
complex protein PAN1
RecName: Full=Probable
transcriptional regulator
SyrB
RecName: Full=Sn1specific diacylglycerol
lipase alpha: Short=DGLalpha: AltName:
Full=Neural stem cellderived dendrite regulator
RecName: Full=Zinc finger
protein 142: AltName:
Full=HA4654
RecName: Full=WiskottAldrich syndrome protein:
Short=WASp
13
3
2
1
8.1
3
5.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1.98
E+0
5
4.93
E+0
5
0.00
E+0
0
2303
33.33
#DI
V/0
!
Q96A
E4.3
13
4
1
1
8.0
8
1.9
0.00
E+0
0
9.22
E+0
5
0.00
E+0
0
3073
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q6A
E64.1
13
5
1
1
8.0
6
2.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1.73
E+0
6
0.00
E+0
0
0.00
E+0
0
5766
66.67
#DI
V/0
!
P102
44.1
13
6
1
1
8.0
5
0.4
0.00
E+0
0
3.06
E+0
5
0.00
E+0
0
1020
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q9B
YW2.
3
13
7
4
1
8.0
4
2.5
0.00
E+0
0
3.56
E+0
5
4.49
E+0
5
2683
33.33
4.29
E+0
5
0.00
E+0
0
4.84
E+0
5
3043
33.33
1.1
3
P076
29.2
13
8
1
1
8.0
3
3.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
4.29
E+0
5
1430
00
#DI
V/0
!
P359
13.2
13
9
1
1
8.0
2
3.7
8.0
1
3.1
14
1
2
1
7.9
6
1.1
3.77
E+0
4
8.06
E+0
5
5.75
E+0
5
0.00
E+0
0
1.10
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
1.2
2
Q86U
P0.1
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1256
6.667
3
0.00
E+0
0
0.00
E+0
0
4.71
E+0
5
0
14
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
14
2
1
1
7.9
5
9.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
1.87
E+0
6
6233
33.33
#DI
V/0
!
O600
96.1
14
3
1
1
7.9
1
4.2
0.00
E+0
0.00
E+0
0.00
E+0
0
0.00
E+0
0.00
E+0
2.15
E+0
7166
66.67
#DI
V/0
A3L
Q86.2
0
1570
00
81
6353
33.33
1916
66.67
Q9N
TN9.
1
P323
16.2
RecName: Full=Far
upstream element-binding
protein 1: Short=FBP:
Short=FUSE-binding
protein 1: AltName:
Full=DNA helicase V:
Short=hDH V
RecName: Full=UDP-Nacetylglucosamine--Nacetylmuramyl(pentapeptide)
pyrophosphorylundecaprenol Nacetylglucosamine
transferase: AltName:
Full=Undecaprenyl-PPMurNAc-pentapeptideUDPGlcNAc GlcNAc
transferase
RecName: Full=Mybrelated protein B: Short=BMyb: AltName: Full=Myblike protein 2
RecName: Full=Histonelysine N-methyltransferase
SETD2: AltName:
Full=HIF-1: AltName:
Full=Huntingtin yeast
partner B: AltName:
Full=Huntingtin-interacting
protein 1: Short=HIP-1:
AltName: Full=Huntingtininteracting protein B:
AltName: Full=Lysine Nmethyltransferase 3A:
AltName: Full=SET
domain-containing protein
2: Short=hSET2: AltName:
Full=p231HBP
RecName: Full=Serum
amyloid P-component:
AltName: Full=Female
protein: Short=FP:
AltName: Full=SAP(FP):
Flags: Precursor
RecName: Full=Rod cGMPspecific 3',5'-cyclic
phosphodiesterase subunit
beta: Short=GMP-PDE beta:
Flags: Precursor
RecName: Full=Cadherin24: Flags: Precursor
RecName:
Full=Semaphorin-4G: Flags:
Precursor
RecName: Full=Acetyl-CoA
hydrolase: AltName:
Full=Acetyl-CoA deacylase:
Short=Acetyl-CoA acylase
RecName: Full=37S
ribosomal protein S35,
mitochondrial: Flags:
Precursor
RecName: Full=Ribosome
biogenesis protein YTM1
0
0
0
0
0
6
!
14
4
1
1
7.8
9
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
2.73
E+0
6
0.00
E+0
0
9100
00
#DI
V/0
!
A4Y
XQ9.
1
14
5
1
1
7.8
8
1.7
0.00
E+0
0
0.00
E+0
0
6.99
E+0
5
2330
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
A6N
NM3.
3
14
6
1
1
7.8
6
1.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
2.18
E+0
6
7266
66.67
#DI
V/0
!
Q421
91.2
14
7
1
1
7.8
6
0.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
3.41
E+0
6
0.00
E+0
0
0.00
E+0
0
1136
666.7
#DI
V/0
!
Q8N
F91.4
14
8
1
1
7.8
3
1.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
6.49
E+0
5
2163
33.33
#DI
V/0
!
P024
57.3
14
9
1
1
7.8
1
5.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
4.28
E+0
5
1426
66.67
#DI
V/0
!
B1YI
T8.1
15
0
1
1
7.8
1
2.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
6.01
E+0
5
2003
33.33
#DI
V/0
!
Q7V0
51.1
15
1
2
1
7.8
1
3
0.00
E+0
0
0.00
E+0
0
5.40
E+0
5
1800
00
0.00
E+0
0
0.00
E+0
0
2.02
E+0
6
6733
33.33
3.7
4
Q8IX
Q6.2
15
2
1
1
7.8
4.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
5.31
E+0
5
0.00
E+0
0
0.00
E+0
0
1770
00
#DI
V/0
!
Q68D
Y1.2
82
RecName: Full=Glycine
dehydrogenase
[decarboxylating]:
AltName: Full=Glycine
cleavage system P-protein:
AltName: Full=Glycine
decarboxylase
RecName: Full=RIMSbinding protein 3B:
Short=RIM-BP3.B:
AltName: Full=RIMSbinding protein 3.2:
Short=RIM-BP3.2
RecName:
Full=Mitochondrial inner
membrane protein OXA1:
AltName: Full=Oxidase
assembly 1 protein:
Short=AtOXA1: Flags:
Precursor
RecName: Full=Nesprin-1:
AltName: Full=Enaptin:
AltName: Full=Myocyte
nuclear envelope protein 1:
Short=Myne-1: AltName:
Full=Nuclear envelope
spectrin repeat protein 1:
AltName: Full=Synaptic
nuclear envelope protein 1:
Short=Syne-1
RecName: Full=Collagen
alpha-1(I) chain: AltName:
Full=Alpha-1 type I
collagen: Flags: Precursor
RecName: Full=UDP-Nacetylmuramoylalanine--Dglutamate ligase: AltName:
Full=D-glutamic acidadding enzyme: AltName:
Full=UDP-Nacetylmuramoyl-L-alanylD-glutamate synthetase
RecName: Full=2,3bisphosphoglycerateindependent
phosphoglycerate mutase:
Short=BPG-independent
PGAM:
Short=Phosphoglyceromuta
se: Short=iPGM
RecName: Full=Poly [ADPribose] polymerase 9:
Short=PARP-9: AltName:
Full=ADPribosyltransferase diphtheria
toxin-like 9: Short=ARTD9:
AltName: Full=B aggressive
lymphoma protein
RecName: Full=Zinc finger
protein 626
15
3
1
1
7.7
4
0.8
0.00
E+0
0
0.00
E+0
0
1.91
E+0
6
6366
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P225
16.1
15
4
1
1
7.7
3
5.1
0.00
E+0
0
7.06
E+0
6
0.00
E+0
0
2353
333.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
F2Z6
99.1
15
5
1
1
7.7
0.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
4.65
E+0
6
0.00
E+0
0
1550
000
#DI
V/0
!
Q042
17.1
15
6
1
1
7.6
8
0.6
2.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1.48
E+0
6
O603
03.4
7.6
0.00
E+0
0
0.00
E+0
0
0.0
0
1
5.57
E+0
5
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
1856
66.67
15
7
0.00
E+0
0
0.00
E+0
0
4933
33.33
#DI
V/0
!
O141
33.3
15
8
1
1
7.5
9
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
1.47
E+0
6
0.00
E+0
0
4900
00
#DI
V/0
!
C3PF
R3.1
15
9
1
1
7.5
8
8.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
2.28
E+0
6
7600
00
#DI
V/0
!
O001
70.2
16
0
1
1
7.5
7
0.6
8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
C3PH
19.1
7.5
6
0.00
E+0
0
7.74
E+0
6
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
1006
66.67
16
1
3.02
E+0
5
0.00
E+0
0
2580
000
#DI
V/0
!
Q7Z6
M1.1
16
2
1
1
7.5
2
3.6
5.7
0.00
E+0
0
2.38
E+0
6
0.00
E+0
0
0.00
E+0
0
Q8Y
Q88.1
7.5
1
0.00
E+0
0
0.00
E+0
0
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
1990
00
16
3
5.97
E+0
5
0.00
E+0
0
7933
33.33
#DI
V/0
!
Q039
24.5
0
0
0
83
RecName: Full=ATPdependent RNA helicase
CHL1: AltName:
Full=Chromosome loss
protein 1: AltName:
Full=Chromosome
transmission fidelity protein
1
RecName: Full=External
alternative NADHubiquinone oxidoreductase,
mitochondrial: AltName:
Full=External alternative
NADH dehydrogenase:
AltName:
Full=NADH:ubiquinone
reductase (nonelectrogenic): Flags:
Precursor
RecName: Full=Probable
ATP-dependent RNA
helicase DHR1: AltName:
Full=DEAH box RNA
helicase DHR1: AltName:
Full=Extracellular mutant
protein 16
RecName:
Full=Uncharacterized
protein KIAA0556
RecName: Full=ArginyltRNA--protein transferase 1:
Short=Arginyltransferase 1:
Short=R-transferase 1:
AltName: Full=ArgininetRNA--protein transferase 1
RecName: Full=ATP
synthase subunit alpha:
AltName: Full=ATP
synthase F1 sector subunit
alpha: AltName: Full=FATPase subunit alpha
RecName: Full=AH
receptor-interacting protein:
Short=AIP: AltName:
Full=Aryl-hydrocarbon
receptor-interacting protein:
AltName: Full=HBV Xassociated protein 2:
Short=XAP-2: AltName:
Full=Immunophilin
homolog ARA9
RecName: Full=Translation
initiation factor IF-2
RecName: Full=Rab9
effector protein with kelch
motifs: AltName: Full=40
kDa Rab9 effector protein:
AltName: Full=p40
RecName: Full=Putative
ABC transporter ATPbinding protein alr3946
RecName: Full=Zinc finger
protein 117: AltName:
Full=Provirus-linked
krueppel: Short=h-PLK:
AltName: Full=Zinc finger
protein HPF9
16
4
1
1
7.5
1
1.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
1.01
E+0
6
0.00
E+0
0
3366
66.67
#DI
V/0
!
Q0A
C83.1
16
5
1
1
7.5
1
1.3
2.97
E+0
7
0.00
E+0
0
0.00
E+0
0
9900
000
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q5F
WF4.
2
16
6
1
1
7.4
8
1.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
5.18
E+0
6
1726
666.7
#DI
V/0
!
Q68C
P9.2
16
7
1
1
7.4
8
4.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
7.79
E+0
6
0.00
E+0
0
0.00
E+0
0
2596
666.7
#DI
V/0
!
Q8J0
D2.1
16
8
1
1
7.4
1
0.7
0.00
E+0
0
0.00
E+0
0
1.07
E+0
6
3566
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q72K
S4.1
16
9
1
1
7.4
7
7.3
8
6.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1.41
E+0
6
0.00
E+0
0
#DI
V/0
!
0.0
0
Q2G3
S9.1
1
0.00
E+0
0
0.00
E+0
0
4700
00
1
0.00
E+0
0
0.00
E+0
0
0
17
0
0.00
E+0
0
6.02
E+0
6
17
1
1
1
7.3
7
11.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
1.73
E+0
5
0.00
E+0
0
5766
6.667
#DI
V/0
!
Q137
90.2
17
2
1
1
7.3
7
2.9
7.3
7
6.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
3.25
E+0
6
0.00
E+0
0
0.00
E+0
0
0.0
0
1
6.82
E+0
5
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
2273
33.33
17
3
0.00
E+0
0
0.00
E+0
0
1083
333.3
#DI
V/0
!
Q5X
HC1.
1
Q9C
BS7.1
2006
666.7
0
84
0
Q6V
VB1.
2
RecName: Full=LPSassembly protein LptD:
AltName: Full=Organic
solvent tolerance protein:
Flags: Precursor
RecName: Full=DNA
annealing helicase and
endonuclease ZRANB3:
AltName: Full=Annealing
helicase 2: Short=AH2:
AltName: Full=Zinc finger
Ran-binding domaincontaining protein 3:
Includes: RecName:
Full=DNA annealing
helicase ZRANB3:
Includes: RecName:
Full=Endonuclease
ZRANB3
RecName: Full=AT-rich
interactive domaincontaining protein 2:
Short=ARID domaincontaining protein 2:
AltName: Full=BRG1associated factor 200:
Short=BAF200: AltName:
Full=Zinc finger protein
with activation potential:
AltName: Full=Zipzap/p200
RecName:
Full=Oligoxyloglucan
reducing end-specific
cellobiohydrolase:
Short=OXG-RCBH: Flags:
Precursor
RecName: Full=Lon
protease 1: AltName:
Full=ATP-dependent
protease La 1
RecName: Full=Trigger
factor: Short=TF: AltName:
Full=PPIase
RecName: Full=E3
ubiquitin-protein ligase
NHLRC1: AltName:
Full=Malin: AltName:
Full=NHL repeat-containing
protein 1
RecName:
Full=Apolipoprotein F:
Short=Apo-F: AltName:
Full=Lipid transfer inhibitor
protein: Short=LTIP: Flags:
Precursor
RecName: Full=UPF0602
protein C4orf47 homolog
RecName: Full=3-oxoacyl[acyl-carrier-protein]
synthase 1: AltName:
Full=Beta-ketoacyl-ACP
synthase 1: Short=KAS 1
17
4
1
1
7.3
5
2.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
5.97
E+0
6
0.00
E+0
0
0.00
E+0
0
17
5
1
1
7.3
3
2.6
17
6
1
1
7.3
2
0.8
17
7
2
1
7.3
3.8
17
8
1
1
7.2
9
17
9
1
1
18
0
1
18
1
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
5.77
E+0
6
0.00
E+0
0
1923
333.3
#DI
V/0
!
0.0
0
O945
25.1
1.00
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
3333
33.33
0.00
E+0
0
1.16
E+0
6
0.00
E+0
0
1.03
E+0
6
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q8J1
G4.1
7300
00
#DI
V/0
!
P398
20.3
6.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
4.92
E+0
5
0.00
E+0
0
1640
00
#DI
V/0
!
O948
05.1
7.2
8
1.6
1
7.2
5
3.3
0.00
E+0
0
0.00
E+0
0
4.28
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1426
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1.97
E+0
6
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q98J
M5.1
6566
66.67
#DI
V/0
!
P432
84.1
3
1
7.2
5
6.7
5.50
E+0
5
0.00
E+0
0
7.35
E+0
5
4283
33.33
0.00
E+0
0
0.00
E+0
0
1.58
E+0
6
5266
66.67
1.2
3
Q6P4
M0.1
18
2
3
1
7.2
5
4
0.00
E+0
0
5.99
E+0
5
5.53
E+0
5
3840
00
1.09
E+0
6
0.00
E+0
0
0.00
E+0
0
3633
33.33
0.9
5
Q6P5
Z2.1
18
3
1
1
7.2
3
2.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.75
E+0
5
0.00
E+0
0
0.00
E+0
0
9166
6.667
#DI
V/0
!
O441
99.1
1990
000
0
0
85
0
P517
84.3
RecName:
Full=Uncharacterized
ribonuclease C609.01
RecName: Full=Ubiquitin
carboxyl-terminal hydrolase
11: AltName:
Full=Deubiquitinating
enzyme 11: AltName:
Full=Ubiquitin thioesterase
11: AltName:
Full=Ubiquitin-specificprocessing protease 11
RecName: Full=Kinesinlike protein KIP1
RecName: Full=Glutamate
5-kinase 1: AltName:
Full=Gamma-glutamyl
kinase 1: Short=GK 1
RecName: Full=Actin-like
protein 6B: AltName:
Full=53 kDa BRG1associated factor B:
AltName: Full=Actinrelated protein Baf53b:
AltName: Full=ArpNalpha:
AltName: Full=BRG1associated factor 53B:
Short=BAF53B
RecName: Full=DNA
polymerase IV 2: Short=Pol
IV 2
RecName: Full=Tryptophan
synthase beta chain 2,
chloroplastic: AltName:
Full=Orange pericarp 2:
Flags: Precursor
RecName: Full=7dehydrocholesterol
reductase: Short=7-DHC
reductase: AltName:
Full=Sterol Delta(7)reductase
RecName:
Full=Serine/threonineprotein kinase N3:
AltName: Full=Protein
kinase PKN-beta: AltName:
Full=Protein-kinase Crelated kinase 3
RecName: Full=DNA repair
protein rad-50
18
4
1
1
7.2
3
3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
3.13
E+0
6
0.00
E+0
0
0.00
E+0
0
1043
333.3
#DI
V/0
!
Q029
28.1
18
5
3
1
7.2
2
2.1
0.00
E+0
0
6.31
E+0
6
0.00
E+0
0
2103
333.3
2.82
E+0
6
2.64
E+0
6
0.00
E+0
0
1820
000
0.8
7
Q96J
65.2
18
6
1
1
7.1
9
3.7
1
7.1
8
26.8
1
1
7.1
5
14.6
7.83
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
9.46
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
0.0
0
18
8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
2610
00
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
18
7
0.00
E+0
0
1.45
E+0
5
0.00
E+0
0
Q7S
HU8.
1
A0K
EK5.
1
O958
16.1
18
9
1
1
7.1
5
10.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
1.71
E+0
6
19
0
1
1
7.1
5
2.7
0.00
E+0
0
1.29
E+0
6
0.00
E+0
0
4300
00
0.00
E+0
0
19
1
2
1
7.0
9
1
1.04
E+0
6
0.00
E+0
0
1.53
E+0
6
8566
66.67
19
2
1
1
7.0
7
2.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
19
3
1
1
7.0
4
6.2
19
4
1
1
7.0
3
6
0.00
E+0
0
0.00
E+0
0
7.39
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
4833
3.333
0
0
3153
33.33
#DI
V/0
!
0.00
E+0
0
5700
00
#DI
V/0
!
P529
54.2
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q0P4
K8.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q3Y
K19.1
0
0.00
E+0
0
1.92
E+0
4
0.00
E+0
0
6400
#DI
V/0
!
E1BP
36.3
2463
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
2.62
E+0
6
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P187
38.1
8733
33.33
#DI
V/0
!
P0D
D26.1
0
86
RecName:
Full=Cytochrome P450
4A11: AltName: Full=20hydroxyeicosatetraenoic
acid synthase: Short=20HETE synthase: AltName:
Full=CYP4AII: AltName:
Full=CYPIVA11: AltName:
Full=Cytochrome P-450HKomega: AltName:
Full=Cytochrome P450HLomega: AltName:
Full=Fatty acid omegahydroxylase: AltName:
Full=Lauric acid omegahydroxylase: Flags:
Precursor
RecName: Full=Multidrug
resistance-associated protein
9: AltName: Full=ATPbinding cassette sub-family
C member 12
RecName: Full=Probable
dipeptidyl-aminopeptidase
B: Short=DPAP B
RecName:
Full=Sulfurtransferase TusA
homolog
RecName: Full=BAG
family molecular chaperone
regulator 2: Short=BAG-2:
AltName: Full=Bcl-2associated athanogene 2
RecName:
Full=Transcription factor
LBX1: AltName:
Full=Ladybird homeobox
protein homolog 1
RecName: Full=NFATC2interacting protein:
AltName: Full=Nuclear
factor of activated T-cells,
cytoplasmic 2-interacting
protein
RecName: Full=Fanconi
anemia group J protein
homolog: Short=Protein
FACJ: AltName: Full=ATPdependent RNA helicase
BRIP1
RecName: Full=MMS19
nucleotide excision repair
protein homolog: AltName:
Full=MMS19-like protein
RecName: Full=Gastrula
zinc finger protein
XlCGF9.1
RecName: Full=Probable
dipeptidase
Bgi|342165246|sp|P0DD27.
1|PEPDB_STRPQ
RecName: Full=Probable
dipeptidase B
19
5
1
1
7.0
1
3.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
3.16
E+0
5
0.00
E+0
0
1053
33.33
#DI
V/0
!
Q128
74.1
19
6
1
1
6.9
4
1.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
1.03
E+0
7
3433
333.3
#DI
V/0
!
B1LS
97.1
19
7
1
1
6.8
9
1.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
2.82
E+0
5
0.00
E+0
0
9400
0
#DI
V/0
!
Q9S
D67.1
19
8
1
1
6.8
8
5.1
0.00
E+0
0
0.00
E+0
0
3.35
E+0
5
1116
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q03L
V6.1
19
9
3
1
6.8
8
9.7
0.00
E+0
0
0.00
E+0
0
2.26
E+0
6
7533
33.33
7.31
E+0
4
8.86
E+0
6
0.00
E+0
0
2977
700
3.9
5
Q3Z
WY8.
1
20
0
1
1
6.8
6
3.1
0.00
E+0
0
0.00
E+0
0
8.98
E+0
6
2993
333.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q128
51.2
20
1
1
1
6.8
2
0.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
4.62
E+0
7
1540
0000
#DI
V/0
!
Q96
M86.
2
20
2
1
1
6.8
2
17.1
1
6.7
8
2.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
2.56
E+0
6
0.00
E+0
0
0.00
E+0
0
1.05
E+0
4
0.00
E+0
0
3500
1
0.00
E+0
0
0.00
E+0
0
0
20
3
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
Q9B
TA0.
2
Q125
64.1
0
87
8533
33.33
RecName: Full=Splicing
factor 3A subunit 3:
AltName: Full=SF3a60:
AltName:
Full=Spliceosomeassociated protein 61:
Short=SAP 61
RecName: Full=Sulfite
reductase [NADPH]
hemoprotein betacomponent: Short=SiR-HP:
Short=SiRHP
RecName: Full=ATPdependent zinc
metalloprotease FTSH 7,
chloroplastic:
Short=AtFTSH7: Flags:
Precursor
RecName: Full=Glycine-tRNA ligase beta subunit:
AltName: Full=GlycyltRNA synthetase beta
subunit: Short=GlyRS
RecName: Full=30S
ribosomal protein
S16gi|189044378|sp|A5FRP
7.1|RS16_DEHSB
RecName: Full=30S
ribosomal protein S16
RecName: Full=Mitogenactivated protein kinase
kinase kinase kinase 2:
AltName: Full=B
lymphocyte
serine/threonine-protein
kinase: AltName:
Full=Germinal center
kinase: Short=GC kinase:
AltName: Full=MAPK/ERK
kinase kinase kinase 2:
Short=MEK kinase kinase
2: Short=MEKKK 2:
AltName: Full=Rab8interacting protein
RecName: Full=Dynein
heavy chain domaincontaining protein 1:
AltName: Full=Dynein
heavy chain domain 1-like
protein: AltName:
Full=Protein CCDC35
RecName: Full=Protein
FAM167B
RecName: Full=Chitin
synthase A: AltName:
Full=Chitin-UDP acetylglucosaminyl transferase A:
AltName: Full=Class-I
chitin synthase A
20
4
3
1
6.7
2
17.6
0.00
E+0
0
1.34
E+0
5
0.00
E+0
0
4466
6.667
0.00
E+0
0
5.78
E+0
5
0.00
E+0
0
1926
66.67
4.3
1
A1L1
C2.1
20
5
2
1
6.7
1
2.6
4.60
E+0
5
0.00
E+0
0
0.00
E+0
0
1533
33.33
2.93
E+0
6
0.00
E+0
0
0.00
E+0
0
9766
66.67
6.3
7
Q31V
62.1
20
6
1
1
6.7
1
6
1
6.7
2.8
0.00
E+0
0
0.00
E+0
0
1.05
E+0
5
6.26
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
3500
0
1
0.00
E+0
0
0.00
E+0
0
0
20
7
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
Q9V
AS7.
1
Q6T
N15.1
20
8
1
1
6.6
9
4.9
3.84
E+0
5
0.00
E+0
0
0.00
E+0
0
1280
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P598
28.1
20
9
1
1
6.6
7
0.6
6.6
1
1.1
0.00
E+0
0
0.00
E+0
0
1.84
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
0.0
0
Q8T
DJ6.2
1
0.00
E+0
0
0.00
E+0
0
6133
33.33
1
0.00
E+0
0
0.00
E+0
0
0
21
0
0.00
E+0
0
1.07
E+0
6
21
1
1
1
6.5
9
6.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
3.81
E+0
5
1270
00
#DI
V/0
!
Q8E
VD0.
1
21
2
3
1
6.5
6
6.7
0.00
E+0
0
1.92
E+0
6
1.95
E+0
6
1290
000
0.00
E+0
0
0.00
E+0
0
2.20
E+0
6
7333
33.33
0.5
7
A3C
T71.1
21
3
1
1
6.5
6
1.6
6.5
6
1.2
5.10
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
0.0
0
Q7Z3
92.2
1
0.00
E+0
0
5.65
E+0
5
1700
000
2
0.00
E+0
0
0.00
E+0
0
0
21
4
0.00
E+0
0
3.51
E+0
5
Q9C0
99.2
21
5
1
1
6.5
5
7.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
7.18
E+0
5
2393
33.33
#DI
V/0
!
C1A
UB5.
1
0
3566
66.67
3053
33.33
0
88
2086
66.67
0
0
Q562
F6.2
RecName:
Full=Mitochondrial
cardiolipin hydrolase:
AltName: Full=Choline
phosphatase 6: AltName:
Full=Mitochondrial
phospholipase:
Short=MitoPLD: AltName:
Full=Phosphatidylcholinehydrolyzing phospholipase
D6: AltName:
Full=Phospholipase D6:
Short=PLD 6
RecName: Full=Glycine-tRNA ligase beta subunit:
AltName: Full=GlycyltRNA synthetase beta
subunit: Short=GlyRS
RecName: Full=Innexin
inx3: Short=Innexin-3
RecName: Full=Interferoninduced GTP-binding
protein Mx: AltName:
Full=Interferon-inducible
Mx protein
RecName: Full=Poly(betaD-mannuronate) C5
epimerase: Flags: Precursor
RecName: Full=DmX-like
protein 2: AltName:
Full=Rabconnectin-3
RecName: Full=Shugoshinlike 2: AltName:
Full=Shugoshin-2:
Short=Sgo2: AltName:
Full=Tripin
RecName: Full=Glycerol
kinase: AltName:
Full=ATP:glycerol 3phosphotransferase:
AltName:
Full=Glycerokinase:
Short=GK
RecName: Full=Probable
endonuclease 4: AltName:
Full=Endodeoxyribonucleas
e IV: AltName:
Full=Endonuclease IV
RecName: Full=Trafficking
protein particle complex
subunit 11
RecName: Full=Leucinerich repeat and coiled-coil
domain-containing protein
1: AltName:
Full=Centrosomal leucinerich repeat and coiled-coil
domain-containing protein
RecName: Full=Probable
cytosol aminopeptidase:
AltName: Full=Leucine
aminopeptidase:
Short=LAP: AltName:
Full=Leucyl aminopeptidase
21
6
1
1
6.5
4
0.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1.91
E+0
6
5.80
E+0
5
6366
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
O751
28.2
RecName: Full=Protein
cordon-bleu
21
7
1
1
6.5
4
0.8
0
0.0
0
Q8N
DV3.
2
3666
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q9SI
V5.3
6.04
E+0
5
0.00
E+0
0
2013
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1.79
E+0
6
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P507
68.1
RecName: Full=Structural
maintenance of
chromosomes protein 1B:
Short=SMC protein 1B:
Short=SMC-1-beta:
Short=SMC-1B
RecName: Full=Zinc finger
CCCH domain-containing
protein 19: Short=AtC3H19:
AltName: Full=Protein
Needed for RDR2independent DNA
methylation
RecName: Full=Regulatory
protein E2
21
8
1
1
6.5
4
0.3
1.10
E+0
6
0.00
E+0
0
0.00
E+0
0
21
9
1
1
6.5
3
4.5
1
6.5
1.2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
22
0
1
5966
66.67
#DI
V/0
!
Q5JS
H3.1
22
1
1
1
6.4
5
1.1
3.84
E+0
5
0.00
E+0
0
0.00
E+0
0
1280
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P891
05.3
22
2
1
1
6.4
4
0.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.12
E+0
5
0.00
E+0
0
0.00
E+0
0
7066
6.667
#DI
V/0
!
Q75J
N1.1
22
3
1
1
6.4
3
1.7
0.00
E+0
0
4.17
E+0
6
0.00
E+0
0
1390
000
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q141
88.2
22
4
2
1
6.4
2
5.4
4.66
E+0
5
8.45
E+0
5
0.00
E+0
0
4370
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
A1R
Y72.1
22
5
1
1
6.4
2
1.4
4.23
E+0
5
0.00
E+0
0
0.00
E+0
0
1410
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q8B
TM8.
5
22
6
1
1
6.4
2
1.7
0.8
0.00
E+0
0
8.51
E+0
6
0.00
E+0
0
0.00
E+0
0
Q7U
ZL6.1
6.4
2
0.00
E+0
0
0.00
E+0
0
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
1603
33.33
22
7
4.81
E+0
5
0.00
E+0
0
2836
666.7
#DI
V/0
!
Q9U
PN4.
3
22
8
1
1
6.4
1
3.9
0.00
E+0
0.00
E+0
0.00
E+0
0
3.15
E+0
0.00
E+0
0.00
E+0
1050
000
#DI
V/0
C4K4
F9.1
1933
33.33
0
0
89
RecName: Full=WD repeatcontaining protein 44:
AltName: Full=Rabphilin11
RecName: Full=RNA
polymerase-associated
protein CTR9: AltName:
Full=Centromere-binding
factor 1-dependent protein
1: AltName: Full=Cln threerequiring protein 9
RecName: Full=Probable
serine/threonine-protein
kinase ifkC: AltName:
Full=Initiation factor kinase
C
RecName:
Full=Transcription factor
Dp-2: AltName: Full=E2F
dimerization partner 2
RecName: Full=DNA ligase
2: AltName:
Full=Polydeoxyribonucleoti
de synthase [ATP] 2
RecName: Full=Filamin-A:
Short=FLN-A: AltName:
Full=Actin-binding protein
280: Short=ABP-280:
AltName: Full=Alphafilamin: AltName:
Full=Endothelial actinbinding protein: AltName:
Full=Filamin-1: AltName:
Full=Non-muscle filamin
RecName: Full=DNA
mismatch repair protein
MutS
RecName: Full=5azacytidine-induced protein
1: AltName:
Full=Centrosomal protein of
131 kDa: Short=Cep131:
AltName: Full=Preacrosome localization
protein 1
RecName: Full=Elongation
factor G: Short=EF-G
0
0
0
6
0
0
!
22
9
2
1
6.3
9
17.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
1.45
E+0
6
1.37
E+0
6
9400
00
#DI
V/0
!
O065
89.1
23
0
3
1
6.3
9
0.8
6.3
8
1.8
0.0
0
1
6.3
8
5.2
5.18
E+0
5
0.00
E+0
0
1.02
E+0
5
0
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
Q7V
NT4.
1
O760
83.1
23
2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.6
6
1
7.88
E+0
5
0.00
E+0
0
0.00
E+0
0
1726
66.67
2
0.00
E+0
0
1.12
E+0
7
0.00
E+0
0
2626
66.67
23
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
3400
0
#DI
V/0
!
Q54S
A1.1
23
3
1
1
6.3
7
1.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1.51
E+0
6
0.00
E+0
0
0.00
E+0
0
5033
33.33
#DI
V/0
!
P611
34.1
23
4
1
1
6.3
7
1.7
7.7
0.00
E+0
0
6.95
E+0
5
0.00
E+0
0
0.00
E+0
0
Q752
Q3.2
6.3
3
0.00
E+0
0
0.00
E+0
0
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
1276
66.67
23
5
3.83
E+0
5
0.00
E+0
0
2316
66.67
#DI
V/0
!
Q003
25.2
23
6
1
1
6.3
2
3.8
1.59
E+0
5
0.00
E+0
0
0.00
E+0
0
5300
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q9K
UR9.
2
23
7
1
1
6.3
1
4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
7.73
E+0
5
0.00
E+0
0
0.00
E+0
0
2576
66.67
#DI
V/0
!
B3L2
G0.1
23
8
1
1
6.3
1
1.8
6.79
E+0
6
0.00
E+0
0
0.00
E+0
0
2263
333.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q96Q
42.2
3733
333.3
0
0
90
RecName: Full=Imidazole
glycerol phosphate synthase
subunit HisH: AltName:
Full=IGP synthase
glutamine amidotransferase
subunit: AltName: Full=IGP
synthase subunit HisH:
AltName: Full=ImGP
synthase subunit HisH:
Short=IGPS subunit HisH
RecName: Full=Electron
transport complex protein
RnfC
RecName: Full=High
affinity cGMP-specific 3',5'cyclic phosphodiesterase 9A
RecName:
Full=Phospholipase D Z:
AltName: Full=Phosphatase
D3: Short=PLD 3: Flags:
Precursor
RecName:
Full=Complement
component C6: Flags:
Precursor
RecName: Full=Enhancer of
polycomb-like protein 1
RecName: Full=Phosphate
carrier protein,
mitochondrial: AltName:
Full=Phosphate transport
protein: Short=PTP:
AltName: Full=Solute
carrier family 25 member 3:
Flags: Precursor
RecName: Full=LPSassembly protein LptD:
AltName: Full=Organic
solvent tolerance protein:
Flags: Precursor
RecName: Full=tRNA
(guanine(37)-N1)methyltransferase:
AltName: Full=M1Gmethyltransferase:
AltName: Full=tRNA
[GM37] methyltransferase:
AltName: Full=tRNA
methyltransferase 5
homolog
RecName: Full=Alsin:
AltName:
Full=Amyotrophic lateral
sclerosis 2 chromosomal
region candidate gene 6
protein: AltName:
Full=Amyotrophic lateral
sclerosis 2 protein
23
9
2
1
6.2
9
4.2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.09
E+0
6
0.00
E+0
0
1.94
E+0
6
1343
333.3
#DI
V/0
!
Q6X
PS3.2
24
0
1
1
6.2
9
4.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
2.08
E+0
5
6933
3.333
#DI
V/0
!
Q8N
FI3.1
24
1
1
1
6.2
4
6.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
4.48
E+0
5
0.00
E+0
0
0.00
E+0
0
1493
33.33
#DI
V/0
!
Q498
42.2
24
2
1
1
6.2
4
2.3
0.00
E+0
0
2.81
E+0
4
0.00
E+0
0
9366.
6667
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q929
95.2
24
3
1
1
6.2
2.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
8.38
E+0
5
0.00
E+0
0
0.00
E+0
0
2793
33.33
#DI
V/0
!
Q68D
V7.1
24
4
1
1
6.2
3.7
1
6.1
9
2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
5.83
E+0
5
7.34
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
2446
66.67
1
0.00
E+0
0
0.00
E+0
0
0
24
5
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
Q9Z
DC9.
1
Q6Z
V73.2
24
6
1
1
6.1
6
1.5
2.2
0.00
E+0
0
3.83
E+0
5
0.00
E+0
0
0.00
E+0
0
O821
39.1
6.1
5
0.00
E+0
0
0.00
E+0
0
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0
1
3.72
E+0
5
0.00
E+0
0
1240
00
24
7
0.00
E+0
0
0.00
E+0
0
1276
66.67
#DI
V/0
!
Q025
12.2
24
8
1
1
6.1
3
3.8
0.00
E+0
0
4.49
E+0
5
0.00
E+0
0
1496
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
B4U9
K9.1
24
9
1
1
6.1
13.6
0.00
E+0
0
2.17
E+0
5
0.00
E+0
0
7233
3.333
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
A4X
TF3.1
0
0
91
1943
33.33
RecName:
Full=Phosphatidylinositol
3,4,5-trisphosphate 3phosphatase TPTE2:
AltName: Full=Lipid
phosphatase TPIP:
AltName: Full=TPTE and
PTEN homologous inositol
lipid phosphatase
RecName: Full=Cytosolic
endo-beta-Nacetylglucosaminidase:
Short=ENGase
RecName:
Full=(Dimethylallyl)adenosi
ne tRNA
methylthiotransferase MiaB:
AltName: Full=tRNAi(6)A37
methylthiotransferase
RecName: Full=Ubiquitin
carboxyl-terminal hydrolase
13: AltName:
Full=Deubiquitinating
enzyme 13: AltName:
Full=Isopeptidase T-3:
Short=ISOT-3: AltName:
Full=Ubiquitin thioesterase
13: AltName:
Full=Ubiquitin-specificprocessing protease 13
RecName: Full=E3
ubiquitin-protein ligase
RNF43: AltName:
Full=RING finger protein
43: Flags: Precursor
RecName: Full=Putative
carboxypeptidase RP402
RecName: Full=FYVE,
RhoGEF and PH domaincontaining protein 6:
AltName: Full=Zinc finger
FYVE domain-containing
protein 24
RecName:
Full=Cycloartenol Synthase
RecName: Full=Replication
protein E1: AltName:
Full=ATP-dependent
helicase E1
RecName:
Full=Adenylosuccinate
synthetase:
Short=AMPSase:
Short=AdSS: AltName:
Full=IMP--aspartate ligase
RecName: Full=Integration
host factor subunit beta:
Short=IHF-beta
25
0
1
1
6.1
0.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
4.73
E+0
5
0.00
E+0
0
0.00
E+0
0
1576
66.67
#DI
V/0
!
O755
92.3
25
1
1
1
6.0
7
1.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
6.62
E+0
5
0.00
E+0
0
0.00
E+0
0
2206
66.67
#DI
V/0
!
Q9Y2
H2.3
25
2
1
1
6.0
6
1.4
6.0
5
4.6
0.00
E+0
0
4.47
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
2356
66.67
25
3
7.07
E+0
5
0.00
E+0
0
1490
00
#DI
V/0
!
Q9L
VR3.
1
P352
49.2
25
4
1
1
6
2.5
2.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
8.30
E+0
5
Q7U
A23.1
5.9
9
0.00
E+0
0
0.00
E+0
0
0.0
0
1
6.11
E+0
5
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
2036
66.67
25
5
0.00
E+0
0
0.00
E+0
0
2766
66.67
#DI
V/0
!
O150
67.4
25
6
1
1
5.9
8
1.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1.13
E+0
6
0.00
E+0
0
0.00
E+0
0
3766
66.67
#DI
V/0
!
Q8W
TR7.
1
25
7
1
1
5.9
7
5.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
3.81
E+0
5
1270
00
#DI
V/0
!
Q4G1
76.3
25
8
1
1
5.9
7
1.3
1
5.9
7
2.4
0.00
E+0
0
0.00
E+0
0
3.62
E+0
5
4.27
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1206
66.67
1
0.00
E+0
0
0.00
E+0
0
0
25
9
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
Q5V
XU9.
1
Q6U
XZ4.
1
0
0
0
92
1423
333.3
RecName: Full=Probable
E3 ubiquitin-protein ligase
MYCBP2: AltName:
Full=Myc-binding protein 2:
AltName:
Full=Pam/highwire/rpm-1
protein: AltName:
Full=Protein associated with
Myc
RecName:
Full=Phosphatidylinositide
phosphatase SAC2:
AltName: Full=Inositol
polyphosphate 5phosphatase F: AltName:
Full=Sac domain-containing
inositol phosphatase 2:
AltName: Full=Sac domaincontaining phosphoinositide
5-phosphatase 2:
Short=hSAC2
RecName: Full=UPF0496
protein At5g66670
RecName: Full=Replication
factor C subunit 4:
AltName: Full=Activator 1
37 kDa subunit: Short=A1
37 kDa subunit: AltName:
Full=Activator 1 subunit 4:
AltName: Full=Replication
factor C 37 kDa subunit:
Short=RF-C 37 kDa
subunit: Short=RFC37
RecName: Full=DNA
mismatch repair protein
MutS
RecName:
Full=Phosphoribosylformyl
glycinamidine synthase:
Short=FGAM synthase:
Short=FGAMS: AltName:
Full=Formylglycinamide
ribotide amidotransferase:
Short=FGARAT: AltName:
Full=Formylglycinamide
ribotide synthetase
RecName: Full=Zinc finger
protein 473: AltName:
Full=Zinc finger protein 100
homolog: Short=Zfp-100
RecName: Full=Acyl-CoA
synthetase family member
3, mitochondrial: Flags:
Precursor
RecName:
Full=Uncharacterized
protein C9orf84
RecName: Full=Netrin
receptor UNC5D: AltName:
Full=Protein unc-5 homolog
4: AltName: Full=Protein
unc-5 homolog D: Flags:
Precursor
26
0
1
1
5.9
6
1.8
8.50
E+0
5
0.00
E+0
0
0.00
E+0
0
2833
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P263
58.2
26
1
1
1
5.9
5
9.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
2.77
E+0
6
9233
33.33
#DI
V/0
!
O437
09.2
26
2
1
1
5.9
5
1.5
8.5
0.0
0
P367
81.1
1
1
5.9
4
10.7
0.00
E+0
0
0.00
E+0
0
3.55
E+0
5
0
26
4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
P323
86.2
5.9
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1076
666.7
26
3
3.23
E+0
6
1.59
E+0
5
0.00
E+0
0
1183
33.33
#DI
V/0
!
P091
24.2
26
5
1
1
5.9
2
3.8
1
5.9
2
12.6
26
7
1
1
5.9
2.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
3.54
E+0
5
3.83
E+0
5
1.70
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1180
00
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
26
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
#DI
V/0
!
Q0W
VN5.
2
Q1M
PQ7.
1
Q5D
RC2.
1
26
8
1
1
5.8
8
20.8
5.8
7
3.2
1
1
5.8
6
4.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
0.0
0
27
0
4.35
E+0
4
0.00
E+0
0
0.00
E+0
0
Q9BP
H3.1
1
0.00
E+0
0
0.00
E+0
0
6.30
E+0
5
1450
0
1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
26
9
0.00
E+0
0
1.52
E+0
7
0.00
E+0
0
0
0.0
0
27
1
1
1
5.8
5
4.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1.79
E+0
5
5966
6.667
#DI
V/0
!
5300
0
0
0
0
5066
666.7
2100
00
0
93
1276
66.67
5666
66.67
0
Q6Z
W76.
1
Q8K9
B2.1
O947
76.1
RecName: Full=DNA
(cytosine-5)methyltransferase 1:
Short=Dnmt1: AltName:
Full=CXXC-type zinc
finger protein 9: AltName:
Full=DNA
methyltransferase HsaI:
Short=DNA MTase HsaI:
Short=M.HsaI: AltName:
Full=MCMT
RecName:
Full=Uncharacterized
methyltransferase
WBSCR22: AltName:
Full=Williams-Beuren
syndrome chromosomal
region 22 protein
RecName: Full=ATPdependent bile acid
permease
RecName: Full=Regulatory
protein E2
RecName:
Full=Glyceraldehyde-3phosphate dehydrogenase 1:
AltName: Full=NADdependent glyceraldehyde3-phosphate dehydrogenase:
Short=GAPDH
RecName: Full=Cellulose
synthase-like protein G3:
Short=AtCslG3
RecName: Full=30S
ribosomal protein S3
RecName:
Full=Protocadherin gammaA1: Short=PCDH-gammaA1: Flags: Precursor
RecName: Full=Conotoxin
ArMLKM-01: Flags:
Precursor
RecName: Full=Ankyrin
repeat and SAM domaincontaining protein 3
RecName: Full=Fructosebisphosphate aldolase class
2: Short=FBP aldolase:
Short=FBPA: AltName:
Full=Fructose-1,6bisphosphate aldolase:
AltName: Full=Fructosebisphosphate aldolase class
II
RecName: Full=Metastasisassociated protein MTA2:
AltName: Full=Metastasisassociated 1-like 1:
Short=MTA1-L1 protein:
AltName: Full=p53 target
protein in deacetylase
complex
27
2
1
1
5.8
5
3.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
4.83
E+0
5
0.00
E+0
0
0.00
E+0
0
1610
00
#DI
V/0
!
Q095
01.1
27
3
1
1
5.8
5
1.1
0.00
E+0
0
4.72
E+0
5
0.00
E+0
0
1573
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q146
78.3
27
4
1
1
5.8
4
3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
5.91
E+0
5
1970
00
#DI
V/0
!
P307
60.2
27
5
1
1
5.8
2
8.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
3.55
E+0
5
1183
33.33
#DI
V/0
!
C3K3
34.1
27
6
1
1
5.8
2
6.6
0.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
Q9L
V41.1
5.7
6
0.00
E+0
0
0.00
E+0
0
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
8366
66.67
27
7
2.51
E+0
6
1.85
E+0
5
0
0.0
0
Q1J9
C1.1
27
8
1
1
5.7
6
0.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
5.87
E+0
5
0.00
E+0
0
0.00
E+0
0
1956
66.67
#DI
V/0
!
Q8IY
A2.3
6166
6.667
94
RecName:
Full=Intermediate filament
protein ifp-1: AltName:
Full=Cel IF E1: AltName:
Full=Intermediate filament
protein E1: Short=IF-E1
RecName: Full=KN motif
and ankyrin repeat domaincontaining protein 1:
AltName: Full=Ankyrin
repeat domain-containing
protein 15: AltName:
Full=Kidney ankyrin repeatcontaining protein
RecName: Full=DNAdirected RNA polymerase
subunit beta: Short=RNAP
subunit beta: AltName:
Full=RNA polymerase
subunit beta: AltName:
Full=Transcriptase subunit
betagi|254765297|sp|B8ZSC
7.1|RPOB_MYCLB
RecName: Full=DNAdirected RNA polymerase
subunit beta: Short=RNAP
subunit beta: AltName:
Full=RNA polymerase
subunit beta: AltName:
Full=Transcriptase subunit
beta
RecName:
Full=Multifunctional CCA
protein: Includes: RecName:
Full=CCA-adding enzyme:
AltName: Full=CCA tRNA
nucleotidyltransferase:
AltName: Full=tRNA CCApyrophosphorylase:
AltName: Full=tRNA
adenylyl-/cytidylyltransferase: AltName:
Full=tRNA
nucleotidyltransferase:
AltName: Full=tRNA-NT:
Includes: RecName:
Full=2'-nucleotidase:
Includes: RecName:
Full=2',3'-cyclic
phosphodiesterase: Includes:
RecName:
Full=Phosphatase
RecName: Full=Putative Fbox/kelch-repeat protein
At3g24610
RecName: Full=DNA
mismatch repair protein
MutSgi|166232143|sp|Q1JJ
H0.1|MUTS_STRPC
RecName: Full=DNA
mismatch repair protein
MutS
RecName: Full=Coiled-coil
domain-containing protein
144C
27
9
1
1
5.7
4
0.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
28
0
1
1
5.7
4
5.2
28
1
2
1
5.7
3
6.4
28
2
1
1
5.3
4
6.4
28
3
1
1
5.7
1
3
28
4
1
1
5.7
1
28
5
1
1
28
6
2
28
7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1.71
E+0
6
7.73
E+0
5
1.26
E+0
6
0.00
E+0
0
6.88
E+0
5
4200
00
0.00
E+0
0
1.20
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
7.73
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
2576
66.67
2.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
2.62
E+0
5
5.7
8.2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
1
5.6
9
1.6
1
1
5.6
8
0.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
4.66
E+0
6
0.00
E+0
0
28
8
1
1
5.6
7
1.2
28
9
1
1
5.6
5
2.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
6.87
E+0
5
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
0
0
4000
00
0
2290
00
95
5700
00
4870
00
#DI
V/0
!
#DI
V/0
!
#DI
V/0
!
P357
24.1
RecName: Full=Manganese
resistance protein MNR2
Q5H
ZH2.
1
Q9N
S85.1
RecName: Full=Ribosome
biogenesis protein TSR3
homolog
RecName: Full=Carbonic
anhydrase-related protein
10: AltName:
Full=Carbonic anhydraserelated protein X:
Short=CA-RP X:
Short=CARP X: AltName:
Full=Cerebral protein
15gi|47115606|sp|P61215.1|
CAH10_MOUSE
RecName: Full=Carbonic
anhydrase-related protein
10: AltName:
Full=Carbonic anhydraserelated protein X:
Short=CA-RP X:
Short=CARP
Xgi|52000736|sp|Q9N085.1|
CAH10_MACFA
RecName: Full=Carbonic
anhydrase-related protein
10gi|75041009|sp|Q5R4U0.
1|CAH10_PONAB
RecName: Full=Carbonic
anhydrase-related protein 10
RecName: Full=Carbonic
anhydrase-related protein 10
#DI
V/0
!
0.0
0
A0JN
41.1
8733
3.333
#DI
V/0
!
P305
01.1
3.16
E+0
5
1053
33.33
#DI
V/0
!
O489
15.1
3.63
E+0
6
0.00
E+0
0
0.00
E+0
0
5.63
E+0
6
2763
333.3
#DI
V/0
!
#DI
V/0
!
Q5IF
00.1
6.27
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
2090
000
0
1876
666.7
0
#DI
V/0
!
0.0
0
O431
59.2
Q8R5
08.1
P355
56.3
B3W
6N4.1
RecName: Full=Ribosomal
RNA-processing protein 8:
AltName: Full=Cerebral
protein 1: AltName:
Full=Nucleomethylin
RecName: Full=HLA class I
histocompatibility antigen,
Cw-2 alpha chain: AltName:
Full=MHC class I antigen
Cw*2: Flags: Precursor
RecName: Full=Protein
NDR1: AltName:
Full=Non-race specific
disease resistance protein 1:
Short=AtNDR1: Flags:
Precursor
RecName: Full=Autophagyrelated protein 28
RecName:
Full=Protocadherin Fat 3:
AltName: Full=FAT tumor
suppressor homolog 3:
Flags: Precursor
RecName: Full=Fibrillin-2:
Flags: Precursor
RecName:
Full=Chromosomal
replication initiator protein
DnaA
29
0
1
1
5.6
4
6.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1.15
E+0
6
4.83
E+0
5
0.00
E+0
0
0.00
E+0
0
29
1
1
1
5.6
4
2.4
29
2
1
1
5.6
3
4.4
29
3
1
1
5.6
3
3.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
29
4
1
1
5.6
2
1.3
0.00
E+0
0
0.00
E+0
0
29
5
1
1
5.6
1
3
0.00
E+0
0
29
6
1
1
5.6
2
29
7
1
1
5.5
9
5.1
29
8
1
1
5.5
9
2.8
29
9
1
1
5.5
7
2.3
30
0
1
1
5.5
7
30
1
1
1
30
2
1
1
1610
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
3.12
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q494
20.1
RecName: Full=Probable
cysteine desulfurase
1040
000
#DI
V/0
!
0.0
0
Q5R4
P8.1
RecName: Full=Zinc finger
protein 574
Q091
79.2
1186
66.67
#DI
V/0
!
Q8C
XQ6.
1
0.00
E+0
0
2510
000
#DI
V/0
!
A1L0
20.1
0.00
E+0
0
0.00
E+0
0
1693
33.33
#DI
V/0
!
Q15N
V5.1
4.68
E+0
5
0.00
E+0
0
0.00
E+0
0
1560
00
#DI
V/0
!
A4W
5D0.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
O276
98.1
0
0.0
0
Q68D
I1.2
RecName: Full=Glutamine
synthetase: Short=GS:
AltName: Full=Glutamate-ammonia ligase
RecName: Full=tRNA
(guanine-N(1)-)methyltransferase:
AltName: Full=M1Gmethyltransferase:
AltName: Full=tRNA
[GM37] methyltransferase
RecName: Full=RNAbinding protein MEX3A:
AltName: Full=RING finger
and KH domain-containing
protein 4
RecName: Full=3-methyl-2oxobutanoate
hydroxymethyltransferase:
AltName:
Full=Ketopantoate
hydroxymethyltransferase:
Short=KPHMT
RecName: Full=Isocitrate
dehydrogenase
kinase/phosphatase:
Short=IDH
kinase/phosphatase:
Short=IDHK/P
RecName:
Full=Anthranilate
phosphoribosyltransferase
RecName: Full=Zinc finger
protein 776
0
3.56
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
7.53
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
5.08
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
2.39
E+0
6
2.74
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
5.82
E+0
5
0.00
E+0
0
9133
3.333
0
0.0
0
Q5X
G99.2
6.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
9.69
E+0
5
0.00
E+0
0
0.00
E+0
0
3230
00
#DI
V/0
!
Q9B
QY9.
3
5.5
6
1.7
0.00
E+0
0
1.15
E+0
6
0.00
E+0
0
3833
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
A4S6
Y4.1
5.5
6
0.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
3.22
E+0
6
0.00
E+0
0
0.00
E+0
0
1073
333.3
#DI
V/0
!
P981
58.1
0
3833
33.33
1940
00
7966
66.67
96
0
RecName: Full=LysM and
putative peptidoglycanbinding domain-containing
protein 4
RecName: Full=Dysbindin
domain-containing protein
2: Short=Casein kinase-1
binding protein: AltName:
Full=CK1BP: AltName:
Full=HSMNP1
RecName: Full=Lon
protease homolog,
mitochondrial: Flags:
Precursor
RecName: Full=Lowdensity lipoprotein receptorrelated protein 2:
Short=LRP-2: AltName:
Full=Glycoprotein 330:
Short=gp330: AltName:
Full=Megalin: Flags:
Precursor
30
3
1
1
5.5
3
0.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.23
E+0
6
0.00
E+0
0
0.00
E+0
0
7433
33.33
#DI
V/0
!
Q8IY
B8.1
30
4
1
1
5.5
2
0.7
5.5
1
2.7
0.00
E+0
0
2.61
E+0
5
1.10
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
O149
24.1
1
0.00
E+0
0
0.00
E+0
0
3666
66.67
1
0.00
E+0
0
0.00
E+0
0
0
30
5
0.00
E+0
0
0.00
E+0
0
30
6
1
1
5.5
1
31.1
0.00
E+0
0
4.70
E+0
6
0.00
E+0
0
1566
666.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P051
09.1
30
7
1
1
5.4
8
1.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
7.22
E+0
5
0.00
E+0
0
2406
66.67
#DI
V/0
!
P487
36.3
30
8
1
1
5.4
8
5.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
5.10
E+0
6
0.00
E+0
0
0.00
E+0
0
1700
000
#DI
V/0
!
P524
24.1
0
97
8700
0
B2IC
30.1
RecName: Full=ATPdependent RNA helicase
SUPV3L1, mitochondrial:
AltName: Full=Suppressor
of var1 3-like protein 1:
Short=SUV3-like protein 1:
Flags: Precursor
RecName: Full=Regulator
of G-protein signaling 12:
Short=RGS12
RecName: Full=Formate-tetrahydrofolate ligase:
AltName:
Full=Formyltetrahydrofolate
synthetase: Short=FHS:
Short=FTHFS
RecName: Full=Protein
S100-A8: AltName:
Full=Calgranulin-A:
AltName: Full=Calprotectin
L1L subunit: AltName:
Full=Cystic fibrosis antigen:
Short=CFAG: AltName:
Full=Leukocyte L1 complex
light chain: AltName:
Full=Migration inhibitory
factor-related protein 8:
Short=MRP-8: Short=p8:
AltName: Full=S100
calcium-binding protein A8:
AltName: Full=Urinary
stone protein band A
RecName:
Full=Phosphatidylinositol
4,5-bisphosphate 3-kinase
catalytic subunit gamma
isoform: Short=PI3-kinase
subunit gamma:
Short=PI3K-gamma:
Short=PI3Kgamma:
Short=PtdIns-3-kinase
subunit gamma: AltName:
Full=Phosphatidylinositol
4,5-bisphosphate 3-kinase
110 kDa catalytic subunit
gamma: Short=PtdIns-3kinase subunit p110gamma: Short=p110gamma:
AltName:
Full=Phosphoinositide-3kinase catalytic gamma
polypeptide: AltName:
Full=Serine/threonine
protein kinase PIK3CG:
AltName: Full=p120-PI3K
RecName:
Full=Phosphoribosylformyl
glycinamidine cyclo-ligase,
chloroplastic/mitochondrial:
AltName: Full=AIR
synthase: Short=AIRS:
AltName:
Full=Phosphoribosylaminoimidazole synthetase:
AltName: Full=VUpur5:
Flags: Precursor
30
9
1
1
5.4
8
4.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1.58
E+0
5
0.00
E+0
0
0.00
E+0
0
5266
6.667
#DI
V/0
!
Q581
75.2
31
0
1
1
5.4
8
0.7
4.73
E+0
6
0.00
E+0
0
0.00
E+0
0
1576
666.7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q5T
HR3.
1
31
1
1
1
5.4
8
6.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
3.10
E+0
5
1033
33.33
#DI
V/0
!
Q969
X2.1
31
2
1
1
5.4
7
5.2
2.59
E+0
5
0.00
E+0
0
0.00
E+0
0
8633
3.333
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q9N
Q79.2
31
3
1
1
5.4
6
2.8
0.00
E+0
0
0.00
E+0
0
2.59
E+0
5
8633
3.333
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
A4W
TP4.1
31
4
1
1
5.4
6
4.9
5.4
6
4.2
1
5.4
5
6.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
6000
00
2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
0.0
0
Q38
WL5.
1
Q6M
FS1.1
31
6
0.00
E+0
0
1.80
E+0
6
0.00
E+0
0
0.0
0
1
2.94
E+0
5
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
2.30
E+0
5
9800
0
31
5
0.00
E+0
0
0.00
E+0
0
2.35
E+0
5
31
7
1
1
5.4
5
12.4
1
1
5.4
3
1.8
0.00
E+0
0
1.19
E+0
6
0.00
E+0
0
0.00
E+0
0
0
31
8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
6.22
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1550
00
3966
66.67
98
0
2073
33.33
0
#DI
V/0
!
0.0
0
D2Y2
83.1
Q571
33.1
B7IF
R8.1
RecName:
Full=Hydroxylamine
reductase: AltName:
Full=Hybrid-cluster protein:
Short=HCP
RecName: Full=EF-hand
calcium-binding domaincontaining protein 6:
AltName: Full=CAPbinding protein complexinteracting protein 1:
AltName: Full=DJ-1binding protein:
Short=DJBP
RecName: Full=Alpha-Nacetylgalactosaminide
alpha-2,6-sialyltransferase
6: AltName: Full=GalNAc
alpha-2,6-sialyltransferase
VI: AltName:
Full=ST6GalNAc VI:
Short=ST6GalNAcVI:
Short=hST6GalNAc VI:
AltName:
Full=Sialyltransferase 7F:
Short=SIAT7-F
RecName: Full=Cartilage
acidic protein 1: AltName:
Full=68 kDa chondrocyteexpressed protein:
Short=CEP-68: AltName:
Full=ASPIC: Flags:
Precursor
RecName: Full=GMP
synthase [glutaminehydrolyzing]: AltName:
Full=GMP synthetase:
AltName: Full=Glutamine
amidotransferase
RecName: Full=Methionine
import ATP-binding protein
MetN
RecName: Full=Exocyst
complex protein EXO70
RecName:
Full=Hainantoxin-XVI-13:
Short=HNTX-XVI-13:
Flags: Precursor
RecName:
Full=Uncharacterized
protein HI_0973
RecName: Full=tRNA(Ile)lysidine synthase: AltName:
Full=tRNA(Ile)-2-lysylcytidine synthase: AltName:
Full=tRNA(Ile)-lysidine
synthetase
31
9
1
1
5.4
3
7.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1.51
E+0
6
0.00
E+0
0
0.00
E+0
0
5033
33.33
#DI
V/0
!
O190
74.1
32
0
1
1
5.4
2
3.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
2.68
E+0
5
8933
3.333
#DI
V/0
!
P280
28.3
32
1
1
1
5.4
2
0.1
0.00
E+0
0
0.00
E+0
0
2.67
E+0
6
8900
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P785
27.3
32
2
1
1
5.3
9
5.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.28
E+0
6
0.00
E+0
0
0.00
E+0
0
7600
00
#DI
V/0
!
Q8N
GM1.
1
32
3
1
1
5.3
8
2.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
2.87
E+0
6
9566
66.67
#DI
V/0
!
Q8Y
H20.1
32
4
1
1
5.3
7
0.8
1
5.3
7
1.3
0.00
E+0
0
0.00
E+0
0
5.22
E+0
5
6.64
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1740
00
1
0.00
E+0
0
0.00
E+0
0
0
32
5
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
B4G
BA9.
2
Q6Q7
59.1
32
6
1
1
5.3
2
6.7
1
5.3
2
1.1
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
6.50
E+0
5
0.00
E+0
0
0.00
E+0
0
9.63
E+0
5
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
P0DI
62.1
1
0.00
E+0
0
0.00
E+0
0
0
32
7
0.00
E+0
0
0.00
E+0
0
32
8
1
1
5.3
1
3.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
4.60
E+0
5
0.00
E+0
0
0.00
E+0
0
1533
33.33
#DI
V/0
!
Q2N
NU1.
1
32
9
1
1
5.3
1
0
1.10
E+0
6
0.00
E+0
0
0.00
E+0
0
3666
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q91Z
U6.1
33
0
1
1
5.3
1
3.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
5.02
E+0
6
0.00
E+0
0
0.00
E+0
0
1673
333.3
#DI
V/0
!
Q927
83.3
0
0
99
2213
333.3
3210
00
2166
66.67
Q9U
SI6.1
RecName: Full=Cytidine
monophosphate-Nacetylneuraminic acid
hydroxylase: Short=CMPN-acetylneuraminic acid
hydroxylase: AltName:
Full=CMP-Nacetylneuraminate
monooxygenase: AltName:
Full=CMP-Neu5Ac
hydroxylase: AltName:
Full=CMP-NeuAc
hydroxylase
RecName:
Full=Serine/threonineprotein kinase B-raf:
AltName: Full=Protooncogene B-Raf
RecName: Full=DNAdependent protein kinase
catalytic subunit:
Short=DNA-PK catalytic
subunit: Short=DNA-PKcs:
AltName: Full=DNPK1:
AltName: Full=p460
RecName: Full=Olfactory
receptor 4C15: AltName:
Full=Olfactory receptor
OR11-127: AltName:
Full=Olfactory receptor
OR11-134
RecName: Full=Beta-(1->2)glucan export ATPbinding/permease protein
NdvA
RecName: Full=Protein
teflon
RecName: Full=Spermassociated antigen 17:
AltName: Full=Projection
protein PF6 homolog
RecName: Full=Casparian
strip membrane protein 1
RecName: Full=Myosin
type-2 heavy chain 1:
AltName: Full=Myosin type
II heavy chain 1
RecName: Full=E3
ubiquitin-protein ligase IE2:
AltName: Full=Immediateearly protein IE2
RecName: Full=Dystonin:
AltName: Full=Bullous
pemphigoid antigen 1:
Short=BPA: AltName:
Full=Dystonia musculorum
protein: AltName:
Full=Hemidesmosomal
plaque protein: AltName:
Full=Microtubule actin
cross-linking factor 2
RecName: Full=Signal
transducing adapter
molecule 1: Short=STAM-1
33
1
1
1
5.3
7.9
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
0.00
E+0
0
1.14
E+0
5
0.00
E+0
0
3.92
E+0
4
0.00
E+0
0
4.62
E+0
7
0.00
E+0
0
0.00
E+0
0
33
2
1
1
5.2
9
8.9
33
3
1
1
5.2
9
5.7
33
4
2
1
5.2
8
0
4.26
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
1420
00
4.36
E+0
5
0.00
E+0
0
0.00
E+0
0
3.16
E+0
5
0.00
E+0
0
0.00
E+0
0
1453
33.33
1.0
2
A2A
SS6.1
33
5
1
1
5.2
8
8.2
1053
33.33
#DI
V/0
!
P464
39.3
33
6
2
1
5.2
8
0.5
0.00
E+0
0
1.06
E+0
6
0.00
E+0
0
3533
33.33
0.00
E+0
0
2.65
E+0
6
0.00
E+0
0
8833
33.33
2.5
0
Q86U
R5.1
33
7
1
1
5.2
7
4.9
0.00
E+0
0
0.00
E+0
0
5.97
E+0
5
1990
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q095
44.1
33
8
1
1
5.2
6
5.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
5.11
E+0
5
0.00
E+0
0
0.00
E+0
0
1703
33.33
#DI
V/0
!
B7L0
43.1
33
9
1
1
5.2
5
13.5
0.00
E+0
0
5.40
E+0
5
0.00
E+0
0
1800
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q7V6
D4.1
34
0
1
1
5.2
4
3.8
0.00
E+0
0
0.00
E+0
0
2.79
E+0
5
9300
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q96R
27.2
34
1
1
1
5.2
2
2.8
0.00
E+0
0
0.00
E+0
0
1.10
E+0
6
3666
66.67
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P136
82.4
0
0
0
100
1540
0000
1306
6.667
3800
0
#DI
V/0
!
#DI
V/0
!
#DI
V/0
!
P709
02.1
A6Q5
99.1
Q9B
V10.1
RecName: Full=Variable
large protein 15/16: Flags:
Precursor
RecName: Full=UPF0102
protein NIS_1551
RecName: Full=Dol-PMan:Man(7)GlcNAc(2)-PPDol alpha-1,6mannosyltransferase:
AltName: Full=Asparaginelinked glycosylation protein
12 homolog:
Short=hALG12: AltName:
Full=Dolichyl-PMan:Man(7)GlcNAc(2)-PPdolichyl-alpha-1,6mannosyltransferase:
AltName:
Full=Mannosyltransferase
ALG12 homolog: AltName:
Full=Membrane protein
SB87
RecName: Full=Titin:
AltName: Full=Connectin
RecName: Full=Glutathione
S-transferase Mu 5:
AltName: Full=GST classmu 5: AltName:
Full=GSTM5-5
RecName: Full=Regulating
synaptic membrane
exocytosis protein 1:
AltName: Full=Rab-3interacting molecule 1:
Short=RIM 1: AltName:
Full=Rab-3-interacting
protein 2
RecName: Full=ATP
synthase subunit delta,
mitochondrial: AltName:
Full=F-ATPase delta
subunit: Flags: Precursor
RecName: Full=3-deoxymanno-octulosonate
cytidylyltransferase:
AltName: Full=CMP-2keto-3-deoxyoctulosonic
acid synthase: Short=CKS:
Short=CMP-KDO synthase
RecName: Full=Aldehyde
decarbonylase: Short=AD:
AltName: Full=Fatty
aldehyde decarbonylase
RecName: Full=Olfactory
receptor 2M4: AltName:
Full=HTPCRX18:
AltName: Full=OST710:
AltName: Full=Olfactory
receptor OR1-55: AltName:
Full=Olfactory receptor
TPCR100
RecName: Full=Zinc finger
protein 35: AltName:
Full=Zinc finger protein
HF.10
34
2
1
1
5.2
1.2
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
2.37
E+0
6
0.00
E+0
0
7900
00
#DI
V/0
!
P511
60.2
34
3
1
1
5.2
4.2
7.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
Q96S
K2.2
5.1
9
0.00
E+0
0
6.33
E+0
5
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0
1
1.41
E+0
6
0.00
E+0
0
4700
00
34
4
0.00
E+0
0
0.00
E+0
0
2110
00
#DI
V/0
!
C5A4
B7.1
34
5
1
1
5.1
7
5.8
0.00
E+0
0
0.00
E+0
0
3.76
E+0
5
1253
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
P467
18.2
34
6
1
1
5.1
7
2
0.00
E+0
0
9.07
E+0
5
0.00
E+0
0
3023
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q9U
S47.2
34
7
1
1
5.1
5
7
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
3.85
E+0
6
0.00
E+0
0
0.00
E+0
0
1283
333.3
#DI
V/0
!
Q5B1
31.1
34
8
1
1
5.1
5
6
0.00
E+0
0
0.00
E+0
0
4.72
E+0
5
1573
33.33
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q9B
XC0.
1
34
9
1
1
5.1
4
0.3
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
2.39
E+0
6
0.00
E+0
0
7966
66.67
#DI
V/0
!
P08F
94.1
35
0
1
1
5.1
4
11.4
2.35
E+0
5
0.00
E+0
0
0.00
E+0
0
7833
3.333
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
Q9N
X76.1
35
1
1
1
5.1
3
6.8
5.1
2
2.5
6.49
E+0
6
6.85
E+0
5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
Q581
44.1
1
0.00
E+0
0
0.00
E+0
0
2163
333.3
1
0.00
E+0
0
0.00
E+0
0
0
35
2
0.00
E+0
0
0.00
E+0
0
35
3
1
1
5.1
2
2.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
4.95
E+0
5
0.00
E+0
0
0.00
E+0
0
1650
00
0
0
101
2283
33.33
#DI
V/0
!
Q0W
486.1
Q6G
QV1.
1
RecName: Full=Cone
cGMP-specific 3',5'-cyclic
phosphodiesterase subunit
alpha': AltName:
Full=cGMP
phosphodiesterase 6C:
Flags: Precursor
RecName:
Full=Transmembrane
protein 209
RecName: Full=Sadenosylmethionine
synthase: Short=AdoMet
synthase: AltName:
Full=Methionine
adenosyltransferase
RecName:
Full=Programmed cell death
protein 2: AltName:
Full=Zinc finger protein Rp8
RecName: Full=Putative
succinate-semialdehyde
dehydrogenase C1002.12c
[NADP(+)]: Short=SSDH
RecName: Full=Probable
carboxypeptidase AN5749:
AltName: Full=Peptidase
M20 domain-containing
protein AN5749: Flags:
Precursor
RecName:
Full=Hydroxycarboxylic
acid receptor 1: AltName:
Full=G-protein coupled
receptor 104: AltName:
Full=G-protein coupled
receptor 81
RecName: Full=Fibrocystin:
AltName: Full=Polycystic
kidney and hepatic disease 1
protein: AltName:
Full=Polyductin: AltName:
Full=Tigmin: Flags:
Precursor
RecName: Full=CKLF-like
MARVEL transmembrane
domain-containing protein
6: AltName:
Full=Chemokine-like factor
superfamily member 6
RecName: Full=Putative
rubrerythrin
RecName: Full=O-phosphoL-seryl-tRNA:Cys-tRNA
synthase 2: AltName:
Full=Sep-tRNA:Cys-tRNA
synthase 2: Short=SepCysS
2
RecName: Full=Protein
FAM196B
35
4
1
1
5.1
2
4.4
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
1.15
E+0
5
0.00
E+0
0
0.00
E+0
0
3833
3.333
#DI
V/0
!
Q8T
DR2.
2
35
5
1
1
5.0
9
1.3
5.0
7
7.3
0.00
E+0
0
9.34
E+0
4
2.79
E+0
6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
#DI
V/0
!
#DI
V/0
!
Q140
31.3
1
0.00
E+0
0
0.00
E+0
0
9300
00
1
0.00
E+0
0
0.00
E+0
0
0
35
6
0.00
E+0
0
0.00
E+0
0
35
7
1
1
5.0
6
2.5
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.08
E+0
6
0.00
E+0
0
0.00
E+0
0
6933
33.33
#DI
V/0
!
Q9N
SB2.2
35
8
1
1
5.0
5
9.5
0.00
E+0
0
0.00
E+0
0
2.61
E+0
5
8700
0
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
E9D
BV9.
1
35
9
1
1
5.0
5
9.3
0.6
0.00
E+0
0
6.65
E+0
5
0.00
E+0
0
0.00
E+0
0
Q484
45.1
5.0
5
0.00
E+0
0
0.00
E+0
0
0.0
0
1
0.00
E+0
0
0.00
E+0
0
0
1
0.00
E+0
0
0.00
E+0
0
7100
0
36
0
2.13
E+0
5
0.00
E+0
0
2216
66.67
#DI
V/0
!
Q8N
EZ4.3
36
1
1
1
5.0
4
2.6
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.00
E+0
0
1.26
E+0
6
0.00
E+0
0
4200
00
#DI
V/0
!
O147
30.2
36
2
1
1
5.0
2
4.8
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
2.07
E+0
5
0.00
E+0
0
0.00
E+0
0
6900
0
#DI
V/0
!
A4G2
T7.1
36
3
1
1
5.0
2
9.6
6.96
E+0
5
0.00
E+0
0
0.00
E+0
0
2320
00
0.00
E+0
0
0.00
E+0
0
0.00
E+0
0
0
0.0
0
C5B
HP3.
1
0
0
102
3113
3.333
C6DF
34.1
RecName:
Full=Serine/threonineprotein kinase 35: AltName:
Full=CLP-36-interacting
kinase 1: Short=CLIK-1:
AltName: Full=PDLIM1interacting kinase 1:
AltName:
Full=Serine/threonineprotein kinase 35 L1
RecName: Full=Collagen
alpha-6(IV) chain: Flags:
Precursor
RecName: Full=Ribose-5phosphate isomerase A:
AltName:
Full=Phosphoriboisomerase
A: Short=PRI
RecName: Full=Keratin,
type II cuticular Hb4:
AltName: Full=Keratin-84:
Short=K84: AltName:
Full=Type II hair keratin
Hb4: AltName: Full=TypeII keratin Kb24
RecName: Full=Leucine
aminopeptidase 1: AltName:
Full=Leucyl aminopeptidase
1: Short=LAP1: Flags:
Precursor
RecName: Full=UPF0053
protein in cps region:
AltName: Full=ORF19
RecName: Full=Histonelysine N-methyltransferase
MLL3: AltName:
Full=Homologous to ALR
protein: AltName:
Full=Lysine Nmethyltransferase 2C:
Short=KMT2C: AltName:
Full=Myeloid/lymphoid or
mixed-lineage leukemia
protein 3
RecName:
Full=Serine/threonineprotein kinase RIO3:
AltName: Full=RIO kinase
3: AltName: Full=sudD
homolog
RecName: Full=tRNA
(guanine-N(1)-)methyltransferase:
AltName: Full=M1Gmethyltransferase:
AltName: Full=tRNA
[GM37] methyltransferase
RecName: Full=DNA
gyrase inhibitor
Table S8. Details of the pathways associated with the differentially expressed proteins identified
in meningiomas defined by DAVID (A) and PANTHER (B) analysis
(A) Summary of DAVID Analysis
BIOCARTA
Category
Term
Co
unt
%
pValue
BIOCARTA
h_intrinsicPathway
:Intrinsic
Prothrombin
Activation Pathway
11
7.74
6479
7.83E14
BIOCARTA
h_alternativePathw
ay:Alternative
Complement
Pathway
9
6.33
8028
BIOCARTA
h_compPathway:C
omplement
Pathway
10
7.04
2254
Gen
es
P02
671,
P00
742,
P01
042,
P00
740,
P05
155,
P04
070,
P01
008,
P03
952,
P00
748,
P00
734,
P07
225
7.80E- P01
13
031,
P07
357,
P00
751,
P02
748,
P13
671,
P01
024,
P10
643,
P27
918,
P06
681
6.24E- P01
12
031,
P07
357,
P00
751,
103
List
Total
Pop
Hits
Po
p
To
tal
14
37
Fold
Enrich
ment
Bonfer
roni
Benja
mini
FDR
32
17
29.056
98529
2.19E12
2.19E12
6.55E
-11
32
10
14
37
40.415
625
2.18E11
1.09E11
6.52E
-10
32
17
14
37
26.415
44118
1.75E10
5.82E11
5.22E
-09
BIOCARTA
h_classicPathway:
Classical
Complement
Pathway
9
6.33
8028
8.34E12
BIOCARTA
h_lectinPathway:L
ectin Induced
Complement
Pathway
8
5.63
3803
7.82E10
BIOCARTA
h_amiPathway:Acu
te Myocardial
Infarction
7
4.92
9577
9.39E08
P02
748,
P09
871,
P13
671,
P01
024,
P10
643,
P0C
0L5,
P06
681
P01
031,
P07
357,
P02
748,
P09
871,
P13
671,
P01
024,
P10
643,
P0C
0L5,
P06
681
P01
031,
P07
357,
P02
748,
P13
671,
P01
024,
P10
643,
P0C
0L5,
P06
681
P02
671,
P00
742,
P04
070,
P01
008,
P00
747,
P00
734,
104
32
12
14
37
33.679
6875
2.33E10
5.83E11
6.97E
-09
32
12
14
37
29.937
5
2.19E08
4.38E09
6.54E
-07
32
13
14
37
24.180
28846
2.63E06
4.38E07
7.86E
-05
P07
225
BIOCARTA
h_extrinsicPathway
:Extrinsic
Prothrombin
Activation Pathway
6
4.22
5352
1.41E06
P02
32
671,
P00
742,
P04
070,
P01
008,
P00
734,
P07
225
2.81 0.0042 P01
32
6901 12541 031,
P13
671,
P01
024,
P10
643
2.11 0.0147 P00
32
2676 60043 740,
P00
747,
P00
734
2.11 0.0219 P02
32
2676
52
671,
P00
747,
P00
734
KEGG_PATHWAY
BIOCARTA
h_LairPathway:Cel
ls and Molecules
involved in local
acute inflammatory
response
4
BIOCARTA
h_plateletAppPath
way:Platelet
Amyloid Precursor
Protein Pathway
3
BIOCARTA
h_fibrinolysisPath
way:Fibrinolysis
Pathway
3
Category
Term
Co
unt
%
pValue
Gen
es
KEGG_PATH
WAY
hsa04610:Comple
ment and
coagulation
cascades
36
25.3
5211
1.45E55
P01
031,
P07
357,
P07
358,
P04
003,
P05
546,
P04
070,
P08
603,
P09
871,
P13
105
11
14
37
24.494
31818
3.96E05
5.65E06
0.001
1818
16
14
37
11.226
5625
0.1114
81934
0.0146
66422
3.469
8726
9
14
37
14.968
75
0.3405
58211
0.0452
08605
11.69
7122
11
14
37
12.247
15909
0.4628
63402
0.0602
58352
16.94
674
List
Total
Pop
Hits
Fold
Enrich
ment
Bonfer
roni
Benja
mini
FDR
57
69
Po
p
To
tal
50
85
46.544
62243
4.64E54
4.64E54
1.26E
-52
KEGG_PATH
WAY
hsa05020:Prion
diseases
7
4.92
9577
1.72E06
671,
P10
643,
P00
751,
P01
008,
P01
009,
P08
697,
P01
024,
P05
160,
P00
734,
P01
023,
P07
225,
P06
681,
P02
671,
P01
042,
P02
748,
P07
360,
P20
851,
P00
742,
P05
154,
P05
155,
P00
740,
P05
156,
P04
275,
P03
952,
P00
748,
P00
747,
P0C
0L5,
Q96
IY4
P01
031,
P07
357,
P07
106
57
35
50
85
17.842
10526
5.51E05
1.84E05
0.001
4912
358,
P02
748,
P07
360,
P13
671,
P10
643
0.0155 P02
0365
751,
P04
275,
P04
004,
P07
996
BBID
KEGG_PATH
WAY
hsa04512:ECMreceptor interaction
4
2.81
6901
Category
Term
Co
unt
%
pValue
BBID
79.B_cell_Activati
on
2
1.40
8451
0.0737
4001
Category
Term
Co
unt
%
pValue
Gen
es
PANTHER_P
ATHWAY
P00011:Blood
coagulation
19
13.3
8028
6.96E26
P02
671,
P01
042,
P05
546,
P04
070,
P08
519,
P00
742,
P36
955,
P00
740,
P01
008,
P01
009,
P04
275,
P08
107
Gen
es
57
84
50
85
4.2481
20301
0.8816
01249
0.4134
07129
43.86
9258
List
Total
Pop
Hits
Po
p
To
tal
35
8
Fold
Enrich
ment
Bonfer
roni
Benja
mini
FDR
19.888
88889
0.4981
24327
0.4981
24327
35.65
0122
Po
p
To
tal
28
57
Fold
Enrich
ment
Bonfer
roni
Benja
mini
FDR
34.033
22884
1.04E24
1.04E24
4.84E
-23
P01
4
871,
P01
857,
P01
854
PANTHER_PATHWAY
9
List
Total
Pop
Hits
29
55
697,
P03
952,
P00
748,
P05
160,
P01
023,
P00
747,
P00
734,
P07
225
4.22 1.46E- P02
29
5352
06
671,
P36
955,
P08
697,
P00
747,
P08
519,
Q96
IY4
REACTOME_PATHWAY
PANTHER_P
ATHWAY
P00050:Plasminog
en activating
cascade
6
Category
Term
Co
unt
%
PValu
e
Gen
es
REACTOME_
PATHWAY
REACT_604:Hem
ostasis
27
19.0
1408
3.08E17
P04
196,
P02
751,
P04
114,
P04
070,
P02
775,
P01
008,
P09
486,
P01
009,
P08
697,
P05
160,
P07
996,
P00
734,
P01
023,
108
22
28
57
26.868
33856
2.19E05
1.09E05
0.001
015
List
Total
Pop
Hits
Fold
Enrich
ment
Bonfer
roni
Benja
mini
FDR
54
235
Po
p
To
tal
33
98
7.2297
87234
6.17E16
6.17E16
2.35E
-14
REACTOME_
PATHWAY
REACT_6900:Sign
aling in Immune
system
17
11.9
7183
3.54E06
P07
225,
P02
671,
P02
787,
P01
042,
P02
768,
P00
742,
P05
155,
P00
740,
P10
909,
P04
275,
P03
952,
P00
748,
P00
747,
P02
647
P02
751,
P01
031,
P07
357,
P07
358,
P04
114,
P02
748,
P04
070,
P07
360,
P09
871,
P13
671,
P10
643,
P01
834,
P00
751,
P01
024,
P00
734,
P06
681,
109
54
286
33
98
3.7403
5224
7.09E05
3.54E05
0.002
6962
P07
225
REACTOME_
PATHWAY
REACT_602:Meta
bolism of lipids
and lipoproteins
8
5.63
3803
0.0079
28057
REACTOME_
PATHWAY
REACT_13552:Int
egrin cell surface
interactions
5
3.52
1127
0.0362
70994
P04
114,
P02
649,
P02
768,
P02
655,
P06
727,
P02
656,
P02
652,
P02
647
P02
671,
P02
751,
P04
275,
P04
004,
P07
996
54
150
33
98
3.3560
49383
0.1471
68269
0.0516
81004
5.878
1772
54
81
33
98
3.8843
16415
0.5223
62292
0.1686
67706
24.51
1242
(B) Summary of PANTHER Analysis
Pathways
List Total
Count
Expected
+/-
p-value
Unclassified
17174
99
109.05
-
1.00E+00
Blood coagulation
57
17
0.36
+
3.79E-21
Plasminogen activating cascade
18
5
0.11
+
2.43E-05
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
38
1
0.24
+
4.30E-02
FAS signaling pathway
38
1
0.24
+
4.50E-02
Integrin signalling pathway
209
1
1.33
-
3.90E-02
p53 pathway
109
1
0.69
+
1.00E+00
Transcription regulation by bZIP transcription factor
58
1
0.37
+
1.00E+00
Nicotinic acetylcholine receptor signaling pathway
105
1
0.67
+
1.00E+00
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
63
1
0.4
+
1.00E+00
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
60
1
0.38
+
1.00E+00
110
Arginine biosynthesis
9
1
0.06
+
1.00E+00
Gonadotropin releasing hormone receptor pathway
282
1
1.79
-
1.00E+00
Inflammation mediated by chemokine and cytokine signaling pathway
289
1
1.84
-
1.00E+00
Huntington disease
164
1
1.04
-
1.00E+00
General transcription regulation
41
1
0.26
+
1.00E+00
Biological Process
List Total
Count
Expected
+/-
p- value
Proteolysis
1131
53
7.18
+
4.04E-30
Complement activation
99
22
0.63
+
4.92E-25
Blood coagulation
271
28
1.72
+
2.43E-23
Response to external stimulus
271
28
1.72
+
2.43E-23
Immune system process
2480
53
15.75
+
2.24E-14
Unclassified
6816
6
43.28
-
1.93E-13
Immune response
725
28
4.6
+
2.46E-12
Response to stimulus
1767
42
11.22
+
3.40E-12
Protein metabolic process
3178
55
20.18
+
3.90E-11
Cell-cell adhesion
724
24
4.6
+
5.69E-09
Cell adhesion
1301
28
8.26
+
1.79E-06
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3782
5
24.02
-
9.89E-05
Metabolic process
8127
77
51.61
+
7.45E-04
Lipid transport
220
9
1.4
+
2.23E-03
Primary metabolic process
7813
73
49.61
+
3.52E-03
Transcription
2224
2
14.12
-
7.65E-03
Transcription from RNA polymerase II promoter
2214
2
14.06
-
8.14E-03
Molecular Function
List Total
Count
Expected
+/-
p- value
Lipid transporter activity
102
24
0.65
+
4.23E-28
Serine-type peptidase activity
350
30
2.22
+
6.57E-23
Serine-type endopeptidase inhibitor activity
125
21
0.79
+
2.10E-21
Peptidase inhibitor activity
196
22
1.24
+
8.82E-19
Peptidase activity
717
33
4.55
+
3.40E-17
Enzyme inhibitor activity
389
22
2.47
+
1.17E-12
Metallopeptidase activity
233
17
1.48
+
3.16E-11
Hydrolase activity
2223
40
14.12
+
8.57E-08
Unclassified
7724
18
49.05
-
1.87E-07
Transporter activity
1049
25
6.66
+
1.55E-06
Protein binding
3073
44
19.51
+
9.98E-06
Nucleic acid binding
3715
4
23.59
-
2.24E-05
Enzyme regulator activity
1216
23
7.72
+
3.66E-04
Calmodulin binding
279
10
1.77
+
1.97E-03
DNA binding
2309
2
14.66
-
3.93E-03
Calcium-dependent phospholipid binding
139
7
0.88
+
5.04E-03
Transcription factor activity
2041
2
12.96
-
2.05E-02
111
Transcription regulator activity
2041
2
12.96
-
2.05E-02
Transferase activity
1601
1
10.17
-
4.49E-02
Cellular Component
List Total
Count
Expected
+/-
p- value
Extracellular region
601
18
3.82
+
2.04E-06
Intermediate filament cytoskeleton
87
5
0.55
+
9.18E-03
Extracellular matrix
558
11
3.54
+
3.28E-02
Unclassified
17814
101
113.12
-
4.34E-02
PANTHER Protein Class
List Total
Count
Expected
+/-
p- value
Apolipoprotein
102
24
0.65
+
5.10E-28
Serine protease
350
30
2.22
+
7.94E-23
Complement component
90
20
0.57
+
1.33E-22
Transfer/carrier protein
475
32
3.02
+
2.30E-21
Serine protease inhibitor
125
21
0.79
+
2.54E-21
Protease inhibitor
196
22
1.24
+
1.07E-18
Protease
717
33
4.55
+
4.11E-17
Defense/immunity protein
694
30
4.41
+
1.26E-14
Metalloprotease
233
17
1.48
+
3.82E-11
Hydrolase
1852
40
11.76
+
3.95E-10
Unclassified
6898
11
43.8
-
1.96E-09
Cell adhesion molecule
668
19
4.24
+
9.40E-06
Nucleic acid binding
2724
3
17.3
-
2.31E-03
Intracellular calcium-sensing protein
279
10
1.77
+
2.38E-03
Calmodulin
279
10
1.77
+
2.38E-03
Annexin
139
7
0.88
+
6.09E-03
Enzyme modulator
1540
23
9.78
+
1.85E-02
Transcription factor
2041
2
12.96
-
2.47E-02
Intermediate filament
87
5
0.55
+
4.59E-02
112
Table S9. ELISA-based measurement of serum HPX, Apo E, Apo A1 and RBP in healthy
controls and different grades of meningioma patients
A. ELISA-based measurement of serum HPX
HC
HC 01
HC 02
HC 03
HC 04
HC 05
HC 06
HC 07
HC 08
HC 09
HC 10
HC 11
HC 12
HC 13
HC 14
HC 15
HC 16
HC 17
HC 18
HC 19
HC 20
HC 21
HC 22
HC 23
Conc.
(g/L)
1.21
1.09
0.89
0.78
0.83
0.68
1.23
1.07
1.06
1.31
0.82
0.67
1.33
1.32
0.98
0.49
1.06
1.28
0.84
0.93
1.18
1.21
0.97
HC
HC 24
HC 25
HC 26
HC 27
HC 28
HC 29
HC 30
HC 31
HC 32
HC 33
HC 34
HC 35
HC 36
HC 37
HC 38
HC 39
HC 40
HC 41
HC 42
HC 43
HC 44
HC 45
Conc.
(g/L)
1.18
1.07
1.02
0.97
0.69
0.85
0.7
0.49
0.93
1.11
1.23
1.05
0.89
1.07
1.02
0.68
0.7
0.67
0.91
1.23
1.17
1.08
MG I
MG I (1)
MG I (2)
MG I (3)
MG I (4)
MG I (5)
MG I (6)
MG I (7)
MG I (8)
MG I (9)
MG I (10)
MG I (11)
MG I (12)
MG I (13)
MG I (14)
Conc.
(g/L)
1.71
1.03
1.16
0.59
2.19
0.56
0.91
1.8
1.43
1.37
0.67
1.78
1.87
1.61
MG II
Conc. (g/L)
MG II (1)
MG II (2)
MG II (3)
MG II (4)
MG II (5)
MG II (1)
1.04
2.63
2.68
2.43
3.71
1.04
MG III*
MG III (1)
MG III (2)
MG III (3)
Conc. (g/L)
3.7
3.65
3.82
HC
MG I
MG II
MG III*
Number of subjects
45
14
5
3
Minimum
0.49
0.56
1.04
3.65
25% Percentile
0.83
0.85
1.74
3.65
Median
1.02
1.4
2.63
3.7
75% Percentile
1.18
1.78
3.19
3.82
113
Maximum
1.33
2.19
3.71
3.82
Mean
0.97
1.33
2.49
3.72
Std. Deviation
0.22
0.52
0.95
0.09
Std. Error of Mean
0.03
0.14
0.43
0.05
B. ELISA-based measurement of serum Apo E
HC
Conc.
(mg/L)
HC
Conc.
(mg/L)
MG I
Conc.
(mg/L)
MG II
Conc. (mg/L)
HC 01
HC 02
HC 03
HC 04
HC 05
HC 06
HC 07
HC 08
HC 09
HC 10
HC 11
HC 12
HC 13
HC 14
HC 15
HC 16
HC 17
HC 18
HC 19
HC 20
HC 21
HC 22
HC 23
42.78
56.09
146.1
65.09
151.24
49.87
157.67
102.6
43.89
149.08
60.45
147.09
42.89
40.87
60.46
77.89
89.76
49.8
56.03
48.1
53.95
48.03
65.23
HC 24
HC 25
HC 26
HC 27
HC 28
HC 29
HC 30
HC 31
HC 32
HC 33
HC 34
HC 35
HC 36
HC 37
HC 38
HC 39
HC 40
HC 41
HC 42
HC 43
HC 44
HC 45
49.48
50.9
59.4
50.62
60.62
44.89
47.98
102.9
101.78
98.09
45.02
126.9
62.8
50.75
49.3
52.87
70.64
80.67
180.91
121.23
51.17
101.08
MG I (1)
MG I (2)
MG I (3)
MG I (4)
MG I (5)
MG I (6)
MG I (7)
MG I (8)
MG I (9)
MG I (10)
MG I (11)
MG I (12)
MG I (13)
MG I (14)
120.56
109.45
98.58
167.89
122.74
112.03
72.61
83.26
184.35
138.76
148.03
157.3
43.29
155.04
MG II (1)
MG II (2)
MG II (3)
MG II (4)
MG II (5)
MG II (1)
106.23
176.05
61.87
92.99
183.77
106.23
MG III*
MG III (1)
MG III (2)
MG III (3)
Conc. (mg/L)
109.67
112.78
119.67
HC
MG I
MG II
MG III*
Number of subjects
45
14
5
3
Minimum
40.87
43.29
61.87
109.7
25% Percentile
49.64
94.75
77.43
109.7
114
Median
60.45
121.7
106.2
112.8
75% Percentile
101.4
155.6
179.9
119.7
Maximum
180.9
184.4
183.8
119.7
Mean
77
122.4
124.2
114
Std. Deviation
38.13
39.45
53.43
5.118
Std. Error of Mean
5.684
10.54
23.89
2.955
C. ELISA-based measurement of serum Apo AI
HC
Conc.
(g/L)
HC
Conc.
(g/L)
MG I
Conc.
(g/L)
MG II
Conc. (g/L)
HC 01
HC 02
HC 03
HC 04
HC 05
HC 06
HC 07
HC 08
HC 09
HC 10
HC 11
HC 12
HC 13
HC 14
HC 15
HC 16
HC 17
HC 18
HC 19
HC 20
HC 21
HC 22
HC 23
1.5
1.32
1.11
0.98
1.54
1.26
0.94
1.37
1.27
1.18
0.78
1.17
1.16
1.03
1.42
1.35
0.86
0.52
1.32
1.18
1.67
1.03
0.79
HC 24
HC 25
HC 26
HC 27
HC 28
HC 29
HC 30
HC 31
HC 32
HC 33
HC 34
HC 35
HC 36
HC 37
HC 38
HC 39
HC 40
HC 41
HC 42
HC 43
HC 44
HC 45
0.56
1.26
1.45
1.34
1.29
1.41
1.17
1.21
1.39
1.22
1.18
1.27
1.15
0.73
0.94
1.03
1.12
0.67
0.91
1.23
1.17
1.08
MG I (1)
MG I (2)
MG I (3)
MG I (4)
MG I (5)
MG I (6)
MG I (7)
MG I (8)
MG I (9)
MG I (10)
MG I (11)
MG I (12)
MG I (13)
MG I (14)
3.19
2.53
3.82
0.92
0.95
1.52
0.81
0.58
2.12
2.31
0.48
0.75
2.21
2.91
MG II (1)
MG II (2)
MG II (3)
MG II (4)
MG II (5)
8.04
2.63
7.68
4.43
6.71
MG III*
MG III (1)
MG III (2)
MG III (3)
Conc. (g/L)
115
15.67
14.98
15.78
HC
MG I
MG II
MG III*
Number of subjects
45
14
5
3
Minimum
0.52
0.48
2.63
14.98
25% Percentile
1.005
0.795
3.53
14.98
Median
1.18
1.82
6.71
15.67
75% Percentile
1.32
2.63
7.86
15.78
Maximum
1.67
3.82
8.04
15.78
Mean
1.15
1.79
5.89
15.48
Std. Deviation
0.25
1.08
2.30
0.43
Std. Error of Mean
0.038
0.29
1.03
0.25
D. ELISA-based measurement of serum plasma RBP
HC
Conc.
(mg/L)
HC
Conc.
(mg/L)
MG I
Conc.
(mg/L)
MG II
Conc. (mg/L)
HC 01
HC 02
HC 03
HC 04
HC 05
HC 06
HC 07
HC 08
HC 09
HC 10
HC 11
HC 12
HC 13
HC 14
HC 15
HC 16
24.05
29.8
45.98
52.56
33.98
21.9
29.89
37.02
67.89
55.43
27.56
23.98
33.05
31.78
33.02
28.97
12.78
13.09
41.94
18.56
32.93
HC 24
HC 25
HC 26
HC 27
HC 28
HC 29
HC 30
HC 31
HC 32
HC 33
HC 34
HC 35
HC 36
HC 37
HC 38
HC 39
39.78
50.02
47.43
36.56
31.9
29.78
32.78
45.09
48.67
56.9
65.09
45.9
43.01
36.89
38.32
49.45
52.31
80.67
80.91
21.23
51.17
MG I (1)
MG I (2)
MG I (3)
MG I (4)
MG I (5)
MG I (6)
MG I (7)
MG I (8)
MG I (9)
MG I (10)
MG I (11)
MG I (12)
MG I (13)
MG I (14)
36.56
31.9
29.78
32.78
45.09
48.67
56.9
65.09
45.9
43.01
36.89
38.32
49.45
52.31
MG II (1)
MG II (2)
MG II (3)
MG II (4)
MG II (5)
MG II (1)
56.23
36.05
61.87
62.99
53.77
56.23
MG III*
MG III (1)
MG III (2)
MG III (3)
Conc. (mg/L)
HC 17
HC 18
HC 19
HC 20
HC 21
HC 40
HC 41
HC 42
HC 43
HC 44
116
43.56
35.89
41.67
HC 22
HC 23
36.73
41.78
HC 45
31.08
HC
MG I
MG II
MG III*
Number of subjects
45
14
5
3
Minimum
12.78
29.78
36.05
35.89
25% Percentile
29.85
35.62
44.91
35.89
Median
36.89
44.05
56.23
41.67
75% Percentile
49.06
50.17
62.43
43.56
Maximum
80.91
65.09
62.99
43.56
Mean
39.77
43.76
54.18
40.37
Std. Deviation
15.31
10.19
10.84
4.00
Std. Error of Mean
2.28
2.72
4.85
2.31
* MG III sample was analyzed in three technical replicates
117
Table S10. Statistical summary of ROC curve analysis for evaluating performance of
different serum proteins for prediction of grade I and grade II meningiomas
Classifier protein
HC vs. MG I
Apolipoprotein E
(Apo E)
Hemopexin (HPX)
Apolipoprotein A-I
(Apo A-I)
Plasma retinolbinding protein
(RBP4)
HC vs. MG II
MG I vs. MG II
AUC
95% CI
AUC
95% CI
AUC
95% CI
0.794
0.654 - 0.933
0.813
0.647-0.979
0.514
0.164-0.864
0.699
0.616
0.492 - 0.906
0.383 - 0.849
0.906
0.937
0.738 - 1.07
0.783 - 0.987
0.871
0.957
0.636-0.987
0.862-1.052
0.608
0.457 - 0.759
0.804
0.624 - 0.985
0.757
0.479- 0.94
Table S11. Comparison of the fold changes of the differentially expressed proteins identified from
iTRAQ data with proteins reported in published literature in tissue and CSF samples
Name of Protein
Vitamin D-binding
protein
Apolipoprotein A-I
α-1-antitrypsin
iTRAQ results obtained from Q-TOF
data
Benign
Atypical
Anaplastic
0.85
1.2
0.78
2.28
1.69
Name of Protein
Serum albumin precursor
Apolipoprotein E
α-1-antitrypsin
Transthyretin
7.09
6.24
Meningioma tissue proteomics data17
13.26
7.33
Benign
0.735
Atypical
0.374
Anaplastic
0.628
3.951
1.841
1.87
1.067
1.937
2.349
iTRAQ results obtained from QTOF data
Meningioma CSF proteomics
data20
Benign
Atypical
Anaplastic
Meningioma vs. Non brain tumor
samples
0.63
2.39
1
1
1.05
1.48
6.24
1.42
0.61
2.03
7.33
1.86
4.51
2.87
2.73
-3.1
118