Jessica Holttum and Jordan Standlee
 Statistics
 Molecular
Biology
 Symptoms
 Transmission
 Treatment
 Infamous
Strains
 Conclusion

5-20% of U.S.
infected


3-5 million
severe cases
worldwide


200,000
hospitalized
250,000-500,000
deaths
300 million doses
of vaccine
administered
worldwide
Source: cdc.gov
 Enveloped
virus
 HA and NA proteins



3



Hemagglutinin
Neuraminidase
“H1N1”
subtypes
A – animals/humans
B – humans only
C - asymptomatic
Source: www.micro.magnet.fsu.edu
 (-)

ssRNA genome
~14,000nt total; 8 segments
Source: www.virology.ws
 Last

1-2 day incubation
 May







about a week
include:
Fever/chills
Cough
Sore throat
Runny/stuffy nose
Muscle/Headaches
Fatigue
Vomiting/diarrhea
Source: newshealth.net
 Bacterial
pneumonia
 Ear/sinus infections
 Bronchitis
 Worsening of preexisting conditions



Asthma
Diabetes
Congestive heart disease
 Link
to schizophrenia
 Inhalation
of infected fluid particles
 Hand-to-mouth contact
 Flu “season”


Not due to temperature
Bad weather  people stay indoors  extended
close contact with others
Source: shanghaiist.com
 Rest
 Vitamin
C&A
 Fluids

Hot drinks/soup
 OTC
Medication
 Antivirals
 Prevention




Avoid crowds
Cover coughs, sneezes
Wash hands
Skip school/work
Source: recipesfromhomeonline.com
2

types
TIV



Injection
Dead virus
LAIV



Nasal spray
Attenuated virus
Cold-adapted
Source:
IFPMA
H1N1
 1/3 world population infected
 30-50 million dead

675,000 in U.S.
 Over half were age 20-40

Transmission linked to high
humidity
 3 waves in one year





Spring 1918
Fall 1918
Winter 1918-1919
“Mother of all pandemics”
Source: 1918.pandemicflu.gov
 H5N1
 First

detected 1996
Human detection 1997
 Outbreak
begins 2003
 Rare in humans; common
in birds


Attacks lower respiratory
tract
~60% mortality
 Expected
to remain in
circulation
Source:
hogueprophecy.com
 H1N1


Less virulent
Quadruple reassortant
 First
case 2009,
California
 Public Health
Emergency expired
6/23/10
 Likely to continue
seasonal spread
Source: freewebs.com














http://www.cdc.gov/flu/professionals/vaccination/vax-s
http://www.cdc.gov/flu/about/viruses/types.htm
http://www.cdc.gov/flu/keyfacts.htm
http://www.cdc.gov/flu/weekly/
http://www.cdc.gov/h1n1flu/cdcresponse.htm
http://www.cdc.gov/flu/about/qa/hospital.htm
http://www.cdc.gov/media/pressrel/2010/r100224.htm
http://www.cdc.gov/flu/about/qa/fluvaccine.htm
http://www.cdc.gov/flu/avian/outbreaks/current.htm
http://www.cdc.gov/ncidod/eid/vol12no01/05-0979.htm
http://virus.stanford.edu/uda/
http://1918.pandemicflu.gov
http://micro.magnet.fsu.edu/cells/viruses/influenzavirus.html
http://biology.kenyon.edu/BMB/Chime2/2005/CerchiaraHolsberry/FRAMES/start.htm













http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of
_the_month/pdb113_1.html
http://www.ifpma.org/Influenza/index.php?id=4234
http://health.nytimes.com/health/guides/disease/theflu/treatment.html
http://www.who.int/csr/disease/swineflu/notes/h1n1_vaccine_20090806
/en/index.htmlummary.htm
http://www.who.int/mediacentre/factsheets/fs211/en/index.html
http://www.who.int/csr/don/2009_04_24/en/index.html
http://www.who.int/csr/disease/avian_influenza/2011_01_24_h5n1_avia
n_influenza_timeline_updates.pdf
http://www.virology.ws/2009/05/01/influenza-virus-rna-genome/
http://www.sciencedaily.com/releases/2004/08/040803100609.htm
http://www.medicalnewstoday.com/articles/142829.php
http://www.ncbi.nlm.nih.gov/pubmed/21307188
http://www.nlm.nih.gov/medlineplus/ency/article/000080.htm
http://www.nlm.nih.gov/medlineplus/flu.html