Gene Therapy and Genetic Engineering Your Goals: • Create a Concept Map to organize what you know about gene therapy. • Use the Learn.Genetics gene therapy website to help you. • Integrate what you have learned about Genetic Engineering into your Gene Therapy Concept Map. • Gene Therapy Vector Engineering Project. Concept Map Overview • A concept map is a technique used to organize information or thoughts. • Concept maps allow you to organize lots of information into a form that is easily understood. • Concept maps allow you to visualize connections within the information. Gene Therapy Word List • Targeting the right tissue • Immune response • Vectors • Single gene disorders • Naked DNA • Activating the gene • Disruption of existing genes • in vivo •Integrating the gene •Fit inside vectors •Keys to success •Viruses •Candidate diseases •Liposomes •Procedure •Integration into the germline •Risks/Challenges •ex vivo Gene Therapy AND Genetic Engineering Word List • • • • • • • • Plasmids Hemophilia Identical DNA copy Recombinant DNA tools ADA Deficiency Restriction Enzymes Adeno Associated virus Sickle Cell Anemia • Herpes Simplex Virus • Identical organism copy • Ligase • Huntingtons Disease • Retrovirus • Cloning • Adenovirus Creating a Concept Map Step 1 – Start by placing your Main Idea in the center circle or graphic. Step 2 – Decide which of the choices are your Large Topics and place them in a circle around your Main Idea. – Draw lines connecting the Main Idea and the Large Topics. Large topic Large topic Main Idea Large topic Large topic Creating a Concept Map Step 3 – Decide which Subtopics belong with each Large Topic and place them near the appropriate branch. • Cut the Topics out of the Word List so you can easily rearrange them until you have it right. – Paste your Concept Map to your poster. Concept Map! subtopics Large topic Large topic subtopics Main Idea Large topic subtopics Large topic subtopics