Meiosis QuickTime™ and a decompressor are needed to see this picture. Presented by: Kyle Beers & Annalisa Hughsam Introduction to Meiosis Meiosis is a form of cellular division that sexual reproducing organisms must be able to correctly perform in order to pass on their genes. Meiosis involves two successive divisions of a diploid (2N) eukaryotic cell of a sexually reproducing organism that results in four haploid (N) progeny cells, each with half of the genetic material of the original cell. QuickTime™ and a decompressor are needed to see this picture. Introduction to Meiosis Continued Through the mechanisms by which paternal and maternal chromosomes segregate, and the process of crossing-over, genetic variation is produced in the haploid cells. Meiosis consists of two successive nuclear divisions, meiosis I and meiosis II. Each division consists of these stages: prophase, metaphase, anaphase, and telophase. QuickTi me™ and a decompressor are needed to see thi s pi ctur e. QuickTime™ and a decompressor are needed to see this picture. Introduction Continued Below is a fun mash-up video about meiosis. It could be an excellent hook for the students. The pace of the video is quick so feel free to pause and rewind if necessary. http://www.youtube.com/watch?v=mKf8cJbgbIY&feature=related Lets start with a quick multiple choice quiz that can be used to diagnostically assess students. http://www.biology.arizona.edu/cell_bio/tutorials/meiosis/problems.h tml Ministry Expectations • Overall Expectations • D2. investigate genetic processes, including those that occur during meiosis • Specific Expectations • D2.1 use appropriate terminology related to genetic processes • D2.2 investigate the process of meiosis, using a microscope or similar instrument, or a computer simulation, and draw biological diagrams to help explain the main phases in the process • D3.1 explain the phases in the process of meiosis in terms of cell division, the movement of chromosomes, and crossing over of genetic material QuickTime™ and a decompressor are needed to see this picture. Challenges & Misconceptions Difficulty Possible Solutions Students may confuse the different stages of Use a variety of teaching/learning strategies so all types of learners are reached. The use visuals and manipulative are also very beneficial when trying to teach this concept. meiosis. Students may confuse mitosis with meiosis. A thorough recap of mitosis should be done before moving forward with meiosis. Since what happens at each stage is somewhat similar between mitosis and meiosis it will remind them of what each stage does. This is also a good time to discuss WHY we have both mitosis and meiosis. Be sure to assess if they can differentiate between the two concepts. A flowchart comparing the two process may also help. Students may confuse terms, such as chromatid with chromosome, centrosome with centrioles, and centrosome with centromere Provide manipulative that students can use to construct cells or parts of cells going through meiosis. This will help them put structure and function to the terms and understand how the terms are related to one another. Lesson 1: Mitosis Review Lesson Materials Needed at Number Station and Topic Lesson #1 Ğ 1. Vocabulary words Vocabu lary and definitions on Game cue cards Discussion 2. Computer, Projector 3. Textbook Lesson Instructions Assessment Mitosis Review 1. This is a short cli p (under 2 mi nutes) that quickly goes through the stages of meiosis in an amusing way! http://www. youtube.com/watch?v=mKf8cJbgbIY&feature=re lated - The video is fast paced so pausing at key parts that you would like to discuss may be beneficial. 1. Start with a quick multiple choice quiz to diagnostically assess students. Students wil l use pencil and paper to record their answers whil e the questions are projected by an LCD projector. There are 10 problems. -Correct matching of vocabulary - Speak to individual students and have them put concepts in own terms -Diagnostic assessment from video K/U http://www. biology.arizona.edu/ce ll _bio/tutorials/meiosis/problems.html 2. Students play memory game in which they match terms to definitions. Handout provided below. In pairs students take turns fli pping over two cards. If you have a match (a vocabulary term with the correct definition), you may remove both cards from the board. No match; they get fli pped back. Play until all cards are gone. Student with most pairs wins. 3. As a class discuss why mi tosis is im portant. Could there be other types of cell division that anim als use? What are they and why are they needed or useful? Link: http://www.youtube.com/watch?v=mKf8cJY&feature=related http://www.biology.arizona.edu/cell_bio/tutorials/meiosis/problems.html Lesson 2: Overview of Meiosis Lesson #2 Ğ Video Concept Map - Computer, projector - Concept map, lined paper - Textbook Overview of Meiosis 1. Play video A rubric would be used to http://www.su manasinc.com/webcontent/animations/content/meiosis.html assess the 2. Do short quiz as class. students work based 3. Provide students with concept map of the stages of meiosis. We on the used one that has both mitosis and meiosis on it. achievement strands. - http://www.anatomytime.com/2010 /09/meiosis-vs-mitosis.html 4. On a separate piece of paper students must write a description of what occurs in each stage of meiosis I and II. Some students may need to use textbook f or reference. 5. Have Students compare and contrast mitosis and meiosis on the same sheet of paper as their descriptions of the processes. Also, in a few sentences they must summarize what is the purpose of mitosis and meiosis and why are they useful? Use examples. Link- http://www.sumanasinc.com/webcontent/animations/content/meiosis.html http://www.anatomytime.com/2010/09/meiosis-vs-mitosis.html Lesson 3: Genetic Variation Lesson #3 PowerPoint - Computer, Projector Genetic Variation 1. View and discuss the PowerPoint Question Hand out for students - www.biology4teachers.com/Cell%20Division/MEIOSIS.ppt 2. Students complete questions. They are provided below. Link: www.biology4teachers.com/Cell%20Division/MEIOSIS.ppt Lesson #4 Questions 1. What is meiosis? 2. Compare and contrast spermatogenesis and oogenesis. 3. How many phases are in meiosis? What are they? 4. Which phase is the longest? 5. What are tetrads? Assess students responses to the questions - T/I, Com Lesson 3 Questions Continued 6. Explain the importance of crossing over. 7. In terms of independent assortment – how many different combinations of sperm could a human male produce? 8. What are 3 sexual sources of genetic variation? 9. A cell containing 20 chromosomes (diploid) at the beginning of the meiosis would, at its completion, produce cells containing how many chromosomes? 10. What is karyotype? 11. Describe what happens during fertilization. 12. A cell containing 40 chromatids at the beginning of meiosis would, at its completion, produce cells containing how many chromosomes? Lesson 4: Karyotyping Lesson #4 Lab Gizmo 1. Computer lab 2. Gizmo work sheet Karyotyping and Chromosome linked diseases 1. Have students complete the following gizmo in pairs A rubric would be used to http://www.explorelea rning.com/index.cfm?me thod=cResource.dspDetail&ResourceID=440 assess the 2. Students complete the all of the exercise associated with this Gizmo students work based 3. End with a class discussion about various topics discussed in the Gizmo and how it is on the related to meiosis achievement strands. Link: http://www.explorelearning.com/index.cfm?method=cResource.dspDetail&ResourceID=440 QuickTime™ and a decompressor are needed to see this picture. Karyotype images of a male and female QuickTime™ and a decompressor are needed to see this picture. Lesson 5: Construction of Meiotic Cells Lesson #5 Dough 1. Computer 2. Diff erent colours of plasticine 3. Digital Camera Construction of Meiotic Cells 1. Watch the video. - http://ww w.youtube.com/watch?v=GIkGCG24xNM 2. Students work in pairs or groups of 3. They will use plasticine to construct cell going through the stages of meiosis. 3. Take a picture of each stage with the digital camera. A rubric would be used to assess the students work based on the achievement strands. Link: http://www.youtube.com/watch?v=GlkGCG24xNM QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. Application & Extensions There are some very important applications of meiosis. Genes code for everything about us, with saying this, meiosis is a process in which genes are distributed. Meiosis is really the first step of embryology, which studies the development before birth of an organism. Every animal starts out as one cell, an egg and sperm coming together. From this cell they develop tissues, and complex organ systems. It may help us understand our anatomy and why some individuals have disease or disability. It is the process that ensures no two people are alike. In meiosis, each a mother and father provide half the genetic material needed. QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. Application & Extensions Continued An understanding of meiosis is needed to move a head with genetics and evolution. With a solid grasp of meiosis students can begin to explore chromosome trait inheritance and ethics surrounding such issues. Meiosis has only been around for 1.2-5 million years so organisms had to of evolved this type of cell division. Students could also move on to study how the genes code for proteins. QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. Resources Annotated References & Internet Addresses 1) Videos This youtube video quickly introduces the stages of meiosis with a montage of songs in the background. http://www.youtube.com/watch?v=mKf8cJbgbIY&feature=related This youtube video shows meiosis in stop-motion with playdough. http://www.youtube.com/watch?v=GIkGCG24xNM 2) URLs This link is The Biology Project at the University of Arizona. It is an interactive resource for learning biology concepts. At this particular part of the resource, students can take a self-correcting tutorial related to the stages of meiosis. It has 10 questions. http://www.biology.arizona.edu/cell_bio/tutorials/meiosis/problems.html This link provides a narrated video of meiosis, a step-by-step phase tutorial and a self-correcting quiz. http://www.sumanasinc.com/webcontent/animations/content/meiosis.html This link provides a t-chart and labeled diagram that compares and contrasts mitosis and meiosis. http://www.anatomytime.com/2010/09/meiosis-vs-mitosis.html This link takes students to a gizmo. Students can sort and pair images of human chromosomes to find out specific diseases as well as the gender of a patient. There is also a vocabulary page, teacher guide, and assessment questions. http://www.explorelearning.com/index.cfm?method=cResource.dspDetail&ResourceID=440 Resources Continued 3) PowerPoints This slide show details the stages of meiosis. It introduces and explains important vocabulary and intermittently posts questions related to the content. www.biology4teachers.com/Cell%20Division/MEIOSIS.ppt 4) Ministry Documents This document outlines all curriculum expectations for the topic Meiosis. http://www.edu.gov.on.ca/eng/curriculum/secondary/2009science11_12.pdf 5) Textbooks Dunlop et al. (2011). Biology 11. Toronto: McGraw-Hill Ryerson. This textbook provides a detailed explanation of many concepts meiosis. Through the use of tables, charts, diagrams and text students are able to explore various concepts such as the stages of mitosis and meiosis, genetic variation, karyotyping, and chromosome linked diseases.