Q10
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6 Beginning of the Chapter NutriMe Complete: Personalized Micronutrients Based on Your Genetic Profile Genetically Personalized Dietary Supplements MICRONUTRIENTS Genetics allows us to recognize the micronutrient requirements Bone health Osteoporosis (calcium, vitamin D, magnesium) Eye health Macular degeneration (antioxidants) Heart health Cholesterol (Omega3) Homocysteine (folic acid, vitamin B) Food intolerances Lactose intolerance (calcium) Gluten intolerance (multivitamin) Joint health Rheumatoid Arthritis (Omega3) Metabolism health Hemochromatosis (iron) Mental health Alzheimer's disease (antioxidants) Detoxification Heavy metals (calcium, selenium, iron) MICRONUTRIENTS An example of a micronutrient needed in higher doses OXIDATIVE STRESS GPX1 – A Selenoprotein which neutralizes free radicals GPX1 GPX1 Free Radical OXIDATIVE STRESS GPX1 – A Selenoprotein which neutralizes free radicals Selenium GPX1 GPX1 Free Radical OXIDATIVE STRESS GPX1 – A Selenoprotein which neutralizes free radicals GPX1 GPX1 Selenium Free Radical OXIDATIVE STRESS GPX1 – A Selenoprotein which neutralizes free radicals GPX1 GPX1 Selenium OXIDATIVE STRESS GPX1 – A Selenoprotein which neutralizes free radicals GPX1 GPX1 Selenium Neutralized OXIDATIVE STRESS GPX1 – A Selenoprotein which neutralizes free radicals Selenium deficiency 30% activity OXIDATIVER STRESS Selenium deficiency and GPX1 activity Selenium deficiency More selenium 30% activity 70% activity OXIDATIVE STRESS Genetic variations reduce activity GPX1 GPX1 Free Radical OXIDATIVE STRESS Genetic variations reduce activity GPX1 GPX1 Selenium Free Radical OXIDATIVE STRESS Genetic variations reduce activity GPX1 GPX1 Selenium weaker binding (e.g., 50% less) OXIDATIVE STRESS Genetic variations reduce activity Normal selenium 35% activity OXIDATIVE STRESS Genetic variations reduce activity Normal selenium 35% activity More selenium 60% activity OXIDATIVE STRESS The GPX1 Gene OXIDATIVE STRESS Dosage Based on Genetics GPX1 55 µg / day OXIDATIVE STRESS Dosage Based on Genetics GPX1 55 µg / Day GPX1 96 µg / Day OXIDATIVE STRESS An example of how a micronutrient has no effect OXIDATIVE STRESS Coenzyme Q10 must be activated Q10 Q10 – No effect OXIDATIVE STRESS Coenzyme Q10 must be activated Q10 Q10 – No effect NQO1 Q10 Ubiquinol antioxidant protection UBI OXIDATIVE STRESS Coenzyme Q10 must be activated Q10 Q10 – No effect NQO1 Q10 Ubiquinol antioxidant protection UBI UBI Free Radical OXIDATIVE STRESS NQO1 Activates the Q10 Coenzyme OXIDATIVE STRESS Coenzyme Q10 Must Be Activated Q10 Q10 – No effect NQO1 Q10 OXIDATIVE STRESS Coenzyme Q10 Must Be Activated Q10 Q10 – No effect NQO1 Q10 Free Radicals OXIDATIVE STRESS Coenzyme Q10 Must Be Activated Q10 – No effect Q10 NQO1 Q10 UBI UBI Free UBI Radicals UBI UBI UBI UBI OXIDATIVE STRESS Coenzyme Q10 Must Be Activated Q10 – No effect Q10 NQO1 Q10 E ALA C C Free Radicals E E E C ALA ALA OXIDATIVE STRESS Coenzyme Q10 Must Be Activated NQO1 Q10 OXIDATIVE STRESS Coenzyme Q10 Must Be Activated NQO1 NQO1 E Q10 Q10 C UBI ALA MIKRONÄHRSTOFFE Various factors which affect the calcium requirement Factor 1) Lactose intolerance MICRONUTRIENTS Lactose Intolerance and Calcium Age++ Lactase gene LACTOSE TOLERANT = 600mg calcium through diet MICRONUTRIENTS Lactose Intolerance and Calcium Age++ Lactase gene LACTOSE TOLERANT = 600mg Calcium through diet Calcium RDA 800mg/day Ca Ca 200mg/day = 800mg Calcium/day MICRONUTRIENTS Lactose Intolerance and Calcium Age++ Age++ Lactase gene LACTOSE INTOLERANT LACTOSE TOLERANT = 600mg Calcium through diet Calcium RDA 800mg/day Ca Ca Lactase gene 200mg/day = 800mg Calcium/day = 30mg Calcium through diet MICRONUTRIENTS Lactose Intolerance and Calcium Alter++ Age++ Lactase gene LACTOSE INTOLERANT LACTOSE TOLERANT = 600mg Calcium through diet Calcium RDA 800mg/day = 30mg Calcium through diet Ca Ca Ca Ca Lactase gene 770mg/day 200mg/day Ca Ca Ca = 800mg Calcium/day Ca Ca MICRONUTRIENTS Various factors which affect the calcium requirement Factor 1) Lactose intolerance Factor 2) Osteoporosis OSTEOPOROSIS Bone Density and Age Normal: bone density increases until 30 years of age and then gradually decreases Bone density Gene variations: The bone density decreases faster Osteopenia Osteoporosis 10 20 30 40 50 Age (years) 60 70 OSTEOPOROSIS Bone Density and Age Bone density PREVENTION Osteopenia Osteoporosis 10 20 30 40 50 Age(years) 60 70 OSTEOPOROSIS What Calcium Dosage is Optimal? 1500 mg 800 mg 0 mg RDA according to EFSA OSTEOPOROSIS What Calcium Dosage is Optimal? 1500 mg 1200 mg 800 mg 0 mg Effective, according to studies RDA according to EFSA OSTEOPOROSIS What Calcium Dosage is Optimal? 1500 mg 1200 mg Normal (low) risk 800 mg 800mg 0 mg Effective, according to studies RDA according to EFSA OSTEOPOROSIS What Calcium Dosage is Optimal? 1500 mg Maximum risk Normal (low) risk 1200 mg 1200mg 800 mg 800mg 0 mg Effective, according to studies RDA according to EFSA MICRONUTRIENTS Various factors which affect the calcium requirement Factor 1) Lactose intolerance Factor 2) Osteoporosis Factor 3) Detoxification of heavy metals MICRONUTRIENTS Is the RDA sufficient?? Detoxification of heavy metals PHASE 2 DETOXIFICATION Enzymes remove heavy metals from the body LEAD GSTM1 GSTT1 GSTP1 Enzymatic modification Removed by the kidneys Neutralized PHASE 2 DETOXIFICATION Genetic variation leads to less protection against lead LEAD GSTM1 GSTT1 GSTP1 Poisoning, cancer PHASE 2 DETOXIFICATION Genetic variation leads to less protection against lead LEAD GSTM1 Calcium supplement binds lead GSTT1 Ca GSTP1 Ca Ca Removed by kidneys Calcium binds lead MICRONUTRIENTS Various Factors Which Affect the Calcium Intake Factor 1) Lactose intolerance Factor 2) Osteoporosis Factor 3) Detoxification of heavy metals To summarize: what is the right dosage? CALCIUM What affects the optimal calcium intake? Recommended RDA Lactose intolerant Osteoporosis risk Limited detoxification No +0 mg No +0 mg No +0 mg Yes +150 mg No +0 mg Yes +100 mg NO +0 mg Yes +150 mg No +0 mg Yes +150 mg Yes +150 mg Yes +100 mg =800mg =1050mg 800 mg =950mg =1200mg MICRONUTRIENTS An example of how a micronutrient can have different effects OMEGA 3 An observations often made by doctors Person 1 with low HDL cholesterol The doctor recommends omega 3 supplements HDL cholesterol improves OMEGA 3 An Observations Often Made by Doctors Person 1 with low HDL cholesterol The doctor recommends omega 3 supplements HDL cholesterol improves Person 2 with low HDL cholesterol The doctor recommends omega 3 supplements HDL cholesterol is becoming worse What is the difference? APOA1 (A/A) APOA1 (G/G) OMEGA 3 An Observations Often Made by Doctors Person 1 with low HDL cholesterol APOA1 (A/A) The doctor recommends omega 3 supplements HDL cholesterol improves Person 2 with low HDL cholesterol APOA1 (G/G) The doctor recommends omega 3 supplements The doctor recommends phytosterols HDL cholesterol improves Various micronutrients achieve similar results OMEGA 3 What dosage is optimal? RDA: 250 mg Based on studies: 1000-2900mg OMEGA 3 What dosage is optimal? Daily dose 3000 mg 2900mg Study 3 1500mg Study 1 1000mg Study 2 250mg RDA according to EFSA Effective dose, according to studies Dose recommended for the general population = RDA 0 mg CHOLESTEROL Cholesterol is affected by genes CETP HDL APOA5 Cholesterol OK Genes that influence HDL CHOLESTEROL Cholesterol is affected by genes CETP HDL APOA5 Cholesterol OK Genes that influence HDL APOA1 250mg OMEGA3 CHOLESTEROL Cholesterol is affected by genes CETP HDL APOA5 Cholesterol OK Genes that influence HDL APOA1 250mg OMEGA3 APOA1 250mg Phytoster. CHOLESTEROL Cholesterol is affected by genes CETP HDL APOA5 Cholesterol OK Genes that influence HDL CETP HDL APOA5 Cholesterol too low APOA1 250mg OMEGA3 APOA1 250mg Phytoster. CHOLESTEROL Cholesterol is affected by genes CETP HDL APOA5 Cholesterol OK Genes that influence HDL CETP HDL APOA5 Cholesterol too low APOA1 250mg OMEGA3 APOA1 250mg Phytoster. APOA1 1500mg OMEGA3 CHOLESTEROL Cholesterol is affected by genes CETP HDL APOA5 Cholesterol OK Genes that influence HDL CETP HDL APOA5 Cholesterol too low APOA1 250mg OMEGA3 APOA1 250mg Phytoster. APOA1 1500mg OMEGA3 APOA1 1500mg Phytoster. SUMMARY Genes Influence the Micronutrient requirement Genes influence the effect of MN’s Genes influence the necessary dosage By analysing 50+ genes, we can individually dose 20 + micronutrients For 50 genes, there are 717 000 000 000 000 000 000 000 possible genetic profiles Each nutrient mixture is unique MICRONUTRIENTS How can you follow such a detailed requirement? MICRONUTRIENTS How Can You Follow Such an Extensive Recommendation? Standard products? The dosages are always too high or too low Personalized mixed capsules? Very expensive Microtransporter technology Easy to produce Optimal absorption MICRONUTRIENTS How Can You Follow Such an Extensive Recommendation? Various micro transporters are mixed in different ratios to produce an unique combination Vitamin C mix Vitamin A mix Zinc mix 50% w/w 4% w/w 11% w/w Molecule of filler Molecule of Vitamin C Molecule of Vitamin A Molecule of Zinc 6g 38g 22g Zinc mix Mixture for one genetic profile Vitamin A mix Vitamin C mix Instructions: ingest 8g/day Amounts differ depending on genetic profile MICRONUTRIENTS A spoon of microtransporters MICRONUTRIENTS A spoon of microtransporters Slow Release – absorbed by the body over a period of 8 hours Absorption-inhibiting micronutrients are released at different locations in the intestine The pellets can be swallowed or mixed with yogurt 6 End of the Chapter NutriMe Complete: Personalized micronutrients based on your genetic profile
