Milsana® Fungicide
Nick Macris
Director, Business Development
nmacris@marroneorganics.com
(727) 742-2571 (mobile)
(530) 750-2800 (office)
www.marroneorganics.com
Milsana® Fungicide Overview

Source: Extract from giant knotweed Reynoutria
sachalinensis (REYSA).

Target pathogens: Milsana® effectively controls powdery
mildew, gray mold, rust, and bacterial blight on ornamental
plants and edible crops.

Mode of Action: Induction of plant defense responses.
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
Reactive oxygen species
Enzymes of the phenolic pathway
Lignification of cell walls
Papilla formation
Phytoalexins
Has EPA crop and non crop registrations as biochemical
biopesticide. California - non crop label only.
Milsana® Label Recommendations

Apply at the rate of 0.5-1.0% in 50 to 100 gallons of
water per acre.

Add 0.02% wetting agent such as Nu-Film P.

Use the spray mixture preventatively at the 4-6 leaf
plant stage and repeat spraying every 7-14 days
depending on disease pressure.
Milsana® on Ornamentals
Begonias
 Lisianthus
 Salvias
 Crape myrtle
 Petunias
 Snapdragons

Freesias
 Poinsettias
 Zinnias
 Gerbera
 Roses

Diseases
Powdery Mildew (Oidium spp)
Gray Mold (Botrytis cinerea)
Rust (Puccinia antirrhini)
Milsana® on Food Crops
Cucumbers
 Melons
 Squash
 Grapes
 Peppers *

Strawberries
 Lettuce
 Pumpkins
 Tomatoes

Diseases
Powdery Mildew (Sphaerotheca spp, Erysiphe cichoracearum )
Gray Mold (Botrytis cinerea)
Bacterial blight (Xanthomonas campestris)*
Summary of Milsana® Activity
Summary of REYSA Extract Activity on Various Edible Crops and Diseases, 1994-2001
Crop / Plant
Cucumbers
Diseases
Sphaerotheca fuliginea
Induction Activity
+++
Squash
S. fuliginea
+++
Melons
S. fuliginea
+++
Grapes
Uncinula necator
+++
Peppers
Xanthomonas spp.
++
Pumpkin
S. fuliginea
++
Lettuce
Erysiphe cichoriasearum
++
Strawberries
S. macularis
++
Wheat
Erysiphe graminis
++
Beans
Botrytis cinerea
Sclerotinia
+
(-)
Field Data
Grape powdery mildew trial,
(W.D. Gubler, Univ. of California, Davis, July 2000)
Trt#
Product, sequence
Severity %
Incidence
%
(among 24 combinations tested)
1
Untreated
62.0 a
100 a
2
Serenade® WP + Rally® WP, 7x
4.0 b
40.0 b
3
Milsana®, 7x
2.2 b
28.8 b
4
Mankocide® + Microthiol® 80 DF,
5x and Sulfur 80 DF, 7x
2.0 b
32.5 b
5
Sulfur 80 DF 1x followed by
Procure® 50 WS + Sulfur 80 DF,7x
1.3 b
21.3 b
6
Serenade® WP, (low) 13x
1.2 b
33.1 b
7
Abound® 2.08 SC, 7x
0.5 b
13.8 b
Field Data
Botrytis disease ratings and yield of “Trust”
Tomatoes
(Central Mississippi Research Center, 2003)
Treatment
Untreated Control
Milsana®
Elevate® 50WG
Switch® 62.5 WG
Serenade®
Scala®
Disease
rating
(0-100%)
53.3 a
26.7 b
16.7 b
26.7 b
20.0 b
53.3 a
Marketable yield
per plant (lb)
9.6 a
11.4 b
11.2 b
11.4 b
10.7 a
10.7 a
Regulatory/Toxicology

Current EPA registration for crop and non crop
(ornamentals) uses.

CA non crop label only (MOI will submit crop label
by the end of 2007).

More targets will be added (e.g. tomato, turf).

All other crops and diseases are opportunities for
IR-4 priorities.

MOI is working on an organic formulation.
Potential IR-4 Projects

Test Milsana® as part of IPM programs in
ornamentals, vegetables, fruit, vines (Botrytis,
mildews, bacterial diseases. Other diseases ?

Test Milsana® on turf diseases.

Test efficacy against other pathogens, such as
oomycetes (Phytophthora spp. and downy
mildew).